Henry R Kranzler

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses
    Huiping Zhang
    Departments of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Behav Brain Funct 8:23. 2012
  2. pmc Post-treatment outcomes in a double-blind, randomized trial of sertraline for alcohol dependence
    Henry R Kranzler
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, USA
    Alcohol Clin Exp Res 36:739-44. 2012
  3. pmc Comparison of alcoholism subtypes as moderators of the response to sertraline treatment
    Henry R Kranzler
    Department of Psychiatry, Perelman School of Medicine of the University of Pennsylvania and the VISN 4 MIRECC, Philadelphia VAMC, Philadelphia, Pennsylvania, USA
    Alcohol Clin Exp Res 36:509-16. 2012
  4. pmc A CRHR1 haplotype moderates the effect of adverse childhood experiences on lifetime risk of major depressive episode in African-American women
    Henry R Kranzler
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Med Genet B Neuropsychiatr Genet 156:960-8. 2011
  5. pmc A double-blind, randomized trial of sertraline for alcohol dependence: moderation by age of onset [corrected] and 5-hydroxytryptamine transporter-linked promoter region genotype
    Henry R Kranzler
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT, USA
    J Clin Psychopharmacol 31:22-30. 2011
  6. pmc Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Neuropsychopharmacology 34:1504-13. 2009
  7. ncbi Mutation screen of the GAD2 gene and association study of alcoholism in three populations
    Jaakko Lappalainen
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 144:183-92. 2007
  8. ncbi Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations
    Joel Gelernter
    Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Hum Mol Genet 15:3498-507. 2006
  9. ncbi ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studies
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 31:1085-95. 2006
  10. pmc Interactive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on posttraumatic stress disorder diagnosis in 2 independent populations
    Pingxing Xie
    Department of Genetics, Yale University School of Medicine, New Haven, CT, USA
    Arch Gen Psychiatry 66:1201-9. 2009

Detail Information

Publications105 found, 100 shown here

  1. pmc Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses
    Huiping Zhang
    Departments of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Behav Brain Funct 8:23. 2012
    ..Variation in these genes may alter their transcription and thereby influence the function of G protein-coupled receptors, including opioid receptors, and modify risk for substance dependence...
  2. pmc Post-treatment outcomes in a double-blind, randomized trial of sertraline for alcohol dependence
    Henry R Kranzler
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, USA
    Alcohol Clin Exp Res 36:739-44. 2012
    ..Pharmacotherapy studies in alcohol dependence (AD) are generally of short duration and do not include post-treatment follow-up. We examined the durability of treatment effects in a placebo-controlled trial of sertraline for AD...
  3. pmc Comparison of alcoholism subtypes as moderators of the response to sertraline treatment
    Henry R Kranzler
    Department of Psychiatry, Perelman School of Medicine of the University of Pennsylvania and the VISN 4 MIRECC, Philadelphia VAMC, Philadelphia, Pennsylvania, USA
    Alcohol Clin Exp Res 36:509-16. 2012
    ..We compared 3 different methods to subtype alcoholics...
  4. pmc A CRHR1 haplotype moderates the effect of adverse childhood experiences on lifetime risk of major depressive episode in African-American women
    Henry R Kranzler
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Med Genet B Neuropsychiatr Genet 156:960-8. 2011
    ..The complex structure of CRHR1 may help to explain why some variants in the gene moderate the effects of an ACE only on depression risk while others moderate the effect of an ACE only on AD risk...
  5. pmc A double-blind, randomized trial of sertraline for alcohol dependence: moderation by age of onset [corrected] and 5-hydroxytryptamine transporter-linked promoter region genotype
    Henry R Kranzler
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT, USA
    J Clin Psychopharmacol 31:22-30. 2011
    ..Because AD is common, particularly in medical settings, and selective serotonin reuptake inhibitors are widely prescribed by practitioners, these findings have potential public health significance and warrant further evaluation...
  6. pmc Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Neuropsychopharmacology 34:1504-13. 2009
    ..019). We conclude that two independent CNR1 variants have significant interaction effects on risk for CD in EAs; they may also have effects on risk for CD in AAs...
  7. ncbi Mutation screen of the GAD2 gene and association study of alcoholism in three populations
    Jaakko Lappalainen
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 144:183-92. 2007
    ..The functional promoter GAD2 -243 A > G variant may influence risk for AD in some populations, or its role may be limited to susceptibility to severe AD...
