Genomes and Genes
Affiliation: University of California
- Fatal neonatal myocarditis caused by a recombinant human enterovirus-B variantPaul Krogstad
Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Pediatr Infect Dis J 27:668-9. 2008..Whole genome sequence analysis revealed the virus to be a genomic chimera that likely arose from recombination between coxsackievirus B3 and two recently identified enteroviruses, EV 86 and EV97...
- Nucleoside-analogue reverse-transcriptase inhibitors plus nevirapine, nelfinavir, or ritonavir for pretreated children infected with human immunodeficiency virus type 1Paul Krogstad
University of California, Los Angeles School of Medicine, Departments of Pediatrics and Molecular and Medical Pharmacology, Los Angeles, CA, 90095, USA
Clin Infect Dis 34:991-1001. 2002..These regimens were similar in their drug activity, but the 4-drug regimen offered slightly more durable suppression of viremia...
- Molecular biology of the human immunodeficiency virus: current and future targets for interventionPaul Krogstad
Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Semin Pediatr Infect Dis 14:258-68. 2003..This review presents an overview of HIV replication, emphasizing recently recognized cellular and viral molecules that may be exploited in future pharmacological approaches to prevent and treat infection with HIV...
- Mother-to-child transmission in the United States of subtypes D and A/G human immunodeficiency virus type 1Paul Krogstad
Department of Pediatrics, University of California Los Angeles School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
AIDS Res Hum Retroviruses 18:413-7. 2002..Non-B subtypes should be considered in the management of HIV-1-infected pregnant women and children to optimize strategies to prevent and treat pediatric HIV-1 infection...
- Human immunodeficiency virus nucleocapsid protein polymorphisms modulate the infectivity of RNA packaging mutantsPaul Krogstad
Department of Pediatrics, University of California, Los Angeles School of Medicine, Los Angeles, California 90095 1732, USA
Virology 294:282-8. 2002..Conservative amino acid differences between HXB2 and NL4-3 NCs were sufficient to explain the difference in infectivity of viruses carrying the R10A and K11A mutations...
- Short communication: enhanced CD8+ T cell apoptosis in HIV-infected adolescents with virologic failure on protease inhibitor-based therapyJun Zuo
David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
AIDS Res Hum Retroviruses 26:681-4. 2010..However, there was a higher degree of apoptosis among viremic patients receiving PI therapy, suggesting an immunologically adverse effect of continuing PI(+) therapy after virological failure...
- Nelfinavir pharmacokinetics in stable human immunodeficiency virus-positive children: Pediatric AIDS Clinical Trials Group Protocol 377Leslie Carstensen Floren
Drug Research Unit, Department of Clinical Pharmacy, University of California, San Francisco, California, USA
Pediatrics 112:e220-7. 2003..NFV dosed at 55 mg/kg BID in children who are <30 kg provides comparable exposure to that measured in children who are >25 kg and receiving NFV 30 mg/kg TID...
- Neuropsychological functioning and viral load in stable antiretroviral therapy-experienced HIV-infected childrenRita J Jeremy
Pediatric Clinical Research Center, Department of Pediatrics, School of Medicine, University of California San Francisco, 505 Parnassus Ave, San Francisco, CA 94143 0105, USA
Pediatrics 115:380-7. 2005..Neuropsychological functioning and its correlation with viral load were investigated for previously treated HIV-infected children who underwent a change in treatment regimen...
- Functional analysis of HIV type 1 Nef gene variants from adolescent and adult survivors of perinatal infectionJun Zuo
UCLA AIDS Institute and the David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1752, USA
AIDS Res Hum Retroviruses 28:486-92. 2012..Survival into adulthood with HIV infection acquired in infancy is not uniformly linked to loss of function in nef. The Nef protein remains a potential target for immunization or pharmacologic intervention...
- Packaging limits and stability of HIV-1 sequences in a coxsackievirus B vectorJohn P Miller
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA 90095, United States
Vaccine 27:3992-4000. 2009..These studies suggest that CVB3 vectors may be useful as vaccine vector candidates, if hurdles in class I antigen presentation and stability can be overcome...
- Thymic function and impaired maintenance of peripheral T cell populations in children with congenital heart disease and surgical thymectomyNancy J Halnon
Division of Pediatric, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
Pediatr Res 57:42-8. 2005....
- SARS: the first pandemic of the 21st centuryJames D Cherry
David Geffen School of Medicine at UCLA and Mattel's Children's Hospital at UCLA, Department of Pediatrics, Los Angeles, CA 90095-1752, USA
Pediatr Res 56:1-5. 2004
- HIV type 1 glycoprotein 120 inhibits cardiac myocyte contractionFuhua Chen
UCLA School of Medicine, 675 C E Young Drive South, MRL 3754, Los Angeles, CA 90095 7045, USA
AIDS Res Hum Retroviruses 18:777-84. 2002..These results suggest that HIV-1 gp120 may directly contribute to cardiac dysfunction as seen in many HIV patients...
- New Delhi metallo-β-lactamase (NDM-1)-producing Klebsiella pneumoniae: case report and laboratory detection strategiesA Brian Mochon
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Brentwood Annex, Los Angeles, CA 90095 1732, USA
J Clin Microbiol 49:1667-70. 2011..We describe strategies for the detection of this novel resistance mechanism encountered in an isolate of Klebsiella pneumoniae...
