Jeffrey A Kraut

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Treatment of acute metabolic acidosis: a pathophysiologic approach
    Jeffrey A Kraut
    Division of Nephrology, Veterans Health Administration Greater Los Angeles Heathcare System, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Nat Rev Nephrol 8:589-601. 2012
  2. pmc Differential diagnosis of nongap metabolic acidosis: value of a systematic approach
    Jeffrey A Kraut
    Medical and Research Services, Veterans Administration Greater Los Angeles Healthcare System, California 90073, USA
    Clin J Am Soc Nephrol 7:671-9. 2012
  3. ncbi request reprint Approach to patients with acid-base disorders
    J A Kraut
    University of California, Los Angeles, School of Medicine, USA
    Respir Care 46:392-403. 2001
  4. doi request reprint Approach to the evaluation of a patient with an increased serum osmolal gap and high-anion-gap metabolic acidosis
    Jeffrey A Kraut
    Medical and Research Services Veterans Administration Greater Los Angeles VHAGLA Healthcare System, Los Angeles, CA 90073, USA
    Am J Kidney Dis 58:480-4. 2011
  5. ncbi request reprint Toxic alcohol ingestions: clinical features, diagnosis, and management
    Jeffrey A Kraut
    Medical and Research Services, UCLA Membrane Biology Laboratory, VHAGLA Healthcare System, Los Angeles, CA 90073, USA
    Clin J Am Soc Nephrol 3:208-25. 2008
  6. ncbi request reprint Serum anion gap: its uses and limitations in clinical medicine
    Jeffrey A Kraut
    Medical and Research Services VHAGLA Healthcare System, UCLA Membrane Biology Laboratory, and Division of Nephrology VHAGLA Healthcare System and David Geffen School of Medicine, Los Angeles, California 90073, USA
    Clin J Am Soc Nephrol 2:162-74. 2007
  7. ncbi request reprint Use of base in the treatment of acute severe organic acidosis by nephrologists and critical care physicians: results of an online survey
    Jeffrey A Kraut
    Medical and Research Services VHAGLA Healthcare System, Division of Nephrology VHAGLA Healthcare System and David Geffen School of Medicine, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Clin Exp Nephrol 10:111-7. 2006
  8. ncbi request reprint Metabolic acidosis of CKD: diagnosis, clinical characteristics, and treatment
    Jeffrey A Kraut
    Division of Nephrology, Veterans Affairs Greater Los Angeles Health Care System, Los Angeles, CA 90073, USA
    Am J Kidney Dis 45:978-93. 2005
  9. ncbi request reprint Use of base in the treatment of severe acidemic states
    J A Kraut
    Division of Nephrology, Veterans Administration Greater Los Angeles Health Care System, Los Angeles, CA 90073, USA
    Am J Kidney Dis 38:703-27. 2001
  10. ncbi request reprint Detection and localization of H+-K+-ATPase isoforms in human kidney
    J A Kraut
    Division of Nephrology, Research Service and Department of Medicine, Veterans Affairs Greater Los Angeles Health Care System, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
    Am J Physiol Renal Physiol 281:F763-8. 2001

