Henry R Kranzler

Summary

Affiliation: University of Connecticut Health Center
Country: USA

Publications

  1. ncbi request reprint Pharmacogenetics of alcohol and alcohol dependence treatment
    Henry R Kranzler
    Departments of Psychiatry and Genetics and Developmental Biology, University of Connecticut Health, Center, 263 Farmington Ave Farmington, CT 06030 2103, USA
    Curr Pharm Des 16:2141-8. 2010
  2. pmc Variation in the gene encoding the serotonin transporter is associated with a measure of sociopathy in alcoholics
    Aryeh I Herman
    Department of Psychiatry, University of Connecticut Health Center, Farmington, CT 06030 2103, USA
    Addict Biol 16:124-32. 2011
  3. pmc Subtypes of major depression in substance dependence
    Mark J Niciu
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Addiction 104:1700-9. 2009
  4. pmc Persistence with oral naltrexone for alcohol treatment: implications for health-care utilization
    Henry R Kranzler
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Addiction 103:1801-8. 2008
  5. pmc Adverse childhood events as risk factors for substance dependence: partial mediation by mood and anxiety disorders
    Kara R Douglas
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Addict Behav 35:7-13. 2010
  6. pmc Placebo-controlled trial of zonisamide for the treatment of alcohol dependence
    Albert J Arias
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    J Clin Psychopharmacol 30:318-22. 2010
  7. pmc Effects of naltrexone treatment for alcohol-related disorders on healthcare costs in an insured population
    Henry R Kranzler
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
    Alcohol Clin Exp Res 34:1090-7. 2010
  8. pmc Markers in the 5'-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene
    Jonathan Covault
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, CT 06030 1410, USA
    Neuropsychopharmacology 33:837-48. 2008
  9. pmc The validity of cocaine dependence subtypes
    Henry R Kranzler
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, United States
    Addict Behav 33:41-53. 2008
  10. doi request reprint Acamprosate efficacy in alcohol-dependent patients: summary of results from three pivotal trials
    Henry R Kranzler
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Am J Addict 17:70-6. 2008

