Research Topics
Genomes and Genes | David KrizajSummaryAffiliation: University of Utah Country: USA Publications
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Publications
Calcium stores in vertebrate photoreceptorsDavid Krizaj
Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
Adv Exp Med Biol 740:873-89. 2012..CICR and SOCE may also modulate the transmission of afferent and efferent signals in the outer retina. Thus, Ca(2+) stores provide additional complexity, adaptability, tuneability and speed to photoreceptor signaling...- Plasticity of TRPM1 expression and localization in the wild type and degenerating mouse retinaDavid Krizaj
Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, Salt Lake City, UT 84132, United States
Vision Res 50:2460-5. 2010..These findings show that expression and localization of the TRPM1 in the mouse retina is plastic, modulated by use-dependence and availability of sustained excitatory input... - Intracellular pH modulates inner segment calcium homeostasis in vertebrate photoreceptorsDavid Krizaj
Department of Ophthalmology, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, 84132, USA
Am J Physiol Cell Physiol 300:C187-97. 2011..In summary, this data suggest that endogenously produced protons continually modulate the membrane potential, release from Ca²(+) stores, and intracellular Ca²(+) buffering in rod and cone inner segments... - Localization and phenotype-specific expression of ryanodine calcium release channels in C57BL6 and DBA/2J mouse strainsWei Huang
Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
Exp Eye Res 93:700-9. 2011..While RyR1 signals can be regulated in a strain-specific manner, our data also suggest that RyR1 transcription is induced by early glial activation and/or elevation in intraocular pressure... - Anatomical and neurochemical characterization of dopaminergic interplexiform processes in mouse and rat retinasPaul Witkovsky
Department of Ophthalmology, New York University School of Medicine, New York, New York 10016, USA
J Comp Neurol 510:158-74. 2008..Outer retinal varicosities of this putative GABAergic IPC did colocalize synaptic vesicle protein 2a, suggesting they possessed a conventional vesicular release mechanism... - The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cellsDaniel A Ryskamp
Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, Interdepartmental Program in Neuroscience, and Department of Physiology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
J Neurosci 31:7089-101. 2011..Excessive Ca2+ influx through TRPV4 predisposes RGCs to activation of Ca2+ -dependent proapoptotic signaling pathways, indicating that TRPV4 is a component of the response mechanism to pathological elevations of intraocular pressure... - Scotopic visual signaling in the mouse retina is modulated by high-affinity plasma membrane calcium extrusionJacque L Duncan
Department of Ophthalmology, University of California San Francisco School of Medicine, San Francisco, California 94143 0730, USA
J Neurosci 26:7201-11. 2006..These results suggest that PMCA2-mediated Ca2+ extrusion modulates the amplitude and timing of the high-sensitivity rod pathway to a much greater extent than that of the cone pathway... - Missing optomotor head-turning reflex in the DBA/2J mousePeter Barabas
Department of Ophthalmology and Visual Sciences, John Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
Invest Ophthalmol Vis Sci 52:6766-73. 2011.... - Depletion of calcium stores regulates calcium influx and signal transmission in rod photoreceptorsTamas Szikra
Department of Ophthalmology, UCSF School of Medicine, San Francisco, CA 94143, USA
J Physiol 586:4859-75. 2008..Rods were immunopositive for TRPC1 whereas cone inner segments immunostained with TRPC6 channel antibodies. Thus, SOCE modulates Ca(2+) homeostasis and light-evoked neurotransmission at the rod photoreceptor synapse mediated by TRPC1... - Ryanodine stores and calcium regulation in the inner segments of salamander rods and conesDavid Krizaj
Department of Ophthalmology, UCSF School of Medicine, San Francisco, CA 94143, USA
J Physiol 547:761-74. 2003.... - Intracellular organelles and calcium homeostasis in rods and conesTamas Szikra
Department of Ophthalmology, UCSF School of Medicine, San Francisco, California, USA
Vis Neurosci 24:733-43. 2007..Local [Ca2+]i levels are set by interactions between the plasma membrane Ca2+ channels and transporters, ER and mitochondria. Mitochondria are likely to play an essential role in temporal and spatial buffering of photoreceptor Ca2+... - Expression of calcium transporters in the retina of the tiger salamander (Ambystoma tigrinum)David Krizaj
Department of Ophthalmology, University of California, San Francisco, School of Medicine, San Francisco, California 94143 0730, USA
J Comp Neurol 475:463-80. 2004..These results indicate that Ca2+ transporters in the salamander retina are expressed in a cell type-specific manner... 
Trafficking of Presynaptic PMCA Signaling Complexes in Mouse Photoreceptors Requires Cav1.4 α(1) SubunitsWei Xing
Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT, 84132, USA
Adv Exp Med Biol 723:739-44. 2012- Ontogeny of plasma membrane Ca2+ ATPase isoforms in the neural retina of the postnatal ratRENE C RENTERIA
Department of Ophthalmology, University of California, San Francisco, 94143, USA
Vis Neurosci 22:263-74. 2005..Their expression patterns are consistent with the hypothesis that inner and outer retinal neurons have different Ca(2+) handling needs... 
Role of ELOVL4 and very long-chain polyunsaturated fatty acids in mouse models of Stargardt type 3 retinal degenerationPeter Barabas
Department of Ophthalmology and Visual Sciences, Moran Eye Institute, University of Utah, Salt Lake City, UT 84132, USA
Proc Natl Acad Sci U S A 110:5181-6. 2013....- Store-operated channels regulate intracellular calcium in mammalian rodsTünde Molnár
Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
J Physiol 590:3465-81. 2012.... - Glutamate-induced internalization of Ca(v)1.3 L-type Ca(2+) channels protects retinal neurons against excitotoxicityFengxia Mizuno
Department of Ophthalmology, NYU Medical Center, New York, NY 10016, USA
J Physiol 588:953-66. 2010..3 L-type Ca(2+) channels are subject to rapid glutamate-induced internalization, which may serve as a negative feedback mechanism protecting retinal neurons against glutamate-induced excitotoxicity... - Do calcium channel blockers rescue dying photoreceptors in the Pde6b ( rd1 ) mouse?Peter Barabas
Department of Ophthalmology and Visual Sciences, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
Adv Exp Med Biol 664:491-9. 2010..We also discuss potential involvement of recently identified Ca(2+)-dependent mechanisms that include protective calcium ATPase mechanisms, ryanodine and IP3 calcium stores, and store operated channels in Pde6b ( rd1 ) neurodegeneration...
Research Grants
- REGULATION OF NEUROTRANSMISSION IN THE RETINADavid Krizaj; Fiscal Year: 2005....
- REGULATION OF NEUROTRANSMISSION IN THE RETINADavid Krizaj; Fiscal Year: 2007....
- REGULATION OF NEUROTRANSMISSION IN THE RETINADavid Krizaj; Fiscal Year: 2010....