Arnold Kriegstein

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Mitotic spindle orientation predicts outer radial glial cell generation in human neocortex
    Bridget E Lamonica
    Department of Neurology, University of California, San Francisco, 35 Medical Center Way, San Francisco, California 94143, USA
    Nat Commun 4:1665. 2013
  2. doi request reprint Commentary: the prospect of cell-based therapy for epilepsy
    Arnold R Kriegstein
    Department of Neurology, University of California, San Francisco, California 94143 0525, USA
    Neurotherapeutics 6:295-9. 2009
  3. ncbi request reprint Patterns of neural stem and progenitor cell division may underlie evolutionary cortical expansion
    Arnold Kriegstein
    Institute for Stem Cell and Tissue Biology, University of California, San Francisco, 513 Parnassus Ave, HSW, 1201, San Francisco, California, USA
    Nat Rev Neurosci 7:883-90. 2006
  4. ncbi request reprint Progress in corticogenesis
    Arnold Kriegstein
    Institute for Stem Cell and Tissue Biology, University of California at San Francisco, USA
    Cereb Cortex 16:i1-2. 2006
  5. pmc The glial nature of embryonic and adult neural stem cells
    Arnold Kriegstein
    The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Department of Neurology, University of California, San Francisco, California 94143 0525, USA
    Annu Rev Neurosci 32:149-84. 2009
  6. pmc Connexin 43 mediates the tangential to radial migratory switch in ventrally derived cortical interneurons
    Laura A B Elias
    Neuroscience Graduate Program, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 30:7072-7. 2010
  7. ncbi request reprint Dividing precursor cells of the embryonic cortical ventricular zone have morphological and molecular characteristics of radial glia
    Stephen C Noctor
    Department of Neurology, Columbia College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosci 22:3161-73. 2002
  8. pmc Distinct behaviors of neural stem and progenitor cells underlie cortical neurogenesis
    Stephen C Noctor
    Department of Neurology, University of California, San Francisco, San Francisco, California 94143, USA
    J Comp Neurol 508:28-44. 2008
  9. doi request reprint Importing human pluripotent stem cell lines derived at another institution: tailoring review to ethical concerns
    Bernard Lo
    Program in Medical Ethics, University of California San Francisco, San Francisco, CA 94143, USA
    Cell Stem Cell 4:115-23. 2009
  10. doi request reprint Clinical trials in stem cell transplantation: guidelines for scientific and ethical review
    Bernard Lo
    Program in Medical Ethics and Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0903, USA
    Clin Trials 5:517-22. 2008

Research Grants

  1. The Physiology of Radial Units in Corticogenesis
    Arnold Kriegstein; Fiscal Year: 2009
  2. The Physiology of Radial Units in Corticogenesis
    Arnold Kriegstein; Fiscal Year: 2007
  3. INTERCELLULAR SIGNALING IN NEOCORTICAL DEVELOPMENT
    Arnold Kriegstein; Fiscal Year: 2001
  4. INTERCELLULAR SIGNALING IN NEOCORTICAL DEVELOPMENT
    Arnold Kriegstein; Fiscal Year: 2001
  5. INTERCELLULAR SIGNALING IN NEOCORTICAL DEVELOPMENT
    Arnold Kriegstein; Fiscal Year: 2003
  6. The Physiology of Radial Units in Corticogenesis
    Arnold Kriegstein; Fiscal Year: 2004
  7. INTERCELLULAR SIGNALING IN NEOCORTICAL DEVELOPMENT
    Arnold Kriegstein; Fiscal Year: 2009
  8. Neurobiology of Disease -- Teaching Workshop
    Arnold Kriegstein; Fiscal Year: 2005
  9. INTERCELLULAR SIGNALING IN NEOCORTICAL DEVELOPMENT
    Arnold Kriegstein; Fiscal Year: 2005
  10. The Physiology of Radial Units in Corticogenesis
    Arnold Kriegstein; Fiscal Year: 2003

Collaborators

Detail Information

Publications43

  1. pmc Mitotic spindle orientation predicts outer radial glial cell generation in human neocortex
    Bridget E Lamonica
    Department of Neurology, University of California, San Francisco, 35 Medical Center Way, San Francisco, California 94143, USA
    Nat Commun 4:1665. 2013
    ..Our results suggest that altered regulation of mitotic spindle orientation increased outer radial glial cell number, and ultimately neuronal number, during human brain evolution...