  8. ncbi Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations
    Joel Gelernter
    Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Hum Mol Genet 15:3498-507. 2006
    ..Functional studies of these loci are warranted. These results provide additional information useful in evaluating the many earlier discrepant findings regarding association of DRD2 with substance dependence...
  9. ncbi ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studies
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 31:1085-95. 2006
    ..SNP2 or SNP6 was the marker genetically closest to the functional risk loci for both alcohol dependence and drug dependence...
  10. pmc Interactive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on posttraumatic stress disorder diagnosis in 2 independent populations
    Pingxing Xie
    Department of Genetics, Yale University School of Medicine, New Haven, CT, USA
    Arch Gen Psychiatry 66:1201-9. 2009
    ..Previous studies generally focused on its effect on depressive symptoms; little is known about its moderation of the development of posttraumatic stress disorder (PTSD)...
  11. pmc Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Hum Mol Genet 16:380-90. 2007
    ..These findings, obtained using a series of powerful and reliable analytic methods, may also help to explain the high rate of co-morbidity between AD and DD...
  12. pmc Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence
    Bao zhu Yang
    Department of Psychiatry, Division of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Alcohol Clin Exp Res 32:2117-27. 2008
    ..Because comorbid AD with DD (AD+DD) is common, we hypothesized that heterogeneity of the SD diagnoses studied might have contributed to the inconsistency of prior results...
  13. pmc Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence
    Huiping Zhang
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 141:387-93. 2006
    ..The negative results for AFDs, PTSD, and schizophrenia could be due to the low statistical power. Further study with larger samples is warranted...
  14. ncbi Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples
    Bao zhu Yang
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Hum Mol Genet 16:2844-53. 2007
    ..The complexity of these relationships, many of which replicate between our independent samples, may explain prior inconsistent results...
  15. ncbi CNR1 variation modulates risk for drug and alcohol dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, New Haven, CT 06516, USA
    Biol Psychiatry 62:616-26. 2007
    ..Following initial reports of association of CNR1 with SD, we studied multiple markers at this locus in a large case-control sample...
  16. ncbi Population-specific effects of the Asn40Asp polymorphism at the mu-opioid receptor gene (OPRM1) on HPA-axis activation
    Carlos A Hernandez-Avila
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
    Pharmacogenet Genomics 17:1031-8. 2007
    ....
  17. pmc Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4
    Chupong Ittiwut
    Department of Psychiatry, Yale School of Medicine, New Haven, CT 06510, USA
    Genomics 91:61-9. 2008
    ..These findings may aid in understanding the genetic association of this locus with alcohol dependence in several populations...
  18. pmc Subtypes of major depression in substance dependence
    Mark J Niciu
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Addiction 104:1700-9. 2009
    ..Design  Secondary data analysis using pooled data from family-based and case-control genetic studies of SD...
  19. pmc GABRG1 and GABRA2 variation associated with alcohol dependence in African Americans
    Chupong Ittiwut
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Alcohol Clin Exp Res 36:588-93. 2012
    ....
  20. pmc 5-HTTLPR as a potential moderator of the effects of adverse childhood experiences on risk of antisocial personality disorder
    Kara Douglas
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, USA
    Psychiatr Genet 21:240-8. 2011
    ..Childhood abuse is an important predictor of ASPD. We examined 5-HTTLPR genotype and adverse childhood events (ACEs) as risk factors for ASPD in a SD sample...
  21. pmc Population admixture modulates risk for alcohol dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, VA Psychiatry 116A2, West Haven, CT 06516, USA
    Hum Genet 125:605-13. 2009
    ..We cannot exclude the possibility that the results might have been influenced by selection bias due to the multisite nature of the study...
  22. ncbi GABRA2 alleles moderate the subjective effects of alcohol, which are attenuated by finasteride
    Amira Pierucci-Lagha
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, CT 06030, USA
    Neuropsychopharmacology 30:1193-203. 2005
    ..The effects of finasteride provide indirect evidence for a mediating role of neuroactive steroids in some of the subjective effects of alcohol...
  23. pmc Pro-opiomelanocortin gene variation related to alcohol or drug dependence: evidence and replications across family- and population-based studies
    Huiping Zhang
    Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Biol Psychiatry 66:128-36. 2009
    ..The pro-opiomelanocortin gene (POMC) encodes several peptides important for endogenous opioidergic neurotransmission. We tested whether POMC genetic variation affects risk for substance dependence...
