Research Topics
Species | Matthew D KrasowskiSummaryAffiliation: University of Iowa Country: USA Publications
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Detail Information
Publications
Positive hepatitis B surface antigen tests due to recent vaccination: a persistent problemCarolyn D Rysgaard
Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242, USA
BMC Clin Pathol 12:15. 2012..abstract:..
Extremely high myoglobin plasma concentrations producing hook effect in a critically ill patientMichelle Kurt-Mangold
Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
Clin Chim Acta 414:179-81. 2012..The patient required extended cardiopulmonary resuscitation and had further complications including compartment syndrome...- Clinical decision support of therapeutic drug monitoring of phenytoin: measured versus adjusted phenytoin plasma concentrationsMatthew D Krasowski
Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
BMC Med Inform Decis Mak 12:7. 2012..The measured free phenytoin plasma concentration was used as the gold standard... - A retrospective analysis of glycol and toxic alcohol ingestion: utility of anion and osmolal gapsMatthew D Krasowski
Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242, USA
BMC Clin Pathol 12:1. 2012..abstract:.. - Evolutionary diversity of bile salts in reptiles and mammals, including analysis of ancient human and extinct giant ground sloth coprolitesLee R Hagey
Department of Medicine, University of California San Diego, La Jolla, CA, USA
BMC Evol Biol 10:133. 2010..We greatly extend prior surveys of bile salt diversity in both reptiles and mammals, including analysis of 8,000 year old human coprolites and coprolites from the extinct Shasta ground sloth (Nothrotherium shastense)... - The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian speciesMatthew D Krasowski
Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
BMC Biochem 12:5. 2011..We utilize homology modelling, docking, and pharmacophore studies to understand the structural features of the Tetraodon receptors... - Evolution of promiscuous nuclear hormone receptors: LXR, FXR, VDR, PXR, and CARMatthew D Krasowski
Department of Pathology, University of Iowa Hospitals and Clinics, RCP 6233, 200 Hawkins Drive, Iowa City, IA 52242, USA
Mol Cell Endocrinol 334:39-48. 2011.... - Evolution of the bile salt nuclear receptor FXR in vertebratesErica J Reschly
Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
J Lipid Res 49:1577-87. 2008..Our observations present an integrated picture of the coevolution of bile salt structure and of the binding pocket of their target nuclear receptor FXR... - Drug monitoring: simultaneous analysis of lamotrigine, oxcarbazepine, 10-hydroxycarbazepine, and zonisamide by HPLC-UV and a rapid GC method using a nitrogen-phosphorus detector for levetiracetamElizabeth Greiner Sosanko
Toxicology and Therapeutic Drug Monitoring Laboratory, Division of Clinical Chemistry, Department of Pathology, University of Pittsburgh Medical Center, Children s Hospital Main Tower 5812, Pittsburgh, PA 15213, USA
J Chromatogr Sci 45:616-22. 2007.... - Functional evolution of the vitamin D and pregnane X receptorsErica J Reschly
Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
BMC Evol Biol 7:222. 2007..In addition, several assays were used to search for evidence of PXR-mediated hepatic effects in three model non-mammalian species: sea lamprey (Petromyzon marinus), zebrafish (Danio rerio), and African clawed frog (Xenopus laevis)... - Functional evolution of the pregnane X receptorManisha Iyer
Department of Pathology, University of Pittsburgh, Scaife Hall S-730, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Expert Opin Drug Metab Toxicol 2:381-97. 2006..Research into the evolutionary history of the PXR gene has also provided insight into the function of PXR in humans and other animals... - Molecular similarity methods for predicting cross-reactivity with therapeutic drug monitoring immunoassaysMatthew D Krasowski
Department of Pathology, University of Pittsburgh, Scaife Hall S 737, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Ther Drug Monit 31:337-44. 2009.... - Chemoinformatic methods for predicting interference in drug of abuse/toxicology immunoassaysMatthew D Krasowski
Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
Clin Chem 55:1203-13. 2009..To date, there has been little systematic investigation using computational tools to predict cross-reactive compounds... - Evolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile saltsMatthew D Krasowski
University of Pittsburgh, Department of Pathology, 200 Lothrop, Pittsburgh, PA 15213, USA
Mol Endocrinol 19:1720-39. 2005..PXR specificity for bile salts has thus paralleled the increasing complexity of the bile salt synthetic pathway during vertebrate evolution, an unusual example of ligand-receptor coevolution in the nuclear hormone receptor superfamily... - Intrinsic disorder in nuclear hormone receptorsMatthew D Krasowski
Department of Pathology, University of Pittsburgh, Scaife Hall S 737, 3550 Terrace Street Pittsburgh, Pennsylvania 15261, USA
J Proteome Res 7:4359-72. 2008..This information enables further understanding of these therapeutic targets... - Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compoundsE J Reschly
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Curr Drug Metab 7:349-65. 2006..This review examines the insights that phylogenetic and experimental studies provide into the function of VDR, PXR, and CAR, and how the functions of these receptors have expanded to evolutionary advantage in humans and other animals... - Using molecular similarity to highlight the challenges of routine immunoassay-based drug of abuse/toxicology screening in emergency medicineMatthew D Krasowski
Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
BMC Emerg Med 9:5. 2009..For immunoassays targeted at a particular class of drugs, there can also be false negatives if there is failure to detect some drugs or their metabolites within that class... - Unresolved discrepancies between cannabinoid test results for infant urineVilte E Barakauskas
Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA
Clin Chem 58:1364-7. 2012..This study investigated the rate of unconfirmed positive screen results in infant and noninfant urine samples and evaluated possible reasons for differences... - Simultaneous determination of lamotrigine, zonisamide, and carbamazepine in human plasma by high-performance liquid chromatographyElizabeth Greiner Sosanko
Toxicology and Therapeutic Drug Monitoring Laboratory, Division of Clinical Chemistry, Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Biomed Chromatogr 21:225-8. 2007..Other anti-epileptic medications tested did not interfere with the assay. The method is appropriate for determining lamotrigine, carbamazepine and zonisamide serum or plasma concentrations for therapeutic monitoring... - Pathology consultation on vitamin D testingMatthew D Krasowski
Department of Pathology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA
Am J Clin Pathol 136:507-14. 2011..This article presents a common clinical case scenario regarding vitamin D and an up-to-date discussion and review of the literature on vitamin D testing...