Richard Kramer

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Tyrosine phosphorylation of rod cyclic nucleotide-gated channels switches off Ca2+/calmodulin inhibition
    Jeffrey L Krajewski
    Deparment of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    J Neurosci 23:10100-6. 2003
  2. pmc Light-activated ion channels for remote control of neuronal firing
    Matthew Banghart
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    Nat Neurosci 7:1381-6. 2004
  3. pmc A positive feedback synapse from retinal horizontal cells to cone photoreceptors
    Skyler L Jackman
    Department of Physics, University of California, Berkeley, Berkeley, California, United States of America
    PLoS Biol 9:e1001057. 2011
  4. pmc Rapid optical control of nociception with an ion-channel photoswitch
    Alexandre Mourot
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, USA
    Nat Methods 9:396-402. 2012
  5. ncbi request reprint Optogenetic pharmacology for control of native neuronal signaling proteins
    Richard H Kramer
    University of California, Berkeley, California, USA
    Nat Neurosci 16:816-23. 2013
  6. pmc New photochemical tools for controlling neuronal activity
    Richard H Kramer
    Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, United States
    Curr Opin Neurobiol 19:544-52. 2009
  7. ncbi request reprint Photochemical tools for remote control of ion channels in excitable cells
    Richard H Kramer
    Department of Molecular and Cell Biology, 142 Life Sciences Addition, University of California, Berkeley, Berkeley, California 94720, USA
    Nat Chem Biol 1:360-5. 2005
  8. pmc Subunit contributions to phosphorylation-dependent modulation of bovine rod cyclic nucleotide-gated channels
    Elena Molokanova
    Deparment of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    J Physiol 552:345-56. 2003
  9. pmc Photochemical control of endogenous ion channels and cellular excitability
    Doris L Fortin
    Department of Molecular and Cell Biology, University of California Berkeley, 121 Life Sciences Addition, Berkeley, California 94720, USA
    Nat Methods 5:331-8. 2008
  10. ncbi request reprint Metabolic modulation of potassium channels
    Dirk Trauner
    Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA
    Sci STKE 2004:pe22. 2004

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Tyrosine phosphorylation of rod cyclic nucleotide-gated channels switches off Ca2+/calmodulin inhibition
    Jeffrey L Krajewski
    Deparment of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    J Neurosci 23:10100-6. 2003
    ....
  2. pmc Light-activated ion channels for remote control of neuronal firing
    Matthew Banghart
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    Nat Neurosci 7:1381-6. 2004
    ....
  3. pmc A positive feedback synapse from retinal horizontal cells to cone photoreceptors
    Skyler L Jackman
    Department of Physics, University of California, Berkeley, Berkeley, California, United States of America
    PLoS Biol 9:e1001057. 2011
    ..By locally offsetting the effects of negative feedback, positive feedback may amplify photoreceptor synaptic release without sacrificing HC-mediated contrast enhancement...
  4. pmc Rapid optical control of nociception with an ion-channel photoswitch
    Alexandre Mourot
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, USA
    Nat Methods 9:396-402. 2012
    ..Because intracellular QAQ accumulation is a consequence of nociceptive ion-channel activity, QAQ-mediated photosensitization is a platform for understanding signaling mechanisms in acute and chronic pain...
  5. ncbi request reprint Optogenetic pharmacology for control of native neuronal signaling proteins
    Richard H Kramer
    University of California, Berkeley, California, USA
    Nat Neurosci 16:816-23. 2013
    ..Now that the tools for manipulating endogenous neuronal signaling proteins are available, they can be implemented in vivo to enhance our understanding of the molecular bases of brain function and dysfunctions. ..
  6. pmc New photochemical tools for controlling neuronal activity
    Richard H Kramer
    Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, United States
    Curr Opin Neurobiol 19:544-52. 2009
    ..The three families of photochemical tools have different capabilities and uses, but they all share in enabling precise and noninvasive exploration of neural function with light...
  7. ncbi request reprint Photochemical tools for remote control of ion channels in excitable cells
    Richard H Kramer
    Department of Molecular and Cell Biology, 142 Life Sciences Addition, University of California, Berkeley, Berkeley, California 94720, USA
    Nat Chem Biol 1:360-5. 2005
    ..The development of chemical tools for optically stimulating or inhibiting signaling proteins has particular relevance for the nervous system, where precise, noninvasive control is an experimental and medical necessity...
