HENRY RICHARD KRANZLER

Summary

Affiliation: University of Connecticut Health Center
Country: USA

Publications

  1. pmc Recessive genetic mode of an ADH4 variant in substance dependence in African-Americans: A model of utility of the HWD test
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Behav Brain Funct 4:42. 2008
  2. pmc Characterization of a likelihood based method and effects of markers informativeness in evaluation of admixture and population group assignment
    Bao zhu Yang
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    BMC Genet 6:50. 2005
  3. pmc Demographic changes and marker properties affect detection of human population differentiation
    Jennifer B Listman
    Dept Anthropology, New York Univ, NY, USA
    BMC Genet 8:21. 2007
  4. pmc Identification of population substructure among Jews using STR markers and dependence on reference populations included
    Jennifer B Listman
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    BMC Genet 11:48. 2010
  5. pmc Sequence variation and linkage disequilibrium in the GABA transporter-1 gene (SLC6A1) in five populations: implications for pharmacogenetic research
    Rungnapa Hirunsatit
    Yale University School of Medicine, Department of Psychiatry, New Haven, CT, USA
    BMC Genet 8:71. 2007
  6. ncbi request reprint Using daily interactive voice response technology to measure drinking and related behaviors in a pharmacotherapy study
    Henry R Kranzler
    Lowell P Weicker, Jr General Clinical Research Center, Department of Psychiatry, University of Connecticut Health Center, Farmington, Connecticut 06030 2103, USA
    Alcohol Clin Exp Res 28:1060-4. 2004
  7. ncbi request reprint Naltrexone depot for treatment of alcohol dependence: a multicenter, randomized, placebo-controlled clinical trial
    Henry R Kranzler
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, USA
    Alcohol Clin Exp Res 28:1051-9. 2004
  8. pmc The validity of cocaine dependence subtypes
    Henry R Kranzler
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, United States
    Addict Behav 33:41-53. 2008
  9. ncbi request reprint Targeted naltrexone treatment moderates the relations between mood and drinking behavior among problem drinkers
    Henry R Kranzler
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    J Consult Clin Psychol 72:317-27. 2004
  10. ncbi request reprint Sertraline treatment of co-occurring alcohol dependence and major depression
    Henry R Kranzler
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    J Clin Psychopharmacol 26:13-20. 2006

Research Grants

  1. Sertraline Pharmacotherapy for Alcoholism Subtypes
    Henry Kranzler; Fiscal Year: 2003
  2. GENETICS OF COCAINE DEPENDENCE
    Henry Kranzler; Fiscal Year: 2009
  3. Novel Approaches to Alcoholism Pharmacotherapy and Risk
    Henry Kranzler; Fiscal Year: 2008
  4. GENETICS OF COCAINE DEPENDENCE
    Henry Kranzler; Fiscal Year: 2008
  5. Sertraline Pharmacotherapy for Alcoholism Subtypes
    Henry Kranzler; Fiscal Year: 2007
  6. GENETICS OF COCAINE DEPENDENCE
    Henry Kranzler; Fiscal Year: 2007
  7. Planning for a CTSA Application at the University of Connecticut
    Judith Fifield; Fiscal Year: 2006
  8. Novel Approaches to Alcoholism Pharmacotherapy and Risk
    Henry Kranzler; Fiscal Year: 2006
  9. Sertraline Pharmacotherapy for Alcoholism Subtypes
    Henry Kranzler; Fiscal Year: 2006
  10. GENETICS OF COCAINE DEPENDENCE
    Henry Kranzler; Fiscal Year: 2006

Detail Information

Publications84

  1. pmc Recessive genetic mode of an ADH4 variant in substance dependence in African-Americans: A model of utility of the HWD test
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Behav Brain Funct 4:42. 2008
    ..abstract:..
  2. pmc Characterization of a likelihood based method and effects of markers informativeness in evaluation of admixture and population group assignment
    Bao zhu Yang
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    BMC Genet 6:50. 2005
    ....
  3. pmc Demographic changes and marker properties affect detection of human population differentiation
    Jennifer B Listman
    Dept Anthropology, New York Univ, NY, USA
    BMC Genet 8:21. 2007
    ....
  4. pmc Identification of population substructure among Jews using STR markers and dependence on reference populations included
    Jennifer B Listman
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    BMC Genet 11:48. 2010
    ....
