William Kremen

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc VETSA: the Vietnam Era Twin Study of Aging
    William S Kremen
    Department of Psychiatry, University of California, San Diego, CA, USA
    Twin Res Hum Genet 16:399-402. 2013
  2. pmc Heritability of brain ventricle volume: converging evidence from inconsistent results
    William S Kremen
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neurobiol Aging 33:1-8. 2012
  3. pmc Genetic architecture of context processing in late middle age: more than one underlying mechanism
    William S Kremen
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, USA
    Psychol Aging 26:852-63. 2011
  4. pmc Twin studies of posttraumatic stress disorder: differentiating vulnerability factors from sequelae
    William S Kremen
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neuropharmacology 62:647-53. 2012
  5. doi request reprint Salivary cortisol and prefrontal cortical thickness in middle-aged men: A twin study
    William S Kremen
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neuroimage 53:1093-102. 2010
  6. ncbi request reprint A discordant twin study of premorbid cognitive ability in schizophrenia
    William S Kremen
    Institute of Behavioral Genomics, Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, 92093 0603, USA
    J Clin Exp Neuropsychol 28:208-24. 2006
  7. pmc Genetic and environmental influences on the size of specific brain regions in midlife: the VETSA MRI study
    William S Kremen
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive MC 0738, La Jolla, CA 92093, USA
    Neuroimage 49:1213-23. 2010
  8. ncbi request reprint Genetics of verbal working memory processes: a twin study of middle-aged men
    William S Kremen
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, CA 92093 0738, USA
    Neuropsychology 21:569-80. 2007
  9. ncbi request reprint Pretrauma cognitive ability and risk for posttraumatic stress disorder: a twin study
    William S Kremen
    Department of Psychiatry and Center for Behavioral Genomics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Arch Gen Psychiatry 64:361-8. 2007
  10. ncbi request reprint Heritability of word recognition in middle-aged men varies as a function of parental education
    William S Kremen
    Department of Psychiatry, Institute of Behavioral Genomics, University of California, San Diego, La Jolla, CA 92093 0603, USA
    Behav Genet 35:417-33. 2005

Research Grants

Detail Information

Publications42

  1. pmc VETSA: the Vietnam Era Twin Study of Aging
    William S Kremen
    Department of Psychiatry, University of California, San Diego, CA, USA
    Twin Res Hum Genet 16:399-402. 2013
    ..These features make the VETSA ideal for studying the heterogeneity of within-individual trajectories from midlife to old age, and for early detection of risk factors for cognitive decline...
  2. pmc Heritability of brain ventricle volume: converging evidence from inconsistent results
    William S Kremen
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neurobiol Aging 33:1-8. 2012
    ..These conclusions have implications for the basic understanding of the genetic and environmental underpinnings of normative and pathological brain aging...
  3. pmc Genetic architecture of context processing in late middle age: more than one underlying mechanism
    William S Kremen
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, USA
    Psychol Aging 26:852-63. 2011
    ..In contrast, the reactive control component was unrelated to general cognitive ability...
  4. pmc Twin studies of posttraumatic stress disorder: differentiating vulnerability factors from sequelae
    William S Kremen
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neuropharmacology 62:647-53. 2012
    ..The creation of new twin registries would do much toward accomplishing this goal. This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'...
  5. doi request reprint Salivary cortisol and prefrontal cortical thickness in middle-aged men: A twin study
    William S Kremen
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neuroimage 53:1093-102. 2010
    ..Longitudinal assessments are underway to elucidate the direction of the associations and the genetic underpinnings of longitudinal phenotypes for changes in cortisol and brain morphology...
  6. ncbi request reprint A discordant twin study of premorbid cognitive ability in schizophrenia
    William S Kremen
    Institute of Behavioral Genomics, Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, 92093 0603, USA
    J Clin Exp Neuropsychol 28:208-24. 2006
    ..Educational advancement may be slightly slowed by this familial vulnerability, but results were equivocal with regard to attenuation of one's ultimate educational attainment...
