Paul Krogstad

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Fatal neonatal myocarditis caused by a recombinant human enterovirus-B variant
    Paul Krogstad
    Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Pediatr Infect Dis J 27:668-9. 2008
  2. ncbi request reprint Nucleoside-analogue reverse-transcriptase inhibitors plus nevirapine, nelfinavir, or ritonavir for pretreated children infected with human immunodeficiency virus type 1
    Paul Krogstad
    University of California, Los Angeles School of Medicine, Departments of Pediatrics and Molecular and Medical Pharmacology, Los Angeles, CA, 90095, USA
    Clin Infect Dis 34:991-1001. 2002
  3. ncbi request reprint Molecular biology of the human immunodeficiency virus: current and future targets for intervention
    Paul Krogstad
    Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Semin Pediatr Infect Dis 14:258-68. 2003
  4. ncbi request reprint Mother-to-child transmission in the United States of subtypes D and A/G human immunodeficiency virus type 1
    Paul Krogstad
    Department of Pediatrics, University of California Los Angeles School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    AIDS Res Hum Retroviruses 18:413-7. 2002
  5. ncbi request reprint Human immunodeficiency virus nucleocapsid protein polymorphisms modulate the infectivity of RNA packaging mutants
    Paul Krogstad
    Department of Pediatrics, University of California, Los Angeles School of Medicine, Los Angeles, California 90095 1732, USA
    Virology 294:282-8. 2002
  6. pmc Short communication: enhanced CD8+ T cell apoptosis in HIV-infected adolescents with virologic failure on protease inhibitor-based therapy
    Jun Zuo
    David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    AIDS Res Hum Retroviruses 26:681-4. 2010
  7. ncbi request reprint Nelfinavir pharmacokinetics in stable human immunodeficiency virus-positive children: Pediatric AIDS Clinical Trials Group Protocol 377
    Leslie Carstensen Floren
    Drug Research Unit, Department of Clinical Pharmacy, University of California, San Francisco, California, USA
    Pediatrics 112:e220-7. 2003
  8. ncbi request reprint Neuropsychological functioning and viral load in stable antiretroviral therapy-experienced HIV-infected children
    Rita J Jeremy
    Pediatric Clinical Research Center, Department of Pediatrics, School of Medicine, University of California San Francisco, 505 Parnassus Ave, San Francisco, CA 94143 0105, USA
    Pediatrics 115:380-7. 2005
  9. pmc Functional analysis of HIV type 1 Nef gene variants from adolescent and adult survivors of perinatal infection
    Jun Zuo
    UCLA AIDS Institute and the David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1752, USA
    AIDS Res Hum Retroviruses 28:486-92. 2012
  10. pmc Packaging limits and stability of HIV-1 sequences in a coxsackievirus B vector
    John P Miller
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA 90095, United States
    Vaccine 27:3992-4000. 2009

Research Grants

  1. Design and Testing of a Parechovirus Vaccine Vector
    Paul Krogstad; Fiscal Year: 2005
  2. HIV Replication and Thymopoiesis in Adolescents
    Paul Krogstad; Fiscal Year: 2007
  3. Cellular Immunology of Enterovirus Infection
    Paul Krogstad; Fiscal Year: 2007

