MARTIN E KREITMAN

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi request reprint Coding sequence evolution
    M Kreitman
    Department of Ecology and Evolution, University of Chicago, Chicago, 60637, USA
    Curr Opin Genet Dev 9:637-41. 1999
  2. ncbi request reprint The neutral theory is dead. Long live the neutral theory
    M Kreitman
    Department of Ecology and Evolution, University of Chicago, IL 60637, USA
    Bioessays 18:678-83; discussion 683. 1996
  3. ncbi request reprint Methods to detect selection in populations with applications to the human
    M Kreitman
    Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637, USA
    Annu Rev Genomics Hum Genet 1:539-59. 2000
  4. ncbi request reprint Nucleotide variation in the triosephosphate isomerase (Tpi) locus of Drosophila melanogaster and Drosophila simulans
    E Hasson
    Department of Ecology and Evolution, State University of New York, Stony Brook 11794, USA
    Mol Biol Evol 15:756-69. 1998
  5. ncbi request reprint Evolutionary dynamics of the enhancer region of even-skipped in Drosophila
    M Z Ludwig
    Department of Ecology and Evolution, University of Chicago, Illinois 60637, USA
    Mol Biol Evol 12:1002-11. 1995
  6. pmc Molecular variation at the In(2L)t proximal breakpoint site in natural populations of Drosophila melanogaster and D. simulans
    P Andolfatto
    Committee on Genetics, Department of Ecology and Evolution, University of Chicago, IL 60637, USA
    Genetics 154:1681-91. 2000
  7. pmc Unraveling selection in the mitochondrial genome of Drosophila
    J W Ballard
    Department of Ecology and Evolution, University of Chicago, Illinois 60637
    Genetics 138:757-72. 1994
  8. ncbi request reprint Fitness costs of R-gene-mediated resistance in Arabidopsis thaliana
    D Tian
    Department of Ecology and Evolution, University of Chicago, 1101 E 57th Street, Chicago, Illinois 60637, USA
    Nature 423:74-7. 2003
  9. ncbi request reprint Molecular population genetics of ref(2)P, a locus which confers viral resistance in Drosophila
    M L Wayne
    Department of Ecology and Evolution, University of Chicago, USA
    Mol Biol Evol 13:191-9. 1996
  10. ncbi request reprint Evolutionary dynamics of plant R-genes
    J Bergelson
    Department of Ecology and Evolution, University of Chicago, 1101 East 57th Street, Chicago, IL 60637, USA
    Science 292:2281-5. 2001

Research Grants

  1. Evolution of Canalizing Mechanisms in Gene Expression
    Martin Kreitman; Fiscal Year: 2009
  2. Evolutionary Mechanisms Governing Gene Regulation
    Martin Kreitman; Fiscal Year: 2005
  3. Evolution of Canalizing Mechanisms in Gene Expression
    MARTIN E KREITMAN; Fiscal Year: 2010