  5. pmc Sequence variation and linkage disequilibrium in the GABA transporter-1 gene (SLC6A1) in five populations: implications for pharmacogenetic research
    Rungnapa Hirunsatit
    Yale University School of Medicine, Department of Psychiatry, New Haven, CT, USA
    BMC Genet 8:71. 2007
    ....
  6. ncbi request reprint Using daily interactive voice response technology to measure drinking and related behaviors in a pharmacotherapy study
    Henry R Kranzler
    Lowell P Weicker, Jr General Clinical Research Center, Department of Psychiatry, University of Connecticut Health Center, Farmington, Connecticut 06030 2103, USA
    Alcohol Clin Exp Res 28:1060-4. 2004
    ..Despite these advantages, no published studies have used IVR in alcohol pharmacotherapy trials...
  7. ncbi request reprint Naltrexone depot for treatment of alcohol dependence: a multicenter, randomized, placebo-controlled clinical trial
    Henry R Kranzler
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, USA
    Alcohol Clin Exp Res 28:1051-9. 2004
    ..Efforts to improve naltrexone compliance have included the development of injectable, long-acting depot formulations...
  8. pmc The validity of cocaine dependence subtypes
    Henry R Kranzler
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, United States
    Addict Behav 33:41-53. 2008
    ..These findings support the validity of the methods used to derive homogeneous subgroups of CD subjects and the resulting CD subtypes. Independent replication of these findings would provide further validation of this approach...
  9. ncbi request reprint Targeted naltrexone treatment moderates the relations between mood and drinking behavior among problem drinkers
    Henry R Kranzler
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    J Consult Clin Psychol 72:317-27. 2004
    ..These findings underscore the utility of daily measurement for understanding the processes that underlie pharmacological interventions for problem drinking...
  10. ncbi request reprint Sertraline treatment of co-occurring alcohol dependence and major depression
    Henry R Kranzler
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    J Clin Psychopharmacol 26:13-20. 2006
    ..This multicenter, double-blind, placebo-controlled trial of sertraline was designed to address many of the potential methodological shortcomings of studies of co-occurring disorders...
  11. ncbi request reprint Dual diagnosis: alcoholism and co-morbid psychiatric disorders
    Henry R Kranzler
    Department of Psychiatry and the Alcohol Research Center, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Am J Addict 12:S26-40. 2003
    ..Despite the difficulties inherent in treating dual diagnosis patients, the clinician must recognize that it is possible to derive valid diagnoses and deliver efficacious treatment to such patients...
  12. ncbi request reprint Acamprosate efficacy in alcohol-dependent patients: summary of results from three pivotal trials
    Henry R Kranzler
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Am J Addict 17:70-6. 2008
    ..01). These findings support the use of acamprosate in the treatment of alcohol dependence and illustrate some of the issues that can arise in the FDA process for approval of medications to treat the disorder...
  13. pmc Effects of aripiprazole on subjective and physiological responses to alcohol
    Henry R Kranzler
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
    Alcohol Clin Exp Res 32:573-9. 2008
    ..The present study examined whether aripiprazole modifies the behavioral and physiological effects of a moderate dose of alcohol in a group of social drinkers...
  14. ncbi request reprint Advances in the pharmacotherapy of alcoholism: challenging misconceptions
    Henry R Kranzler
    Department of Psychiatry, University of Connecticut Health Center, Farmington, Connecticut, USA
    Alcohol Clin Exp Res 30:272-81. 2006
    ..Gastfriend; (5) System Challenges in the Adoption of Pharmacotherapy, by Robert M. Swift; and (6) Pharmacotherapy for Alcohol Dependence: Strengths, Challenges, and Future Directions, by Mark L. Willenbring...
  15. ncbi request reprint Effects of ondansetron in early- versus late-onset alcoholics: a prospective, open-label study
    Henry R Kranzler
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, USA
    Alcohol Clin Exp Res 27:1150-5. 2003
    ..This study compared the tolerability and potential efficacy of an oral solution of ondansetron in EOAs versus LOAs...
  16. pmc Effects of naltrexone treatment for alcohol-related disorders on healthcare costs in an insured population
    Henry R Kranzler
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
    Alcohol Clin Exp Res 34:1090-7. 2010
    ..To determine the impact of treatment with oral naltrexone on healthcare costs in patients with alcohol-related disorders...
