J Kreth

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Streptococcal antagonism in oral biofilms: Streptococcus sanguinis and Streptococcus gordonii interference with Streptococcus mutans
    Jens Kreth
    Department of Diagnostic and Biological Sciences, University of Minnesota, 17 252 Moos Tower, 515 Delaware St, SE, Minneapolis, MN 55455, USA
    J Bacteriol 190:4632-40. 2008
  2. doi request reprint Role of sucrose in the fitness of Streptococcus mutans
    J Kreth
    School of Dentistry, University of Minnesota, Minneapolis, MN 55455, USA
    Oral Microbiol Immunol 23:213-9. 2008
  3. pmc The two-component system BfrAB regulates expression of ABC transporters in Streptococcus gordonii and Streptococcus sanguinis
    Yongshu Zhang
    Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN 55455, USA
    Microbiology 155:165-73. 2009
  4. pmc Characterization of hydrogen peroxide-induced DNA release by Streptococcus sanguinis and Streptococcus gordonii
    Jens Kreth
    Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Bacteriol 191:6281-91. 2009
  5. ncbi request reprint Functional characterization of cell-wall-associated protein WapA in Streptococcus mutans
    Lin Zhu
    School of Dentistry, University of California, Los Angeles, CA 90095, USA
    Microbiology 152:2395-404. 2006
  6. ncbi request reprint Consequences of a sortase A mutation in Streptococcus gordonii
    Angela H Nobbs
    Department of Diagnostic and Biological Sciences, School of Dentistry, Medical School, University of Minnesota, Minneapolis, MN 55455, USA
    Microbiology 153:4088-97. 2007
  7. pmc Mechanism of adhesion maintenance by methionine sulphoxide reductase in Streptococcus gordonii
    Y Lei
    Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN 55455, USA
    Mol Microbiol 80:726-38. 2011
  8. pmc Systematic approach to optimizing specifically targeted antimicrobial peptides against Streptococcus mutans
    Jian He
    School of Dentistry, University of California, Los Angeles, California 90095, USA
    Antimicrob Agents Chemother 54:2143-51. 2010
  9. ncbi request reprint Nanomechanical properties of glucans and associated cell-surface adhesion of Streptococcus mutans probed by atomic force microscopy under in situ conditions
    Sarah E Cross
    UCLA Department of Chemistry and Biochemistry, Los Angeles, CA 90095, USA
    Microbiology 153:3124-32. 2007
  10. pmc Competition and coexistence between Streptococcus mutans and Streptococcus sanguinis in the dental biofilm
    Jens Kreth
    Department of Oral Biology and Medicine, UCLA School of Dentistry, P O Box 951668, Los Angeles, CA 90095 1668, USA
    J Bacteriol 187:7193-203. 2005