  24. pmc ADH1A variation predisposes to personality traits and substance dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 153:376-86. 2010
    ..008 <or= P <or= 0.060). The present study demonstrates that the ADH1A variation may contribute to the genetic component of variation in personality traits and SD...
  25. pmc Association between two mu-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence
    Huiping Zhang
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Hum Mol Genet 15:807-19. 2006
    ..These findings suggest that OPRM1 intronic variants play a role in susceptibility to AD and DD in populations of European ancestry...
  26. pmc Variation in OPRM1 moderates the effect of desire to drink on subsequent drinking and its attenuation by naltrexone treatment
    Henry R Kranzler
    Department of Psychiatry, Treatment Research Center, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, 19104, USA
    Addict Biol 18:193-201. 2013
    ....
  27. ncbi NOTCH4 gene haplotype is associated with schizophrenia in African Americans
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 55:112-7. 2004
    ..The goal of this study was to investigate the relationship between the NOTCH4 gene and schizophrenia in African American (AA) and European American (EA) subjects...
  28. ncbi Risk factors for cocaine-induced paranoia in cocaine-dependent sibling pairs
    Rasmon Kalayasiri
    Department of Psychiatry, Yale School of Medicine, New Haven, CT 06520, USA
    Drug Alcohol Depend 84:77-84. 2006
    ..Both environmental and genetic factors are thought to play a role, but the specific nature of such contributions is poorly understood...
  29. ncbi Alleles of a functional serotonin transporter promoter polymorphism are associated with major depression in alcoholics
    Maggie Nellissery
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington 06030 2103, USA
    Alcohol Clin Exp Res 27:1402-8. 2003
    ..Because the convergence of these disorders may provide a refined phenotype, we examined the association of serotonin (5-HT) transporter linked polymorphic region (5-HTTLPR) alleles to comorbid alcohol dependence and major depression...
  30. pmc Empirically derived subtypes of opioid use and related behaviors
    Grace Chan
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT, USA
    Addiction 106:1146-54. 2011
    ..To identify and validate homogeneous subtypes of opioid use and related behaviors...
  31. pmc Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder
    Pingxing Xie
    Department of Genetics, Yale University School of Medicine, New Haven, CT, USA
    Neuropsychopharmacology 35:1684-92. 2010
    ..This study provides further evidence of a gene x environment effect of FKBP5 and childhood abuse on the risk for PTSD in AAs. Further study is required in other populations...
  32. ncbi CHRM2 variation predisposes to personality traits of agreeableness and conscientiousness
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Hum Mol Genet 16:1557-68. 2007
    ..002). CHRM2 variation may contribute to the genetic component of variation in personality traits. Personality traits might substantially underlie the heritable component of SD...
  33. pmc Personality traits of agreeableness and extraversion are associated with ADH4 variation
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 61:599-608. 2007
    ..Strong associations between ADH4 variation and SD have been reported. We aimed to investigate the relationship between ADH4 variation and personality traits in the present study...
  34. pmc Genomewide linkage scan for opioid dependence and related traits
    Joel Gelernter
    Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Am J Hum Genet 78:759-69. 2006
    ..These results are an initial step in identifying genes for opioid dependence on the basis of a genomewide investigation (i.e., a study not conditioned on prior physiological candidate-gene hypotheses)...
  35. pmc Variation in the gene encoding the serotonin transporter is associated with a measure of sociopathy in alcoholics
    Aryeh I Herman
    Department of Psychiatry, University of Connecticut Health Center, Farmington, CT 06030 2103, USA
    Addict Biol 16:124-32. 2011
    ..The basis for this finding is unknown, but it may have implications for sub-typing alcoholics...
  36. pmc A serotonin transporter gene polymorphism (5-HTTLPR), drinking-to-cope motivation, and negative life events among college students
    Stephen Armeli
    Department of Community Medicine, MC 6325, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030 6325, USA
    J Stud Alcohol Drugs 69:814-23. 2008
    ..We examined reward drinking (drinking-to-enhance motives) as a comparison and to see whether these effects varied across gender...
  37. ncbi Interactive effects of the serotonin transporter 5-HTTLPR polymorphism and stressful life events on college student drinking and drug use
    Jonathan Covault
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA
    Biol Psychiatry 61:609-16. 2007
    ..We examined this polymorphism as it interacted with negative life events to predict drinking and drug use in college students...