  17. ncbi request reprint Efficacy of naltrexone and acamprosate for alcoholism treatment: a meta-analysis
    H R Kranzler
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA
    Alcohol Clin Exp Res 25:1335-41. 2001
    ..In the absence of studies that compare the effects of these medications, we used a meta-analytic approach to the literature to compare their efficacy in alcoholism treatment...
  18. ncbi request reprint PROP taster status and parental history of alcohol dependence
    H R Kranzler
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington 06030 2103, USA
    Drug Alcohol Depend 52:109-13. 1998
    ..We conclude that no reliable association exists between taste sensitivity to PROP and either a diagnosis of alcohol dependence or a parental history of alcohol dependence...
  19. ncbi request reprint Screening for health behaviors in ambulatory clinical settings: does smoking status predict hazardous drinking?
    Henry R Kranzler
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington 06030, USA
    Addict Behav 27:737-49. 2002
    ..These findings suggest that patients who report current smoking should routinely be asked about their current alcohol consumption. Interventions should then be tailored to address smoking and, if appropriate, hazardous drinking as well...
  20. ncbi request reprint Association study of alcoholism subtypes with a functional promoter polymorphism in the serotonin transporter protein gene
    Henry Kranzler
    Department of Psychiatry, Alchohol Research Center, University of Connecticut School of Medicine, Farmington, Connecticult 06030 2103, USA
    Alcohol Clin Exp Res 26:1330-5. 2002
    ....
  21. pmc Targeted naltrexone for problem drinkers
    Henry R Kranzler
    Department of Psychiatry, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030 2103, USA
    J Clin Psychopharmacol 29:350-7. 2009
    ....
  22. pmc Association of markers in the 3' region of the GluR5 kainate receptor subunit gene to alcohol dependence
    Henry R Kranzler
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, University Health Center, Farmington, CT 06030 2103, USA
    Alcohol Clin Exp Res 33:925-30. 2009
    ..We focused specifically on this gene because topiramate, a glutamate modulator that binds to the GluR5 subunit, has shown robust efficacy in the treatment of AD...
  23. pmc Persistence with oral naltrexone for alcohol treatment: implications for health-care utilization
    Henry R Kranzler
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Addiction 103:1801-8. 2008
    ..We examined prescriptions for oral naltrexone in a large, nationally distributed treatment population to identify characteristics and health-care utilization patterns associated with persistence...
  24. ncbi request reprint Targeted naltrexone for early problem drinkers
    Henry R Kranzler
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06030 2103, USA
    J Clin Psychopharmacol 23:294-304. 2003
    ..Efforts to replicate these findings are warranted, since they suggest that schedules of medication administration other than daily should be evaluated for treatment of problem drinking...
  25. ncbi request reprint Sweet taste preference as a risk factor for alcohol dependence
    H R Kranzler
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Am J Psychiatry 158:813-5. 2001
    ..Previous research has found that alcoholics have a greater preference for sweet solutions than comparison subjects. This study tested the hypothesis that preference for sweet solutions is a marker for alcoholism risk...
  26. ncbi request reprint GABRA2 alleles moderate the subjective effects of alcohol, which are attenuated by finasteride
    Amira Pierucci-Lagha
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, CT 06030, USA
    Neuropsychopharmacology 30:1193-203. 2005
    ..The effects of finasteride provide indirect evidence for a mediating role of neuroactive steroids in some of the subjective effects of alcohol...
  27. ncbi request reprint CNR1 variation modulates risk for drug and alcohol dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, New Haven, CT 06516, USA
    Biol Psychiatry 62:616-26. 2007
    ..Following initial reports of association of CNR1 with SD, we studied multiple markers at this locus in a large case-control sample...
  28. ncbi request reprint Association between alcoholism and gamma-amino butyric acid alpha2 receptor subtype in a Russian population
    Jaakko Lappalainen
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Alcohol Clin Exp Res 29:493-8. 2005
    ..The goal of this study was to test whether GABRA2 is associated with alcohol dependence in a sample of Russian alcohol-dependent men...