Research Grants

Collaborators

Detail Information

Publications16

  1. pmc Streptococcal antagonism in oral biofilms: Streptococcus sanguinis and Streptococcus gordonii interference with Streptococcus mutans
    Jens Kreth
    Department of Diagnostic and Biological Sciences, University of Minnesota, 17 252 Moos Tower, 515 Delaware St, SE, Minneapolis, MN 55455, USA
    J Bacteriol 190:4632-40. 2008
    ..sanguinis and S. gordonii. These data provide new insights into ecological factors that determine the outcome of competition between pioneer colonizing oral streptococci and the survival mechanisms of S. mutans in the oral biofilm...
  2. doi request reprint Role of sucrose in the fitness of Streptococcus mutans
    J Kreth
    School of Dentistry, University of Minnesota, Minneapolis, MN 55455, USA
    Oral Microbiol Immunol 23:213-9. 2008
    ..The following study explores the competitiveness and fitness of S. mutans when grown with different concentrations of sucrose...
  3. pmc The two-component system BfrAB regulates expression of ABC transporters in Streptococcus gordonii and Streptococcus sanguinis
    Yongshu Zhang
    Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN 55455, USA
    Microbiology 155:165-73. 2009
    ..These data suggest, therefore, that S. gordonii BfrAB controls biofilm formation by regulating multiple ABC-transporter systems...
  4. pmc Characterization of hydrogen peroxide-induced DNA release by Streptococcus sanguinis and Streptococcus gordonii
    Jens Kreth
    Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Bacteriol 191:6281-91. 2009
    ..Since eDNA promotes cell-to-cell adhesion, release appears to support oral biofilm formation and facilitates exchange of genetic material among competent strains...
  5. ncbi request reprint Functional characterization of cell-wall-associated protein WapA in Streptococcus mutans
    Lin Zhu
    School of Dentistry, University of California, Los Angeles, CA 90095, USA
    Microbiology 152:2395-404. 2006
    ..These results suggest that the WapA protein plays an important structural role on the cell surface, which ultimately affects sucrose-independent cell-cell aggregation and biofilm architecture...
  6. ncbi request reprint Consequences of a sortase A mutation in Streptococcus gordonii
    Angela H Nobbs
    Department of Diagnostic and Biological Sciences, School of Dentistry, Medical School, University of Minnesota, Minneapolis, MN 55455, USA
    Microbiology 153:4088-97. 2007
    ..These data therefore imply that in addition to its role in processing LPXTG-containing adhesins, sortase A has the novel function of contributing to transcriptional regulation of adhesin gene expression...
  7. pmc Mechanism of adhesion maintenance by methionine sulphoxide reductase in Streptococcus gordonii
    Y Lei
    Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN 55455, USA
    Mol Microbiol 80:726-38. 2011
    ..gordonii in response to exogenous oxidants therefore msrA is upregulated, methionine oxidation of adhesins and perhaps other proteins is reversed, and adhesion and biofilm formation is maintained...
  8. pmc Systematic approach to optimizing specifically targeted antimicrobial peptides against Streptococcus mutans
    Jian He
    School of Dentistry, University of California, Los Angeles, California 90095, USA
    Antimicrob Agents Chemother 54:2143-51. 2010
    ..These results suggest that potent and selective STAMP molecules can be designed and improved via a tunable "building-block" approach...
  9. ncbi request reprint Nanomechanical properties of glucans and associated cell-surface adhesion of Streptococcus mutans probed by atomic force microscopy under in situ conditions
    Sarah E Cross
    UCLA Department of Chemistry and Biochemistry, Los Angeles, CA 90095, USA
    Microbiology 153:3124-32. 2007
    ..In addition, a possible role of the Gtf proteins in sucrose-independent attachment is supported by the decreased adhesion properties of the GtfBCD mutant compared to the wild-type...
  10. pmc Competition and coexistence between Streptococcus mutans and Streptococcus sanguinis in the dental biofilm
    Jens Kreth
    Department of Oral Biology and Medicine, UCLA School of Dentistry, P O Box 951668, Los Angeles, CA 90095 1668, USA
    J Bacteriol 187:7193-203. 2005
    ..These sophisticated interspecies interactions could play an essential part in balancing competition/coexistence within multispecies microbial communities...
  11. ncbi request reprint In situ and non-invasive detection of specific bacterial species in oral biofilms using fluorescently labeled monoclonal antibodies
    Fang Gu
    School of Dentistry and Dental Research Institute, University of California, 10833 Le Conte Avenue, Los Angeles, CA 90095 1668, United States
    J Microbiol Methods 62:145-60. 2005
    ..These studies indicate that MAbs based bacterial detection with CLSM is a versatile tool which permits new insights into the ecology of oral biofilm development...
  12. ncbi request reprint Non-disruptive, real-time analyses of the metabolic status and viability of Streptococcus mutans cells in response to antimicrobial treatments
    Justin Merritt
    UCLA, School of Dentistry, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90025, United States
    J Microbiol Methods 61:161-70. 2005
    ..In addition, we modified the biofilm assay into the 96-well format and demonstrated the feasibility of high throughput drug screening of biofilm embedded S. mutans...
  13. pmc The response regulator ComE in Streptococcus mutans functions both as a transcription activator of mutacin production and repressor of CSP biosynthesis
    Jens Kreth
    UCLA School of Dentistry, Los Angeles, CA 90095, USA
    Microbiology 153:1799-807. 2007
    ..mutans is fundamentally different from that reported for S. pneumoniae, which implicates a unique regulatory mechanism that allows the coordination of bacteriocin production with competence development...
  14. ncbi request reprint Cell density- and ComE-dependent expression of a group of mutacin and mutacin-like genes in Streptococcus mutans
    Jens Kreth
    Department of Oral Biology and Medicine, UCLA School of Dentistry, University of California Los Angeles, Los Angeles, CA 90095, USA
    FEMS Microbiol Lett 265:11-7. 2006
    ..Interestingly, high cell density was able to bypass the requirement for CSP addition. However, both cell density and CSP-dependent gene expression had a strict requirement for the ComE response regulator...
  15. ncbi request reprint LuxS controls bacteriocin production in Streptococcus mutans through a novel regulatory component
    Justin Merritt
    UCLA Molecular Biology Institute, Los Angeles, CA 90095, USA
    Mol Microbiol 57:960-9. 2005
    ..These findings reveal a novel regulatory pathway for mutacin I gene expression, which may provide clues to the regulatory mechanisms of other cellular functions regulated by luxS in S. mutans...
  16. pmc Co-ordinated bacteriocin production and competence development: a possible mechanism for taking up DNA from neighbouring species
    Jens Kreth
    Department of Oral Biology and Medicine, UCLA School of Dentistry, P O Box 951668, Los Angeles, CA 90095 1668, USA
    Mol Microbiol 57:392-404. 2005
    ..This hypothesis is also consistent with a well-known phenomenon that a large genomic diversity exists among different S. mutans strains. This diversity may have resulted from extensive horizontal gene transfer...

Research Grants2

  1. Interspecies Streptococcal Antagonisms in Oral Biofilms
    Jens Kreth; Fiscal Year: 2007
    ..Relevance: Virulence factors will be characterized that specify inter-species competition in the oral biofilm, contributing to better understanding and control of the overgrowth of cariogenic S. mutans. ..