  8. pmc Subunit contributions to phosphorylation-dependent modulation of bovine rod cyclic nucleotide-gated channels
    Elena Molokanova
    Deparment of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    J Physiol 552:345-56. 2003
    ..Hence both CNGA1 and CNGB1 subunits contribute to phosphorylation-dependent modulation of rod CNG channels, but the phosphorylation states of the two subunits are regulated in different ways...
  9. pmc Photochemical control of endogenous ion channels and cellular excitability
    Doris L Fortin
    Department of Molecular and Cell Biology, University of California Berkeley, 121 Life Sciences Addition, Berkeley, California 94720, USA
    Nat Methods 5:331-8. 2008
    ....
  10. ncbi request reprint Metabolic modulation of potassium channels
    Dirk Trauner
    Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA
    Sci STKE 2004:pe22. 2004
    ..Although the exact function of the beta subunit associated with voltage-gated potassium channels is still unclear, its crystal structure suggests that membrane excitability is directly coupled to metabolism...
  11. pmc LiGluR restores visual responses in rodent models of inherited blindness
    Natalia Caporale
    Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720 2020, USA
    Mol Ther 19:1212-9. 2011
    ....
  12. ncbi request reprint Light-induced depolarization of neurons using a modified Shaker K(+) channel and a molecular photoswitch
    James J Chambers
    Department of Molecular and Cell Biology, University of California, Berkley, CA 94720, USA
    J Neurophysiol 96:2792-6. 2006
    ..Hence, hyper- and depolarizing SPARK channels provide a means for eliciting opposite effects on neurons in response to the same light stimulus...
  13. pmc Allosteric control of an ionotropic glutamate receptor with an optical switch
    Matthew Volgraf
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    Nat Chem Biol 2:47-52. 2006
    ..Our device has potential uses not only in biology but also in bioelectronics and nanotechnology...
  14. pmc Role of the synaptic ribbon in transmitting the cone light response
    Skyler L Jackman
    Departments of Physics, University of California Berkeley, Berkeley, California 94720, USA
    Nat Neurosci 12:303-10. 2009
    ..Phasic release extends the operating range of the cone synapse to more accurately encode changes in light intensity, accentuating features that are salient to photopic vision...
  15. pmc Optogenetic photochemical control of designer K+ channels in mammalian neurons
    Doris L Fortin
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3200, USA
    J Neurophysiol 106:488-96. 2011
    ..These light-regulated channels may be overexpressed in genetically targeted neurons or substituted for native channels with gene knockin technology to enable precise optopharmacological manipulation of channel function...
  16. pmc Light regulation of Ca2+ in the cone photoreceptor synaptic terminal
    Sue Yeon Choi
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3200, USA
    Vis Neurosci 25:693-700. 2008
    ....
  17. ncbi request reprint Staples, tape measures, and bungee cords: a variety of bifunctional reagents for understanding and controlling ion channels
    Alexandre Mourot
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California 94720 3200, USA
    ACS Chem Biol 2:451-3. 2007
    ..In a new paper, researchers stretch the technique a bit further by using a reactive derivative of a peptide toxin to probe the subunit composition of a voltage-gated K+ channel...
  18. ncbi request reprint Remote control of neuronal activity with a light-gated glutamate receptor
    Stephanie Szobota
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Neuron 54:535-45. 2007
    ..Our studies show that LiGluR provides robust control over neuronal activity, enabling the dissection and manipulation of neural circuitry in vivo...
  19. ncbi request reprint Imaging light-modulated release of synaptic vesicles in the intact retina: retinal physiology at the dawn of the post-electrode era
    Sue Yeon Choi
    Department of Molecular and Cell Biology, University of California, Berkeley, USA
    Vision Res 45:3487-95. 2005
    ....
  20. ncbi request reprint Patch cramming reveals the mechanism of long-term suppression of cyclic nucleotides in intact neurons
    Bhavya Trivedi
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33101, USA
    J Neurosci 22:8819-26. 2002
    ..Because the molecular machinery underlying LTS is common to many cells, LTS may be a widespread mechanism for long-term silencing of cyclic nucleotide signaling...