  2. doi request reprint Commentary: the prospect of cell-based therapy for epilepsy
    Arnold R Kriegstein
    Department of Neurology, University of California, San Francisco, California 94143 0525, USA
    Neurotherapeutics 6:295-9. 2009
    ..Herein we summarize the current status and future perspectives of cell-based therapies in the treatment of epilepsy...
  3. ncbi request reprint Patterns of neural stem and progenitor cell division may underlie evolutionary cortical expansion
    Arnold Kriegstein
    Institute for Stem Cell and Tissue Biology, University of California, San Francisco, 513 Parnassus Ave, HSW, 1201, San Francisco, California, USA
    Nat Rev Neurosci 7:883-90. 2006
    ....
  4. ncbi request reprint Progress in corticogenesis
    Arnold Kriegstein
    Institute for Stem Cell and Tissue Biology, University of California at San Francisco, USA
    Cereb Cortex 16:i1-2. 2006
  5. pmc The glial nature of embryonic and adult neural stem cells
    Arnold Kriegstein
    The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Department of Neurology, University of California, San Francisco, California 94143 0525, USA
    Annu Rev Neurosci 32:149-84. 2009
    ..Identification of NSCs and IPCs is critical to understand brain development and adult neurogenesis and to develop new strategies for brain repair...
  6. pmc Connexin 43 mediates the tangential to radial migratory switch in ventrally derived cortical interneurons
    Laura A B Elias
    Neuroscience Graduate Program, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 30:7072-7. 2010
    ..These findings provide mechanistic and structural support for a gap junction-mediated interaction between migrating interneurons and radial glia during the switch from tangential to radial migration...
  7. ncbi request reprint Dividing precursor cells of the embryonic cortical ventricular zone have morphological and molecular characteristics of radial glia
    Stephen C Noctor
    Department of Neurology, Columbia College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosci 22:3161-73. 2002
    ....
  8. pmc Distinct behaviors of neural stem and progenitor cells underlie cortical neurogenesis
    Stephen C Noctor
    Department of Neurology, University of California, San Francisco, San Francisco, California 94143, USA
    J Comp Neurol 508:28-44. 2008
    ..We propose a model for predicting daughter cell fate that considers precursor cell type, stage of development, and the planar segregation of fate determinants...
  9. doi request reprint Importing human pluripotent stem cell lines derived at another institution: tailoring review to ethical concerns
    Bernard Lo
    Program in Medical Ethics, University of California San Francisco, San Francisco, CA 94143, USA
    Cell Stem Cell 4:115-23. 2009
    ..To maintain public trust, research institutions need to justify why they allow researchers to use lines whose derivation would not have been permitted locally...
  10. doi request reprint Clinical trials in stem cell transplantation: guidelines for scientific and ethical review
    Bernard Lo
    Program in Medical Ethics and Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0903, USA
    Clin Trials 5:517-22. 2008
    ..Transplantation of cells derived through the manipulation of pluripotent stem cells may involve great uncertainty and the possibility of serious risks...
  11. ncbi request reprint Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases
    Stephen C Noctor
    Department of Neurology, Columbia University College of Physicians and Surgeons, 630 W 168th Street, New York, New York 10032, USA
    Nat Neurosci 7:136-44. 2004
    ..These findings provide a comprehensive and new view of the dynamics of cortical neurogenesis and migration...
  12. ncbi request reprint Developmental genetics of vertebrate glial-cell specification
    David H Rowitch
    Howard Hughes Medical Institute, University of California, San Francisco, USA
    Nature 468:214-22. 2010
    ..Gaining insight into the developmental genetics of macroglia has great potential to improve our understanding of a variety of neurological disorders in humans...
  13. pmc Gap junctions: multifaceted regulators of embryonic cortical development
    Laura A B Elias
    Neuroscience Graduate Program, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Trends Neurosci 31:243-50. 2008
    ..Gap junctions are thus emerging as multifaceted regulators of cortical development playing diverse roles in intercellular communication...
  14. ncbi request reprint Neural stem and progenitor cells in cortical development
    Stephen C Noctor
    Department of Neurology, UCSF School of Medicine, 513 Parnassus Avenue, San Francisco, CA 94143 0525, USA
    Novartis Found Symp 288:59-73; discussion 73-8, 96-8. 2007
    ..In this model, a temporal sequence of gene expression changes in asymmetrically dividing self-renewed RG cells could lead to the differential inheritance of cell identity genes in cortical cells generated at different cell cycles...
