Research Topics
| DANIEL KRIPKESummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Does bright light have an anxiolytic effect? - an open trialShawn D Youngstedt
Department of Exercise Science, Norman J, Arnold School of Public Health University of South Carolina, Columbia, SC 29208 USA
BMC Psychiatry 7:62. 2007..The aim of this open trial was to examine the influence of acute bright light exposure on anxiety in older and young adults...- Bright green light treatment of depression for older adults [ISRCTN69400161]Richard T Loving
Department of Psychiatry, University of California, San Diego, USA
BMC Psychiatry 5:42. 2005..Because spectral responsiveness may differ by age, we examined whether green light would provide efficient antidepressant treatment in an elder age group... - Measurement of illumination exposure in postpartum womenEmily J Wang
Department of Psychiatry, University of California, San Diego 92093 0667, USA
BMC Psychiatry 3:5. 2003..The goal of this study was to examine the levels of illumination experienced by postpartum mothers and to discover any relationship between light exposure and mood levels experienced during the postpartum period... - Bright light treatment of depression for older adults [ISRCTN55452501]Richard T Loving
Department of Psychiatry, University of California, San Diego, USA
BMC Psychiatry 5:41. 2005..The incidence of insomnia and depression in the elder population is significant. It is hoped that use of light treatment for this group could provide safe, economic, and effective rapid recovery... 
PRC bisection testsDaniel F Kripke
Department of Psychiatry, University of California, San Diego, California 92093 0667, USA
Chronobiol Int 20:1117-23. 2003..Also, the bisection procedure yields an estimate of the inflection point of the phase response curve. A method is given to estimate the power of the PRC bisection test...- Polymorphisms in melatonin synthesis pathways: possible influences on depressionDaniel F Kripke
Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
J Circadian Rhythms 9:8. 2011..abstract:.. - Weak evidence of bright light effects on human LH and FSHDaniel F Kripke
Department of Psychiatry, University of California, San Diego, La Jolla, California 92093, USA
J Circadian Rhythms 8:5. 2010..There is some evidence that seasonal breeding in humans is regulated by similar mechanisms, and that light stimulates LH secretion, but primate responses seem complex... - Melatonin excretion with affect disorders over age 60Daniel F Kripke
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0667, USA
Psychiatry Res 118:47-54. 2003..These results are only weakly consistent with a photoperiodic hypothesis of depression... - Ethnicity, sleep, mood, and illumination in postmenopausal womenDaniel F Kripke
Department of Psychiatry, University of California, San Diego, CA, USA
BMC Psychiatry 4:8. 2004..This study examined how ethnic differences in sleep and depression were related to environmental illumination and circadian rhythms... - Actigraphy suggests age-related differences in napping and nocturnal sleepIn Young Yoon
Department of Psychiatry and Sam and Rose Stein, Institute for Research on Aging, University of California, San Diego, CA 92093 0667, USA
J Sleep Res 12:87-93. 2003..Maintaining alertness during the evening (e.g. by bright light exposure or moderate exercise) would be a possible approach to delay wake-up times in older adults... - Melatonin: marvel or marker?D F Kripke
Department of Psychiatry and the Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, La Jolla 92093 0667, USA
Ann Med 30:81-7. 1998..These data suggest that melatonin is a useful marker of circadian rhythm phase disorders, but suggest a need for more caution in melatonin administration... - Circadian phase response curves to light in older and young women and menDaniel F Kripke
Department of Psychiatry and Sam and Rose Stein Institute on Aging, University of California, San Diego 0667, La Jolla, California 92093 0667, USA
J Circadian Rhythms 5:4. 2007..This study tested the hypotheses that older adults have absent or weaker phase-shift responses to light (3000 lux), and that women's responses might differ from those of men... - Circadian phase in adults of contrasting agesD F Kripke
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0667, USA
Chronobiol Int 22:695-709. 2005..In summary, there was no evidence for circadian desynchronization associated with aging, but there was evidence of some rearrangement of the internal phase-angles among the studied circadian rhythms... 