- Youth-specific considerations in the development of preexposure prophylaxis, microbicide, and vaccine research trialsBret J Rudy
Department of Pediatrics, New York University School of Medicine, New York, NY, USA
J Acquir Immune Defic Syndr 54:S31-42. 2010..In this article, we will discuss issues around implementing each of these biomedical prevention modalities in trials among adolescents and young adults to help to guide future successful research targeting this population...
- Genetic and stochastic influences on the interaction of human immunodeficiency virus type 1 and cytotoxic T lymphocytes in identical twinsOtto O Yang
UCLA AIDS Institute and Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
J Virol 79:15368-75. 2005..These results indicate that while CTL targeting is predominately genetically determined, stochastic influences render the interaction of HIV-1 and host immunity, and therefore viral escape and CTL efficacy, unpredictable...
- Assessment of thymic activity in human immunodeficiency virus-negative and -positive adolescents by real-time PCR quantitation of T-cell receptor rearrangement excision circlesThao Pham
David Geffen School of Medicine, University of California, Los Angeles, California, USA
Clin Diagn Lab Immunol 10:323-8. 2003..These data demonstrate the utility of TREC assessment in adolescents and that HIV infection does not uniformly result in accelerated thymic involution in childhood...
- Fluoxetine is a potent inhibitor of coxsackievirus replicationJun Zuo
Department of Pediatrics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California, USA
Antimicrob Agents Chemother 56:4838-44. 2012..In view of its favorable pharmacokinetics and safety profile, fluoxetine warrants additional study as a potential antiviral agent for enterovirus infections...
- In Vivo Validation of a Bioinformatics Based Tool to Identify Reduced Replication Capacity in HIV-1Christina M R Kitchen
Department of Biostatistics, UCLA School of Public Health, Los Angeles, California 90095, USA
Open Med Inform J 4:225-32. 2010..Thus, in this study we have verified an in silico bioinformatics result with a biological assessment to identify a unique mutation in HIV-1 that has a significant fitness defect in vivo...
- Two-tiered universal newborn screening strategy for severe combined immunodeficiencySean A McGhee
Department of Pediatrics Immunology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
Mol Genet Metab 86:427-30. 2005..Sensitivity was 85% for IL-7 screening and 100% for TREC screening. A two-tiered strategy may be of sufficient accuracy to enable universal SCID screening, and should be assessed in a prospective trial...
- Progressive neurodegeneration in patients with primary immunodeficiency disease on IVIG treatmentUlrike H M Ziegner
Department of Pediatrics, UCLA School of Medicine, Los Angeles, California, USA
Clin Immunol 102:19-24. 2002..To help determine the etiology of this rare complication, an international surveillance system for primary immunodeficiency patients who develop progressive neurodegeneration of unknown cause is recommended...
- Thymic volume, T-cell populations, and parameters of thymopoiesis in adolescent and adult survivors of HIV infection acquired in infancyJason C Lee
David Geffen School of Medicine at UCLA, Los Angeles, California 90095-1721, USA
AIDS 20:667-74. 2006..CONCLUSIONS: Long term survivors of pediatric HIV infection appear to have retained or recovered thymic volume and thymic activity approximating uninfected youths...
- Growth of human immunodeficiency virus-infected children receiving highly active antiretroviral therapySharon A Nachman
Department of Pediatrics, State University of New York Health Science Center at Stony Brook, Stony Brook, NY 11794, USA
Pediatr Infect Dis J 24:352-7. 2005..Previous reports of the effect of highly active antiretroviral therapy (HAART) on the growth of HIV-infected children have been contradictory...
- Reported adherence as a determinant of response to highly active antiretroviral therapy in children who have human immunodeficiency virus infectionRussell B Van Dyke
Department of Pediatrics, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
Pediatrics 109:e61. 2002..Little is known about the adherence of children to HAART. The objective of this study was to identify correlates of adherence to HAART and the relationship between adherence and study outcomes in a pediatric clinical trial...
- Immunological response to highly active antiretroviral therapy in children with clinically stable HIV-1 infectionHoward M Rosenblatt
Allergy and Immunology Section, Texas Children s Hospital, Houston 77030, USA
J Infect Dis 192:445-55. 2005..At week 44 of HAART, the major immunological parameters in these HIV-1-infected children moved from baseline values to about halfway to two-thirds of the way toward the values in healthy, uninfected children...
- Resistance to antiretroviral drugs: a threat to the prevention and treatment of pediatric HIV infectionPaul A Krogstad
J Infect Dis 195:1393-5. 2007
- Tetanus immunity after diphtheria, tetanus toxoids, and acellular pertussis vaccination in children with clinically stable HIV infectionHoward M Rosenblatt
Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
J Allergy Clin Immunol 116:698-703. 2005..HIV infection often impairs the immune response to childhood vaccines...
- Design and Testing of a Parechovirus Vaccine VectorPaul Krogstad; Fiscal Year: 2005..We propose to construct and complete the initial in vitro testing of a parechovirus based vaccine vector, based on strategies already employed in the successful construction of enteroviral vectors. ..
- HIV Replication and Thymopoiesis in AdolescentsPaul Krogstad; Fiscal Year: 2007....
- Cellular Immunology of Enterovirus InfectionPaul Krogstad; Fiscal Year: 2007..These studies will provide a foundation for further studies of host-pathogen relationships in picornavirus disease and the potential utility of picornaviruses as enterally delivered vaccine vectors. ..