  38. pmc Association between polymorphisms in catechol-O-methyltransferase (COMT) and cocaine-induced paranoia in European-American and African-American populations
    Rungnapa Ittiwut
    Yale University School of Medicine, Department of Psychiatry, New Haven, Connecticut 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 156:651-60. 2011
    ..Based on our robust family-controlled and unrelated-affected analyses, we conclude that COMT is associated with CIP, possibly as a result of its role in the metabolism of dopamine and norepinephrine...
  39. pmc Association study of DTNBP1 with schizophrenia in a US sample
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Psychiatr Genet 19:292-304. 2009
    ..This study aimed to test the association in two common US populations by using powerful analytic methods...
  40. ncbi ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Pharmacogenet Genomics 15:755-68. 2005
    ..Using rigorous study designs that account for possible population stratification, these findings confirm and extend our original observations indicating that variation at ADH4 predisposes to alcohol and drug dependence...
  41. pmc Dense genomewide linkage scan for alcohol dependence in African Americans: significant linkage on chromosome 10
    Joel Gelernter
    Department of Psychiatry, Division of Human Genetics, Yale University School of Medicine, New Haven, CT, USA
    Biol Psychiatry 65:111-5. 2009
    ..Risk loci in several populations have been identified with genetic linkage analysis. To date, there has been no published linkage study of AD focused on African Americans (AAs)...
  42. doi A prospective cohort study investigating factors associated with depression during medical internship
    Srijan Sen
    Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA
    Arch Gen Psychiatry 67:557-65. 2010
    ....
  43. ncbi Genomewide linkage scan for nicotine dependence: identification of a chromosome 5 risk locus
    Joel Gelernter
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Biol Psychiatry 61:119-26. 2007
    ..Nicotine dependence (ND) is costly to societies worldwide, moderately heritable, and genetically complex. Risk loci can be identified with genetic linkage analysis independent of prior physiological hypotheses...
  44. pmc Targeted naltrexone for problem drinkers
    Henry R Kranzler
    Department of Psychiatry, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030 2103, USA
    J Clin Psychopharmacol 29:350-7. 2009
    ....
  45. pmc ADH7 variation modulates extraversion and conscientiousness in substance-dependent subjects
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 147:179-86. 2008
    ..The present study demonstrated that the ADH7 variation may contribute to the genetic component of variation in personality traits, with the risk for SD and personality traits being partially shared...
  46. pmc Tryptophan hydroxylase 2 gene and alcohol use among college students
    Paul Gacek
    Public Health Program, Department of Community Medicine and Health Care, University of Connecticut Health Center, Farmington, CT 06030 6325, USA
    Addict Biol 13:440-8. 2008
    ....
  47. pmc Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Am J Hum Genet 78:973-87. 2006
    ..We also found that several ADH genes and the ALDH2 gene were susceptibility loci for AD, and the associations were best explained by several independent risk genes...
  48. ncbi Comorbid psychiatric diagnoses and their association with cocaine-induced psychosis in cocaine-dependent subjects
    Yi lang Tang
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Health Care System, West Haven, CT, USA
    Am J Addict 16:343-51. 2007
    ..Comorbid substance use and psychiatric disorders are very common among individuals with cocaine dependence. Comorbid ADHD increases the odds of an individual endorsing CIP, suggesting some common basis for these phenomena...
  49. pmc Hypermethylation of OPRM1 promoter region in European Americans with alcohol dependence
    Huiping Zhang
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    J Hum Genet 57:670-5. 2012
    ..6%) (P=0.049). Sex and CA did not significantly influence OPRM1 promoter methylation levels. Our findings suggest that OPRM1 promoter hypermethylation may increase the risk for AD and other substance dependence disorders...
  50. pmc Childhood adversity increases risk for nicotine dependence and interacts with α5 nicotinic acetylcholine receptor genotype specifically in males
    Pingxing Xie
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 37:669-76. 2012
    ..80, 95% CI=1.18-2.73, P=0.0044; FTND: OR=1.79, 95% CI=1.11-2.88, P=0.012). No interaction was found in women. This study provides evidence of a sex-specific gene × environment effect of CHRNA5 and childhood adversity on the risk for ND...