  7. pmc Genetic and environmental influences on the size of specific brain regions in midlife: the VETSA MRI study
    William S Kremen
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive MC 0738, La Jolla, CA 92093, USA
    Neuroimage 49:1213-23. 2010
    ..Longitudinal analysis will be needed to determine whether the degree of genetic and environmental influences changes for different ROIs from midlife to later life...
  8. ncbi request reprint Genetics of verbal working memory processes: a twin study of middle-aged men
    William S Kremen
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, CA 92093 0738, USA
    Neuropsychology 21:569-80. 2007
    ..The genetic influences that were specific to reading span were concluded to most likely reflect an executive function component. Implications for genetic studies of aging and prefrontal brain function are discussed...
  9. ncbi request reprint Pretrauma cognitive ability and risk for posttraumatic stress disorder: a twin study
    William S Kremen
    Department of Psychiatry and Center for Behavioral Genomics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Arch Gen Psychiatry 64:361-8. 2007
    ..Cognitive deficits are associated with posttraumatic stress disorder (PTSD), but whether such deficits reflect sequelae or risk factors is not fully resolved...
  10. ncbi request reprint Heritability of word recognition in middle-aged men varies as a function of parental education
    William S Kremen
    Department of Psychiatry, Institute of Behavioral Genomics, University of California, San Diego, La Jolla, CA 92093 0603, USA
    Behav Genet 35:417-33. 2005
    ..Our results suggest that shared environmental factors in families with low parental education have long-lasting effects on word recognition ability, well beyond any critical period for developing reading proficiency...
  11. doi request reprint IQ decline in cross-sectional studies of schizophrenia: methodology and interpretation
    William S Kremen
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego School of Medicine, 9500 Gilman Drive MC 0738, La Jolla, CA 92093 0738, USA
    Psychiatry Res 158:181-94. 2008
    ..Overall, these results strongly suggest that differences in current neuropsychological function in schizophrenia are attributable primarily to current IQ instead of to IQ trajectory over time...
  12. ncbi request reprint Heterogeneity of schizophrenia: a study of individual neuropsychological profiles
    William S Kremen
    Department of Psychiatry and Behavioral Sciences, University of California, Davis School of Medicine, 2230 Stockton Boulevard, Sacramento, CA 95817, USA
    Schizophr Res 71:307-21. 2004
    ..Further research-probably including neuroimaging and genetic studies-will also be needed to determine the validity and the utility of this strategy for identifying neuropsychological profile types...
  13. pmc Storage and executive components of working memory: integrating cognitive psychology and behavior genetics in the study of aging
    William S Kremen
    Department of Psychiatry, Center for Behavioral Genomics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, USA
    J Gerontol B Psychol Sci Soc Sci 63:P84-91. 2008
    ..We discuss the findings in the context of research suggesting that new genetic influences come into play if demand continues to increase beyond a certain threshold, a threshold that may change with task difficulty and with age...
  14. pmc Cognitive decline in schizophrenia from childhood to midlife: a 33-year longitudinal birth cohort study
    William S Kremen
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, CA, United States
    Schizophr Res 118:1-5. 2010
    ....
  15. pmc Factor structure of planning and problem-solving: a behavioral genetic analysis of the Tower of London task in middle-aged twins
    William S Kremen
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, La Jolla, CA 92093 0738, USA
    Behav Genet 39:133-44. 2009
    ..The different phenotypic and genetic factor results suggest that relying solely on the former could obscure genetic associations...
  16. pmc A twin study of spatial and non-spatial delayed response performance in middle age
    William S Kremen
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, La Jolla, CA 92093 0738, USA
    Brain Cogn 76:43-51. 2011
    ..Compared with findings from small, selected control samples, high "failure" rates in this community-based sample raise concerns about interpretation of brain dysfunction in elderly or patient samples...
