Lumir Krejci

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. ncbi request reprint Mending the break: two DNA double-strand break repair machines in eukaryotes
    Lumir Krejci
    Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA
    Prog Nucleic Acid Res Mol Biol 74:159-201. 2003
  2. ncbi request reprint Of forks and ends
    Lumir Krejci
    Department of Molecular Medicine Institute of Biotechnology, University of Texas Health Science Center, San Antonio, TX 78245, USA
    Trends Biochem Sci 27:225-6. 2002
  3. ncbi request reprint Interaction with Rad51 is indispensable for recombination mediator function of Rad52
    Lumir Krejci
    Department of Molecular Medicine Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245 3207, USA
    J Biol Chem 277:40132-41. 2002
  4. ncbi request reprint DNA helicase Srs2 disrupts the Rad51 presynaptic filament
    Lumir Krejci
    Institute of Biotechnology and Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, Texas 78245, USA
    Nature 423:305-9. 2003
  5. ncbi request reprint Effect of amino acid substitutions in the rad50 ATP binding domain on DNA double strand break repair in yeast
    Ling Chen
    Department of Molecular Medicine, Institute of Biotechnology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA
    J Biol Chem 280:2620-7. 2005
  6. ncbi request reprint ATPase and DNA helicase activities of the Saccharomyces cerevisiae anti-recombinase Srs2
    Stephen Van Komen
    Institute of Biotechnology and Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, Texas 78245, USA
    J Biol Chem 278:44331-7. 2003
  7. ncbi request reprint Biochemical characterization of the RECQ4 protein, mutated in Rothmund-Thomson syndrome
    Margaret A Macris
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, 333 Cedar St, C130 Sterling Hall of Medicine, New Haven, CT 06520 8024, USA
    DNA Repair (Amst) 5:172-80. 2006
  8. ncbi request reprint RPA not that different from SSB
    Lumir Krejci
    Structure 10:601-2. 2002
  9. pmc Recombination mediator and Rad51 targeting activities of a human BRCA2 polypeptide
    Joseph San Filippo
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 281:11649-57. 2006
  10. ncbi request reprint Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p
    Efterpi Papouli
    Cancer Research UK, Clare Hall Laboratories, Blanche Lane, South Mimms, Herts EN6 3LD, United Kingdom
    Mol Cell 19:123-33. 2005

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Mending the break: two DNA double-strand break repair machines in eukaryotes
    Lumir Krejci
    Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA
    Prog Nucleic Acid Res Mol Biol 74:159-201. 2003
  2. ncbi request reprint Of forks and ends
    Lumir Krejci
    Department of Molecular Medicine Institute of Biotechnology, University of Texas Health Science Center, San Antonio, TX 78245, USA
    Trends Biochem Sci 27:225-6. 2002
  3. ncbi request reprint Interaction with Rad51 is indispensable for recombination mediator function of Rad52
    Lumir Krejci
    Department of Molecular Medicine Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245 3207, USA
    J Biol Chem 277:40132-41. 2002
    ..These results thus demonstrate the significance of the Rad51-Rad52 interaction in homologous recombination...
  4. ncbi request reprint DNA helicase Srs2 disrupts the Rad51 presynaptic filament
    Lumir Krejci
    Institute of Biotechnology and Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, Texas 78245, USA
    Nature 423:305-9. 2003
    ....
  5. ncbi request reprint Effect of amino acid substitutions in the rad50 ATP binding domain on DNA double strand break repair in yeast
    Ling Chen
    Department of Molecular Medicine, Institute of Biotechnology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA
    J Biol Chem 280:2620-7. 2005
    ..These results provide a molecular explanation for the observed in vivo defects of the rad50 Walker mutant strains and reveal a novel ATP-independent function for Rad50 in DNA end-bridging...
  6. ncbi request reprint ATPase and DNA helicase activities of the Saccharomyces cerevisiae anti-recombinase Srs2
    Stephen Van Komen
    Institute of Biotechnology and Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, Texas 78245, USA
    J Biol Chem 278:44331-7. 2003
    ..The ability of Srs2 to unwind helicase substrates with a long duplex region is enhanced by the inclusion of the single-strand DNA-binding factor replication protein A...
  7. ncbi request reprint Biochemical characterization of the RECQ4 protein, mutated in Rothmund-Thomson syndrome
    Margaret A Macris
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, 333 Cedar St, C130 Sterling Hall of Medicine, New Haven, CT 06520 8024, USA
    DNA Repair (Amst) 5:172-80. 2006
    ..Unlike the previously characterized members of the RecQ family, RECQ4 lacks a detectable DNA helicase activity...
  8. ncbi request reprint RPA not that different from SSB
    Lumir Krejci
    Structure 10:601-2. 2002
    ..Biochemical, mutational, and crystallographic analyses have provided insights into the switch between these two states...
  9. pmc Recombination mediator and Rad51 targeting activities of a human BRCA2 polypeptide
    Joseph San Filippo
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 281:11649-57. 2006
    ..The results thus clarify the role of BRCA2 in Rad51-dependent DNA recombination and repair, and the experimental strategies described herein should be valuable for systematically deciphering this BRCA2 function...
  10. ncbi request reprint Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p
    Efterpi Papouli
    Cancer Research UK, Clare Hall Laboratories, Blanche Lane, South Mimms, Herts EN6 3LD, United Kingdom
    Mol Cell 19:123-33. 2005
    ..Our findings suggest a mechanism by which SUMO and ubiquitin cooperatively control the choice of pathway for the processing of DNA lesions during replication...
  11. ncbi request reprint Saccharomyces cerevisiae MPH1 gene, required for homologous recombination-mediated mutation avoidance, encodes a 3' to 5' DNA helicase
    Rohit Prakash
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 280:7854-60. 2005
    ..These results, thus, establish Mph1 as an ATP-dependent DNA helicase, and the availability of purified Mph1 should facilitate efforts at deciphering the role of this protein in homologous recombination and mutation avoidance...
  12. ncbi request reprint Role of ATP hydrolysis in the antirecombinase function of Saccharomyces cerevisiae Srs2 protein
    Lumir Krejci
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 279:23193-9. 2004
    ..These results highlight the importance of the ATP hydrolysisfueled DNA motor activity in SRS2 functions...
  13. ncbi request reprint Rad51 recombinase and recombination mediators
    Patrick Sung
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 278:42729-32. 2003
  14. pmc Molecular anatomy of the recombination mediator function of Saccharomyces cerevisiae Rad52
    Changhyun Seong
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 283:12166-74. 2008
    ..Our results provide a mechanistic framework for rationalizing the multi-faceted role of Rad52 in recombination and DNA repair...