Possibility that certain hypnotics might cause cancer in skinDaniel F Kripke
Department of Psychiatry, University of California, San Diego and The Scripps Clinic Sleep Center, La Jolla, California 92093 0667, USA
J Sleep Res 17:245-50. 2008..Together with the epidemiologic data and laboratory studies, the available evidence signals that new hypnotics may increase cancer risk. Due to limitations in available data, confirmatory research is needed...- Mortality related to actigraphic long and short sleepDaniel F Kripke
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92037, USA
Sleep Med 12:28-33. 2011..5 h or shorter than 6.5 h predicts increased mortality risk. This study examined if prospectively-determined objective sleep duration, as estimated by wrist actigraphy, was associated with mortality risks... - Circadian polymorphisms associated with affective disordersDaniel F Kripke
Department of Psychiatry 0939, University of California, San Diego, La Jolla, CA 92093 0939, USA
J Circadian Rhythms 7:2. 2009..Since genetic susceptibilities contribute a strong component to affective disorders, we explored whether circadian gene polymorphisms were associated with affective disorders in four complementary studies... - Mortality associated with sleep duration and insomniaDaniel F Kripke
Department of Psychiatry 0667, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0667, USA
Arch Gen Psychiatry 59:131-6. 2002..Treatment strategies may be guided by what sleep durations predict optimal survival and whether insomnia might signal mortality risks... - Light treatment for nonseasonal depression: speed, efficacy, and combined treatmentD F Kripke
Department of Psychiatry, University of California, San Diego, La Jolla 92093 0667, USA
J Affect Disord 49:109-17. 1998..Using bright light for treating major depressive disorders which are not seasonal needs reassessment... - Greater incidence of depression with hypnotic use than with placeboDaniel F Kripke
The Scripps Clinic Sleep Center, 10666 North Torrey Pines Road, La Jolla, California 92037, USA
BMC Psychiatry 7:42. 2007..This study contrasted the incidence of depression among subjects receiving hypnotics in randomized controlled trials versus those receiving placebo... - Meta-analyses of hypnotics and infections: eszopiclone, ramelteon, zaleplon, and zolpidemFlorendo L Joya
Scripps Clinic Sleep Center, La Jolla, CA 92037, USA
J Clin Sleep Med 5:377-83. 2009..Recent meta-analyses raising concern about risks of hypnotics suggest a need for more clarification of these risks... - Twenty-four-hour intraocular pressure pattern associated with early glaucomatous changesJohn H K Liu
Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, La Jolla, California 92093, USA
Invest Ophthalmol Vis Sci 44:1586-90. 2003.... - Illumination of upper and middle visual fields produces equivalent suppression of melatonin in older volunteersJulian S Smith
The Sam and Rose Stein Institute for Research on Aging, Department of Psychiatry, University of California, San Diego, La Jolla 92093-0667, USA
Chronobiol Int 19:883-91. 2002..Clinical comparative testing would be valuable. In addition, this study demonstrates that significant suppression of melatonin may be achieved through the use of bright light in healthy older volunteers... - No association of 6-sulfatoxymelatonin with in-bed 60-Hz magnetic field exposure or illumination level among older adultsShawn D Youngstedt
Department of Psychiatry, University of California at San Diego, La Jolla, California, 92093, USA
Environ Res 89:201-9. 2002..Illumination acrophase and amplitude were significantly associated with aMT6s acrophase. These data suggest no influence of nocturnal environmental MF exposure on aMT6s excretion in older adults... - Effect of laser trabeculoplasty on nocturnal intraocular pressure in medically treated glaucoma patientsAlexander C Lee
Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, La Jolla, California 92093 0946, USA
Ophthalmology 114:666-70. 2007..To evaluate the effects of laser trabeculoplasty on 24-hour intraocular pressure (IOP) in a group of medically treated open-angle glaucoma patients... - Comparison of the nocturnal effects of once-daily timolol and latanoprost on intraocular pressureJohn H K Liu
Hamilton Glaucoma Center and Department of Ophthalmology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0946, USA