  15. pmc Blocking early GABA depolarization with bumetanide results in permanent alterations in cortical circuits and sensorimotor gating deficits
    Doris D Wang
    Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco CA 94143, USA
    Cereb Cortex 21:574-87. 2011
    ....
  16. ncbi request reprint The role of intermediate progenitor cells in the evolutionary expansion of the cerebral cortex
    Veronica Martinez-Cerdeno
    Department of Neurology and the Institute for Stem Cell and Tissue Biology, University of California San Francisco, San Francisco, CA 94143, USA
    Cereb Cortex 16:i152-61. 2006
    ..We propose that the evolution of this two-step pattern of neurogenesis played an important role in the amplification of cell numbers underlying the radial and tangential expansion of the cerebral cortex...
  17. ncbi request reprint Gap junction adhesion is necessary for radial migration in the neocortex
    Laura A B Elias
    Neuroscience Graduate Program, University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143, USA
    Nature 448:901-7. 2007
    ....
  18. ncbi request reprint A new era in the ethics of human embryonic stem cell research
    Bernard Lo
    Program in Medical Ethics and Division of General Internal Medicine, University of California San Francisco, San Francisco, California, USA
    Stem Cells 23:1454-9. 2005
    ..Lack of attention to the special ethical concerns raised by clinical trials of hESC transplantation and their implications for the derivation of new hESC lines may undermine or delay progress toward stem cell therapies...
  19. ncbi request reprint Constructing circuits: neurogenesis and migration in the developing neocortex
    Arnold R Kriegstein
    Department of Neurology, University of California, San Francisco, San Francisco, California 94143, USA
    Epilepsia 46:15-21. 2005
    ..These new findings have increased our understanding of the mechanisms underlying certain developmental disorders and, in doing so, reveal potentially useful modes of therapeutic intervention...
  20. ncbi request reprint Contribution of intermediate progenitor cells to cortical histogenesis
    Stephen C Noctor
    Department of Neurology, Institute for Regeneration Medicine, University of California San Francisco, San Francisco, California 94143, USA
    Arch Neurol 64:639-42. 2007
    ..These findings have refined our understanding of cortical neurogenesis, with implications for understanding the causes of neurodevelopmental disorders and for their potential treatment...
  21. pmc Defining the role of GABA in cortical development
    Doris D Wang
    Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA 94143, USA
    J Physiol 587:1873-9. 2009
    ..Here, we present recent evidence supporting the multiple functions of GABA during embryonic development and adult neurogenesis, from regulating progenitor proliferation to influencing the migration and maturation of newborn neurons...
  22. doi request reprint Neurogenic radial glia in the outer subventricular zone of human neocortex
    David V Hansen
    Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, San Francisco, California 94143, USA
    Nature 464:554-561. 2010
    ..The establishment of non-ventricular radial glia-like cells may have been a critical evolutionary advance underlying increased cortical size and complexity in the human brain...
  23. pmc Embryonic MGE precursor cells grafted into adult rat striatum integrate and ameliorate motor symptoms in 6-OHDA-lesioned rats
    Veronica Martinez-Cerdeno
    Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Cell Stem Cell 6:238-50. 2010
    ..Our data suggest that MGE cell transplantation into the striatum is a promising approach to investigate the potential benefits of remodeling basal ganglia circuitry in neurodegenerative diseases...
  24. ncbi request reprint Radial glia diversity: a matter of cell fate
    Arnold R Kriegstein
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Glia 43:37-43. 2003
    ..These findings highlight the important but complex role of radial glia as participants in key steps of brain development...
  25. pmc A stem cell niche for intermediate progenitor cells of the embryonic cortex
    Ashkan Javaherian
    Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94143, USA
    Cereb Cortex 19:i70-7. 2009
    ..These data provide novel evidence for the presence of a neurogenic niche for intermediate progenitors in the embryonic SVZ and suggest blood vessels are important for proper patterning of neurogenesis...
  26. ncbi request reprint Estradiol stimulates progenitor cell division in the ventricular and subventricular zones of the embryonic neocortex
    Veronica Martinez-Cerdeno
    Department of Neurology and Program in Developmental and Stem Cell Biology, 513 Parnassus Avenue, HSW 1201, Box 0525, University of California San Francisco, San Francisco, California 94143, USA
    Eur J Neurosci 24:3475-88. 2006
    ..These findings demonstrate a new functional role for E2 as a proliferative agent during critical stages of cerebral cortex development...
