Research Topics
| N E KrebsSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
Research Grants
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Detail Information
Publications
Bone mineral density changes during lactation: maternal, dietary, and biochemical correlatesN F Krebs
Department of Pediatrics, University of Colorado School of Medicine, Denver 80262, USA
Am J Clin Nutr 65:1738-46. 1997..The results also suggest that the bone loss may be attenuated by a generous dietary ratio of calcium to protein...- Comprehensive integration of nutrition into medical trainingNancy F Krebs
Department of Pediatrics, University of Colorado School of Medicine, 4200 East Ninth Avenue, Box C225, Denver, CO 80262, USA
Am J Clin Nutr 83:945S-950S. 2006..Finally, a coordinator is needed to monitor the many "fronts" of the integrated nutrition curriculum and to continue networking and program implementation... - Screening for overweight in children and adolescents: a call to actionNancy F Krebs
Department of Pediatrics, University of Colorado Health Sciences Center School of Medicine Denver, CO 80262-0001, USA
Pediatrics 116:238-9. 2005 - Exchangeable zinc pool size at birth is smaller in small-for-gestational-age than in appropriate-for-gestational-age preterm infantsNancy F Krebs
Section of Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Denver, CO 80262, USA
Am J Clin Nutr 84:1340-3. 2006..Small-for-gestational-age (SGA) infants are susceptible to postnatal zinc deficiency, but whether this susceptibility is due to intrauterine factors or to high postnatal growth requirements is unknown... - Food choices to meet nutritional needs of breast-fed infants and toddlers on mixed dietsNancy F Krebs
University of Colorado Health Science Center, Department of Pediatrics, Denver, CO 80262 0001, USA
J Nutr 137:511S-517S. 2007..In contrast to current practices in both developed and developing countries, meats should be considered as an early complementary food for breast-fed infants to provide essential micronutrients... - Exchangeable zinc pool size in infants is related to key variables of zinc homeostasisNancy F Krebs
Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Nutr 133:1498S-501S. 2003..We conclude that the amount of absorbed zinc is not tightly regulated, and that endogenous fecal zinc is dependent on and responsive to the zinc status of the organism... - Complementary feeding: clinically relevant factors affecting timing and compositionNancy F Krebs
Section of Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Denver, CO 80252, USA
Am J Clin Nutr 85:639S-645S. 2007.... - Meat as a first complementary food for breastfed infants: feasibility and impact on zinc intake and statusNancy F Krebs
Section of Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
J Pediatr Gastroenterol Nutr 42:207-14. 2006..This study was undertaken to assess the feasibility and effects of consuming either meat or iron-fortified infant cereal as the first complementary food... - Zinc supplementation during lactationN F Krebs
Center for Human Nutrition, University of Colorado School of Medicine, Denver 80262, USA
Am J Clin Nutr 68:509S-512S. 1998..The studies that have examined the zinc status of breast-fed infants are also reviewed... - Bioavailability of dietary supplements and impact of physiologic state: infants, children and adolescentsN F Krebs
Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado 80262, USA
J Nutr 131:1351S-4S. 2001.... - Zinc metabolism and homeostasis: the application of tracer techniques to human zinc physiologyN E Krebs
Department of Pediatrics, University of Colorado School of Medicine, Denver, USA
Biometals 14:397-412. 2001.... - Assessment of child and adolescent overweight and obesityNancy F Krebs
Department of Pediatrics, University of Colorado School of Medicine, 4200 E Ninth Ave, Box C225, Denver, CO 80262, USA
Pediatrics 120:S193-228. 2007..With this information, clinicians should find themselves better equipped to face the challenges of assessing childhood overweight and obesity accurately... - Dysprosium as a nonabsorbable fecal marker in studies of zinc homeostasisXiao-Yang Sheng
Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Am J Clin Nutr 82:1017-23. 2005..95) with those from the fecal monitoring and dual-isotope-tracer ratio methods. CONCLUSION: Administration of dysprosium is a useful means of determining the completeness of fecal collections and of measuring zinc absorption... - Zinc homeostasis in Malawian children consuming a high-phytate, maize-based dietMark J Manary
Department of Pediatrics, Washington University School of Medicine, St Louis, USA
Am J Clin Nutr 75:1057-61. 2002..The gastrointestinal tract plays a central role in absorbing and conserving zinc, yet it has not been carefully studied in such children... 