Detail Information

Publications19

  1. doi request reprint Treatment of acute metabolic acidosis: a pathophysiologic approach
    Jeffrey A Kraut
    Division of Nephrology, Veterans Health Administration Greater Los Angeles Heathcare System, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Nat Rev Nephrol 8:589-601. 2012
    ..Given the important effects of acute metabolic acidosis on clinical outcomes, more intensive study of the pathogenesis of the associated cellular dysfunction and novel methods of treatment is indicated...
  2. pmc Differential diagnosis of nongap metabolic acidosis: value of a systematic approach
    Jeffrey A Kraut
    Medical and Research Services, Veterans Administration Greater Los Angeles Healthcare System, California 90073, USA
    Clin J Am Soc Nephrol 7:671-9. 2012
    ..It also provides a systematic and cost-effective approach to the differential diagnosis of nongap metabolic acidosis...
  3. ncbi request reprint Approach to patients with acid-base disorders
    J A Kraut
    University of California, Los Angeles, School of Medicine, USA
    Respir Care 46:392-403. 2001
    ..Strict adherence to these principles will enable the clinician to diagnose the acid-base disturbance in the majority of cases. To illustrate these principles, 5 cases of patients with acid-base disturbances are analyzed...
  4. doi request reprint Approach to the evaluation of a patient with an increased serum osmolal gap and high-anion-gap metabolic acidosis
    Jeffrey A Kraut
    Medical and Research Services Veterans Administration Greater Los Angeles VHAGLA Healthcare System, Los Angeles, CA 90073, USA
    Am J Kidney Dis 58:480-4. 2011
    ..In this teaching case, we present a systematic approach to diagnosing high serum osmolality and increased serum osmolal gap with or without high-anion-gap metabolic acidosis...
  5. ncbi request reprint Toxic alcohol ingestions: clinical features, diagnosis, and management
    Jeffrey A Kraut
    Medical and Research Services, UCLA Membrane Biology Laboratory, VHAGLA Healthcare System, Los Angeles, CA 90073, USA
    Clin J Am Soc Nephrol 3:208-25. 2008
    ....
  6. ncbi request reprint Serum anion gap: its uses and limitations in clinical medicine
    Jeffrey A Kraut
    Medical and Research Services VHAGLA Healthcare System, UCLA Membrane Biology Laboratory, and Division of Nephrology VHAGLA Healthcare System and David Geffen School of Medicine, Los Angeles, California 90073, USA
    Clin J Am Soc Nephrol 2:162-74. 2007
    ..Despite these caveats, calculation of the serum anion gap remains an inexpensive and effective tool that aids detection of various acid-base disorders, hematologic malignancies, and intoxications...
  7. ncbi request reprint Use of base in the treatment of acute severe organic acidosis by nephrologists and critical care physicians: results of an online survey
    Jeffrey A Kraut
    Medical and Research Services VHAGLA Healthcare System, Division of Nephrology VHAGLA Healthcare System and David Geffen School of Medicine, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Clin Exp Nephrol 10:111-7. 2006
    ..Nephrologists and critical care specialists are often the physicians developing recommendations for the treatment of severe acid-base disorders...
  8. ncbi request reprint Metabolic acidosis of CKD: diagnosis, clinical characteristics, and treatment
    Jeffrey A Kraut
    Division of Nephrology, Veterans Affairs Greater Los Angeles Health Care System, Los Angeles, CA 90073, USA
    Am J Kidney Dis 45:978-93. 2005
    ..In the present review, we describe clinical and laboratory characteristics of metabolic acidosis, discuss potential adverse effects, and address benefits and complications of therapy...
  9. ncbi request reprint Use of base in the treatment of severe acidemic states
    J A Kraut
    Division of Nephrology, Veterans Administration Greater Los Angeles Health Care System, Los Angeles, CA 90073, USA
    Am J Kidney Dis 38:703-27. 2001
    ..The potential value of base therapy in the treatment of severe acidemia remains an important issue, and further studies are required to determine which patients should be administered base therapy and what base should be used...
  10. ncbi request reprint Detection and localization of H+-K+-ATPase isoforms in human kidney
    J A Kraut
    Division of Nephrology, Research Service and Department of Medicine, Veterans Affairs Greater Los Angeles Health Care System, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
    Am J Physiol Renal Physiol 281:F763-8. 2001
    ..These data indicate that HKalpha(1) and HKalpha(4) are present in the collecting ducts of the human kidney. In this location, these isoforms might contribute to hydrogen and potassium transport by the kidney...
  11. doi request reprint Metabolic acidosis: pathophysiology, diagnosis and management
    Jeffrey A Kraut
    Division of Nephrology, Veterans Administration Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Nat Rev Nephrol 6:274-85. 2010
    ..By contrast, the administration of base for the treatment of chronic metabolic acidosis is associated with improved cellular function and few complications...
  12. pmc Simple diagnostic tests to detect toxic alcohol intoxications
    Jai Moo Shin
    Medical and Research Services VHAGLA Healthcare System, UCLA Membrane Biology Laboratory, Division of Nephrology VHAGLA Healthcare System and David Geffen School of Medicine, Los Angeles, CA, USA
    Transl Res 152:194-201. 2008
    ..The relatively high sensitivity and specificity of the tests as a whole will facilitate the rapid diagnosis of each of these alcohol intoxications...
  13. pmc The serum anion gap in the evaluation of acid-base disorders: what are its limitations and can its effectiveness be improved?
    Jeffrey A Kraut
    Medical and Research Services, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, Membrane Biology Laboratory, University of California, Los Angeles, California, Division of Nephrology, Veterans Affairs Greater Los Angeles Healthcare System, David Geffen School of Medicine, Los Angeles, California
    Clin J Am Soc Nephrol 8:2018-24. 2013
    ..The possibility of identifying the baseline value for individuals to optimize the use of the calculation in the detection of metabolic acidosis is suggested. ..
  14. doi request reprint Acid stress increases gene expression of proinflammatory cytokines in Madin-Darby canine kidney cells
    Suraja Raj
    Medical Services, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Am J Physiol Renal Physiol 304:F41-8. 2013
    ..With extracellular pH (pH(o)) of 7.0, pH(i) fell and remained depressed. These findings suggest that a pH stress alone can increase renal expression of proinflammatory and other genes that contribute to renal injury...
  15. pmc Consequences and therapy of the metabolic acidosis of chronic kidney disease
    Jeffrey A Kraut
    Medical and Research Services, VHAGLA Healthcare System, UCLA Membrane Biology Laboratory, Los Angeles, CA, USA
    Pediatr Nephrol 26:19-28. 2011
    ....
  16. doi request reprint Spurious elevation in serum creatinine caused by ingestion of nitromethane: implication for the diagnosis and treatment of methanol intoxication
    Anjay Rastogi
    Division of Nephrology, UCLA Center for Health Sciences and David Geffen School of Medicine, Los Angeles, CA 90073, USA
    Am J Kidney Dis 52:181-7. 2008
  17. doi request reprint Acid-base regulation of angiotensin receptors in the kidney
    Glenn T Nagami
    Nephrology Section and Nephrology Research Laboratory, Department of Medicine and Research Service, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Curr Opin Nephrol Hypertens 19:91-7. 2010
    ..Here we review the impact of Ang II on acid-base transport in specific nephron segments and discuss the recently described role of acid loading in sensitizing the proximal tubule to Ang II...
  18. pmc Role of N-glycosylation in trafficking of apical membrane proteins in epithelia
    Olga Vagin
    Department of Physiology, David Geffen School of Medicine at University of California, Bldg 113, Rm 324, 11301 Wilshire Blvd, Los Angeles, California 90073, USA
    Am J Physiol Renal Physiol 296:F459-69. 2009
    ..Finally, we review existing hypotheses on the mechanism of apical sorting and discuss the potential roles of the lectins, VIP36 and galectin-3, as putative apical sorting receptors...
  19. ncbi request reprint What unique acid-base considerations exist in dialysis patients?
    Man S Oh
    Department of Medicine, State University of New York, Downstate Medical Center, Brooklyn, New York 11203, USA
    Semin Dial 17:351-64. 2004