  29. ncbi request reprint Analysis of variations in the tryptophan hydroxylase-2 (TPH2) gene in cocaine dependence
    John P Dahl
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, USA
    Addict Biol 11:76-83. 2006
    ..This work suggests that variations in the TPH2 gene are not a risk factor for the development of cocaine dependence, but these findings require confirmation in larger, independent samples of cocaine-dependent and control subjects...
  30. ncbi request reprint Allelic and haplotypic association of GABRA2 with alcohol dependence
    Jonathan Covault
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
    Am J Med Genet B Neuropsychiatr Genet 129:104-9. 2004
    ..003). These findings replicate and extend recently reported findings, which together underscore the potential contribution of polymorphic variation at the GABRA2 locus to the risk for alcohol dependence...
  31. ncbi request reprint Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European-Americans
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 120:97-108. 2003
    ..These findings suggest that OPRM1 may play a role in the pathophysiology of substance dependence and this role is population- and diagnosis-specific...
  32. ncbi request reprint A functional neuropeptide Y Leu7Pro polymorphism associated with alcohol dependence in a large population sample from the United States
    Jaakko Lappalainen
    Yale University School of Medicine, Department of Psychiatry, VA Connecticut Healthcare System, 950 Campbell Ave, Psychiatry 116A2, West Haven, CT 06516, USA
    Arch Gen Psychiatry 59:825-31. 2002
    ..We tested whether the Pro7 allele is associated with alcohol dependence in European Americans (EA)...
  33. ncbi request reprint Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations
    Joel Gelernter
    Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Hum Mol Genet 15:3498-507. 2006
    ..Functional studies of these loci are warranted. These results provide additional information useful in evaluating the many earlier discrepant findings regarding association of DRD2 with substance dependence...
  34. pmc Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4
    Chupong Ittiwut
    Department of Psychiatry, Yale School of Medicine, New Haven, CT 06510, USA
    Genomics 91:61-9. 2008
    ..These findings may aid in understanding the genetic association of this locus with alcohol dependence in several populations...
  35. ncbi request reprint Alleles of a functional serotonin transporter promoter polymorphism are associated with major depression in alcoholics
    Maggie Nellissery
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington 06030 2103, USA
    Alcohol Clin Exp Res 27:1402-8. 2003
    ..Because the convergence of these disorders may provide a refined phenotype, we examined the association of serotonin (5-HT) transporter linked polymorphic region (5-HTTLPR) alleles to comorbid alcohol dependence and major depression...
  36. ncbi request reprint ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Pharmacogenet Genomics 15:755-68. 2005
    ..Using rigorous study designs that account for possible population stratification, these findings confirm and extend our original observations indicating that variation at ADH4 predisposes to alcohol and drug dependence...
  37. pmc Genomewide linkage scan for opioid dependence and related traits
    Joel Gelernter
    Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Am J Hum Genet 78:759-69. 2006
    ..These results are an initial step in identifying genes for opioid dependence on the basis of a genomewide investigation (i.e., a study not conditioned on prior physiological candidate-gene hypotheses)...
  38. ncbi request reprint Interactive effects of the serotonin transporter 5-HTTLPR polymorphism and stressful life events on college student drinking and drug use
    Jonathan Covault
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA
    Biol Psychiatry 61:609-16. 2007
    ..We examined this polymorphism as it interacted with negative life events to predict drinking and drug use in college students...
  39. ncbi request reprint Efficacy of extended-release naltrexone in alcohol-dependent patients who are abstinent before treatment
    STEPHANIE S O'MALLEY
    Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, New Haven, CT 06519, USA
    J Clin Psychopharmacol 27:507-12. 2007
    ..In conclusion, XR-NTX 380 mg prolonged abstinence and reduced the number of heavy drinking days and drinking days in patients who were abstinent for as few as 4 days before treatment initiation...
  40. pmc Variation in GABRA2 predicts drinking behavior in project MATCH subjects
    Lance O Bauer
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
    Alcohol Clin Exp Res 31:1780-7. 2007
    ..The present study examines the association of a GABRA2 SNP with another definition of alcohol involvement and with the effects of psychosocial treatment...
  41. pmc A serotonin transporter gene polymorphism (5-HTTLPR), drinking-to-cope motivation, and negative life events among college students
    Stephen Armeli
    Department of Community Medicine, MC 6325, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030 6325, USA
    J Stud Alcohol Drugs 69:814-23. 2008
    ..We examined reward drinking (drinking-to-enhance motives) as a comparison and to see whether these effects varied across gender...