  51. doi Autosomal linkage scan for loci predisposing to comorbid dependence on multiple substances
    Bao zhu Yang
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 159:361-9. 2012
    ..This is the first linkage evidence supporting existence of genetic loci influencing risk for several comorbid disorders simultaneously in two major US populations...
  52. pmc Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 37:557-66. 2012
    ..TNN is involved in neurite outgrowth and cell migration in hippocampal explants, and TNR is an extracellular matrix protein expressed primarily in the central nervous system...
  53. pmc Correlates of co-occurring ADHD in drug-dependent subjects: prevalence and features of substance dependence and psychiatric disorders
    Albert J Arias
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030, USA
    Addict Behav 33:1199-207. 2008
    ..We examined the prevalence and course of psychiatric and substance dependence (SD) disorders in subjects with SD and attention deficit hyperactivity disorder (ADHD)...
  54. pmc Cognitive flexibility is associated with KIBRA variant and modulated by recent tobacco use
    Huiping Zhang
    Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 34:2508-16. 2009
    ..We conclude that variation in KIBRA influences cognitive flexibility in a population-specific way, and that current smoking status moderates this effect...
  55. pmc Effect of extended-release naltrexone (XR-NTX) on quality of life in alcohol-dependent patients
    Helen M Pettinati
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Alcohol Clin Exp Res 33:350-6. 2009
    ..2005). A 24-week, randomized, double-blind, placebo-controlled study established the efficacy and safety of XR-NTX in this patient population. In this report, the effect of XR-NTX on quality of life (QOL) was examined...
  56. ncbi Meta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence
    Richard Feinn
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
    Am J Med Genet B Neuropsychiatr Genet 133:79-84. 2005
    ..34 (95% CI = 1.11-1.63)]. Allelic variation at 5-HTTLPR contributes to risk for AD, with the greatest effect observed among individuals with a co-occurring clinical feature...
  57. pmc Adverse childhood events as risk factors for substance dependence: partial mediation by mood and anxiety disorders
    Kara R Douglas
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Addict Behav 35:7-13. 2010
    ..Adverse childhood events (ACEs) are associated with negative health outcomes. We examined ACEs as risk factors for substance dependence (SD) and the mediating effects of mood and anxiety disorders on the relations between ACEs and SD risk...
  58. pmc Variation in GABRA2 predicts drinking behavior in project MATCH subjects
    Lance O Bauer
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
    Alcohol Clin Exp Res 31:1780-7. 2007
    ..The present study examines the association of a GABRA2 SNP with another definition of alcohol involvement and with the effects of psychosocial treatment...
  59. pmc Variation in NGFB is associated with primary affective disorders in women
    Donghong Cui
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 156:401-12. 2011
    ..07, P = 4.2E-05). No SNPs or haplotypes were associated with PAFDs in men or with CAFDs in either sex. We conclude that variation in NGFB is a risk factor for PAFDs in women, but not for CAFD...
  60. pmc Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence
    Aryeh I Herman
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 141:499-503. 2006
    ..These findings fail to replicate the original report of an association between SNPs adjacent to an alternative CNR1 exon 3 transcription start site and polysubstance abuse...
  61. ncbi Association between alcoholism and gamma-amino butyric acid alpha2 receptor subtype in a Russian population
    Jaakko Lappalainen
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Alcohol Clin Exp Res 29:493-8. 2005
    ..The goal of this study was to test whether GABRA2 is associated with alcohol dependence in a sample of Russian alcohol-dependent men...
  62. ncbi Efficacy of extended-release naltrexone in alcohol-dependent patients who are abstinent before treatment
    STEPHANIE S O'MALLEY
    Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, New Haven, CT 06519, USA
    J Clin Psychopharmacol 27:507-12. 2007
    ..In conclusion, XR-NTX 380 mg prolonged abstinence and reduced the number of heavy drinking days and drinking days in patients who were abstinent for as few as 4 days before treatment initiation...
  63. ncbi Mutation screen of the glutamate decarboxylase-67 gene and haplotype association to unipolar depression
    Jaakko Lappalainen
    Yale University School of Medicine, Department of Psychiatry, VA Connecticut Healthcare System, New Haven, Connecticut 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 124:81-6. 2004
    ..Furthermore, these results suggest that common genetic variation within the GAD67 gene does not play a major role in the predisposition to unipolar depression...
