Research Topics
| W S KremenSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
IQ decline during childhood and adult psychotic symptoms in a community sample: a 19-year longitudinal studyW S Kremen
Department of Psychiatry, University of California, Davis, School of Medicine, Sacramento, CA 95817, USA
Am J Psychiatry 155:672-7. 1998..The goal of this study was to examine cognitive antecedents of psychosis by determining whether variability in IQ during childhood was predictive of psychotic symptoms in adulthood...- Neuropsychological risk indicators for schizophrenia: a preliminary study of female relatives of schizophrenic and bipolar probandsW S Kremen
Department of Psychiatry, University of California, Davis School of Medicine, Sacramento 95817, USA
Psychiatry Res 79:227-40. 1998..Replication with a larger REL-BP sample and with male relatives is needed to evaluate the generalizability of the results... - Sex differences in self-reported schizotypal traits in relatives of schizophrenic probandsW S Kremen
Department of Psychiatry, University of California, Davis School of Medicine, Sacramento 95817, USA
Schizophr Res 34:27-37. 1998.... - The paradox of normal neuropsychological function in schizophreniaW S Kremen
Department of Psychiatry, University of California, Davis, School of Medicine, 4430 V Street, Sacramento, California 95817, USA
J Abnorm Psychol 109:743-52. 2000..Our results favor the view that even neuropsychologically normal schizophrenia patients have compromised cognitive function relative to their presumed expected or premorbid level of intellectual ability... - Is there disproportionate impairment in semantic or phonemic fluency in schizophrenia?William S Kremen
Department of Psychiatry, University of California, Davis School of Medicine, 2230 Stockton Blvd, Sacramento, CA 95817, USA
J Int Neuropsychol Soc 9:79-88. 2003..48 < rs < .79). These results mirror a literature that overall suggests a small degree of disproportionate semantic fluency impairment in schizophrenia, but also some heterogeneity in fluency deficits... - Intelligence quotient and neuropsychological profiles in patients with schizophrenia and in normal volunteersW S Kremen
Department of Psychiatry, University of California, Davis School of Medicine, 2516 Stockton Boulevard, Sacramento, CA 95817, USA
Biol Psychiatry 50:453-62. 2001..The results strengthen the argument that neurocognitive deficits are core deficits of schizophrenic illness... - Functional connectivity and working memory in schizophrenia: an EEG studyA Peled
Department of Psychiatry, University of California Davis Medical Center, Sacramento, California, USA
Int J Neurosci 106:47-61. 2001..If distinct deficits in cortical network activations would correlate with mental disorders it would be relevant to diagnosis and treatment of psychiatric disorders... - Association of estrogen levels with neuropsychological performance in women with schizophreniaA L Hoff
University of California, Davis Napa Psychiatric Research Center, Napa State Hospital, CA 94558, USA
Am J Psychiatry 158:1134-9. 2001..This study sought to determine the relationship of estrogen levels with psychiatric symptoms and neuropsychological function in female patients with schizophrenia... 
IQ decline in cross-sectional studies of schizophrenia: methodology and interpretationWilliam S Kremen
Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego School of Medicine, 9500 Gilman Drive MC 0738, La Jolla, CA 92093 0738, USA
Psychiatry Res 158:181-94. 2008..Overall, these results strongly suggest that differences in current neuropsychological function in schizophrenia are attributable primarily to current IQ instead of to IQ trajectory over time...- A discordant twin study of premorbid cognitive ability in schizophreniaWilliam S Kremen
Institute of Behavioral Genomics, Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, 92093 0603, USA
J Clin Exp Neuropsychol 28:208-24. 2006..Educational advancement may be slightly slowed by this familial vulnerability, but results were equivocal with regard to attenuation of one's ultimate educational attainment... - The impact of psychiatric diagnosis on length of stay in a university medical center in the managed care eraJames A Bourgeois
Department of Psychiatry and Behavioral Sciences, University of California, Davis Medical Center, 2230 Stockton Blvd, Sacramento, CA 95817, USA
Psychosomatics 46:431-9. 2005..Other psychiatric patients had lengths of stay between these extremes. Excepting substance use disorders, increased lengths of stay with psychiatric comorbidity have persisted into the managed care era... - Heterogeneity of schizophrenia: a study of individual neuropsychological profilesWilliam S Kremen
Department of Psychiatry and Behavioral Sciences, University of California, Davis School of Medicine, 2230 Stockton Boulevard, Sacramento, CA 95817, USA
Schizophr Res 71:307-21. 2004..Further research-probably including neuroimaging and genetic studies-will also be needed to determine the validity and the utility of this strategy for identifying neuropsychological profile types... 