Zinc bioavailability and homeostasisK Michael Hambidge
Department of Pediatrics, Section of Nutrition, University of Colorado Denver, Denver, CO, USA
Am J Clin Nutr 91:1478S-1483S. 2010..The effects of phytate on intestinal losses of endogenous zinc merit further investigation but are probably not of the same magnitude as its inhibitory effects on absorption of exogenous zinc...- Zinc absorption from a low-phytic acid maizeChristina L Adams
Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver 80220, USA
Am J Clin Nutr 76:556-9. 2002..30 +/- 0.13 and 0.17 +/- 0.11, respectively (P < 0.005). CONCLUSION: Substitution of a low-phytic acid grain in a maize-based diet is associated with a substantial increase in zinc absorption... - Meat as an early complementary food for infants: implications for macro- and micronutrient intakesNancy F Krebs
Section of Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado, USA
Nestle Nutr Workshop Ser Pediatr Program 60:221-9; discussion 229-33. 2007..This pattern of macronutrient intake is contrary to that of the period when the human genome evolved, and may influence the metabolic profile in young children, especially under conditions of nutritional abundance... - Zinc absorption as a function of the dose of zinc sulfate in aqueous solutionCuong D Tran
Section of Nutrition, Department of Pediatrics, The University of Colorado Health Science Center, Denver, USA
Am J Clin Nutr 80:1570-3. 2004..Zinc supplements are used extensively in medicine and research and for public health purposes in the prevention and treatment of zinc deficiency. However, little is known about the efficiency of zinc utilization after different doses... - Relationships among plasma zinc, plasma prolactin, milk transfer, and milk zinc in lactating womenNancy F Krebs
University of Colorado Cancer Center, Denver 80262, USA
J Hum Lact 23:179-83. 2007..67, P<.001) and 7 months (r=.53, P<.01), consistent with PRL role in lactation maintenance. Studies including zinc-deficient lactating women are required to clarify the interrelationships between zinc status and PRL secretion... - A mathematical model of zinc absorption in humans as a function of dietary zinc and phytateLeland V Miller
Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Nutr 137:135-41. 2007..The model was judged to be valid and of immediate value for studying and predicting absorption. A version of the model incorporating a passive absorption mechanism was not supported by the available data... - Dietary reference intakes for zinc may require adjustment for phytate intake based upon model predictionsK Michael Hambidge
Department of Pediatrics, Section of Nutrition, University of Colorado, School of Medicine, Denver, CO 80262, USA
J Nutr 138:2363-6. 2008..4 mg Zn/d. Extrapolation of the model suggested, for example, that with 900 mg/d phytate, 100 mg dietary Zn is required to attain 6.4 mg absorbed Zn/d. Experimental studies with higher Zn intakes are required to test these predictions... - Zinc deficiency: a special challengeK Michael Hambidge
Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80220, USA
J Nutr 137:1101-5. 2007..Barriers to acceptability and availability of affordable meat are considered, but these are neither universal nor irresolvable in all populations... - Zinc absorption during late pregnancy in rural southern EthiopiaK Michael Hambidge
Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO, USA
Am J Clin Nutr 84:1102-6. 2006..Little is yet known about zinc absorption in late pregnancy, and no information on absorption from the total diet is available... - Measurements of zinc absorption: application and interpretation in research designed to improve human zinc nutritureK Michael Hambidge
Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Box C225, 4200 E 9th Av, Denver, Colorado, 80262, USA
Int J Vitam Nutr Res 75:385-93. 2005..They also suggest the potential utility of measurements of the quantity of zinc absorbed when evaluating the zinc status of populations... - Intestinal excretion of endogenous zinc in Guatemalan school childrenK Michael Hambidge
Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Nutr 137:1747-9. 2007..Supported by other recent childhood data, these results suggest that the current estimates of EFZ(PR) used in the calculation of Zn requirements for children are misleadingly low... - Changes in zinc absorption during developmentK Michael Hambidge
Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Pediatr 149:S64-8. 2006..Normal homeostatic mechanisms in the premature infant prevented efficient absorption of the quantity of Zn required or/and optimal conservation of endogenous Zn... - Zinc and breastfed infants: if and when is there a risk of deficiency?Nancy F Krebs
University of Colorado, School of Medicine, Denver 80262, USA
Adv Exp Med Biol 503:69-75. 2002.... - Zinc absorption from low-phytate hybrids of maize and their wild-type isohybridsK Michael Hambidge
University of Colorado Health Sciences Center, Department of Pediatrics, Section of Nutrition, Denver 80262, USA
Am J Clin Nutr 79:1053-9. 2004.... - Zinc homeostasis during lactation in a population with a low zinc intakeLei Sian
Section of Nutrition, The Department of Pediatrics, The University of Colorado Health Sciences Center, Denver, CO 80262, USA
Am J Clin Nutr 75:99-103. 2002.... - Absorption of calcium from tortilla meals prepared from low-phytate maizeK Michael Hambidge
Department of Pediatrics, Section of Nutrition, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Am J Clin Nutr 82:84-7. 2005..Bioavailability of calcium is, however, compromised by phytate, which is present in large quantities in maize kernels and is only modestly reduced by nixtamalization... - Major variables of zinc homeostasis in Chinese toddlersXiao Yang Sheng
Department of Child and Adolescent Health, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Am J Clin Nutr 84:389-94. 2006..The data required for this approach have not been available for toddlers, whose requirements have been estimated by extrapolation from other age groups... - Community-based dietary phytate reduction and its effect on iron status in Malawian childrenMark J Manary
Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, One Children s Place, St Louis, MO 63110, USA
Ann Trop Paediatr 22:133-6. 2002..Phytate was removed by soaking maize flour in excess water with phytase and decanting the water before cooking the flour. Iron status, as measured by soluble transferrin receptor and zinc protoporphyrin, was improved but not normal... - Validation of a food frequency questionnaire in preschool childrenLezlie A Parrish
Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver 80262, USA
Epidemiology 14:213-7. 2003..In addition, the validity of the FFQ using parental report does not appear to be compromised when there are meal providers in addition to the parents... - The use of dysprosium to measure endogenous zinc excretion in feces eliminates the necessity of complete fecal collectionsLeland V Miller
University of Colorado Denver, Department of Pediatrics, Aurora, CO 80045, USA
J Nutr 140:1524-8. 2010..We found that the measurement of the sample Dy:Zn ratio was useful for selecting samples for measurement. We conclude that the Dy method of determining EFZ is a valid and less burdensome alternative to current techniques... - Efficacy and safety of a high protein, low carbohydrate diet for weight loss in severely obese adolescentsNancy F Krebs
Department of Pediatrics, Section of Nutrition, University of Colorado Denver, Aurora, CO 80045, USA
J Pediatr 157:252-8. 2010..To evaluate the efficacy and safety of a carbohydrate restricted versus a low fat diet on weight loss, metabolic markers, body composition, and cardiac function tests in severely obese adolescents... - Early growth faltering in healthy term infants predicts longitudinal growthErin S Ross
Section of Nutrition, Department of Pediatrics, School of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
Early Hum Dev 85:583-8. 2009..Early growth monitoring may not identify infants at-risk for later growth faltering because it is difficult for the provider to recognize how large of a negative shift might be problematic... - Disease severity at time of referral for pediatric failure to thrive and obesity: time for a paradigm shift?Laurie A Miller
Section of Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Denver 80262, USA
J Pediatr 141:121-4. 2002..Results indicated that underweight children were mildly underweight, whereas the overweight children were severely so. In primary care settings, underweight children may be referred more aggressively than overweight children... 