  64. pmc Transient cocaine-associated behavioral symptoms rated with a new instrument, the scale for assessment of positive symptoms for cocaine-induced psychosis (SAPS-CIP)
    Yi lang Tang
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Health Care System, West Haven, Connecticut, USA
    Am J Addict 18:339-45. 2009
    ..CRBs also correlate with hallucinations and delusions induced by cocaine, but to a lesser degree. Our findings suggest that there may be some common vulnerability factors that contribute to both cocaine-induced psychosis and CRBs...
  65. pmc A functional serotonin transporter gene polymorphism and depressive effects associated with interferon-alpha treatment
    Amira Pierucci-Lagha
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Psychosomatics 51:137-48. 2010
    ..Interferon-alpha (IFN-alpha) treatment frequently induces depression, potentially leading to early dose reductions or a shorter duration of treatment, which can adversely affect outcomes, including quality of life...
  66. ncbi Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European-Americans
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 120:97-108. 2003
    ..These findings suggest that OPRM1 may play a role in the pathophysiology of substance dependence and this role is population- and diagnosis-specific...
  67. ncbi Diagnostic reliability of the Semi-structured Assessment for Drug Dependence and Alcoholism (SSADDA)
    Amira Pierucci-Lagha
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Drug Alcohol Depend 80:303-12. 2005
    ..This study examines the diagnostic reliability of the SSADDA for substance use disorders and for other DSM-IV disorders that are commonly associated with substance use disorders...
  68. ncbi Allelic and haplotypic association of GABRA2 with alcohol dependence
    Jonathan Covault
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
    Am J Med Genet B Neuropsychiatr Genet 129:104-9. 2004
    ..003). These findings replicate and extend recently reported findings, which together underscore the potential contribution of polymorphic variation at the GABRA2 locus to the risk for alcohol dependence...
  69. pmc Characterization of a likelihood based method and effects of markers informativeness in evaluation of admixture and population group assignment
    Bao zhu Yang
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    BMC Genet 6:50. 2005
    ....
  70. pmc Effects of aripiprazole on subjective and physiological responses to alcohol
    Henry R Kranzler
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
    Alcohol Clin Exp Res 32:573-9. 2008
    ..The present study examined whether aripiprazole modifies the behavioral and physiological effects of a moderate dose of alcohol in a group of social drinkers...
  71. pmc Markers in the 5'-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene
    Jonathan Covault
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, CT 06030 1410, USA
    Neuropsychopharmacology 33:837-48. 2008
    ....
  72. ncbi Analysis of variations in the tryptophan hydroxylase-2 (TPH2) gene in cocaine dependence
    John P Dahl
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, USA
    Addict Biol 11:76-83. 2006
    ..This work suggests that variations in the TPH2 gene are not a risk factor for the development of cocaine dependence, but these findings require confirmation in larger, independent samples of cocaine-dependent and control subjects...
  73. pmc Association of psychiatric and substance use disorder comorbidity with cocaine dependence severity and treatment utilization in cocaine-dependent individuals
    Julian D Ford
    Department of Psychiatry, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 2103, United States
    Drug Alcohol Depend 99:193-203. 2009
    ..Results suggest that co-occurring substance dependence and psychiatric disorders warrant attention in cocaine dependence assessment, treatment, and self-help...
  74. ncbi Transdermal nicotine for smoking cessation in postmenopausal women
    Cheryl Oncken
    Department of Medicine, University of Connecticut School of Medicine, Farmington, CT 06030 3940, USA
    Addict Behav 32:296-309. 2007
    ..However, efforts are needed to improve long-term abstinence rates and smoking outcomes among women with a history of depression...
  75. ncbi Association of a long-chain fatty acid-CoA ligase 4 gene polymorphism with depression and with enhanced niacin-induced dermal erythema
    Jonathan Covault
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
    Am J Med Genet B Neuropsychiatr Genet 127:42-7. 2004
    ..38%; P = 0.003) and a non-significant excess of the T allele in schizophrenia (44%; P = 0.29). The allele frequency for subjects with alcohol dependence did not differ from controls...
  76. ncbi Genomewide linkage scan for cocaine dependence and related traits: significant linkages for a cocaine-related trait and cocaine-induced paranoia
    Joel Gelernter
    Yale University School of Medicine, Department of Psychiatry, Division of Human Genetics and VA CT Healthcare Center, West Haven, CT 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 136:45-52. 2005
    ..35 for membership in the "Moderate Cocaine and Opioid Abuse" cluster on chromosome 18. These results provide a basis for the identification of specific genes contributing to risk for these traits...