Detail Information

Publications33

  1. ncbi request reprint Pharmacogenetics of alcohol and alcohol dependence treatment
    Henry R Kranzler
    Departments of Psychiatry and Genetics and Developmental Biology, University of Connecticut Health, Center, 263 Farmington Ave Farmington, CT 06030 2103, USA
    Curr Pharm Des 16:2141-8. 2010
    ..We recommend that, whenever possible, treatment trials include the collection of DNA samples to permit pharmacogenetic analyses, and that such analyses look broadly for relevant genetic variation...
  2. pmc Variation in the gene encoding the serotonin transporter is associated with a measure of sociopathy in alcoholics
    Aryeh I Herman
    Department of Psychiatry, University of Connecticut Health Center, Farmington, CT 06030 2103, USA
    Addict Biol 16:124-32. 2011
    ..The basis for this finding is unknown, but it may have implications for sub-typing alcoholics...
  3. pmc Subtypes of major depression in substance dependence
    Mark J Niciu
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Addiction 104:1700-9. 2009
    ..Design  Secondary data analysis using pooled data from family-based and case-control genetic studies of SD...
  4. pmc Persistence with oral naltrexone for alcohol treatment: implications for health-care utilization
    Henry R Kranzler
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Addiction 103:1801-8. 2008
    ..We examined prescriptions for oral naltrexone in a large, nationally distributed treatment population to identify characteristics and health-care utilization patterns associated with persistence...
  5. pmc Adverse childhood events as risk factors for substance dependence: partial mediation by mood and anxiety disorders
    Kara R Douglas
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Addict Behav 35:7-13. 2010
    ..Adverse childhood events (ACEs) are associated with negative health outcomes. We examined ACEs as risk factors for substance dependence (SD) and the mediating effects of mood and anxiety disorders on the relations between ACEs and SD risk...
  6. pmc Placebo-controlled trial of zonisamide for the treatment of alcohol dependence
    Albert J Arias
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    J Clin Psychopharmacol 30:318-22. 2010
    ..This pilot clinical trial evaluated the safety, tolerability, and efficacy of zonisamide for the treatment of alcohol dependence...
  7. pmc Effects of naltrexone treatment for alcohol-related disorders on healthcare costs in an insured population
    Henry R Kranzler
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
    Alcohol Clin Exp Res 34:1090-7. 2010
    ..To determine the impact of treatment with oral naltrexone on healthcare costs in patients with alcohol-related disorders...
  8. pmc Markers in the 5'-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene
    Jonathan Covault
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, CT 06030 1410, USA
    Neuropsychopharmacology 33:837-48. 2008
    ....
  9. pmc The validity of cocaine dependence subtypes
    Henry R Kranzler
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, United States
    Addict Behav 33:41-53. 2008
    ..These findings support the validity of the methods used to derive homogeneous subgroups of CD subjects and the resulting CD subtypes. Independent replication of these findings would provide further validation of this approach...
  10. doi request reprint Acamprosate efficacy in alcohol-dependent patients: summary of results from three pivotal trials
    Henry R Kranzler
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Am J Addict 17:70-6. 2008
    ..01). These findings support the use of acamprosate in the treatment of alcohol dependence and illustrate some of the issues that can arise in the FDA process for approval of medications to treat the disorder...
  11. pmc Effects of aripiprazole on subjective and physiological responses to alcohol
    Henry R Kranzler
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
    Alcohol Clin Exp Res 32:573-9. 2008
    ..The present study examined whether aripiprazole modifies the behavioral and physiological effects of a moderate dose of alcohol in a group of social drinkers...
  12. pmc Correlates of co-occurring ADHD in drug-dependent subjects: prevalence and features of substance dependence and psychiatric disorders
    Albert J Arias
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030, USA
    Addict Behav 33:1199-207. 2008
    ..We examined the prevalence and course of psychiatric and substance dependence (SD) disorders in subjects with SD and attention deficit hyperactivity disorder (ADHD)...
  13. pmc Nicotine gum for pregnant smokers: a randomized controlled trial
    Cheryl Oncken
    Departments of Medicine and Obstetrics and Gynecology, University of Connecticut School of Medicine, Farmington, Connecticut 06030 3940, USA
    Obstet Gynecol 112:859-67. 2008
    ..To estimate the safety and efficacy of treatment with 2-mg nicotine gum for smoking cessation during pregnancy...
  14. pmc Effects of nicotine patch or nasal spray on nicotine and cotinine concentrations in pregnant smokers
    Cheryl Oncken
    Department of Medicine, University of Connecticut School of Medicine, Farmington, Connecticut, USA
    J Matern Fetal Neonatal Med 22:751-8. 2009
    ..To examine the short-term effects of the nicotine patch or nasal spray on measures of nicotine exposure, withdrawal symptoms, and on maternal and fetal heart rates in pregnant smokers...
  15. ncbi request reprint Transdermal nicotine for smoking cessation in postmenopausal women
    Cheryl Oncken
    Department of Medicine, University of Connecticut School of Medicine, Farmington, CT 06030 3940, USA
    Addict Behav 32:296-309. 2007
    ..However, efforts are needed to improve long-term abstinence rates and smoking outcomes among women with a history of depression...
  16. ncbi request reprint Advances in the pharmacotherapy of alcoholism: challenging misconceptions
    Henry R Kranzler
    Department of Psychiatry, University of Connecticut Health Center, Farmington, Connecticut, USA
    Alcohol Clin Exp Res 30:272-81. 2006
    ..Gastfriend; (5) System Challenges in the Adoption of Pharmacotherapy, by Robert M. Swift; and (6) Pharmacotherapy for Alcohol Dependence: Strengths, Challenges, and Future Directions, by Mark L. Willenbring...
  17. ncbi request reprint Screening for health behaviors in ambulatory clinical settings: does smoking status predict hazardous drinking?
    Henry R Kranzler
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington 06030, USA
    Addict Behav 27:737-49. 2002