Storage and executive components of working memory: integrating cognitive psychology and behavior genetics in the study of agingWilliam S Kremen
Department of Psychiatry, Center for Behavioral Genomics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, USA
J Gerontol B Psychol Sci Soc Sci 63:P84-91. 2008..We discuss the findings in the context of research suggesting that new genetic influences come into play if demand continues to increase beyond a certain threshold, a threshold that may change with task difficulty and with age...- Sex differences in the corpus callosum of patients with schizophreniaMatthew S Panizzon
UC Davis-Napa Psychiatric Research Center, Napa State Hospital, T-10, 2100 Napa-Vallejo Highway, Napa, CA 94558, USA
Schizophr Res 62:115-22. 2003..CC size was not related to psychiatric symptoms nor cognitive functioning in this group of patients... - A comparative profile analysis of neuropsychological functioning in patients with schizophrenia and bipolar psychosesLarry J Seidman
Harvard Medical School Department of Psychiatry at Massachusetts Mental Health Center, and Harvard Institute of Psychiatric Epidemiology and Genetics, 74 Fenwood Road, Boston, MA 02115, USA
Schizophr Res 53:31-44. 2002..Further research is required to determine whether similar mechanisms underly the neurocognitive deficits in these disorders... - Genetics of verbal working memory processes: a twin study of middle-aged menWilliam S Kremen
Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, CA 92093 0738, USA
Neuropsychology 21:569-80. 2007..The genetic influences that were specific to reading span were concluded to most likely reflect an executive function component. Implications for genetic studies of aging and prefrontal brain function are discussed... - Spiritual well-being and healthMing T Tsuang
Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego 92037, and Massachusetts General Hospital, Boston, Massachusetts, USA
J Nerv Ment Dis 195:673-80. 2007..quot; We concluded that studies of SWB and health should continue to distinguish between explicitly religious variables and others that more closely approximate the psychological construct of personal well-being... - Genetic influence on contrast sensitivity in middle-aged male twinsAlice Cronin-Golomb
Department of Psychology, Boston University, 648 Beacon St, 2nd Floor, Boston, MA 02215, USA
Vision Res 47:2179-86. 2007..Identifying the types of individual-specific events that impact contrast sensitivity may suggest interventions to modulate this ability and thereby improve overall quality of life as adults age... - Is the Wisconsin Card Sorting Test a useful neurocognitive endophenotype?William S Kremen
Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, La Jolla, California 92093 0738, USA
Am J Med Genet B Neuropsychiatr Genet 144:403-6. 2007..Rather, we believe that our results suggest that some properties of this particular test make it undesirable for use as an endophenotype... - Pretrauma cognitive ability and risk for posttraumatic stress disorder: a twin studyWilliam S Kremen
Department of Psychiatry and Center for Behavioral Genomics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Arch Gen Psychiatry 64:361-8. 2007..Cognitive deficits are associated with posttraumatic stress disorder (PTSD), but whether such deficits reflect sequelae or risk factors is not fully resolved... - Genes, environment, and time: the Vietnam Era Twin Study of Aging (VETSA)William S Kremen
Department of Psychiatry, University of California-San Diego, San Diego, CA, USA
Twin Res Hum Genet 9:1009-22. 2006.... - Left hippocampal volume as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric study of nonpsychotic first-degree relativesLarry J Seidman
Neuropsychology Laboratory, Massachusetts Mental Health Center, 74 Fenwood Rd, Boston, MA 02115, USA
Arch Gen Psychiatry 59:839-49. 2002.... - Comparative gene expression analysis of blood and brain provides concurrent validation of SELENBP1 up-regulation in schizophreniaStephen J Glatt
Center for Behavioral Genomics, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 102:15533-8. 2005..The identification of valid peripheral biomarkers for SZ may ultimately facilitate early identification, intervention, and prevention efforts as well... - Nicotine and familial vulnerability to schizophrenia: a discordant twin studyMichael J Lyons
Department of Psychology, Boston University, Massachusetts 02215, USA
J Abnorm Psychol 111:687-93. 2002..Results are consistent with the hypothesis that nicotine use is influenced by familial vulnerability to schizophrenia, not just clinical schizophrenia per se... - Heritability of word recognition in middle-aged men varies as a function of parental educationWilliam S Kremen
Department of Psychiatry, Institute of Behavioral Genomics, University of California, San Diego, La Jolla, CA 92093 0603, USA
Behav Genet 35:417-33. 2005..Our results suggest that shared environmental factors in families with low parental education have long-lasting effects on word recognition ability, well beyond any critical period for developing reading proficiency... - Structural brain abnormalities among relatives of patients with schizophrenia: implications for linkage studiesStephen V Faraone
Harvard Medical School Department of Psychiatry at the Massachusetts Mental Health Center, Boston, MA, USA
Schizophr Res 60:125-40. 2003.... - Organizational and visual memory deficits in schizophrenia and bipolar psychoses using the Rey-Osterrieth complex figure: effects of duration of illnessLarry J Seidman
Harvard Medical, School Department of Psychiatry at Massachusetts Mental Health Center, Harvard Institute of Psychiatric Epidemiology and Genetics, Boston, MA 02115, USA
J Clin Exp Neuropsychol 25:949-64. 2003..Further research is required to determine whether similar mechanisms underlie the neurocognitive deficits in these psychotic disorders...