Matthew D Krasowski

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Chemoinformatic methods for predicting interference in drug of abuse/toxicology immunoassays
    Matthew D Krasowski
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Clin Chem 55:1203-13. 2009
  2. pmc Molecular similarity methods for predicting cross-reactivity with therapeutic drug monitoring immunoassays
    Matthew D Krasowski
    Department of Pathology, University of Pittsburgh, Scaife Hall S 737, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Ther Drug Monit 31:337-44. 2009
  3. pmc Using molecular similarity to highlight the challenges of routine immunoassay-based drug of abuse/toxicology screening in emergency medicine
    Matthew D Krasowski
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
    BMC Emerg Med 9:5. 2009
  4. pmc Functional evolution of the vitamin D and pregnane X receptors
    Erica J Reschly
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
    BMC Evol Biol 7:222. 2007
  5. pmc Ligand specificity and evolution of liver X receptors
    Erica J Reschly
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, United States
    J Steroid Biochem Mol Biol 110:83-94. 2008
  6. pmc The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species
    Matthew D Krasowski
    Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    BMC Biochem 12:5. 2011
  7. pmc Evolution of pharmacologic specificity in the pregnane X receptor
    Sean Ekins
    Collaborations in Chemistry, Inc, Jenkintown, PA, USA
    BMC Evol Biol 8:103. 2008
  8. pmc Functional evolution of the pregnane X receptor
    Manisha Iyer
    Department of Pathology, University of Pittsburgh, Scaife Hall S 730, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Expert Opin Drug Metab Toxicol 2:381-97. 2006
  9. pmc Evolution of promiscuous nuclear hormone receptors: LXR, FXR, VDR, PXR, and CAR
    Matthew D Krasowski
    Department of Pathology, University of Iowa Hospitals and Clinics, RCP 6233, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Mol Cell Endocrinol 334:39-48. 2011
  10. pmc Evolution of the bile salt nuclear receptor FXR in vertebrates
    Erica J Reschly
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Lipid Res 49:1577-87. 2008

