Silvia M Kreda

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Receptor-promoted exocytosis of airway epithelial mucin granules containing a spectrum of adenine nucleotides
    Silvia M Kreda
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, 4029A Thurston Bowles Building, Chapel Hill, NC 27599 7248, USA
    J Physiol 588:2255-67. 2010
  2. pmc Coordinated release of nucleotides and mucin from human airway epithelial Calu-3 cells
    Silvia M Kreda
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, 7017 Thurston Bowles Building, Chapel Hill, NC 27599 7248, USA
    J Physiol 584:245-59. 2007
  3. pmc Vesicular nucleotide transporter regulates the nucleotide content in airway epithelial mucin granules
    Juliana I Sesma
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Am J Physiol Cell Physiol 304:C976-84. 2013
  4. pmc Coupled nucleotide and mucin hypersecretion from goblet-cell metaplastic human airway epithelium
    Seiko F Okada
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, 27599, USA
    Am J Respir Cell Mol Biol 45:253-60. 2011
  5. pmc VAMP8 is a vesicle SNARE that regulates mucin secretion in airway goblet cells
    Lisa C Jones
    Cystic Fibrosis Pulmonary Research and Treatment Centre, The University of North Carolina at Chapel Hill, 4029A Thurston Bowles Building, Chapel Hill, NC 27599 7248, USA
    J Physiol 590:545-62. 2012
  6. pmc Rho signaling regulates pannexin 1-mediated ATP release from airway epithelia
    Lucia Seminario-Vidal
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 286:26277-86. 2011
  7. pmc CFTR, mucins, and mucus obstruction in cystic fibrosis
    Silvia M Kreda
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, NC 27517 7248, USA
    Cold Spring Harb Perspect Med 2:a009589. 2012
  8. pmc Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration
    Lucy A Clunes
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    FASEB J 26:533-45. 2012
  9. pmc Endoplasmic reticulum/golgi nucleotide sugar transporters contribute to the cellular release of UDP-sugar signaling molecules
    Juliana I Sesma
    Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7248, USA
    J Biol Chem 284:12572-83. 2009
  10. ncbi request reprint The DeltaF508 mutation results in loss of CFTR function and mature protein in native human colon
    Marcus Mall
    School of Medicine, University of North Carolina at Chapel Hill, NC 27599, USA
    Gastroenterology 126:32-41. 2004