  77. pmc Identification of population substructure among Jews using STR markers and dependence on reference populations included
    Jennifer B Listman
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    BMC Genet 11:48. 2010
    ....
  78. ncbi Opioid-, cannabis- and alcohol-dependent women show more rapid progression to substance abuse treatment
    Carlos A Hernandez-Avila
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Drug Alcohol Depend 74:265-72. 2004
    ..e., "telescoping") of alcohol-related complications. This phenomenon also appears to be evident in drug-dependent women, though the data available to support telescoping in drug dependence is less abundant...
  79. pmc Effects of naltrexone treatment for alcohol-related disorders on healthcare costs in an insured population
    Henry R Kranzler
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
    Alcohol Clin Exp Res 34:1090-7. 2010
    ..To determine the impact of treatment with oral naltrexone on healthcare costs in patients with alcohol-related disorders...
  80. ncbi A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients
    David W Oslin
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania, 3535 Market Street, Room 3002, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 28:1546-52. 2003
    ..If replicated, these results would help to identify alcohol-dependent individuals who may be most likely to respond to treatment with naltrexone...
  81. ncbi A functional neuropeptide Y Leu7Pro polymorphism associated with alcohol dependence in a large population sample from the United States
    Jaakko Lappalainen
    Yale University School of Medicine, Department of Psychiatry, VA Connecticut Healthcare System, 950 Campbell Ave, Psychiatry 116A2, West Haven, CT 06516, USA
    Arch Gen Psychiatry 59:825-31. 2002
    ..We tested whether the Pro7 allele is associated with alcohol dependence in European Americans (EA)...
  82. ncbi Extended-release intramuscular naltrexone: a viewpoint by Henry R Kranzler
    Henry R Kranzler
    University of Connecticut School of Medicine, Farmington, CT, USA
    Drugs 66:1753-4. 2006
  83. ncbi Does effect size in naltrexone trials for alcohol dependence differ for single-site vs. multi-center studies?
    Richard Feinn
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030, USA
    Alcohol Clin Exp Res 29:983-8. 2005
    ..We compared effect sizes for these two kinds of trial design on the hypothesis that multi-center trials introduce sources of variation that reduce the observed effect size...
  84. ncbi Targeted versus daily naltrexone: secondary analysis of effects on average daily drinking
    Carlos A Hernandez-Avila
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA
    Alcohol Clin Exp Res 30:860-5. 2006
    ..Because treatment response may differ by gender, we also compared the effects on this factor...
  85. pmc Persistence with oral naltrexone for alcohol treatment: implications for health-care utilization
    Henry R Kranzler
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Addiction 103:1801-8. 2008
    ..We examined prescriptions for oral naltrexone in a large, nationally distributed treatment population to identify characteristics and health-care utilization patterns associated with persistence...
  86. ncbi Psychometric properties of the short index of problems as a measure of recent alcohol-related problems
    Richard Feinn
    Alcohol Research Center, Department of Psychiatry, University of Connecticut Health Center, Farmington 06030 2103, USA
    Alcohol Clin Exp Res 27:1436-41. 2003
    ..A short form of the DrInC, the Short Index of Problems (SIP), was developed for use when time does not permit completion of the DrInC. This study investigates the psychometric properties of the SIP...
  87. ncbi Association of an Asn40Asp (A118G) polymorphism in the mu-opioid receptor gene with substance dependence: a meta-analysis
    Albert Arias
    Alcohol Research Center, Department of Psychiatry, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 2103, USA
    Drug Alcohol Depend 83:262-8. 2006
    ..Studies examining the association of the mu-opioid receptor gene (genetic locus OPRM1) with substance dependence (SD) have focused on the Asn40Asp (A118G) single nucleotide polymorphism (SNP)...
  88. ncbi Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial
    James C Garbutt
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599 7160, USA
    JAMA 293:1617-25. 2005
    ..However, adherence to daily oral pharmacotherapy can be problematic, and clinical acceptance and utility of oral naltrexone have been limited...
  89. ncbi Targeted naltrexone treatment moderates the relations between mood and drinking behavior among problem drinkers
    Henry R Kranzler
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    J Consult Clin Psychol 72:317-27. 2004
    ..These findings underscore the utility of daily measurement for understanding the processes that underlie pharmacological interventions for problem drinking...