Am J Ophthalmol 138:389-95. 2004..To compare the nocturnal effects of once-daily timolol and latanoprost on intraocular pressure (IOP) in patients with ocular hypertension or early glaucomatous changes... - No association of sleep with total daily physical activity in normal sleepersShawn D Youngstedt
Department of Psychiatry, Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0667, USA
Physiol Behav 78:395-401. 2003..These results fail to support epidemiologic data on the value of exercise for sleep, but are consistent with experimental evidence showing only modest effects of exercise on sleep... - Nocturnal elevation of intraocular pressure is detectable in the sitting positionJohn H K Liu
Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, La Jolla, California 92093, USA
Invest Ophthalmol Vis Sci 44:4439-42. 2003..This study was undertaken to investigate whether a similar elevation of IOP can be detected when experimental subjects are in the sitting position... - Laboratory assessment of diurnal and nocturnal ocular perfusion pressures in humansJohn H K Liu
Department of Opthalmology, University of California, San Diego, La Jolla, California 92093 0946, USA
J Ocul Pharmacol Ther 19:291-7. 2003..The diurnal-to-nocturnal increase of ocular perfusion pressure was larger in the older group than in the younger group... - Circadian phase-delaying effects of bright light alone and combined with exercise in humansShawn D Youngstedt
Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0667, USA
Am J Physiol Regul Integr Comp Physiol 282:R259-66. 2002..Within the limited exercise and light parameters of this study, the results suggest that exercise does not reliably modulate phase-shifting effects of late night bright light in humans... - Plasma melatonin circadian rhythm disturbances during pregnancy and postpartum in depressed women and women with personal or family histories of depressionBarbara L Parry
Department of Psychiatry, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0804, USA
Am J Psychiatry 165:1551-8. 2008..The purpose of this study was to test the hypothesis that disturbances in levels of plasma melatonin differentiate pregnant and postpartum women with major depression from matched pregnant and postpartum healthy comparison women... - Effect of light treatment on sleep and circadian rhythms in demented nursing home patientsSonia Ancoli-Israel
Department of Psychiatry, University of California San Diego, USA
J Am Geriatr Soc 50:282-9. 2002..To determine whether fragmented sleep in nursing home patients would improve with increased exposure to bright light... - Twenty-four-hour pattern of intraocular pressure in young adults with moderate to severe myopiaJohn H K Liu
Department of Ophthalmology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0946, USA
Invest Ophthalmol Vis Sci 43:2351-5. 2002..To characterize the 24-hour change of intraocular pressure (IOP) in young adults with moderate to severe myopia... - Bright light augments antidepressant effects of medication and wake therapyRichard T Loving
Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0667, USA
Depress Anxiety 16:1-3. 2002..002). The group receiving placebo did not improve, except for one outlier. The benefit of bright light was significant compared to placebo with removal of the outlier (P<0.025)... - Luteinizing hormone following light exposure in healthy young menIn-Young Yoon
Department of Psychiatry and Sam and Rose Stein, Institute for Research on Aging, 0667, University of California, 9500 Gilman Drive, La Jolla, San Diego, CA 92093-0667, USA
Neurosci Lett 341:25-8. 2003..The acrophases and offsets of aMT6s were advanced, but the duration of aMT6s excretion was not changed after BL. Light stimulation of LH could have interesting applications in psychiatry and reproductive endocrinology... - Self-reported sleep complaints with long and short sleep: a nationally representative sampleMichael A Grandner
San Diego State University University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California 92093 0667, USA
Psychosom Med 66:239-41. 2004..Recent evidence shows that habitual sleep duration greater than 7 hours is associated with increased rates of mortality. This study compared the rates of sleep problems in both long and short sleepers... - Light exposure is related to social and emotional functioning and to quality of life in older womenMichael A Grandner
Joint Doctoral Program in Clinical Psychology, San Diego State University, and University of California, San Diego, La Jolla, CA, United States