Collaborators

Detail Information

Publications19

  1. pmc Receptor-promoted exocytosis of airway epithelial mucin granules containing a spectrum of adenine nucleotides
    Silvia M Kreda
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, 4029A Thurston Bowles Building, Chapel Hill, NC 27599 7248, USA
    J Physiol 588:2255-67. 2010
    ....
  2. pmc Coordinated release of nucleotides and mucin from human airway epithelial Calu-3 cells
    Silvia M Kreda
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, 7017 Thurston Bowles Building, Chapel Hill, NC 27599 7248, USA
    J Physiol 584:245-59. 2007
    ..Our data suggest that nucleotide release is a mechanism by which mucin-secreting goblet cells produce paracrine signals for mucin hydration within the ASL...
  3. pmc Vesicular nucleotide transporter regulates the nucleotide content in airway epithelial mucin granules
    Juliana I Sesma
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Am J Physiol Cell Physiol 304:C976-84. 2013
    ..By controlling the entry of nucleotides into mucin granules, VNUT contributes to the release of purinergic signaling molecules necessary for the proper hydration of co-released mucins...
  4. pmc Coupled nucleotide and mucin hypersecretion from goblet-cell metaplastic human airway epithelium
    Seiko F Okada
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, 27599, USA
    Am J Respir Cell Mol Biol 45:253-60. 2011
    ....
  5. pmc VAMP8 is a vesicle SNARE that regulates mucin secretion in airway goblet cells
    Lisa C Jones
    Cystic Fibrosis Pulmonary Research and Treatment Centre, The University of North Carolina at Chapel Hill, 4029A Thurston Bowles Building, Chapel Hill, NC 27599 7248, USA
    J Physiol 590:545-62. 2012
    ..Our data indicate that VAMP8 is an essential SNARE in airway mucin granule exocytosis. Reduction of VAMP8 activity/expression may provide a novel therapeutic target to ameliorate airway mucus obstruction in lung diseases...
  6. pmc Rho signaling regulates pannexin 1-mediated ATP release from airway epithelia
    Lucia Seminario-Vidal
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 286:26277-86. 2011
    ..Lastly, knocking down TRPV4 impaired hypotonicity-evoked airway epithelial ATP release. Our data suggest that TRPV4 and Rho transduce cell membrane stretch/strain into pannexin 1-mediated ATP release in airway epithelia...
  7. pmc CFTR, mucins, and mucus obstruction in cystic fibrosis
    Silvia M Kreda
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, NC 27517 7248, USA
    Cold Spring Harb Perspect Med 2:a009589. 2012
    ..In any event, the path between CFTR dysfunction and mucus hyperproduction has proven tortuous, and its unraveling continues to offer its own twists and turns, along with fascinating glimpses into biology...
  8. pmc Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration
    Lucy A Clunes
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    FASEB J 26:533-45. 2012
    ..Furthermore, our data suggest that strategies to rehydrate airway surfaces may provide a novel form of therapy for patients with CB...
  9. pmc Endoplasmic reticulum/golgi nucleotide sugar transporters contribute to the cellular release of UDP-sugar signaling molecules
    Juliana I Sesma
    Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7248, USA
    J Biol Chem 284:12572-83. 2009
    ..Our results illustrate that ER/Golgi lumen constitutes a significant source of extracellular UDP-sugars and therefore plays a critical role in nucleotide sugar-promoted cell signaling...
  10. ncbi request reprint The DeltaF508 mutation results in loss of CFTR function and mature protein in native human colon
    Marcus Mall
    School of Medicine, University of North Carolina at Chapel Hill, NC 27599, USA
    Gastroenterology 126:32-41. 2004
    ..However, data with respect to the processing block of DeltaF508 protein in native epithelia are limited and conflicting...
  11. doi request reprint Imaging CFTR protein localization in cultured cells and tissues
    Silvia M Kreda
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Methods Mol Biol 742:15-33. 2011
    ..Tagging of CFTR with an extracellular epitope permits detection exclusively at the cell surface and subsequent chasing allows visualization of endocytic trafficking...
  12. pmc Characterization of wild-type and deltaF508 cystic fibrosis transmembrane regulator in human respiratory epithelia
    Silvia M Kreda
    Cystic Fibrosis Pulmonary Research and Treatment Center, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7248, USA
    Mol Biol Cell 16:2154-67. 2005
    ..In sum, our data demonstrate that WT CFTR is predominantly expressed in ciliated cells, and deltaF508 CFTR pathogenesis in native tissues, like heterologous cells, reflects loss of normal protein processing...
  13. doi request reprint Molecular mechanisms of purine and pyrimidine nucleotide release
    Eduardo R Lazarowski
    Cystic Fibrosis Pulmonary Research and Treatment Center, School of Medicine, University of North Carolina, Chapel Hill, USA
    Adv Pharmacol 61:221-61. 2011
    ....
  14. doi request reprint Nucleotide release by airway epithelia
    Eduardo R Lazarowski
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, 7011 Thurston Bowles Building, Chapel Hill, NC, 27599, USA
    Subcell Biochem 55:1-15. 2011
    ..Together, these pathways provide fine tuning of epithelial responses regulated by purinergic signaling events...
  15. pmc Physiological regulation of ATP release at the apical surface of human airway epithelia
    Seiko F Okada
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, NC, USA
    J Biol Chem 281:22992-3002. 2006
    ....
  16. ncbi request reprint The cystic fibrosis transmembrane conductance regulator is regulated by a direct interaction with the protein phosphatase 2A
    William R Thelin
    Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 280:41512-20. 2005
    ..Furthermore, PP2A may be a clinically relevant drug target for CF, which should be considered in future studies...
  17. pmc The UDP-sugar-sensing P2Y(14) receptor promotes Rho-mediated signaling and chemotaxis in human neutrophils
    Juliana I Sesma
    Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7248, USA
    Am J Physiol Cell Physiol 303:C490-8. 2012
    ..These results support the notion that UDP-glucose is a stable and potent proinflammatory mediator that promotes P2Y(14)-R-mediated neutrophil motility via Rho/Rho kinase activation...
  18. pmc Direct interaction with filamins modulates the stability and plasma membrane expression of CFTR
    William R Thelin
    Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 117:364-74. 2007
    ..In addition, we elucidate the molecular defect associated with the S13F mutation...
  19. pmc Development of chronic bronchitis and emphysema in beta-epithelial Na+ channel-overexpressing mice
    Marcus A Mall
    Pediatric Pulmonology and Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Am J Respir Crit Care Med 177:730-42. 2008
    ..Previous studies have shown that airway surface dehydration in beta-epithelial Na(+) channel (betaENaC)-overexpressing mice caused a chronic lung disease with high neonatal pulmonary mortality and chronic bronchitis in adult survivors...