Detail Information

Publications23

  1. ncbi request reprint Coding sequence evolution
    M Kreitman
    Department of Ecology and Evolution, University of Chicago, Chicago, 60637, USA
    Curr Opin Genet Dev 9:637-41. 1999
    ..That may be about to change...
  2. ncbi request reprint The neutral theory is dead. Long live the neutral theory
    M Kreitman
    Department of Ecology and Evolution, University of Chicago, IL 60637, USA
    Bioessays 18:678-83; discussion 683. 1996
    ..Despite limitations in the applicability of the neutral theory, it is likely to remain an integral part of the quest to understand molecular evolution...
  3. ncbi request reprint Methods to detect selection in populations with applications to the human
    M Kreitman
    Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637, USA
    Annu Rev Genomics Hum Genet 1:539-59. 2000
    ..The range of plausible alternatives to selection will become better defined, however, as additional population genetic data sets become available, allowing better null models to be constructed...
  4. ncbi request reprint Nucleotide variation in the triosephosphate isomerase (Tpi) locus of Drosophila melanogaster and Drosophila simulans
    E Hasson
    Department of Ecology and Evolution, State University of New York, Stony Brook 11794, USA
    Mol Biol Evol 15:756-69. 1998
    ..Silent variation is slightly higher for D. melanogaster than for D. simulans. Finally, we outline the general lack of evidence for old balanced polymorphisms at allozyme loci in D. melanogaster...
  5. ncbi request reprint Evolutionary dynamics of the enhancer region of even-skipped in Drosophila
    M Z Ludwig
    Department of Ecology and Evolution, University of Chicago, Illinois 60637, USA
    Mol Biol Evol 12:1002-11. 1995
    ..We suggest that the multiplicity of binding sites in the enhancer provides a redundancy in function that allows flexibility in the sequence requirements and structural design of the promoter...
  6. pmc Molecular variation at the In(2L)t proximal breakpoint site in natural populations of Drosophila melanogaster and D. simulans
    P Andolfatto
    Committee on Genetics, Department of Ecology and Evolution, University of Chicago, IL 60637, USA
    Genetics 154:1681-91. 2000
    ..melanogaster and D. simulans, our data appear more consistent with the operation of selection than with simple demographic explanations...
  7. pmc Unraveling selection in the mitochondrial genome of Drosophila
    J W Ballard
    Department of Ecology and Evolution, University of Chicago, Illinois 60637
    Genetics 138:757-72. 1994
    ....
  8. ncbi request reprint Fitness costs of R-gene-mediated resistance in Arabidopsis thaliana
    D Tian
    Department of Ecology and Evolution, University of Chicago, 1101 E 57th Street, Chicago, Illinois 60637, USA
    Nature 423:74-7. 2003
    ....
  9. ncbi request reprint Molecular population genetics of ref(2)P, a locus which confers viral resistance in Drosophila
    M L Wayne
    Department of Ecology and Evolution, University of Chicago, USA
    Mol Biol Evol 13:191-9. 1996
    ....
  10. ncbi request reprint Evolutionary dynamics of plant R-genes
    J Bergelson
    Department of Ecology and Evolution, University of Chicago, 1101 East 57th Street, Chicago, IL 60637, USA
    Science 292:2281-5. 2001
    ..Here we document these features in available data and discuss them in light of the evolutionary dynamics they likely reflect...
  11. pmc The correlation between intron length and recombination in drosophila. Dynamic equilibrium between mutational and selective forces
    J M Comeron
    Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637, USA
    Genetics 156:1175-90. 2000
    ..simulans. We suggest that the study of the proposed dynamic model, taking into account interference among selected sites, might shed light on many aspects of the comparative biology of genome sizes including the C value paradox...
  12. ncbi request reprint Evidence for stabilizing selection in a eukaryotic enhancer element
    M Z Ludwig
    Department of Ecology and Evolution, University of Chicago, Illinois 60637, USA
    Nature 403:564-7. 2000
    ..Sequence differences between species have functional consequences, therefore, but they are masked by other co-evolved differences. On the basis of these results, we present a model for the evolution of eukaryotic regulatory sequences...
  13. ncbi request reprint Analysis of conserved noncoding DNA in Drosophila reveals similar constraints in intergenic and intronic sequences
    C M Bergman
    Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637, USA
    Genome Res 11:1335-45. 2001
    ..The results of this study have implications for the development of alignment and prediction algorithms specific to noncoding DNA, as well as for models of cis-regulatory DNA sequence evolution...
  14. pmc Unusual haplotype structure at the proximal breakpoint of In(2L)t in a natural population of Drosophila melanogaster
    P Andolfatto
    Committee on Genetics, University of Chicago, Chicago, Illinois 60637, USA
    Genetics 153:1297-311. 1999
    ..Certain features of our data suggest that the unusual pattern in standard chromosomes is the product of selection rather than demography...
  15. ncbi request reprint The nonrandom location of synonymous codons suggests that reading frame-independent forces have patterned codon preferences
    M A Antezana
    Department of Ecology and Evolution, University of Chicago, 1101 East 57th Street, Chicago, IL 60637 1573, USA
    J Mol Evol 49:36-43. 1999
    ..The motif preference hypothesis can explain the structuring of codon preferences and the similarities in the codon usages of distantly related organisms...
  16. pmc Natural selection on synonymous sites is correlated with gene length and recombination in Drosophila
    J M Comeron
    Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637, USA
    Genetics 151:239-49. 1999
    ..These simulations show that even with realistic recombination rates, this interference, which we call the "small-scale" Hill-Robertson effect, can have a moderately strong influence on codon bias...
  17. pmc The correlation between synonymous and nonsynonymous substitutions in Drosophila: mutation, selection or relaxed constraints?
    J M Comeron
    Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637, USA
    Genetics 150:767-75. 1998
    ..We, therefore, interpret the excess of double codon substitutions within a lineage as being the result of relaxed constraints on both kinds of substitutions in particular codons...
  18. pmc Genetic variation within and among populations of Arabidopsis thaliana
    J Bergelson
    Department of Ecology and Evolution, University of Chicago, Illinois 60637, USA
    Genetics 148:1311-23. 1998
    ..The low level of polymorphism found in this study is consistent with theoretical models of neutral mutations and background selection in highly self-fertilizing species...
  19. ncbi request reprint Functional analysis of eve stripe 2 enhancer evolution in Drosophila: rules governing conservation and change
    M Z Ludwig
    Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA
    Development 125:949-58. 1998
    ..This view allows for a slow but continual turnover of functionally important changes in the stripe 2 enhancer...
  20. ncbi request reprint Simple strategy for sequencing cDNA clones
    L W Zeng
    Department of Ecology and Evolution, University of Chicago, IL 60636, USA
    Biotechniques 21:446-52. 1996
    ..Using this method, we successfully sequenced five cDNA clones of five Drosophila subobscura genes...
  21. ncbi request reprint Distribution of genetic variation within and among local populations of Arabidopsis thaliana over its species range
    E G Bakker
    Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA
    Mol Ecol 15:1405-18. 2006
    ..Based on the structure of A. thaliana populations, it appears that regional groups of local populations may provide the most appropriate genetic material for linkage disequilibrium mapping of adaptive traits...
  22. pmc Reduced variation in Drosophila simulans mitochondrial DNA
    J W Ballard
    Department of Zoology, Field Museum, Chicago, Illinois 60605 2496, USA
    Genetics 144:1519-28. 1996
    ..Alternatively, the dramatic reduction in mitochondrial diversity may be related to Wolbachia...
  23. ncbi request reprint Reduced variation at concertina, a heterochromatic locus in Drosophila
    M L Wayne
    Department of Ecology and Evolution, University of Chicago, IL 60637, USA
    Genet Res 68:101-8. 1996
    ..Two analyses of background selection demonstrate that the reduction in variation at cta. considered in combination with other loci on chromosome 2L or alone, is consistent with the background selection model...

Research Grants10

  1. Evolution of Canalizing Mechanisms in Gene Expression
    Martin Kreitman; Fiscal Year: 2009
    ....
  2. Evolutionary Mechanisms Governing Gene Regulation
    Martin Kreitman; Fiscal Year: 2005
    ..These experiments will benefit the analysis of eukaryotic genome structure/function and will aid work to decipher the controls of human gene expression. ..
  3. Evolution of Canalizing Mechanisms in Gene Expression
    MARTIN E KREITMAN; Fiscal Year: 2010
    ....