Breastfeeding and WIC enrollment in the Nurse Family Partnership ProgramMaya Bunik
Department of Pediatrics, University of Colorado Denver, Aurora, Colorado, USA
Breastfeed Med 4:145-9. 2009..Our aim was to compare breastfeeding rates at 6 and 12 months in NFP high-risk mothers who were enrolled in WIC to those who were not enrolled in WIC...- Zinc, low birth weight, and breastfeedingK Michael Hambidge
Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Pediatrics 112:1419-20. 2003 - Accuracy of simple techniques for estimating fractional zinc absorption in humansMichael Hambidge
J Nutr 132:322-3. 2002 - Zinc absorption and exchangeable zinc pool sizes in breast-fed infants fed meat or cereal as first complementary foodSanju Jalla
Johns Hopkins University, Baltimore, Maryland, USA
J Pediatr Gastroenterol Nutr 34:35-41. 2002..The significant positive correlation between zinc intake and exchangeable zinc pool size suggests that increasing zinc intake positively affects metabolically available zinc... - Zinc absorption in Guatemalan schoolchildren fed normal or low-phytate maizeManolo Mazariegos
Center for Studies of Sensory Impairments, Aging, and Metabolism, Guatemala City, Guatemala
Am J Clin Nutr 83:59-64. 2006..Poor bioavailability of zinc from high-phytate diets is an important contributory factor to zinc deficiency in low-income populations... - Inadequate intakes of dietary zinc among pregnant women from subsistence households in Sidama, Southern EthiopiaYewelsew Abebe
College of Agriculture, Hawassa University, Awassa, Ethiopia
Public Health Nutr 11:379-86. 2008..To assess the prevalence of zinc inadequacy based on dietary intakes and plasma zinc concentrations and, simultaneously, the prevalence of inadequate intakes of energy, protein, calcium and iron... - Lower calcium absorption in infants fed casein hydrolysate- and soy protein-based infant formulas containing palm olein versus formulas without palm oleinKarin M Ostrom
Research and Development and Scientific Affairs, Ross Products Division, Abbott Laboratories, Columbus, Ohio 43215, USA
J Am Coll Nutr 21:564-9. 2002..These findings corroborate previous reports of this negative effect of PO in cow milk-based infant formulas in which most of the calcium is a component of the cow milk protein source... - Prevention of pediatric overweight and obesityNancy F Krebs
Pediatrics 112:424-30. 2003..This statement proposes strategies for early identification of excessive weight gain by using body mass index, for dietary and physical activity interventions during health supervision encounters, and for advocacy and research... - Longitudinal measurements of zinc absorption in Peruvian children consuming wheat products fortified with iron only or iron and 1 of 2 amounts of zincDaniel Lopez de Romaña
Program in International Nutrition and the Department of Nutrition, University of California, Davis 95616, USA
Am J Clin Nutr 81:637-47. 2005..Information is needed on the fractional absorption of zinc (FAZ) and absorbed zinc (AZ) during prolonged exposure to zinc-fortified foods... - Zinc homeostasis in premature infants does not differ between those fed preterm formula or fortified human milkSanju Jalla
Johns Hopkins Oncology Center, Johns Hopkins University, Baltimore, Maryland 21231, USA
Pediatr Res 56:615-20. 2004..Current zinc intakes from fortified human milk or formula are associated with acceptable weight gain, but whether the observed net zinc absorption was optimal in the human milk group cannot be definitively determined from these data... - Optimizing bone health and calcium intakes of infants, children, and adolescentsFrank R Greer
Pediatrics 117:578-85. 2006..Establishing these practices in childhood is important so that they will be followed throughout the life span... - Zinc, gravida, infection, and iron, but not vitamin B-12 or folate status, predict hemoglobin during pregnancy in Southern EthiopiaRosalind S Gibson
Department of Human Nutrition, University of Otago, Dunedin, New Zealand 9015
J Nutr 138:581-6. 2008..Despite some early functional vitamin B-12 deficiency, there was no macrocytic anemia. Consumption of fermented enset may have increased vitamin B-12 levels in diet and plasma... - Bariatric surgery for severely overweight adolescents: concerns and recommendationsThomas H Inge
Department of Pediatric Surgery, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
Pediatrics 114:217-23. 2004..Surgery should be performed in institutions that are equipped to meet the tertiary care needs of severely obese patients and to collect long-term data on the clinical outcomes of these patients... - Plasma zinc concentrations are depressed during the acute phase response in children with falciparum malariaChristopher Duggan
Division of Gastroenterology and Nutrition, Children's Hospital, Boston, MA, USA
J Nutr 135:802-7. 2005..In children whose age, diet, and/or nutritional status place them at risk of zinc deficiency, those with low plasma zinc levels should be supplemented with oral zinc and followed for clinical and/or biochemical response...
Research Grants
- Intestinal Endogenous Zinc: Role for Metallothionein?Nancy Krebs; Fiscal Year: 2003..abstract_text> ..
- INTEGRATION OF CLINICAL NUTRITION INTO MEDICAL TRAININGNancy Krebs; Fiscal Year: 2004..An evaluation will examine process and impact on learner knowledge, attitudes, and confidence regarding nutrition assessment and counseling. ..
- INSTITUTIONAL TRAINING PROGRAM IN NUTRITIONNancy Krebs; Fiscal Year: 2007....