Collaborators

Detail Information

Publications27

  1. doi request reprint Fatal neonatal myocarditis caused by a recombinant human enterovirus-B variant
    Paul Krogstad
    Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Pediatr Infect Dis J 27:668-9. 2008
    ..Whole genome sequence analysis revealed the virus to be a genomic chimera that likely arose from recombination between coxsackievirus B3 and two recently identified enteroviruses, EV 86 and EV97...
  2. ncbi request reprint Nucleoside-analogue reverse-transcriptase inhibitors plus nevirapine, nelfinavir, or ritonavir for pretreated children infected with human immunodeficiency virus type 1
    Paul Krogstad
    University of California, Los Angeles School of Medicine, Departments of Pediatrics and Molecular and Medical Pharmacology, Los Angeles, CA, 90095, USA
    Clin Infect Dis 34:991-1001. 2002
    ..These regimens were similar in their drug activity, but the 4-drug regimen offered slightly more durable suppression of viremia...
  3. ncbi request reprint Molecular biology of the human immunodeficiency virus: current and future targets for intervention
    Paul Krogstad
    Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Semin Pediatr Infect Dis 14:258-68. 2003
    ..This review presents an overview of HIV replication, emphasizing recently recognized cellular and viral molecules that may be exploited in future pharmacological approaches to prevent and treat infection with HIV...
  4. ncbi request reprint Mother-to-child transmission in the United States of subtypes D and A/G human immunodeficiency virus type 1
    Paul Krogstad
    Department of Pediatrics, University of California Los Angeles School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    AIDS Res Hum Retroviruses 18:413-7. 2002
    ..Non-B subtypes should be considered in the management of HIV-1-infected pregnant women and children to optimize strategies to prevent and treat pediatric HIV-1 infection...
  5. ncbi request reprint Human immunodeficiency virus nucleocapsid protein polymorphisms modulate the infectivity of RNA packaging mutants
    Paul Krogstad
    Department of Pediatrics, University of California, Los Angeles School of Medicine, Los Angeles, California 90095 1732, USA
    Virology 294:282-8. 2002
    ..Conservative amino acid differences between HXB2 and NL4-3 NCs were sufficient to explain the difference in infectivity of viruses carrying the R10A and K11A mutations...
  6. pmc Short communication: enhanced CD8+ T cell apoptosis in HIV-infected adolescents with virologic failure on protease inhibitor-based therapy
    Jun Zuo
    David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    AIDS Res Hum Retroviruses 26:681-4. 2010
    ..However, there was a higher degree of apoptosis among viremic patients receiving PI therapy, suggesting an immunologically adverse effect of continuing PI(+) therapy after virological failure...
  7. ncbi request reprint Nelfinavir pharmacokinetics in stable human immunodeficiency virus-positive children: Pediatric AIDS Clinical Trials Group Protocol 377
    Leslie Carstensen Floren
    Drug Research Unit, Department of Clinical Pharmacy, University of California, San Francisco, California, USA
    Pediatrics 112:e220-7. 2003
    ....
  8. ncbi request reprint Neuropsychological functioning and viral load in stable antiretroviral therapy-experienced HIV-infected children
    Rita J Jeremy
    Pediatric Clinical Research Center, Department of Pediatrics, School of Medicine, University of California San Francisco, 505 Parnassus Ave, San Francisco, CA 94143 0105, USA
    Pediatrics 115:380-7. 2005
    ..Neuropsychological functioning and its correlation with viral load were investigated for previously treated HIV-infected children who underwent a change in treatment regimen...
  9. pmc Functional analysis of HIV type 1 Nef gene variants from adolescent and adult survivors of perinatal infection
    Jun Zuo
    UCLA AIDS Institute and the David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1752, USA
    AIDS Res Hum Retroviruses 28:486-92. 2012
    ..Survival into adulthood with HIV infection acquired in infancy is not uniformly linked to loss of function in nef. The Nef protein remains a potential target for immunization or pharmacologic intervention...
  10. pmc Packaging limits and stability of HIV-1 sequences in a coxsackievirus B vector
    John P Miller
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA 90095, United States
    Vaccine 27:3992-4000. 2009
    ..These studies suggest that CVB3 vectors may be useful as vaccine vector candidates, if hurdles in class I antigen presentation and stability can be overcome...
  11. ncbi request reprint Thymic function and impaired maintenance of peripheral T cell populations in children with congenital heart disease and surgical thymectomy
    Nancy J Halnon
    Division of Pediatric, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    Pediatr Res 57:42-8. 2005
    ....
  12. ncbi request reprint SARS: the first pandemic of the 21st century
    James D Cherry
    David Geffen School of Medicine at UCLA and Mattel s Children s Hospital at UCLA, Department of Pediatrics, Los Angeles, CA 90095 1752, USA
    Pediatr Res 56:1-5. 2004
  13. ncbi request reprint HIV type 1 glycoprotein 120 inhibits cardiac myocyte contraction
    Fuhua Chen
    UCLA School of Medicine, 675 C E Young Drive South, MRL 3754, Los Angeles, CA 90095 7045, USA
    AIDS Res Hum Retroviruses 18:777-84. 2002
    ..These results suggest that HIV-1 gp120 may directly contribute to cardiac dysfunction as seen in many HIV patients...
  14. pmc New Delhi metallo-β-lactamase (NDM-1)-producing Klebsiella pneumoniae: case report and laboratory detection strategies
    A Brian Mochon
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Brentwood Annex, Los Angeles, CA 90095 1732, USA
    J Clin Microbiol 49:1667-70. 2011
    ..We describe strategies for the detection of this novel resistance mechanism encountered in an isolate of Klebsiella pneumoniae...
  15. pmc Youth-specific considerations in the development of preexposure prophylaxis, microbicide, and vaccine research trials