  42. pmc Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Neuropsychopharmacology 34:1504-13. 2009
    ..019). We conclude that two independent CNR1 variants have significant interaction effects on risk for CD in EAs; they may also have effects on risk for CD in AAs...
  43. pmc Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence
    Huiping Zhang
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 141:387-93. 2006
    ..The negative results for AFDs, PTSD, and schizophrenia could be due to the low statistical power. Further study with larger samples is warranted...
  44. ncbi request reprint A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients
    David W Oslin
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania, 3535 Market Street, Room 3002, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 28:1546-52. 2003
    ..If replicated, these results would help to identify alcohol-dependent individuals who may be most likely to respond to treatment with naltrexone...
  45. ncbi request reprint ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studies
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 31:1085-95. 2006
    ..SNP2 or SNP6 was the marker genetically closest to the functional risk loci for both alcohol dependence and drug dependence...
  46. pmc Association between two mu-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence
    Huiping Zhang
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Hum Mol Genet 15:807-19. 2006
    ..These findings suggest that OPRM1 intronic variants play a role in susceptibility to AD and DD in populations of European ancestry...
  47. ncbi request reprint Polymorphism of the 5-HT1B receptor gene (HTR1B): strong within-locus linkage disequilibrium without association to antisocial substance dependence
    Henry R Kranzler
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT, USA
    Neuropsychopharmacology 26:115-22. 2002
    ..Conclusion: Despite no evidence in this study for allelic association of HTR1B to antisocial substance dependence, further evaluation of the hypothesized association is warranted in other population groups...
  48. ncbi request reprint Meta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence
    Richard Feinn
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
    Am J Med Genet B Neuropsychiatr Genet 133:79-84. 2005
    ..34 (95% CI = 1.11-1.63)]. Allelic variation at 5-HTTLPR contributes to risk for AD, with the greatest effect observed among individuals with a co-occurring clinical feature...
  49. ncbi request reprint Comorbid psychiatric diagnoses and their association with cocaine-induced psychosis in cocaine-dependent subjects
    Yi lang Tang
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Health Care System, West Haven, CT, USA
    Am J Addict 16:343-51. 2007
    ..Comorbid substance use and psychiatric disorders are very common among individuals with cocaine dependence. Comorbid ADHD increases the odds of an individual endorsing CIP, suggesting some common basis for these phenomena...
  50. ncbi request reprint CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case-control structured association study
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Hum Mol Genet 14:2421-34. 2005
    ..In addition, a specific diplotype might inversely affect risk for AD and DD and risk for affective disorders...
  51. pmc Effect of extended-release naltrexone (XR-NTX) on quality of life in alcohol-dependent patients
    Helen M Pettinati
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Alcohol Clin Exp Res 33:350-6. 2009
    ..2005). A 24-week, randomized, double-blind, placebo-controlled study established the efficacy and safety of XR-NTX in this patient population. In this report, the effect of XR-NTX on quality of life (QOL) was examined...
  52. ncbi request reprint NOTCH4 gene haplotype is associated with schizophrenia in African Americans
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 55:112-7. 2004
    ..The goal of this study was to investigate the relationship between the NOTCH4 gene and schizophrenia in African American (AA) and European American (EA) subjects...
  53. pmc Pro-opiomelanocortin gene variation related to alcohol or drug dependence: evidence and replications across family- and population-based studies
    Huiping Zhang
    Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Biol Psychiatry 66:128-36. 2009
    ..The pro-opiomelanocortin gene (POMC) encodes several peptides important for endogenous opioidergic neurotransmission. We tested whether POMC genetic variation affects risk for substance dependence...
  54. ncbi request reprint Psychometric properties of the short index of problems as a measure of recent alcohol-related problems
    Richard Feinn
    Alcohol Research Center, Department of Psychiatry, University of Connecticut Health Center, Farmington 06030 2103, USA
    Alcohol Clin Exp Res 27:1436-41. 2003
    ..A short form of the DrInC, the Short Index of Problems (SIP), was developed for use when time does not permit completion of the DrInC. This study investigates the psychometric properties of the SIP...
  55. pmc Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence
    Aryeh I Herman
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 141:499-503. 2006
    ..These findings fail to replicate the original report of an association between SNPs adjacent to an alternative CNR1 exon 3 transcription start site and polysubstance abuse...
