David Krizaj

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. pmc Calcium homeostasis and cone signaling are regulated by interactions between calcium stores and plasma membrane ion channels
    Tamas Szikra
    Department of Ophthalmology, University of California San Francisco School of Medicine, San Francisco, California, United States of America
    PLoS ONE 4:e6723. 2009
  2. pmc Calcium stores in vertebrate photoreceptors
    David Krizaj
    Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Adv Exp Med Biol 740:873-89. 2012
  3. pmc Plasticity of TRPM1 expression and localization in the wild type and degenerating mouse retina
    David Krizaj
    Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, Salt Lake City, UT 84132, United States
    Vision Res 50:2460-5. 2010
  4. pmc Intracellular pH modulates inner segment calcium homeostasis in vertebrate photoreceptors
    David Krizaj
    Department of Ophthalmology, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, 84132, USA
    Am J Physiol Cell Physiol 300:C187-97. 2011
  5. pmc Anatomical and neurochemical characterization of dopaminergic interplexiform processes in mouse and rat retinas
    Paul Witkovsky
    Department of Ophthalmology, New York University School of Medicine, New York, New York 10016, USA
    J Comp Neurol 510:158-74. 2008
  6. pmc Scotopic visual signaling in the mouse retina is modulated by high-affinity plasma membrane calcium extrusion
    Jacque L Duncan
    Department of Ophthalmology, University of California San Francisco School of Medicine, San Francisco, California 94143 0730, USA
    J Neurosci 26:7201-11. 2006
  7. pmc Localization and phenotype-specific expression of ryanodine calcium release channels in C57BL6 and DBA/2J mouse strains
    Wei Huang
    Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Exp Eye Res 93:700-9. 2011
  8. pmc The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells
    Daniel A Ryskamp
    Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, Interdepartmental Program in Neuroscience, and Department of Physiology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    J Neurosci 31:7089-101. 2011
  9. pmc Store-operated channels regulate intracellular calcium in mammalian rods
    Tünde Molnár
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    J Physiol 590:3465-81. 2012
  10. pmc Role of ELOVL4 and very long-chain polyunsaturated fatty acids in mouse models of Stargardt type 3 retinal degeneration
    Peter Barabas
    Department of Ophthalmology and Visual Sciences, Moran Eye Institute, University of Utah, Salt Lake City, UT 84132, USA
    Proc Natl Acad Sci U S A 110:5181-6. 2013

Research Grants

  1. REGULATION OF NEUROTRANSMISSION IN THE RETINA
    David Krizaj; Fiscal Year: 2002
  2. REGULATION OF NEUROTRANSMISSION IN THE RETINA
    David Krizaj; Fiscal Year: 2003
  3. REGULATION OF NEUROTRANSMISSION IN THE RETINA
    David Krizaj; Fiscal Year: 2004
  4. REGULATION OF NEUROTRANSMISSION IN THE RETINA
    David Krizaj; Fiscal Year: 2005
  5. REGULATION OF NEUROTRANSMISSION IN THE RETINA
    David Krizaj; Fiscal Year: 2007
  6. REGULATION OF NEUROTRANSMISSION IN THE RETINA
    David Krizaj; Fiscal Year: 2009
  7. REGULATION OF NEUROTRANSMISSION IN THE RETINA
    David Krizaj; Fiscal Year: 2010