  17. ncbi request reprint Is the Wisconsin Card Sorting Test a useful neurocognitive endophenotype?
    William S Kremen
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, La Jolla, California 92093 0738, USA
    Am J Med Genet B Neuropsychiatr Genet 144:403-6. 2007
    ..Rather, we believe that our results suggest that some properties of this particular test make it undesirable for use as an endophenotype...
  18. ncbi request reprint Genes, environment, and time: the Vietnam Era Twin Study of Aging (VETSA)
    William S Kremen
    Department of Psychiatry, University of California San Diego, San Diego, CA, USA
    Twin Res Hum Genet 9:1009-22. 2006
    ....
  19. ncbi request reprint Genetics of body mass stability and risk for chronic disease: a 28-year longitudinal study
    Carol E Franz
    Department of Psychiatry, University of California San Diego, La Jolla, California 92093, United States of America
    Twin Res Hum Genet 10:537-45. 2007
    ..Our results also provide prospective evidence that early excess BMI may have serious long-term health consequences, and that this risk is not limited to minorities or adults of lower socioeconomic status...
  20. ncbi request reprint Spiritual well-being and health
    Ming T Tsuang
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego 92037, and Massachusetts General Hospital, Boston, Massachusetts, USA
    J Nerv Ment Dis 195:673-80. 2007
    ..quot; We concluded that studies of SWB and health should continue to distinguish between explicitly religious variables and others that more closely approximate the psychological construct of personal well-being...
  21. doi request reprint Positive symptoms of psychosis correlate with expression of ubiquitin proteasome genes in peripheral blood
    Chad A Bousman
    Department of Psychiatry, University of California, San Diego, California, USA
    Am J Med Genet B Neuropsychiatr Genet 153:1336-41. 2010
    ..Our findings suggest that dysregulation of the UPS, specifically ubiquitin conjugation and deubiquitination, may point to a possible underlying biological mechanism for severity of positive but not negative symptoms...
  22. pmc Genetic and environmental influences on cortisol regulation across days and contexts in middle-aged men
    Carol E Franz
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0738, USA
    Behav Genet 40:467-79. 2010
    ..The results suggest that genetic factors influence cortisol responses to specific environmental stressors. Thus, cortisol levels are correlated in identical twins only when they undergo similar experiences...
  23. pmc Genetic patterns of correlation among subcortical volumes in humans: results from a magnetic resonance imaging twin study
    Lisa T Eyler
    Department of Psychiatry, University of California, San Diego, La Jolla, California, USA
    Hum Brain Mapp 32:641-53. 2011
    ....
  24. ncbi request reprint Is there disproportionate impairment in semantic or phonemic fluency in schizophrenia?
    William S Kremen
    Department of Psychiatry, University of California, Davis School of Medicine, 2230 Stockton Blvd, Sacramento, CA 95817, USA
    J Int Neuropsychol Soc 9:79-88. 2003
    ..48 < rs < .79). These results mirror a literature that overall suggests a small degree of disproportionate semantic fluency impairment in schizophrenia, but also some heterogeneity in fluency deficits...
  25. pmc Distinct genetic influences on cortical surface area and cortical thickness
    Matthew S Panizzon
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Cereb Cortex 19:2728-35. 2009
    ..We conclude that using volume in a genetically informative study, or as an endophenotype for a disorder, may confound the underlying genetic architecture of brain structure...
  26. pmc Cortical thickness is influenced by regionally specific genetic factors
    Lars M Rimol
    Department of Radiology, University of California, San Diego, La Jolla, California 92093 0738, USA
    Biol Psychiatry 67:493-9. 2010
    ..Yet, little is known about the patterning of those genetic influences, i.e., whether the same genes influence structure throughout the brain or whether there are regionally specific sets of genes...
  27. pmc Introduction to the special issue, pathways between genes, brain, and behavior
    William S Kremen
    Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA
    Behav Genet 40:111-3. 2010
    ..Most importantly, the breadth of studies proves that in order to be able to trace the pathways between genes, brain, and behavior, we need experts in genetics, neuroscience, psychology, and psychiatry...