Psychiatry Res 143:35-42. 2006..Increased light exposure is related to improved quality of life and social and emotional functioning... - Sustained effect of travoprost on diurnal and nocturnal intraocular pressureArthur J Sit
Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, La Jolla, 92093, USA
Am J Ophthalmol 141:1131-3. 2006..CONCLUSIONS: IOP lowering effect after omission of one to two doses of travoprost is attenuated in the diurnal period but sustained in the nocturnal period, the time corresponding to the highest baseline habitual IOP... - Naps and circadian rhythms in postmenopausal womenIn-Young Yoon
Department of Psychiatry, 0667, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0667, USA
J Gerontol A Biol Sci Med Sci 59:844-8. 2004..Relationships between evening napping and earlier wake-up time may be a common manifestation of advanced circadian rhythms or may be a homeostatic effect... - Depression and endogenous melatonin in postmenopausal womenArja Tuunainen
Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, Dept. 0667, La Jolla, CA 92093-0667, USA
J Affect Disord 69:149-58. 2002.... - Menopause: neuroendocrine changes and hormone replacement therapyBarbara L Parry
Department of Psychiatry, University of California, San Diego, USA
J Am Med Womens Assoc 59:135-45. 2004..Further work is needed on the differential effect of treatment regimens in these disturbances that are evident primarily in baseline neuroendocrine function... - Evening light exposure: implications for sleep and depressionGeralyn M Wallace-Guy
Department of Psychiatry and the Sam and Rose Stein Institute for Research on Aging, University of California San Diego, La Jolla, California 92093, USA
J Am Geriatr Soc 50:738-9. 2002..CONCLUSIONS: Low evening lighting does not appear to be a crucial factor in sleep and mood disturbances of aging, but overall lighting may contribute to these disturbances... - Evaluation of immobility time for sleep latency in actigraphyKyu Young Chae
Scripps Clinic Sleep Center, W207, 10666 N Torrey Pines Road, La Jolla, CA 92037, USA
Sleep Med 10:621-5. 2009..In this study, we examined the accuracy of the Actiwatch-L instrument with Actiware((R)) software version 5.0 (Minimitter-Respironics, Bend, Oregon)... - Long sleep and mortality: rationale for sleep restrictionShawn D Youngstedt
Department of Psychiatry and Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, Mail Code 0667, 9500 Gilman Dr, La Jolla, CA 92093, USA
Sleep Med Rev 8:159-74. 2004..Sleep restriction may be most beneficial for older adults, who tend to spend excessive time in bed and have more sleep fragmentation compared with young adults... - Delayed and advanced sleep phase symptomsKatsuhisa Ando
Department of Psychiatry, University of California, San Diego, California, USA
Isr J Psychiatry Relat Sci 39:11-8. 2002..Thus, complaints suggesting circadian rhythm advance or delay mismatches were common, but evidently such complaints do not usually correspond with objective abnormalities of observed sleep timing... - Examination of the clock gene Cryptochrome 1 in bipolar disorder: mutational analysis and absence of evidence for linkage or associationCaroline M Nievergelt
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Psychiatr Genet 15:45-52. 2005..Additional, more powerful, studies involving Cry1 and other circadian clock genes need to be tested before an association of circadian abnormalities with bipolar disorder can be excluded... - Efficacy of enhanced evening light for advanced sleep phase syndromeChristopher R Palmer
Department of Psychiatry, Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, La Jolla 92093-0667, USA
Behav Sleep Med 1:213-26. 2003..Although compliance was good and the new enhanced evening light therapy design was well tolerated, the benefits were statistically equivocal... - Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorderCaroline M Nievergelt
Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0603, USA
Am J Med Genet B Neuropsychiatr Genet 141:234-41. 2006..However, the trends for ARNTL and PER3 are suggestive of their involvement in bipolar disorder and warrant further study in a larger sample... - Long-term follow-up of periodic limb movements in sleep in older adultsPhilip Gehrman
SDSU/UCSD Joint Doctoral Program in Clinical Psychology, University of California, San Diego, USA
Sleep 25:340-3. 2002..This relationship was not found in men. CONCLUSIONS: Although the prevalence of PLMS is high for older adults, the severity of the disorder does not progressively worsen with increasing age... - Circadian rhythm of CSF monoamines and hypocretin-1 in restless legs syndrome and Parkinson's diseaseJ Steven Poceta