    ..These findings suggest that patients who report current smoking should routinely be asked about their current alcohol consumption. Interventions should then be tailored to address smoking and, if appropriate, hazardous drinking as well...
  18. ncbi request reprint Effect of maternal smoking on fetal catecholamine concentrations at birth
    Cheryl A Oncken
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, U S A
    Pediatr Res 53:119-24. 2003
    ..Further studies are needed to validate these findings and to examine the specific mechanism by which these differences may arise...
  19. ncbi request reprint Targeted naltrexone for early problem drinkers
    Henry R Kranzler
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06030 2103, USA
    J Clin Psychopharmacol 23:294-304. 2003
    ..Efforts to replicate these findings are warranted, since they suggest that schedules of medication administration other than daily should be evaluated for treatment of problem drinking...
  20. ncbi request reprint Effects of ondansetron in early- versus late-onset alcoholics: a prospective, open-label study
    Henry R Kranzler
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, USA
    Alcohol Clin Exp Res 27:1150-5. 2003
    ..This study compared the tolerability and potential efficacy of an oral solution of ondansetron in EOAs versus LOAs...
  21. ncbi request reprint Dual diagnosis: alcoholism and co-morbid psychiatric disorders
    Henry R Kranzler
    Department of Psychiatry and the Alcohol Research Center, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Am J Addict 12:S26-40. 2003
    ..Despite the difficulties inherent in treating dual diagnosis patients, the clinician must recognize that it is possible to derive valid diagnoses and deliver efficacious treatment to such patients...
  22. ncbi request reprint Targeted naltrexone treatment moderates the relations between mood and drinking behavior among problem drinkers
    Henry R Kranzler
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    J Consult Clin Psychol 72:317-27. 2004
    ..These findings underscore the utility of daily measurement for understanding the processes that underlie pharmacological interventions for problem drinking...
  23. ncbi request reprint Association of a long-chain fatty acid-CoA ligase 4 gene polymorphism with depression and with enhanced niacin-induced dermal erythema
    Jonathan Covault
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
    Am J Med Genet B Neuropsychiatr Genet 127:42-7. 2004
    ..38%; P = 0.003) and a non-significant excess of the T allele in schizophrenia (44%; P = 0.29). The allele frequency for subjects with alcohol dependence did not differ from controls...
  24. ncbi request reprint Sertraline treatment of co-occurring alcohol dependence and major depression
    Henry R Kranzler
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    J Clin Psychopharmacol 26:13-20. 2006
    ..This multicenter, double-blind, placebo-controlled trial of sertraline was designed to address many of the potential methodological shortcomings of studies of co-occurring disorders...
  25. ncbi request reprint Association of an Asn40Asp (A118G) polymorphism in the mu-opioid receptor gene with substance dependence: a meta-analysis
    Albert Arias
    Alcohol Research Center, Department of Psychiatry, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 2103, USA
    Drug Alcohol Depend 83:262-8. 2006
    ..Studies examining the association of the mu-opioid receptor gene (genetic locus OPRM1) with substance dependence (SD) have focused on the Asn40Asp (A118G) single nucleotide polymorphism (SNP)...
  26. ncbi request reprint Using daily interactive voice response technology to measure drinking and related behaviors in a pharmacotherapy study
    Henry R Kranzler
    Lowell P Weicker, Jr General Clinical Research Center, Department of Psychiatry, University of Connecticut Health Center, Farmington, Connecticut 06030 2103, USA
    Alcohol Clin Exp Res 28:1060-4. 2004
    ..Despite these advantages, no published studies have used IVR in alcohol pharmacotherapy trials...
  27. ncbi request reprint Naltrexone depot for treatment of alcohol dependence: a multicenter, randomized, placebo-controlled clinical trial
    Henry R Kranzler
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, USA
    Alcohol Clin Exp Res 28:1051-9. 2004
    ..Efforts to improve naltrexone compliance have included the development of injectable, long-acting depot formulations...
  28. ncbi request reprint Opioid-, cannabis- and alcohol-dependent women show more rapid progression to substance abuse treatment
    Carlos A Hernandez-Avila
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Drug Alcohol Depend 74:265-72. 2004
    ..e., "telescoping") of alcohol-related complications. This phenomenon also appears to be evident in drug-dependent women, though the data available to support telescoping in drug dependence is less abundant...
  29. ncbi request reprint Effects of gender and family history of alcohol dependence on a behavioral task of impulsivity in healthy subjects
    Nancy M Petry
    Department of Psychiatry, University of Connecticut Health Center, Farmington 06030 3944, USA
    J Stud Alcohol 63:83-90. 2002
    ....
  30. pmc A functional serotonin transporter gene polymorphism and depressive effects associated with interferon-alpha treatment
    Amira Pierucci-Lagha
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Psychosomatics 51:137-48. 2010
    ..Interferon-alpha (IFN-alpha) treatment frequently induces depression, potentially leading to early dose reductions or a shorter duration of treatment, which can adversely affect outcomes, including quality of life...
  31. pmc Association of markers in the 3' region of the GluR5 kainate receptor subunit gene to alcohol dependence
    Henry R Kranzler
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, University Health Center, Farmington, CT 06030 2103, USA
    Alcohol Clin Exp Res 33:925-30. 2009
    ..We focused specifically on this gene because topiramate, a glutamate modulator that binds to the GluR5 subunit, has shown robust efficacy in the treatment of AD...
  32. ncbi request reprint Association between the cortisol response to opioid blockade and the Asn40Asp polymorphism at the mu-opioid receptor locus (OPRM1)
    Carlos A Hernandez-Avila
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Am J Med Genet B Neuropsychiatr Genet 118:60-5. 2003
    ..The polymorphism occurs commonly in European Americans and some other population groups, underscoring its potential phenotypic significance...
  33. pmc Targeted naltrexone for problem drinkers
    Henry R Kranzler
    Department of Psychiatry, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030 2103, USA
    J Clin Psychopharmacol 29:350-7. 2009
    ....