  28. doi request reprint Preliminary evidence of ubiquitin proteasome system dysregulation in schizophrenia and bipolar disorder: convergent pathway analysis findings from two independent samples
    Chad A Bousman
    Center for Behavioral Genomics, Department of Psychiatry, University of California, San Diego, La Jolla, CA 92039, USA
    Am J Med Genet B Neuropsychiatr Genet 153:494-502. 2010
    ..Findings provide preliminary evidence of UPS dysregulation in BPD and psychosis as well as support further investigation of the UPS and other molecular and cellular pathways for potential biomarkers for SCZ, BPD, and/or psychosis...
  29. pmc Prenatal infection and cavum septum pellucidum in adult schizophrenia
    Alan S Brown
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, Mailman School of Public Health, 1051 Riverside Drive, Unit 23, New York, NY 10032, USA
    Schizophr Res 108:285-7. 2009
    ....
  30. ncbi request reprint Is there heterogeneity among syndromes of substance use disorder for illicit drugs?
    Cheryl Beseler
    Center for Behavioral Genomics, Department of Psychiatry, University of California, 9500 Gilman Drive, Mail Code 0603, La Jolla, San Diego, CA 92093, and Veterans Medical Research Foundation, La Jolla 92161, USA
    Addict Behav 31:929-47. 2006
    ....
  31. ncbi request reprint The impact of psychiatric diagnosis on length of stay in a university medical center in the managed care era
    James A Bourgeois
    Department of Psychiatry and Behavioral Sciences, University of California, Davis Medical Center, 2230 Stockton Blvd, Sacramento, CA 95817, USA
    Psychosomatics 46:431-9. 2005
    ..Other psychiatric patients had lengths of stay between these extremes. Excepting substance use disorders, increased lengths of stay with psychiatric comorbidity have persisted into the managed care era...
  32. pmc Comparative gene expression analysis of blood and brain provides concurrent validation of SELENBP1 up-regulation in schizophrenia
    Stephen J Glatt
    Center for Behavioral Genomics, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 102:15533-8. 2005
    ..The identification of valid peripheral biomarkers for SZ may ultimately facilitate early identification, intervention, and prevention efforts as well...
  33. ncbi request reprint Left hippocampal volume as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric study of nonpsychotic first-degree relatives
    Larry J Seidman
    Neuropsychology Laboratory, Massachusetts Mental Health Center, 74 Fenwood Rd, Boston, MA 02115, USA
    Arch Gen Psychiatry 59:839-49. 2002
    ....
  34. ncbi request reprint Structural brain abnormalities among relatives of patients with schizophrenia: implications for linkage studies
    Stephen V Faraone
    Harvard Medical School Department of Psychiatry at the Massachusetts Mental Health Center, Boston, MA, USA
    Schizophr Res 60:125-40. 2003
    ....
  35. ncbi request reprint Organizational and visual memory deficits in schizophrenia and bipolar psychoses using the Rey-Osterrieth complex figure: effects of duration of illness
    Larry J Seidman
    Harvard Medical, School Department of Psychiatry at Massachusetts Mental Health Center, Harvard Institute of Psychiatric Epidemiology and Genetics, Boston, MA 02115, USA
    J Clin Exp Neuropsychol 25:949-64. 2003
    ..Further research is required to determine whether similar mechanisms underlie the neurocognitive deficits in these psychotic disorders...
  36. ncbi request reprint A comparative profile analysis of neuropsychological functioning in patients with schizophrenia and bipolar psychoses
    Larry J Seidman
    Harvard Medical School Department of Psychiatry at Massachusetts Mental Health Center, and Harvard Institute of Psychiatric Epidemiology and Genetics, 74 Fenwood Road, Boston, MA 02115, USA
    Schizophr Res 53:31-44. 2002
    ..Further research is required to determine whether similar mechanisms underly the neurocognitive deficits in these disorders...