Collaborators

Detail Information

Publications24

  1. pmc Chemoinformatic methods for predicting interference in drug of abuse/toxicology immunoassays
    Matthew D Krasowski
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Clin Chem 55:1203-13. 2009
    ..To date, there has been little systematic investigation using computational tools to predict cross-reactive compounds...
  2. pmc Molecular similarity methods for predicting cross-reactivity with therapeutic drug monitoring immunoassays
    Matthew D Krasowski
    Department of Pathology, University of Pittsburgh, Scaife Hall S 737, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Ther Drug Monit 31:337-44. 2009
    ....
  3. pmc Using molecular similarity to highlight the challenges of routine immunoassay-based drug of abuse/toxicology screening in emergency medicine
    Matthew D Krasowski
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
    BMC Emerg Med 9:5. 2009
    ..For immunoassays targeted at a particular class of drugs, there can also be false negatives if there is failure to detect some drugs or their metabolites within that class...
  4. pmc Functional evolution of the vitamin D and pregnane X receptors
    Erica J Reschly
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
    BMC Evol Biol 7:222. 2007
    ..In addition, several assays were used to search for evidence of PXR-mediated hepatic effects in three model non-mammalian species: sea lamprey (Petromyzon marinus), zebrafish (Danio rerio), and African clawed frog (Xenopus laevis)...
  5. pmc Ligand specificity and evolution of liver X receptors
    Erica J Reschly
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, United States
    J Steroid Biochem Mol Biol 110:83-94. 2008
    ..The results suggest that LXRs have a long evolutionary history, with vertebrate LXRs diverging from invertebrate LXRs in ligand specificity...
  6. pmc The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species
    Matthew D Krasowski
    Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    BMC Biochem 12:5. 2011
    ..We utilize homology modelling, docking, and pharmacophore studies to understand the structural features of the Tetraodon receptors...
  7. pmc Evolution of pharmacologic specificity in the pregnane X receptor
    Sean Ekins
    Collaborations in Chemistry, Inc, Jenkintown, PA, USA
    BMC Evol Biol 8:103. 2008
    ....
  8. pmc Functional evolution of the pregnane X receptor
    Manisha Iyer
    Department of Pathology, University of Pittsburgh, Scaife Hall S 730, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Expert Opin Drug Metab Toxicol 2:381-97. 2006
    ..Research into the evolutionary history of the PXR gene has also provided insight into the function of PXR in humans and other animals...
  9. pmc Evolution of promiscuous nuclear hormone receptors: LXR, FXR, VDR, PXR, and CAR
    Matthew D Krasowski
    Department of Pathology, University of Iowa Hospitals and Clinics, RCP 6233, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Mol Cell Endocrinol 334:39-48. 2011
    ....
  10. pmc Evolution of the bile salt nuclear receptor FXR in vertebrates
    Erica J Reschly
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Lipid Res 49:1577-87. 2008
    ..Our observations present an integrated picture of the coevolution of bile salt structure and of the binding pocket of their target nuclear receptor FXR...
  11. pmc Evolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile salts
    Matthew D Krasowski
    University of Pittsburgh, Department of Pathology, 200 Lothrop, Pittsburgh, PA 15213, USA
    Mol Endocrinol 19:1720-39. 2005
    ..PXR specificity for bile salts has thus paralleled the increasing complexity of the bile salt synthetic pathway during vertebrate evolution, an unusual example of ligand-receptor coevolution in the nuclear hormone receptor superfamily...
  12. pmc Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds
    E J Reschly
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Curr Drug Metab 7:349-65. 2006
    ..This review examines the insights that phylogenetic and experimental studies provide into the function of VDR, PXR, and CAR, and how the functions of these receptors have expanded to evolutionary advantage in humans and other animals...
  13. pmc Intrinsic disorder in nuclear hormone receptors
    Matthew D Krasowski
    Department of Pathology, University of Pittsburgh, Scaife Hall S 737, 3550 Terrace Street Pittsburgh, Pennsylvania 15261, USA
    J Proteome Res 7:4359-72. 2008
    ..This information enables further understanding of these therapeutic targets...
  14. pmc Clinical effects and toxicokinetic evaluation following massive topiramate ingestion
    Michael J Lynch
    Division of Medical Toxicology, Department of Emergency Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    J Med Toxicol 6:135-8. 2010
    ..Toxicokinetic data following large, suicidal ingestion of topiramate were similar to previously published pharmacokinetic information...
  15. pmc Clinical decision support of therapeutic drug monitoring of phenytoin: measured versus adjusted phenytoin plasma concentrations
    Matthew D Krasowski
    Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    BMC Med Inform Decis Mak 12:7. 2012
    ..The measured free phenytoin plasma concentration was used as the gold standard...
  16. doi Unresolved discrepancies between cannabinoid test results for infant urine
    Vilte E Barakauskas
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA
    Clin Chem 58:1364-7. 2012
    ..This study investigated the rate of unconfirmed positive screen results in infant and noninfant urine samples and evaluated possible reasons for differences...
  17. ncbi Ligand- and structure-based pregnane X receptor models
    Sandhya Kortagere
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA
    Methods Mol Biol 929:359-75. 2012
    ..This chapter reviews the various ligand and structure based methods undertaken to date and their results...
  18. pmc PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics
    Bin Zhang
    Center for Pharmacogenetics, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Pharmacogenomics 9:1695-709. 2008
    ....
  19. pmc Drug monitoring: simultaneous analysis of lamotrigine, oxcarbazepine, 10-hydroxycarbazepine, and zonisamide by HPLC-UV and a rapid GC method using a nitrogen-phosphorus detector for levetiracetam
    Elizabeth Greiner-Sosanko
    Toxicology and Therapeutic Drug Monitoring Laboratory, Division of Clinical Chemistry, Department of Pathology, University of Pittsburgh Medical Center, Children s Hospital Main Tower 5812, Pittsburgh, PA 15213, USA
    J Chromatogr Sci 45:616-22. 2007
    ....
  20. doi Pathology consultation on vitamin D testing
    Matthew D Krasowski
    Department of Pathology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Am J Clin Pathol 136:507-14. 2011
    ..This article presents a common clinical case scenario regarding vitamin D and an up-to-date discussion and review of the literature on vitamin D testing...
  21. pmc Machine learning methods and docking for predicting human pregnane X receptor activation
    Akash Khandelwal
    Department of Pharmaceutical Sciences, University of Maryland, 20 Penn Street, Baltimore, Maryland 21201, USA
    Chem Res Toxicol 21:1457-67. 2008
    ..These methods could be used for high throughput virtual screening to assess for PXR activation, prior to in vitro testing to predict potential drug-drug interactions...
  22. pmc Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sites
    Sean Ekins
    ACT LLC, 601 Runnymede Avenue, Jenkintown, PA 19046, USA
    Mol Pharmacol 72:592-603. 2007
    ..These observations bear significant implications for future discovery of molecules that are more selective and potent antagonists...
  23. pmc Functional constraints on the constitutive androstane receptor inferred from human sequence variation and cross-species comparisons
    Emma E Thompson
    Committee on Genetics, University of Chicago, Chicago, IL 60637, USA
    Hum Genomics 2:168-78. 2005
    ....
  24. pmc 4D-QSAR analysis of a set of propofol analogues: mapping binding sites for an anesthetic phenol on the GABA(A) receptor
    Matthew D Krasowski
    Department of Anesthesia and Critical Care, University of Chicago Medical Center, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    J Med Chem 45:3210-21. 2002
    ....