M D Krasowski

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi request reprint GPI-15715 Guilford
    Matthew D Krasowski
    Committee on Clinical Pharmacology and Pharmacogenomics and Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Curr Opin Investig Drugs 6:90-8. 2005
  2. pmc Differential modulatory actions of the volatile convulsant flurothyl and its anesthetic isomer at inhibitory ligand-gated ion channels
    M D Krasowski
    Committee on Neurobiology and the Pritzker School of Medicine, University of Chicago, Whitman Laboratory, 915 East 57th Street, Chicago, IL 60637, USA
    Neuropharmacology 39:1168-83. 2000
  3. pmc The actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutations
    M D Krasowski
    Committee on Neurobiology, University of Chicago, Whitman Laboratory, 915 East 57th Street, Chicago, Illinois, IL 60637, USA
    Br J Pharmacol 129:731-43. 2000
  4. pmc General anaesthetic actions on ligand-gated ion channels
    M D Krasowski
    Committee on Neurobiology, University of Chicago, Whitman Laboratory, Illinois 60637, USA
    Cell Mol Life Sci 55:1278-303. 1999
  5. ncbi request reprint Trichloroethanol modulation of recombinant GABAA, glycine and GABA rho 1 receptors
    M D Krasowski
    Department of Anesthesia and Critical Care, University of Chicago, Illinois, USA
    J Pharmacol Exp Ther 284:934-42. 1998
  6. ncbi request reprint Propofol and other intravenous anesthetics have sites of action on the gamma-aminobutyric acid type A receptor distinct from that for isoflurane
    M D Krasowski
    Department of Committee on Neurobiology, University of Chicago, Chicago, Illinois 60637, USA
    Mol Pharmacol 53:530-8. 1998
  7. pmc Methionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anesthetics
    M D Krasowski
    Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL 60637, USA
    Neuropharmacology 41:952-64. 2001
  8. ncbi request reprint General anesthetic potencies of a series of propofol analogs correlate with potency for potentiation of gamma-aminobutyric acid (GABA) current at the GABA(A) receptor but not with lipid solubility
    M D Krasowski
    Department of Anesthesia and Critical Care, University of Chicago, Chicago, Illinois, USA
    J Pharmacol Exp Ther 297:338-51. 2001
  9. pmc A deficit of functional GABA(A) receptors in neurons of beta 3 subunit knockout mice
    M D Krasowski
    Committee on Neurobiology, University of Chicago, IL 60637, USA
    Neurosci Lett 240:81-4. 1998
  10. pmc 4D-QSAR analysis of a set of propofol analogues: mapping binding sites for an anesthetic phenol on the GABA(A) receptor
    Matthew D Krasowski
    Department of Anesthesia and Critical Care, University of Chicago Medical Center, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    J Med Chem 45:3210-21. 2002

Detail Information

Publications10

  1. ncbi request reprint GPI-15715 Guilford
    Matthew D Krasowski
    Committee on Clinical Pharmacology and Pharmacogenomics and Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Curr Opin Investig Drugs 6:90-8. 2005
    ..In May 2004, Guilford initiated phase III trials in the US to evaluate the sedative effects of this prodrug in several patient populations...
  2. pmc Differential modulatory actions of the volatile convulsant flurothyl and its anesthetic isomer at inhibitory ligand-gated ion channels
    M D Krasowski
    Committee on Neurobiology and the Pritzker School of Medicine, University of Chicago, Whitman Laboratory, 915 East 57th Street, Chicago, IL 60637, USA
    Neuropharmacology 39:1168-83. 2000
    ....
  3. pmc The actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutations
    M D Krasowski
    Committee on Neurobiology, University of Chicago, Whitman Laboratory, 915 East 57th Street, Chicago, Illinois, IL 60637, USA
    Br J Pharmacol 129:731-43. 2000
    ..The implications of these findings for the molecular mechanisms of action of general anaesthetics at GABA(A) and glycine receptors are discussed...
  4. pmc General anaesthetic actions on ligand-gated ion channels
    M D Krasowski
    Committee on Neurobiology, University of Chicago, Whitman Laboratory, Illinois 60637, USA
    Cell Mol Life Sci 55:1278-303. 1999
    ..Exciting future directions include structural biology and gene-targeting approaches to further the understanding of general anaesthetic molecular mechanisms...
  5. ncbi request reprint Trichloroethanol modulation of recombinant GABAA, glycine and GABA rho 1 receptors
    M D Krasowski
    Department of Anesthesia and Critical Care, University of Chicago, Illinois, USA
    J Pharmacol Exp Ther 284:934-42. 1998
    ..In summary, trichloroethanol modulation of GABAA, glycine and GABA rho 1 receptors shares some, but not all, features in common with the requirements for modulation by n-alkanols and volatile anesthetics...
  6. ncbi request reprint Propofol and other intravenous anesthetics have sites of action on the gamma-aminobutyric acid type A receptor distinct from that for isoflurane
    M D Krasowski
    Department of Committee on Neurobiology, University of Chicago, Chicago, Illinois 60637, USA
    Mol Pharmacol 53:530-8. 1998
    ..These data indicate that the receptor structural requirements for positive modulation by volatile and intravenous general anesthetics may be quite distinct...
  7. pmc Methionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anesthetics
    M D Krasowski
    Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL 60637, USA
    Neuropharmacology 41:952-64. 2001
    ..This suggests that mutation of M286 in the GABA(A) beta(2) subunit alters the dimensions of a 'binding pocket' for propofol and related alkylphenol general anesthetics...
  8. ncbi request reprint General anesthetic potencies of a series of propofol analogs correlate with potency for potentiation of gamma-aminobutyric acid (GABA) current at the GABA(A) receptor but not with lipid solubility
    M D Krasowski
    Department of Anesthesia and Critical Care, University of Chicago, Chicago, Illinois, USA
    J Pharmacol Exp Ther 297:338-51. 2001
    ..These data suggest steric constraints for the binding site for propofol on the GABA(A) receptor...
  9. pmc A deficit of functional GABA(A) receptors in neurons of beta 3 subunit knockout mice
    M D Krasowski
    Committee on Neurobiology, University of Chicago, IL 60637, USA
    Neurosci Lett 240:81-4. 1998
    ..We also utilize the subunit selective pharmacology of Zn2+ and the anticonvulsant drug loreclezole to help infer the presence of beta2 and gamma subunits in the GABA(A) receptors remaining in neurons from beta3-/- mice...
  10. pmc 4D-QSAR analysis of a set of propofol analogues: mapping binding sites for an anesthetic phenol on the GABA(A) receptor
    Matthew D Krasowski
    Department of Anesthesia and Critical Care, University of Chicago Medical Center, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    J Med Chem 45:3210-21. 2002
    ....