  27. pmc GABA regulates excitatory synapse formation in the neocortex via NMDA receptor activation
    Doris D Wang
    Institute for Regeneration Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 28:5547-58. 2008
    ..Our study identifies an essential role for GABA in the synaptic integration of newborn cortical neurons and suggests an activity-dependent mechanism for achieving the balance between excitation and inhibition in the developing cortex...
  28. pmc A time and a place for nkx2-1 in interneuron specification and migration
    Laura A B Elias
    Institute for Regeneration Medicine, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Neuron 59:679-82. 2008
    ..demonstrate that postmitotic Nkx2-1 regulates migration and sorting of interneurons to the striatum or cortex by controlling the expression of the guidance receptor, Neuropilin-2...
  29. ncbi request reprint Patterns of neuronal migration in the embryonic cortex
    Arnold R Kriegstein
    Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA
    Trends Neurosci 27:392-9. 2004
    ..Integrating these findings with the molecular machinery underlying migration will provide a more complete picture of how the cerebral cortex is assembled...
  30. pmc Axonal control of the adult neural stem cell niche
    Cheuk Ka Tong
    Department of Neurological Surgery and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell Stem Cell 14:500-11. 2014
    ..Intraventricular infusion of 5HT2C agonist or antagonist increased or decreased V-SVZ proliferation, respectively. These results indicate that supraependymal 5HT axons directly interact with NSCs to regulate neurogenesis via 5HT2C. ..
  31. pmc Forebrain GABAergic neuron precursors integrate into adult spinal cord and reduce injury-induced neuropathic pain
    Joao M Braz
    Department of Anatomy, W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA
    Neuron 74:663-75. 2012
    ..Our findings suggest that MGE-derived GABAergic interneurons overcome the spinal cord hyperexcitability that is a hallmark of nerve injury-induced neuropathic pain...
  32. pmc Cloning mice and men: prohibiting the use of iPS cells for human reproductive cloning
    Bernard Lo
    Program in Medical Ethics, Department of Medicine, The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94143, USA
    Cell Stem Cell 6:16-20. 2010
    ..Professional standards and laws that ban human reproductive cloning by somatic cell nuclear transfer should be revised to also forbid it by other methods, such as iPSCs via tetraploid complementation...
  33. ncbi request reprint Terpene trilactones from Ginkgo biloba are antagonists of cortical glycine and GABA(A) receptors
    Lidija Ivic
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 278:49279-85. 2003
    ....
  34. ncbi request reprint Increased excitability and decreased sensitivity to GABA in an animal model of dysplastic cortex
    Ethan A Benardete
    Department of Neurology and Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons and Department of Neurosurgery, NYU Medical Center, New York, New York 10032, USA
    Epilepsia 43:970-82. 2002
    ..The mechanism underlying seizures with cortical malformations is still poorly understood. To study the physiology of dysplastic cortex, we developed an experimental model of CD...
  35. ncbi request reprint Is there more to GABA than synaptic inhibition?
    David F Owens
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, Building 36, Room 3C09, 36 Convent Drive, Bethesda, Maryland 20892 4092, USA
    Nat Rev Neurosci 3:715-27. 2002
    ..The unique features of the early-appearing GABA signalling systems might help to explain how GABA acts as a developmental signal...
  36. ncbi request reprint Neurons from radial glia: the consequences of asymmetric inheritance
    Gord Fishell
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 550 1st Avenue, New York, NY 10016, USA
    Curr Opin Neurobiol 13:34-41. 2003
    ..We suggest two models that make opposite predictions as to whether the radial glia or nascent neuron inherit the radial glial fiber or the majority of the Numb protein...
  37. ncbi request reprint Neurogenic radial glial cells in reptile, rodent and human: from mitosis to migration
    Tamily Weissman
    Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, 630 W 168th Street, New York, NY 10032, USA
    Cereb Cortex 13:550-9. 2003
    ..Although radial glial cells have traditionally been characterized by their role in guiding migration, their role as neuronal progenitors may represent their defining characteristic throughout the vertebrate CNS...
  38. pmc LIS1 RNA interference blocks neural stem cell division, morphogenesis, and motility at multiple stages
    Jin Wu Tsai
    Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Cell Biol 170:935-45. 2005
    ..Finally, axonal growth also ceased. These results identify multiple distinct and novel roles for LIS1 in nucleokinesis and process dynamics and suggest that nuclear position controls neural progenitor cell division...