  90. ncbi Polymorphism of the 5-HT1B receptor gene (HTR1B): strong within-locus linkage disequilibrium without association to antisocial substance dependence
    Henry R Kranzler
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT, USA
    Neuropsychopharmacology 26:115-22. 2002
    ..Conclusion: Despite no evidence in this study for allelic association of HTR1B to antisocial substance dependence, further evaluation of the hypothesized association is warranted in other population groups...
  91. pmc Effects of opioid receptor gene variation on targeted nalmefene treatment in heavy drinkers
    Albert J Arias
    Alcohol Research Center, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
    Alcohol Clin Exp Res 32:1159-66. 2008
    ..We examined opioid receptor gene polymorphisms as moderators of the therapeutic effects of the opioid antagonist nalmefene...
  92. ncbi Naltrexone depot for treatment of alcohol dependence: a multicenter, randomized, placebo-controlled clinical trial
    Henry R Kranzler
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, USA
    Alcohol Clin Exp Res 28:1051-9. 2004
    ..Efforts to improve naltrexone compliance have included the development of injectable, long-acting depot formulations...
  93. ncbi Association between the cortisol response to opioid blockade and the Asn40Asp polymorphism at the mu-opioid receptor locus (OPRM1)
    Carlos A Hernandez-Avila
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Am J Med Genet B Neuropsychiatr Genet 118:60-5. 2003
    ..The polymorphism occurs commonly in European Americans and some other population groups, underscoring its potential phenotypic significance...
  94. ncbi Adrenocorticotropin and cortisol responses to a naloxone challenge and risk of alcoholism
    Carlos A Hernandez-Avila
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06030 2103, USA
    Biol Psychiatry 51:652-8. 2002
    ....
  95. ncbi Screening for health behaviors in ambulatory clinical settings: does smoking status predict hazardous drinking?
    Henry R Kranzler
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington 06030, USA
    Addict Behav 27:737-49. 2002
    ..These findings suggest that patients who report current smoking should routinely be asked about their current alcohol consumption. Interventions should then be tailored to address smoking and, if appropriate, hazardous drinking as well...
  96. ncbi Targeted naltrexone for early problem drinkers
    Henry R Kranzler
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06030 2103, USA
    J Clin Psychopharmacol 23:294-304. 2003
    ..Efforts to replicate these findings are warranted, since they suggest that schedules of medication administration other than daily should be evaluated for treatment of problem drinking...
  97. ncbi Using daily interactive voice response technology to measure drinking and related behaviors in a pharmacotherapy study
    Henry R Kranzler
    Lowell P Weicker, Jr General Clinical Research Center, Department of Psychiatry, University of Connecticut Health Center, Farmington, Connecticut 06030 2103, USA
    Alcohol Clin Exp Res 28:1060-4. 2004
    ..Despite these advantages, no published studies have used IVR in alcohol pharmacotherapy trials...
  98. pmc Genetics of alcohol dependence
    Joel Gelernter
    Department of Psychiatry, VAMC 116A2, Yale University School of Medicine, 950 Campbell Avenue, West Haven, CT 06516, USA
    Hum Genet 126:91-9. 2009
    ....
  99. pmc Effects of a diagnosis or family history of alcoholism on the taste intensity and hedonic value of sucrose
    Kristen A Tremblay
    Department of Psychiatry, University of Connecticut School of Medicine, Alcohol Research Center, Farmington, Connecticut 06030 2103, USA
    Am J Addict 18:494-9. 2009
    ..These findings do not support the hypothesis that sucrose preference is positively associated with either a personal lifetime history of AD or a family history of alcoholism...
  100. ncbi Measurement and prediction of medication compliance in problem drinkers
    Richard Feinn
    Alcohol and Research Center, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Alcohol Clin Exp Res 27:1286-92. 2003
    ..This study examined the concordance of data on medication compliance that was obtained by using an electronic monitoring system (Medication Event Monitoring System, or MEMS), daily diary reports, and tablet counts...
  101. ncbi Sertraline treatment of co-occurring alcohol dependence and major depression
    Henry R Kranzler
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    J Clin Psychopharmacol 26:13-20. 2006
    ..This multicenter, double-blind, placebo-controlled trial of sertraline was designed to address many of the potential methodological shortcomings of studies of co-occurring disorders...