Collaborators

Detail Information

Publications22

  1. pmc Calcium homeostasis and cone signaling are regulated by interactions between calcium stores and plasma membrane ion channels
    Tamas Szikra
    Department of Ophthalmology, University of California San Francisco School of Medicine, San Francisco, California, United States of America
    PLoS ONE 4:e6723. 2009
    ....
  2. pmc Calcium stores in vertebrate photoreceptors
    David Krizaj
    Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Adv Exp Med Biol 740:873-89. 2012
    ..CICR and SOCE may also modulate the transmission of afferent and efferent signals in the outer retina. Thus, Ca(2+) stores provide additional complexity, adaptability, tuneability and speed to photoreceptor signaling...
  3. pmc Plasticity of TRPM1 expression and localization in the wild type and degenerating mouse retina
    David Krizaj
    Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, Salt Lake City, UT 84132, United States
    Vision Res 50:2460-5. 2010
    ..These findings show that expression and localization of the TRPM1 in the mouse retina is plastic, modulated by use-dependence and availability of sustained excitatory input...
  4. pmc Intracellular pH modulates inner segment calcium homeostasis in vertebrate photoreceptors
    David Krizaj
    Department of Ophthalmology, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, 84132, USA
    Am J Physiol Cell Physiol 300:C187-97. 2011
    ..In summary, this data suggest that endogenously produced protons continually modulate the membrane potential, release from Ca²(+) stores, and intracellular Ca²(+) buffering in rod and cone inner segments...
  5. pmc Anatomical and neurochemical characterization of dopaminergic interplexiform processes in mouse and rat retinas
    Paul Witkovsky
    Department of Ophthalmology, New York University School of Medicine, New York, New York 10016, USA
    J Comp Neurol 510:158-74. 2008
    ..Outer retinal varicosities of this putative GABAergic IPC did colocalize synaptic vesicle protein 2a, suggesting they possessed a conventional vesicular release mechanism...
  6. pmc Scotopic visual signaling in the mouse retina is modulated by high-affinity plasma membrane calcium extrusion
    Jacque L Duncan
    Department of Ophthalmology, University of California San Francisco School of Medicine, San Francisco, California 94143 0730, USA
    J Neurosci 26:7201-11. 2006
    ..These results suggest that PMCA2-mediated Ca2+ extrusion modulates the amplitude and timing of the high-sensitivity rod pathway to a much greater extent than that of the cone pathway...
  7. pmc Localization and phenotype-specific expression of ryanodine calcium release channels in C57BL6 and DBA/2J mouse strains
    Wei Huang
    Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Exp Eye Res 93:700-9. 2011
    ..While RyR1 signals can be regulated in a strain-specific manner, our data also suggest that RyR1 transcription is induced by early glial activation and/or elevation in intraocular pressure...
  8. pmc The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells
    Daniel A Ryskamp
    Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, Interdepartmental Program in Neuroscience, and Department of Physiology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    J Neurosci 31:7089-101. 2011
    ..Excessive Ca2+ influx through TRPV4 predisposes RGCs to activation of Ca2+ -dependent proapoptotic signaling pathways, indicating that TRPV4 is a component of the response mechanism to pathological elevations of intraocular pressure...
  9. pmc Store-operated channels regulate intracellular calcium in mammalian rods
    Tünde Molnár
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    J Physiol 590:3465-81. 2012
    ....
  10. pmc Role of ELOVL4 and very long-chain polyunsaturated fatty acids in mouse models of Stargardt type 3 retinal degeneration
    Peter Barabas
    Department of Ophthalmology and Visual Sciences, Moran Eye Institute, University of Utah, Salt Lake City, UT 84132, USA
    Proc Natl Acad Sci U S A 110:5181-6. 2013
    ....
  11. pmc Depletion of calcium stores regulates calcium influx and signal transmission in rod photoreceptors
    Tamas Szikra
    Department of Ophthalmology, UCSF School of Medicine, San Francisco, CA 94143, USA
    J Physiol 586:4859-75. 2008
    ..Rods were immunopositive for TRPC1 whereas cone inner segments immunostained with TRPC6 channel antibodies. Thus, SOCE modulates Ca(2+) homeostasis and light-evoked neurotransmission at the rod photoreceptor synapse mediated by TRPC1...
  12. pmc Ryanodine stores and calcium regulation in the inner segments of salamander rods and cones
    David Krizaj
    Department of Ophthalmology, UCSF School of Medicine, San Francisco, CA 94143, USA