  39. ncbi request reprint GABA puts the brake on stem cells
    Arnold R Kriegstein
    Nat Neurosci 8:1132-3. 2005
  40. ncbi request reprint Calcium waves propagate through radial glial cells and modulate proliferation in the developing neocortex
    Tamily A Weissman
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Neuron 43:647-61. 2004
    ..Furthermore, we show that wave disruption decreases VZ proliferation during the peak of embryonic neurogenesis. Taken together, these results demonstrate a radial glial signaling mechanism that may regulate cortical neuronal production...
  41. ncbi request reprint Blind patch clamp recordings in embryonic and adult mammalian brain slices
    David R Castaneda-Castellanos
    Department of Physiology and Cellular Biophysics, Columbia University, 630 West 168th Street, New York, New York 10032, USA
    Nat Protoc 1:532-42. 2006
    ..Overall, it takes approximately 3-4 h to set up this procedure...
  42. ncbi request reprint Developmental neurotransmitters?
    David F Owens
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA
    Neuron 36:989-91. 2002
    ..Demarque et al. (in this issue of Neuron) now report that early release of transmitter is unconventional in not requiring action potentials, Ca(2+) entry, or vesicle fusion, thus potentially reconciling the discrepancy...
  43. ncbi request reprint Controlling neuron number: does Numb do the math?
    David R Castaneda-Castellanos
    Nat Neurosci 7:793-4. 2004

Research Grants37

  1. The Physiology of Radial Units in Corticogenesis
    Arnold Kriegstein; Fiscal Year: 2009
    ..The results of this study may help shed light on mechanisms relevant to the etiology of many of them. ..
  2. The Physiology of Radial Units in Corticogenesis
    Arnold Kriegstein; Fiscal Year: 2007
    ..The results of this study may help shed light on mechanisms relevant to the etiology of many of them. ..
  3. INTERCELLULAR SIGNALING IN NEOCORTICAL DEVELOPMENT
    Arnold Kriegstein; Fiscal Year: 2001
    ..These experiments will begin to illuminate how amino acid transmitters in the embryonic neocortex influence critical events in early corticogenesis. ..
  4. INTERCELLULAR SIGNALING IN NEOCORTICAL DEVELOPMENT
    Arnold Kriegstein; Fiscal Year: 2001
    ..These experiments will begin to illuminate how amino acid transmitters in the embryonic neocortex influence critical events in early corticogenesis. ..
  5. INTERCELLULAR SIGNALING IN NEOCORTICAL DEVELOPMENT
    Arnold Kriegstein; Fiscal Year: 2003
    ..The data from these experiments will help us to understand how the critical balance of excitatory and inhibitory cells is regulated and how this affects brain development. ..
  6. The Physiology of Radial Units in Corticogenesis
    Arnold Kriegstein; Fiscal Year: 2004
    ..coupled to one another? Do lineage-related cell contacts determine the pattern of intracolumnar connectivity? Do CR cells and radial glia signal one another and does this signaling influence neurogenesis or migration? ..
  7. INTERCELLULAR SIGNALING IN NEOCORTICAL DEVELOPMENT
    Arnold Kriegstein; Fiscal Year: 2009
    ..Our data is also relevant to planned clinical trials that aim to control seizures in human infants but may inadvertently alter developing cortical circuitry based on the mechanisms that we describe. ..
  8. Neurobiology of Disease -- Teaching Workshop
    Arnold Kriegstein; Fiscal Year: 2005
    ..Society members are encouraged to suggest topics in the SFN Newsletter. ..
  9. INTERCELLULAR SIGNALING IN NEOCORTICAL DEVELOPMENT
    Arnold Kriegstein; Fiscal Year: 2005
    ..The data from these experiments will help us to understand how the critical balance of excitatory and inhibitory cells is regulated and how this affects brain development. ..
  10. The Physiology of Radial Units in Corticogenesis
    Arnold Kriegstein; Fiscal Year: 2003
    ..coupled to one another? Do lineage-related cell contacts determine the pattern of intracolumnar connectivity? Do CR cells and radial glia signal one another and does this signaling influence neurogenesis or migration? ..
  11. Physiology of Radial Units in Corticogenesis
    Arnold Kriegstein; Fiscal Year: 2002
    ..coupled to one another? Do lineage-related cell contacts determine the pattern of intracolumnar connectivity? Do CR cells and radial glia signal one another and does this signaling influence neurogenesis or migration? ..
  12. INTERCELLULAR SIGNALING IN NEOCORTICAL DEVELOPMENT
    Arnold Kriegstein; Fiscal Year: 1999
    ..These experiments will begin to illuminate how amino acid transmitters in the embryonic neocortex influence critical events in early corticogenesis. ..