  56. ncbi request reprint Targeted versus daily naltrexone: secondary analysis of effects on average daily drinking
    Carlos A Hernandez-Avila
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA
    Alcohol Clin Exp Res 30:860-5. 2006
    ..Because treatment response may differ by gender, we also compared the effects on this factor...
  57. ncbi request reprint Extended-release intramuscular naltrexone: a viewpoint by Henry R Kranzler
    Henry R Kranzler
    University of Connecticut School of Medicine, Farmington, CT, USA
    Drugs 66:1753-4. 2006
  58. ncbi request reprint Mutation screen of the GAD2 gene and association study of alcoholism in three populations
    Jaakko Lappalainen
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 144:183-92. 2007
    ..The functional promoter GAD2 -243 A > G variant may influence risk for AD in some populations, or its role may be limited to susceptibility to severe AD...
  59. pmc A functional serotonin transporter gene polymorphism and depressive effects associated with interferon-alpha treatment
    Amira Pierucci-Lagha
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Psychosomatics 51:137-48. 2010
    ..Interferon-alpha (IFN-alpha) treatment frequently induces depression, potentially leading to early dose reductions or a shorter duration of treatment, which can adversely affect outcomes, including quality of life...
  60. ncbi request reprint Effects of gender and family history of alcohol dependence on a behavioral task of impulsivity in healthy subjects
    Nancy M Petry
    Department of Psychiatry, University of Connecticut Health Center, Farmington 06030 3944, USA
    J Stud Alcohol 63:83-90. 2002
    ....
  61. ncbi request reprint Effect of maternal smoking on fetal catecholamine concentrations at birth
    Cheryl A Oncken
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, U S A
    Pediatr Res 53:119-24. 2003
    ..Further studies are needed to validate these findings and to examine the specific mechanism by which these differences may arise...
  62. pmc Nicotine gum for pregnant smokers: a randomized controlled trial
    Cheryl Oncken
    Departments of Medicine and Obstetrics and Gynecology, University of Connecticut School of Medicine, Farmington, Connecticut 06030 3940, USA
    Obstet Gynecol 112:859-67. 2008
    ..To estimate the safety and efficacy of treatment with 2-mg nicotine gum for smoking cessation during pregnancy...
  63. ncbi request reprint Effects of rapid tryptophan depletion on mood and urge to drink in patients with co-morbid major depression and alcohol dependence
    Amira Pierucci-Lagha
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington 06030, USA
    Psychopharmacology (Berl) 171:340-8. 2004
    ..Rapid tryptophan depletion (RTD) has been used to study central serotonin function and may therefore be useful in understanding co-morbid alcohol dependence (AD) and major depressive disorder (MDD)...
  64. pmc Correlates of co-occurring ADHD in drug-dependent subjects: prevalence and features of substance dependence and psychiatric disorders
    Albert J Arias
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030, USA
    Addict Behav 33:1199-207. 2008
    ..We examined the prevalence and course of psychiatric and substance dependence (SD) disorders in subjects with SD and attention deficit hyperactivity disorder (ADHD)...
  65. pmc Placebo-controlled trial of zonisamide for the treatment of alcohol dependence
    Albert J Arias
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    J Clin Psychopharmacol 30:318-22. 2010
    ..This pilot clinical trial evaluated the safety, tolerability, and efficacy of zonisamide for the treatment of alcohol dependence...
  66. pmc Population admixture modulates risk for alcohol dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, VA Psychiatry 116A2, West Haven, CT 06516, USA
    Hum Genet 125:605-13. 2009
    ..We cannot exclude the possibility that the results might have been influenced by selection bias due to the multisite nature of the study...
  67. pmc Markers in the 5'-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene
    Jonathan Covault
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, CT 06030 1410, USA
    Neuropsychopharmacology 33:837-48. 2008
    ....
  68. pmc Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Am J Hum Genet 78:973-87. 2006
    ..We also found that several ADH genes and the ALDH2 gene were susceptibility loci for AD, and the associations were best explained by several independent risk genes...
  69. ncbi request reprint Genomewide linkage scan for nicotine dependence: identification of a chromosome 5 risk locus
    Joel Gelernter
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Biol Psychiatry 61:119-26. 2007
    ..Nicotine dependence (ND) is costly to societies worldwide, moderately heritable, and genetically complex. Risk loci can be identified with genetic linkage analysis independent of prior physiological hypotheses...
