Michael Kremer

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Favored T helper 1 response in a mouse model of hepatosteatosis is associated with enhanced T cell-mediated hepatitis
    Michael Kremer
    Center for Alcohol Studies, The University of North Carolina at Chapel Hill, NC 27599, USA
    Hepatology 44:216-27. 2006
  2. ncbi request reprint Pivotal role of Smad3 in a mouse model of T cell-mediated hepatitis
    Michael Kremer
    Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC 27599, USA
    Hepatology 47:113-26. 2008
  3. ncbi request reprint Impaired liver regeneration and increased oval cell numbers following T cell-mediated hepatitis
    Ian N Hines
    Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Hepatology 46:229-41. 2007
  4. pmc Kupffer cell and interleukin-12-dependent loss of natural killer T cells in hepatosteatosis
    Michael Kremer
    Center for Alcohol Studies, University of North Carolina at Chapel Hill, NC 27599, USA
    Hepatology 51:130-41. 2010
  5. ncbi request reprint LPS signaling enhances hepatic fibrogenesis caused by experimental cholestasis in mice
    Fuyumi Isayama
    Laboratory of Hepatobiology and Toxicology, Department of Pharmacology, University of North Carolina, Chapel Hill, 27599, USA
    Am J Physiol Gastrointest Liver Physiol 290:G1318-28. 2006
  6. ncbi request reprint Extrahepatic cells contribute to the progenitor/stem cell response following reduced-size liver transplantation in mice
    Lars O Conzelmann
    Laboratory of Hepatobiology and Toxicology, Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Exp Biol Med (Maywood) 232:571-80. 2007
  7. pmc Natural killer T cells and non-alcoholic fatty liver disease: fat chews on the immune system
    Michael Kremer
    Department of Surgery, University of Heidelberg, Heidelberg, Germany
    World J Gastroenterol 14:487-8. 2008
  8. ncbi request reprint Graft tumor necrosis factor receptor-1 protects after mouse liver transplantation whereas host tumor necrosis factor receptor-1 promotes injury
    Lars O Conzelmann
    Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, and Department of Trauma, Hand and Reconstructive Surgery, Hospitals of the J W Goethe University, Frankfurt, Germany
    Transplantation 82:1214-20. 2006
  9. pmc Smad3 signaling in the regenerating liver: implications for the regulation of IL-6 expression
    Michael Kremer
    Department of General Surgery, University of Ulm, Ulm, Germany Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC, USA
    Transpl Int 27:748-58. 2014
  10. ncbi request reprint Development and functional consequences of LPS tolerance in sinusoidal endothelial cells of the liver
    Anja Uhrig
    Department of Transplant Surgery, University Mainz, Germany
    J Leukoc Biol 77:626-33. 2005

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Favored T helper 1 response in a mouse model of hepatosteatosis is associated with enhanced T cell-mediated hepatitis
    Michael Kremer
    Center for Alcohol Studies, The University of North Carolina at Chapel Hill, NC 27599, USA
    Hepatology 44:216-27. 2006
    ..In conclusion, these data support the hypothesis that hepatosteatosis caused by CDD is associated with more severe ConA-induced hepatitis due to a predominant shift toward Th1 response...
  2. ncbi request reprint Pivotal role of Smad3 in a mouse model of T cell-mediated hepatitis
    Michael Kremer
    Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC 27599, USA
    Hepatology 47:113-26. 2008
    ..Interruption of this pathway could be beneficial clinically to limit acute fulminant liver pathologies...
  3. ncbi request reprint Impaired liver regeneration and increased oval cell numbers following T cell-mediated hepatitis
    Ian N Hines
    Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Hepatology 46:229-41. 2007
    ..Finally, splenocytes isolated from ConA-pretreated mice exerted cytotoxicity toward autologous bone marrow cells in an NK cell-dependent manner...
  4. pmc Kupffer cell and interleukin-12-dependent loss of natural killer T cells in hepatosteatosis
    Michael Kremer
    Center for Alcohol Studies, University of North Carolina at Chapel Hill, NC 27599, USA
    Hepatology 51:130-41. 2010
    ..Finally, human livers with severe steatosis showed a substantial decrease in NKT cells...
  5. ncbi request reprint LPS signaling enhances hepatic fibrogenesis caused by experimental cholestasis in mice
    Fuyumi Isayama
    Laboratory of Hepatobiology and Toxicology, Department of Pharmacology, University of North Carolina, Chapel Hill, 27599, USA
    Am J Physiol Gastrointest Liver Physiol 290:G1318-28. 2006
    ..In conclusion, these data demonstrate that endotoxin in a CD14-dependent manner exacerbates hepatic fibrogenesis and macrophage activation to produce oxidants and cytokines after bile duct ligation...
  6. ncbi request reprint Extrahepatic cells contribute to the progenitor/stem cell response following reduced-size liver transplantation in mice
    Lars O Conzelmann
    Laboratory of Hepatobiology and Toxicology, Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Exp Biol Med (Maywood) 232:571-80. 2007
    ..Reduced-size liver transplantation using GFP(+) transgenic mice supports the hypothesis that recipient-derived progenitor cells are present and may contribute to liver regeneration following transplantation...
  7. pmc Natural killer T cells and non-alcoholic fatty liver disease: fat chews on the immune system
    Michael Kremer
    Department of Surgery, University of Heidelberg, Heidelberg, Germany
    World J Gastroenterol 14:487-8. 2008
    ....
  8. ncbi request reprint Graft tumor necrosis factor receptor-1 protects after mouse liver transplantation whereas host tumor necrosis factor receptor-1 promotes injury
    Lars O Conzelmann
    Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, and Department of Trauma, Hand and Reconstructive Surgery, Hospitals of the J W Goethe University, Frankfurt, Germany
    Transplantation 82:1214-20. 2006
    ..TNFR1 mediates liver injury after ischemia/reperfusion but is also mitogenic during hepatic regeneration. This study investigated the role of graft and host TNFR1 in early graft injury after liver transplantation in mice...
  9. pmc Smad3 signaling in the regenerating liver: implications for the regulation of IL-6 expression
    Michael Kremer
    Department of General Surgery, University of Ulm, Ulm, Germany Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC, USA
    Transpl Int 27:748-58. 2014
    ..Therapies directed at finely regulating Smad3 activation early within the regenerating liver may prove useful in promoting liver cell proliferation and restoration of liver mass. ..
  10. ncbi request reprint Development and functional consequences of LPS tolerance in sinusoidal endothelial cells of the liver
    Anja Uhrig
    Department of Transplant Surgery, University Mainz, Germany
    J Leukoc Biol 77:626-33. 2005
    ..Our results support the notion that LPS tolerance in organ-resident scavenger LSEC contributes to local hepatic control of inflammation...
  11. ncbi request reprint Identification of differentially expressed genes after partial rat liver ischemia/reperfusion by suppression subtractive hybridization
    Christine Fallsehr
    Institute of Molecular Pathology, University of Heidelberg, Heidelberg, Germany
    World J Gastroenterol 11:1303-16. 2005
    ..To identify potential diagnostic target genes in early reperfusion periods following warm liver ischemia before irreversible liver damage occurs...