  37. ncbi request reprint Stability, consistency, and heritability of electrodermal response lability in middle-aged male twins
    Andrew Crider
    Department of Psychology, Williams College, Williamstown, Massachusetts, USA
    Psychophysiology 41:501-9. 2004
    ..We discuss these findings in terms of an information processing account of individual differences in phasic EDR activation...
  38. pmc Genetic influence on contrast sensitivity in middle-aged male twins
    Alice Cronin-Golomb
    Department of Psychology, Boston University, 648 Beacon St, 2nd Floor, Boston, MA 02215, USA
    Vision Res 47:2179-86. 2007
    ..Identifying the types of individual-specific events that impact contrast sensitivity may suggest interventions to modulate this ability and thereby improve overall quality of life as adults age...
  39. pmc A twin-study of genetic contributions to hearing acuity in late middle age
    Arthur Wingfield
    Department of Psychology, Brandeis University, Waltham, MA 02454 9110, USA
    J Gerontol A Biol Sci Med Sci 62:1294-9. 2007
    ..Declines in hearing acuity, especially in the high frequency range, often appear in middle age. The objective of this study was to characterize genetic and environmental influences that may underlie this pattern...
  40. ncbi request reprint Sex differences in the corpus callosum of patients with schizophrenia
    Matthew S Panizzon
    UC Davis Napa Psychiatric Research Center, Napa State Hospital, T 10, 2100 Napa Vallejo Highway, Napa, CA 94558, USA
    Schizophr Res 62:115-22. 2003
    ..CC size was not related to psychiatric symptoms nor cognitive functioning in this group of patients...
  41. ncbi request reprint Nicotine and familial vulnerability to schizophrenia: a discordant twin study
    Michael J Lyons
    Department of Psychology, Boston University, Massachusetts 02215, USA
    J Abnorm Psychol 111:687-93. 2002
    ..Results are consistent with the hypothesis that nicotine use is influenced by familial vulnerability to schizophrenia, not just clinical schizophrenia per se...
  42. ncbi request reprint Review of twin and family studies on neuroanatomic phenotypes and typical neurodevelopment
    J Eric Schmitt
    Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA
    Twin Res Hum Genet 10:683-94. 2007
    ....

Research Grants20

  1. The VETSA Longitudinal Twin Study of Cortisol and Aging
    William Kremen; Fiscal Year: 2007
    ..Using multivariate twin analytic approaches, we will determine the extent of genetic, and shared and unique environmental factors influencing cortisol in midlife as well as their association with other key measures. ..
  2. The VETSA Longitudinal Twin Study of Cognition and Aging
    William Kremen; Fiscal Year: 2009
    ....
  3. The VETSA Longitudinal MRI Twin Study of Aging
    William Kremen; Fiscal Year: 2009
    ..Moreover, the possibility of identifying predictors of brain aging in midlife, rather than in later life, has important public health implications with regard to intervention or prevention. ..
  4. The VETSA Longitudinal MRI Twin Study of Aging
    William Kremen; Fiscal Year: 2007
    ..We will also create a normative database-a library of scans-that will provide a unique and valuable resource for future researchers. ..
  5. The VETSA Longitudinal Twin Study of Cognition and Aging
    William S Kremen; Fiscal Year: 2010
    ..abstract_text> ..
  6. The VETSA Longitudinal MRI Twin Study of Aging
    William S Kremen; Fiscal Year: 2010
    ..Moreover, the possibility of identifying predictors of brain aging in midlife, rather than in later life, has important public health implications with regard to intervention or prevention. ..
  7. A Longitudinal Twin Study of Cognition and Personality
    William Kremen; Fiscal Year: 2006
    ..abstract_text> ..
  8. The VETSA Longitudinal Twin Study of Cognition and Aging
    William Kremen; Fiscal Year: 2009
    ....