  70. pmc Personality traits of agreeableness and extraversion are associated with ADH4 variation
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 61:599-608. 2007
    ..Strong associations between ADH4 variation and SD have been reported. We aimed to investigate the relationship between ADH4 variation and personality traits in the present study...
  71. ncbi request reprint Association of a long-chain fatty acid-CoA ligase 4 gene polymorphism with depression and with enhanced niacin-induced dermal erythema
    Jonathan Covault
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
    Am J Med Genet B Neuropsychiatr Genet 127:42-7. 2004
    ..38%; P = 0.003) and a non-significant excess of the T allele in schizophrenia (44%; P = 0.29). The allele frequency for subjects with alcohol dependence did not differ from controls...
  72. ncbi request reprint Risk factors for cocaine-induced paranoia in cocaine-dependent sibling pairs
    Rasmon Kalayasiri
    Department of Psychiatry, Yale School of Medicine, New Haven, CT 06520, USA
    Drug Alcohol Depend 84:77-84. 2006
    ..Both environmental and genetic factors are thought to play a role, but the specific nature of such contributions is poorly understood...
  73. ncbi request reprint Typologies of drug dependence: comparative validity of a multivariate and four univariate models
    Debasish Basu
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Drug Alcohol Depend 73:289-300. 2004
    ..This direct method of comparison seemed to demonstrate the superior validity of the multivariate cluster-analytic approach over the univariate approaches to classifying subjects with drug dependence...
  74. ncbi request reprint Genomewide linkage scan for cocaine dependence and related traits: significant linkages for a cocaine-related trait and cocaine-induced paranoia
    Joel Gelernter
    Yale University School of Medicine, Department of Psychiatry, Division of Human Genetics and VA CT Healthcare Center, West Haven, CT 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 136:45-52. 2005
    ..35 for membership in the "Moderate Cocaine and Opioid Abuse" cluster on chromosome 18. These results provide a basis for the identification of specific genes contributing to risk for these traits...
  75. ncbi request reprint Transdermal nicotine for smoking cessation in postmenopausal women
    Cheryl Oncken
    Department of Medicine, University of Connecticut School of Medicine, Farmington, CT 06030 3940, USA
    Addict Behav 32:296-309. 2007
    ..However, efforts are needed to improve long-term abstinence rates and smoking outcomes among women with a history of depression...
  76. ncbi request reprint Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study
    Joel Gelernter
    VA Connecticut Healthcare System, West Haven Campus, West Haven, Connecticut 06516, USA
    Alcohol Clin Exp Res 31:555-63. 2007
    ..A previous report suggested that a functional variant at the genetic locus encoding the mu opioid receptor (Asn40Asp) is such a marker, in short-term (3-month) treatment with the opioid-blocking drug naltrexone (NTX)...
  77. ncbi request reprint Mutation screen of the glutamate decarboxylase-67 gene and haplotype association to unipolar depression
    Jaakko Lappalainen
    Yale University School of Medicine, Department of Psychiatry, VA Connecticut Healthcare System, New Haven, Connecticut 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 124:81-6. 2004
    ..Furthermore, these results suggest that common genetic variation within the GAD67 gene does not play a major role in the predisposition to unipolar depression...
  78. ncbi request reprint Effects of nicotine deprivation on urges to drink and smoke in alcoholic smokers
    Judith L Cooney
    VA Connecticut Healthcare System, Newington, CT, USA
    Addiction 98:913-21. 2003
    ..This study examined the effect of nicotine deprivation on alcohol and smoking urges in a sample of alcohol-dependent smokers in early recovery...
  79. ncbi request reprint Understanding US addiction physicians' low rate of naltrexone prescription
    Tami L Mark
    The MEDSTAT Group, Washington, DC 20008, USA
    Drug Alcohol Depend 71:219-28. 2003
    ..g. by reading more journal articles about naltrexone) were more likely to prescribe it. In summary, multiple factors are contributing to the relatively low naltexone prescription rate...