  13. PHYSIOLOGY OF CAJAL RETZIUS CELLS AND CORTICOGENESIS
    Arnold Kriegstein; Fiscal Year: 2000
    ..These experiments represent the first attempt to define the functional properties of CR cells, which may be central to the developmental organization of the cerebral cortex. ..
  14. INTERCELLULAR SIGNALING IN NEOCORTICAL DEVELOPMENT
    Arnold Kriegstein; Fiscal Year: 2000
    ..These experiments will begin to illuminate how amino acid transmitters in the embryonic neocortex influence critical events in early corticogenesis. ..
  15. The Physiology of Radial Units in Corticogenesis
    Arnold Kriegstein; Fiscal Year: 2010
    ..The results of this study may help shed light on mechanisms relevant to the etiology of many of them. ..
  16. PHYSIOLOGY OF CAJAL RETZIUS CELLS AND CORTICOGENESIS
    Arnold Kriegstein; Fiscal Year: 2001
    ..These experiments represent the first attempt to define the functional properties of CR cells, which may be central to the developmental organization of the cerebral cortex. ..
  17. INTERCELLULAR SIGNALING IN NEOCORTICAL DEVELOPMENT
    Arnold Kriegstein; Fiscal Year: 2002
    ..These experiments will begin to illuminate how amino acid transmitters in the embryonic neocortex influence critical events in early corticogenesis. ..
  18. The Physiology of Radial Units in Corticogenesis
    Arnold Kriegstein; Fiscal Year: 2009
    ..The results of this study may help shed light on mechanisms relevant to the etiology of many of them. ..
  19. INTERCELLULAR SIGNALING IN NEOCORTICAL DEVELOPMENT
    Arnold Kriegstein; Fiscal Year: 2010
    ..Our data is also relevant to planned clinical trials that aim to control seizures in human infants but may inadvertently alter developing cortical circuitry based on the mechanisms that we describe. ..
  20. INTERCELLULAR SIGNALING IN NEOCORTICAL DEVELOPMENT
    Arnold Kriegstein; Fiscal Year: 2007
    ..The data from these experiments will help us to understand how the critical balance of excitatory and inhibitory cells is regulated and how this affects brain development. ..
  21. Neurobiology of Disease -- Teaching Workshop
    Arnold Kriegstein; Fiscal Year: 2007
    ..We are especially interested in covering diseases of the nervous system which are important clinically, but which are in need of enhanced basic cellular and molecular understanding. ..
  22. PHYSIOLOGY OF CAJAL RETZIUS CELLS AND CORTICOGENESIS
    Arnold Kriegstein; Fiscal Year: 1999
    ..These experiments represent the first attempt to define the functional properties of CR cells, which may be central to the developmental organization of the cerebral cortex. ..
  23. PHYSIOLOGY OF CAJAL RETZIUS CELLS AND CORTICOGENESIS
    Arnold Kriegstein; Fiscal Year: 2000
    ..These experiments represent the first attempt to define the functional properties of CR cells, which may be central to the developmental organization of the cerebral cortex. ..
  24. INTERCELLULAR SIGNALING IN NEOCORTICAL DEVELOPMENT
    Arnold Kriegstein; Fiscal Year: 2004
    ..The data from these experiments will help us to understand how the critical balance of excitatory and inhibitory cells is regulated and how this affects brain development. ..
  25. The Physiology of Radial Units in Corticogenesis
    Arnold Kriegstein; Fiscal Year: 2005
    ..coupled to one another? Do lineage-related cell contacts determine the pattern of intracolumnar connectivity? Do CR cells and radial glia signal one another and does this signaling influence neurogenesis or migration? ..
  26. INTERCELLULAR SIGNALING IN NEOCORTICAL DEVELOPMENT
    Arnold Kriegstein; Fiscal Year: 2004
    ..The data from these experiments will help us to understand how the critical balance of excitatory and inhibitory cells is regulated and how this affects brain development. ..
  27. INTERCELLULAR SIGNALING IN NEOCORTICAL DEVELOPMENT
    Arnold Kriegstein; Fiscal Year: 2006
    ..The data from these experiments will help us to understand how the critical balance of excitatory and inhibitory cells is regulated and how this affects brain development. ..
  28. Molecular and cellular mechanism of Microcephaly
    Arnold Kriegstein; Fiscal Year: 2010
    ....