  21. ncbi request reprint Flashy science: controlling neural function with light
    Scott M Thompson
    Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland, 21201, USA
    J Neurosci 25:10358-65. 2005

Research Grants20

  1. Optical studies of the cone photoreceptor synapse
    Richard H Kramer; Fiscal Year: 2011
    ....
  2. MODULATION OF RETINAL FUNCTION BY IGF-1
    Richard Kramer; Fiscal Year: 2001
    ..abstract_text> ..
  3. Light-activated ion chanenls for remote control of neuronal activity
    Richard Kramer; Fiscal Year: 2009
    ..This will provide fundamental information for understanding how the retina functions and adapts to different light conditions and will be useful for designing and evaluating future therapeutic strategies for restoring vision. ..
  4. A universal photoswitch system for optical control of neuronal receptors
    Richard Kramer; Fiscal Year: 2009
    ..The proposed studies benefit from unique features of the scientific environment, subject populations, or employ useful collaborative arrangements. There is evidence of institutional support. ..
  5. Light-activated ion chanenls for remote control of neuronal activity
    Richard Kramer; Fiscal Year: 2009
    ..This will provide fundamental information for understanding how the retina functions and adapts to different light conditions and will be useful for designing and evaluating future therapeutic strategies for restoring vision. ..
  6. Light-activated ion chanenls for remote control of neuronal activity
    Richard H Kramer; Fiscal Year: 2010
    ..This will provide fundamental information for understanding how the retina functions and adapts to different light conditions and will be useful for designing and evaluating future therapeutic strategies for restoring vision. ..
  7. Optical studies of the cone photoreceptor synapse
    Richard H Kramer; Fiscal Year: 2010
    ....
  8. A universal photoswitch system for optical control of neuronal receptors
    Richard H Kramer; Fiscal Year: 2010
    ..The proposed studies benefit from unique features of the scientific environment, subject populations, or employ useful collaborative arrangements. There is evidence of institutional support. ..
  9. Optical studies of the cone photoreceptor synapse
    Richard Kramer; Fiscal Year: 2007
    ..These results will provide fundamental information about the mechanisms of normal vision and will provide insights about synaptic dysfunction that occur in retinal diseases. ..
  10. SYNAPTIC FUNCTION OF CNG CHANNELS IN THE RETINA
    Richard Kramer; Fiscal Year: 2000
    ..Preliminary results indicate that NO produces a sag in light response of horizontal cells in the intact retina. Whether this is due to effects on cones or effects on horizontal cells will be examined. ..
  11. MODULATION OF RETINAL FUNCTION BY IGF-1
    Richard Kramer; Fiscal Year: 2000
    ..abstract_text> ..
  12. SYNAPTIC FUNCTION OF CNG CHANNELS IN THE RETINA
    Richard Kramer; Fiscal Year: 2001
    ..Preliminary results indicate that NO produces a sag in light response of horizontal cells in the intact retina. Whether this is due to effects on cones or effects on horizontal cells will be examined. ..
  13. Optical studies of the cone photoreceptor synapse
    Richard Kramer; Fiscal Year: 2004
    ..These results will provide fundamental information about the mechanisms of normal vision and will provide insights about synaptic dysfunction that occur in retinal diseases. ..
  14. Optical studies of the cone photoreceptor synapse
    Richard Kramer; Fiscal Year: 2005
    ..These results will provide fundamental information about the mechanisms of normal vision and will provide insights about synaptic dysfunction that occur in retinal diseases. ..
  15. Light-activated ion channels for neural control
    Richard Kramer; Fiscal Year: 2006
    ..Light-activated channels provide an accurate and reversible way to regulate neural activity and open a new opto-bioelectronic interface for influencing the nervous system for experimental and therapeutic purposes. ..
  16. Optical studies of the cone photoreceptor synapse
    Richard Kramer; Fiscal Year: 2006
    ..These results will provide fundamental information about the mechanisms of normal vision and will provide insights about synaptic dysfunction that occur in retinal diseases. ..