  80. ncbi request reprint Nefazodone treatment of comorbid alcohol dependence and major depression
    Carlos A Hernandez-Avila
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA
    Alcohol Clin Exp Res 28:433-40. 2004
    ..This study examined the effects of nefazodone, a norepinephrine and serotonin reuptake blocker and 5-hydroxytryptamine-2 receptor antagonist, on mood and anxiety symptoms and drinking behavior in a sample of depressed alcoholics...
  81. ncbi request reprint Serotonin transporter gene polymorphism (5-HTTLPR) and anxiety reactivity in daily life: a daily process approach to gene-environment interaction
    Kathleen C Gunthert
    Department of Psychology, American University, USA
    Psychosom Med 69:762-8. 2007
    ..Based on this model, we argue that genotype differences in anxiety should be stronger in the presence of stress...
  82. pmc Substance dependence low-density whole genome association study in two distinct American populations
    Yi Yu
    Department of Medicine Genetics Program, Boston University Schools of Medicine and Public Health, Boston, MA, USA
    Hum Genet 123:495-506. 2008
    ..Our study provides an initial substance dependence trait-specific blueprint of associated regions for future candidate gene studies...
  83. ncbi request reprint World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Substance Use and Related Disorders, Part 1: Alcoholism
    Michael Soyka
    Psychiatric Hospital Meiringen, Meiringen, Switzerland
    World J Biol Psychiatry 9:6-23. 2008
    ..This first part of the guidelines covers the treatment of alcohol dependence; Part 2 will be devoted to the treatment of drug dependence...
  84. ncbi request reprint Physicians' opinions about medications to treat alcoholism
    Tami L Mark
    Medstat, Washington, DC 20008, USA
    Addiction 98:617-26. 2003
    ..This paper examines physicians' opinions about and use of two alcoholism medications currently approved in the US--disulfiram and naltrexone--and one alcoholism medication--acamprosate--that might be approved...

Research Grants13

  1. Sertraline Pharmacotherapy for Alcoholism Subtypes
    Henry Kranzler; Fiscal Year: 2003
    ..abstract_text> ..
  2. GENETICS OF COCAINE DEPENDENCE
    Henry Kranzler; Fiscal Year: 2009
    ..Knowledge of the gene variants will help to identify people at greatest risk of developing the disorder, thereby improving prevention efforts. ..
  3. Novel Approaches to Alcoholism Pharmacotherapy and Risk
    Henry Kranzler; Fiscal Year: 2008
    ..The proposal will also contribute insights into the genetic risk for alcohol dependence and moderators of treatment response, which have implications both for prevention and treatment of the disorder. ..
  4. GENETICS OF COCAINE DEPENDENCE
    Henry Kranzler; Fiscal Year: 2008
    ..Knowledge of the gene variants will help to identify people at greatest risk of developing the disorder, thereby improving prevention efforts. ..
  5. Sertraline Pharmacotherapy for Alcoholism Subtypes
    Henry Kranzler; Fiscal Year: 2007
    ..abstract_text> ..
  6. GENETICS OF COCAINE DEPENDENCE
    Henry Kranzler; Fiscal Year: 2007
    ..Knowledge of the gene variants will help to identify people at greatest risk of developing the disorder, thereby improving prevention efforts. ..
  7. Planning for a CTSA Application at the University of Connecticut
    Judith Fifield; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  8. Novel Approaches to Alcoholism Pharmacotherapy and Risk
    Henry Kranzler; Fiscal Year: 2006
    ..abstract_text> ..
  9. Sertraline Pharmacotherapy for Alcoholism Subtypes
    Henry Kranzler; Fiscal Year: 2006
    ..abstract_text> ..
  10. GENETICS OF COCAINE DEPENDENCE
    Henry Kranzler; Fiscal Year: 2006
    ..Knowledge of the gene variants will help to identify people at greatest risk of developing the disorder, thereby improving prevention efforts. ..
  11. Sertraline Pharmacotherapy for Alcoholism Subtypes
    Henry Kranzler; Fiscal Year: 2005
    ..abstract_text> ..
  12. Sertraline Pharmacotherapy for Alcoholism Subtypes
    Henry Kranzler; Fiscal Year: 2004
    ..abstract_text> ..
  13. GENETICS OF COCAINE DEPENDENCE
    HENRY RICHARD KRANZLER; Fiscal Year: 2010
    ..Knowledge of the gene variants will help to identify people at greatest risk of developing the disorder, thereby improving prevention efforts. ..