Scripps Clinic Division of Neurology and Scripps Clinic Sleep Center, The Scripps Research Institute, Molecular and Integrative Neurosciences Department, La Jolla, CA, USA
Sleep Med 10:129-33. 2009..This circadian variation could underlie the symptoms of RLS and sleep-related variation in motor function in PD... - Bright-light mask treatment of delayed sleep phase syndromeRoger J Cole
Synchrony Applied Health Sciences, Del Mar, CA 92014 3805, USA
J Biol Rhythms 17:89-101. 2002..04). We conclude that bright-light mask treatment advances circadian phase and provides clinical benefit in DSPS individuals whose initial circadian delay is relatively severe... - Benefits of light treatment for depressionDaniel F Kripke
Am J Psychiatry 163:162-3; author reply 163. 2006 - Factor structure and measurement invariance of the Women's Health Initiative Insomnia Rating ScaleDouglas W Levine
Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Psychol Assess 15:123-36. 2003..Structural equation modeling revealed no major differences in factor structure across age and race-ethnic groups. WHIIRS norms for race-ethnicity and age subgroups are detailed... - Age-related changes of circadian rhythms and sleep-wake cyclesIn-Young Yoon
Department of Psychiatry and Sam and Rose Stein Institute for Research on Aging, University of California at San Diego, La Jolla 92093, USA
J Am Geriatr Soc 51:1085-91. 2003..Early awakening in older adults cannot be explained simply by a relative phase advance of the circadian system. Evening naps and advanced illumination may play a role in the advance of the circadian system in aging... - Brightening depressionAnna Wirz-Justice
Science 303:467-9. 2004 - Suicides in the midnight sun--a study of seasonality in suicides in West GreenlandKarin Sparring Björkstén
Department of Psychiatry, Nacka Hospital, 3 tr, SE 131 83 Nacka, Sweden
Psychiatry Res 133:205-13. 2005..Violent methods of suicide were used by 93%. Depression has been reported uncommonly. High alcohol intake and extended periods of light in the summer may contribute to impulsive-aggressive summer suicides... - Self-reported sleep latency in postmenopausal womenDoo Heum Park
Department of Psychiatry, Konkuk University School of Medicine, Seoul, Korea
J Korean Med Sci 22:1007-14. 2007..Therapeutic approaches suggested for trouble falling asleep might include increased daylight exposure, improvements in general health, and modification of anti-hypertensive pharmacotherapy... - More prominent reactivity in mood than activity and sleep induced by differential light exposure due to seasonal and local differencesDoo Heum Park
Department of Psychiatry, Konkuk University School of Medicine, Seoul, Korea
Chronobiol Int 24:905-20. 2007..Therefore, mood might be more reactive than activity and sleep in the seasonal variation induced by differential light exposure... - Do we sleep too much?Daniel F Kripke
Sleep 27:13-4. 2004 - Ineffectiveness of intermittent zolpidemDaniel F Kripke
Sleep Med Rev 7:193; author reply 195-6. 2003 - Polysomnographic sleep state from wrist activityDaniel F Kripke
Sleep 26:13; author reply 13. 2003 - Reliability and validity of the Women's Health Initiative Insomnia Rating ScaleDouglas W Levine
Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Psychol Assess 15:137-48. 2003..Results showed that differences in the objective indicators could be detected by the WHIIRS. Findings suggest that a between-group mean difference of approximately 0.50 of a standard deviation on the WHIIRS may be clinically meaningful...
Research Grants
- PHASE RESPONSE CURVES FOR EXERCISE AND BRIGHT LIGHTDANIEL KRIPKE; Fiscal Year: 2002..Resultant circadian phases will then be determined to compute the phase response curves, in order to examine interactions of stimulus (exercise vs. light), age, and gender on circadian responsiveness. ..
- VERIFICATION OF CIRCADIAN ABNORMALITIES IN AGINGDANIEL KRIPKE; Fiscal Year: 2002....
- ILLUMINATION IN HUMAN AGING: SLEEP AND MOOD EFFECTSDANIEL KRIPKE; Fiscal Year: 2004..The success of the treatment in lowering the GDS depression score and in reducing sleep complaints will be examined. ..
- GENETIC VARIANTS IN CIRCADIAN RHYTHM SLEEP DISORDERSDANIEL KRIPKE; Fiscal Year: 2006..abstract_text> ..
- Light Stimulation of Luteinizing HormoneDANIEL KRIPKE; Fiscal Year: 2006..abstract_text> ..