    Bret J Rudy
    Department of Pediatrics, New York University School of Medicine, New York, NY, USA
    J Acquir Immune Defic Syndr 54:S31-42. 2010
    ..In this article, we will discuss issues around implementing each of these biomedical prevention modalities in trials among adolescents and young adults to help to guide future successful research targeting this population...
  16. pmc Genetic and stochastic influences on the interaction of human immunodeficiency virus type 1 and cytotoxic T lymphocytes in identical twins
    Otto O Yang
    UCLA AIDS Institute and Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Virol 79:15368-75. 2005
    ..These results indicate that while CTL targeting is predominately genetically determined, stochastic influences render the interaction of HIV-1 and host immunity, and therefore viral escape and CTL efficacy, unpredictable...
  17. pmc Assessment of thymic activity in human immunodeficiency virus-negative and -positive adolescents by real-time PCR quantitation of T-cell receptor rearrangement excision circles
    Thao Pham
    David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Clin Diagn Lab Immunol 10:323-8. 2003
    ..These data demonstrate the utility of TREC assessment in adolescents and that HIV infection does not uniformly result in accelerated thymic involution in childhood...
  18. pmc Fluoxetine is a potent inhibitor of coxsackievirus replication
    Jun Zuo
    Department of Pediatrics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California, USA
    Antimicrob Agents Chemother 56:4838-44. 2012
    ..In view of its favorable pharmacokinetics and safety profile, fluoxetine warrants additional study as a potential antiviral agent for enterovirus infections...
  19. pmc In Vivo Validation of a Bioinformatics Based Tool to Identify Reduced Replication Capacity in HIV-1
    Christina M R Kitchen
    Department of Biostatistics, UCLA School of Public Health, Los Angeles, California 90095, USA
    Open Med Inform J 4:225-32. 2010
    ..Thus, in this study we have verified an in silico bioinformatics result with a biological assessment to identify a unique mutation in HIV-1 that has a significant fitness defect in vivo...
  20. ncbi request reprint Two-tiered universal newborn screening strategy for severe combined immunodeficiency
    Sean A McGhee
    Department of Pediatrics Immunology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Mol Genet Metab 86:427-30. 2005
    ..Sensitivity was 85% for IL-7 screening and 100% for TREC screening. A two-tiered strategy may be of sufficient accuracy to enable universal SCID screening, and should be assessed in a prospective trial...
  21. ncbi request reprint Progressive neurodegeneration in patients with primary immunodeficiency disease on IVIG treatment
    Ulrike H M Ziegner
    Department of Pediatrics, UCLA School of Medicine, Los Angeles, California, USA
    Clin Immunol 102:19-24. 2002
    ..To help determine the etiology of this rare complication, an international surveillance system for primary immunodeficiency patients who develop progressive neurodegeneration of unknown cause is recommended...
  22. ncbi request reprint Thymic volume, T-cell populations, and parameters of thymopoiesis in adolescent and adult survivors of HIV infection acquired in infancy
    Jason C Lee
    David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1721, USA
    AIDS 20:667-74. 2006
    ....
  23. ncbi request reprint Growth of human immunodeficiency virus-infected children receiving highly active antiretroviral therapy
    Sharon A Nachman
    Department of Pediatrics, State University of New York Health Science Center at Stony Brook, Stony Brook, NY 11794, USA
    Pediatr Infect Dis J 24:352-7. 2005
    ..Previous reports of the effect of highly active antiretroviral therapy (HAART) on the growth of HIV-infected children have been contradictory...
  24. ncbi request reprint Reported adherence as a determinant of response to highly active antiretroviral therapy in children who have human immunodeficiency virus infection
    Russell B Van Dyke
    Department of Pediatrics, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Pediatrics 109:e61. 2002
    ..Little is known about the adherence of children to HAART. The objective of this study was to identify correlates of adherence to HAART and the relationship between adherence and study outcomes in a pediatric clinical trial...
  25. ncbi request reprint Immunological response to highly active antiretroviral therapy in children with clinically stable HIV-1 infection
    Howard M Rosenblatt
    Allergy and Immunology Section, Texas Children s Hospital, Houston 77030, USA
    J Infect Dis 192:445-55. 2005
    ..At week 44 of HAART, the major immunological parameters in these HIV-1-infected children moved from baseline values to about halfway to two-thirds of the way toward the values in healthy, uninfected children...
  26. ncbi request reprint Resistance to antiretroviral drugs: a threat to the prevention and treatment of pediatric HIV infection
    Paul A Krogstad
    J Infect Dis 195:1393-5. 2007
  27. ncbi request reprint Tetanus immunity after diphtheria, tetanus toxoids, and acellular pertussis vaccination in children with clinically stable HIV infection
    Howard M Rosenblatt
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    J Allergy Clin Immunol 116:698-703. 2005
    ..HIV infection often impairs the immune response to childhood vaccines...

Research Grants8

  1. Design and Testing of a Parechovirus Vaccine Vector
    Paul Krogstad; Fiscal Year: 2005
    ..We propose to construct and complete the initial in vitro testing of a parechovirus based vaccine vector, based on strategies already employed in the successful construction of enteroviral vectors. ..
  2. HIV Replication and Thymopoiesis in Adolescents
    Paul Krogstad; Fiscal Year: 2007
    ....
  3. Cellular Immunology of Enterovirus Infection
    Paul Krogstad; Fiscal Year: 2007
    ..These studies will provide a foundation for further studies of host-pathogen relationships in picornavirus disease and the potential utility of picornaviruses as enterally delivered vaccine vectors. ..