    J Physiol 547:761-74. 2003
    ....
  13. pmc Ontogeny of plasma membrane Ca2+ ATPase isoforms in the neural retina of the postnatal rat
    RENE C RENTERIA
    Department of Ophthalmology, University of California, San Francisco, 94143, USA
    Vis Neurosci 22:263-74. 2005
    ..Their expression patterns are consistent with the hypothesis that inner and outer retinal neurons have different Ca(2+) handling needs...
  14. pmc Serca isoform expression in the mammalian retina
    David Krizaj
    Dept of Ophthalmology, Beckman Vision Center, UCSF School of Medicine, Rm K 140, 10 Kirkham St, San Francisco, CA 94143 0730, USA
    Exp Eye Res 81:690-9. 2005
    ..These results imply that the SERCA2 isoform controls Ca2+ sequestration into the endoplasmic reticulum in most classes of retinal neuron. A potential role for SERCA3 in cone function is suggested...
  15. pmc Intracellular organelles and calcium homeostasis in rods and cones
    Tamas Szikra
    Department of Ophthalmology, UCSF School of Medicine, San Francisco, California, USA
    Vis Neurosci 24:733-43. 2007
    ..Local [Ca2+]i levels are set by interactions between the plasma membrane Ca2+ channels and transporters, ER and mitochondria. Mitochondria are likely to play an essential role in temporal and spatial buffering of photoreceptor Ca2+...
  16. pmc Expression of calcium transporters in the retina of the tiger salamander (Ambystoma tigrinum)
    David Krizaj
    Department of Ophthalmology, University of California, San Francisco, School of Medicine, San Francisco, California 94143 0730, USA
    J Comp Neurol 475:463-80. 2004
    ..These results indicate that Ca2+ transporters in the salamander retina are expressed in a cell type-specific manner...
  17. pmc Missing optomotor head-turning reflex in the DBA/2J mouse
    Peter Barabas
    Department of Ophthalmology and Visual Sciences, John Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Invest Ophthalmol Vis Sci 52:6766-73. 2011
    ....
  18. pmc Trafficking of Presynaptic PMCA Signaling Complexes in Mouse Photoreceptors Requires Cav1.4 α(1) Subunits
    Wei Xing
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT, 84132, USA
    Adv Exp Med Biol 723:739-44. 2012
  19. pmc Glutamate-induced internalization of Ca(v)1.3 L-type Ca(2+) channels protects retinal neurons against excitotoxicity
    Fengxia Mizuno
    Department of Ophthalmology, NYU Medical Center, New York, NY 10016, USA
    J Physiol 588:953-66. 2010
    ..3 L-type Ca(2+) channels are subject to rapid glutamate-induced internalization, which may serve as a negative feedback mechanism protecting retinal neurons against glutamate-induced excitotoxicity...
  20. pmc Targeted intraceptor nanoparticle therapy reduces angiogenesis and fibrosis in primate and murine macular degeneration
    Ling Luo
    Moran Eye Center, University of Utah, Salt Lake City, Utah 84132, United States
    ACS Nano 7:3264-75. 2013
    ..We found no evidence of ocular or systemic toxicity from nanoparticle treatment. These findings offer a nanoparticle-based platform for targeted, vitreous-sparing, extended-release, nonviral gene therapy...
  21. pmc Cell-specific expression of plasma membrane calcium ATPase isoforms in retinal neurons
    David Krizaj
    Department of Physiology, University of California San Francisco, San Francisco, California 94143 0730, USA
    J Comp Neurol 451:1-21. 2002
    ..We conclude that PMCA isoforms are selectively expressed in retinal neurons and that processes of Ca(2+) clearance are different in rod and cone bipolar cells...
  22. pmc Do calcium channel blockers rescue dying photoreceptors in the Pde6b ( rd1 ) mouse?
    Peter Barabas
    Department of Ophthalmology and Visual Sciences, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Adv Exp Med Biol 664:491-9. 2010
    ..We also discuss potential involvement of recently identified Ca(2+)-dependent mechanisms that include protective calcium ATPase mechanisms, ryanodine and IP3 calcium stores, and store operated channels in Pde6b ( rd1 ) neurodegeneration...

Research Grants8

  1. REGULATION OF NEUROTRANSMISSION IN THE RETINA
    David Krizaj; Fiscal Year: 2002
    ....
  2. REGULATION OF NEUROTRANSMISSION IN THE RETINA
    David Krizaj; Fiscal Year: 2003
    ....
  3. REGULATION OF NEUROTRANSMISSION IN THE RETINA
    David Krizaj; Fiscal Year: 2004
    ....
  4. REGULATION OF NEUROTRANSMISSION IN THE RETINA
    David Krizaj; Fiscal Year: 2005
    ....
  5. REGULATION OF NEUROTRANSMISSION IN THE RETINA
    David Krizaj; Fiscal Year: 2007
    ....
  6. REGULATION OF NEUROTRANSMISSION IN THE RETINA
    David Krizaj; Fiscal Year: 2009
    ....
  7. REGULATION OF NEUROTRANSMISSION IN THE RETINA
    David Krizaj; Fiscal Year: 2010
    ....