Affiliation: University of California
- Treatment of human immunodeficiency virus 1-infected infants and children with the protease inhibitor nelfinavir mesylateP Krogstad
Department of Pediatrics, UCLA, Los Angeles, California, 90095 3075, USA
Clin Infect Dis 28:1109-18. 1999..Suppression of viremia was achieved in children as young as 3 months of age...
- Genetic evaluation of suspected cases of transient HIV-1 infection of infantsL M Frenkel
Department of Pediatrics, University of Rochester, Rochester, NY 14642, USA
Science 280:1073-7. 1998..These findings argue that transient HIV-1 infection, if it exists, will only rarely be satisfactorily documented...
- HIV-1 Gag protein associates with F-actin present in microfilamentsO Rey
Department of Pediatrics, School of Medicine, University of California at Los Angeles 90095, USA
Virology 220:530-4. 1996..In vivo and in vitro analyses of this interaction indicated that the unprocessed Gag polyprotein is capable of association with polymerized actin (F-actin). Binding of Gag to F-actin may be involved in the assembly or budding of HIV-1...
- Cryoelectron microscopic examination of human immunodeficiency virus type 1 virions with mutations in the cyclophilin A binding loopL B Kong
Department of Molecular and Medical Pharmacology and Crump Institute for Biological Imaging, UCLA School of Medicine, Los Angeles, California 90095, USA
J Virol 72:4403-7. 1998..Although viral RNA incorporation and protease cleavage of the Gag precursor were not affected by these mutations, cryoelectron microscopy revealed a loss of virion maturation in P231A particles...
- HIV type 1 Gag and nucleocapsid proteins: cytoskeletal localization and effects on cell motilityF J Ibarrondo
Department of Pediatrics, UCLA School of Medicine, Los Angeles, California 90095, USA
AIDS Res Hum Retroviruses 17:1489-500. 2001..These data suggest that interactions between HIV-1 Gag and actin in infected cells enhance cell motility. Ultimately this enhanced motility of infected cells could promote the dissemination of virus into the brain and other tissues...
- Cells with high cyclophilin A content support replication of human immunodeficiency virus type 1 Gag mutants with decreased ability to incorporate cyclophilin AB Ackerson
Department of Pediatrics, University of California, Los Angeles 90095, USA
J Virol 72:303-8. 1998..These experiments demonstrated that a higher cellular CyPA content of some cells was able to compensate for the decreased binding affinity of P222A mutant Gag for CyPA, allowing virus replication to occur...
- Performance of the applied biosystems ViroSeq human immunodeficiency virus type 1 (HIV-1) genotyping system for sequence-based analysis of HIV-1 in pediatric plasma samplesS Cunningham
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
J Clin Microbiol 39:1254-7. 2001..This genotyping system performs well for analysis of HIV-1 in pediatric plasma samples, including those with low volume and low viral load. The availability of this system should facilitate studies of HIV-1 drug resistance...