Joel Kramer

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Clinical and neuropsychological features of corticobasal degeneration
    Nataliya Belfor
    University of California San Francisco, Memory and Aging Center, 350 Parnassus Avenue, Suite 705, 94143, USA
    Mech Ageing Dev 127:203-7. 2006
  2. pmc Longitudinal MRI and cognitive change in healthy elderly
    Joel H Kramer
    Department of Neurology, San Francisco Medical Center, University of California, San Francisco, CA 94143, USA
    Neuropsychology 21:412-8. 2007
  3. pmc Magnetic resonance imaging correlates of set shifting
    Joel H Kramer
    Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA
    J Int Neuropsychol Soc 13:386-92. 2007
  4. pmc Clinical-neuroimaging characteristics of dysexecutive mild cognitive impairment
    Judy Pa
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94117, USA
    Ann Neurol 65:414-23. 2009
  5. pmc Neuropathological basis of magnetic resonance images in aging and dementia
    William J Jagust
    School of Public Health and Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720 3190, USA
    Ann Neurol 63:72-80. 2008
  6. pmc Cognitive impact of subcortical vascular and Alzheimer's disease pathology
    Helena C Chui
    Department of Neurology, University of Southern California, Los Angeles, USA
    Ann Neurol 60:677-87. 2006
  7. ncbi request reprint White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy
    An Tao Du
    Magnetic Resonance Unit 114M, Department of Veterans Affairs Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA
    Neurobiol Aging 26:553-9. 2005
  8. pmc Do tests of executive functioning predict ability to downregulate emotions spontaneously and when instructed to suppress?
    Anett Gyurak
    Institute of Personality and Social Research, Department of Psychology, University of California, Berkeley, California 94720 5050, USA
    Cogn Affect Behav Neurosci 9:144-52. 2009
  9. doi request reprint Preliminary results of a longitudinal study of changes in cognitive function in breast cancer patients undergoing chemotherapy with doxorubicin and cyclophosphamide
    Catherine E Jansen
    San Francisco Kaiser Permanente Medical Center, San Francisco, CA 94115, USA
    Psychooncology 17:1189-95. 2008
  10. pmc Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer's disease
    Juan Zhou
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94117, USA
    Brain 133:1352-67. 2010

Research Grants

  1. Attention and Executive Functioning in FTD
    Joel Kramer; Fiscal Year: 2007
  2. Mechanisms of Executive Decline in Normal Aging
    Joel Kramer; Fiscal Year: 2009
  3. Mechanisms of Executive Decline in Normal Aging
    Joel H Kramer; Fiscal Year: 2010

Detail Information

Publications85

  1. ncbi request reprint Clinical and neuropsychological features of corticobasal degeneration
    Nataliya Belfor
    University of California San Francisco, Memory and Aging Center, 350 Parnassus Avenue, Suite 705, 94143, USA
    Mech Ageing Dev 127:203-7. 2006
    ..Increasing awareness of this disorder has led to the realization that specific cognitive and imaging changes are common with CBD degeneration and that these changes help with clinical diagnosis...
  2. pmc Longitudinal MRI and cognitive change in healthy elderly
    Joel H Kramer
    Department of Neurology, San Francisco Medical Center, University of California, San Francisco, CA 94143, USA
    Neuropsychology 21:412-8. 2007
    ..The association between WMSH and EXEC further highlights the cognitive sequealae associated with cerebrovascular disease in normal elderly...
  3. pmc Magnetic resonance imaging correlates of set shifting
    Joel H Kramer
    Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA
    J Int Neuropsychol Soc 13:386-92. 2007
    ..Follow-up analyses indicated that frontal contributions to shifting were not related to working memory. Results highlight the importance of carefully controlling for component cognitive processes when studying executive functioning...
  4. pmc Clinical-neuroimaging characteristics of dysexecutive mild cognitive impairment
    Judy Pa
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94117, USA
    Ann Neurol 65:414-23. 2009
    ..The goal of the study was to compare clinical and neuroimaging characteristics of two single-domain MCI subgroups: amnestic MCI and dysexecutive MCI...
  5. pmc Neuropathological basis of magnetic resonance images in aging and dementia
    William J Jagust
    School of Public Health and Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720 3190, USA
    Ann Neurol 63:72-80. 2008
    ..Magnetic resonance (MR) imaging is used widely for assessment of patients with cognitive impairment, but the pathological correlates are unclear, especially when multiple pathologies are present...
  6. pmc Cognitive impact of subcortical vascular and Alzheimer's disease pathology
    Helena C Chui
    Department of Neurology, University of Southern California, Los Angeles, USA
    Ann Neurol 60:677-87. 2006
    ..To assess the interactions among three types of pathology (ie, cerebrovascular disease, hippocampal sclerosis [HS], and Alzheimer's disease [AD]), cognitive status, and apolipoprotein E genotype...
  7. ncbi request reprint White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy
    An Tao Du
    Magnetic Resonance Unit 114M, Department of Veterans Affairs Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA
    Neurobiol Aging 26:553-9. 2005
    ..Further, AD pathology and subcortical vascular disease may independently affect cortical atrophy...
  8. pmc Do tests of executive functioning predict ability to downregulate emotions spontaneously and when instructed to suppress?
    Anett Gyurak
    Institute of Personality and Social Research, Department of Psychology, University of California, Berkeley, California 94720 5050, USA
    Cogn Affect Behav Neurosci 9:144-52. 2009
    ....
  9. doi request reprint Preliminary results of a longitudinal study of changes in cognitive function in breast cancer patients undergoing chemotherapy with doxorubicin and cyclophosphamide
    Catherine E Jansen
    San Francisco Kaiser Permanente Medical Center, San Francisco, CA 94115, USA
    Psychooncology 17:1189-95. 2008
    ....
  10. pmc Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer's disease
    Juan Zhou
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94117, USA
    Brain 133:1352-67. 2010
    ..Further developed, intrinsic connectivity network signatures may provide simple, inexpensive, and non-invasive biomarkers for dementia differential diagnosis and disease monitoring...
  11. ncbi request reprint Mental flexibility: age effects on switching
    Nancy S Wecker
    San Francisco, CA 94131, USA
    Neuropsychology 19:345-52. 2005
    ..The results are discussed in terms of theories of executive control and neurologic correlates across the adult life span...
  12. ncbi request reprint Psychometrically matched measures of global cognition, memory, and executive function for assessment of cognitive decline in older persons
    Dan Mungas
    Department of Neurology, School of Medicine, University of California, Davis, Sacramento 95817, USA
    Neuropsychology 17:380-92. 2003
    ..Association of measures with quantitative structural magnetic resonance imaging variables followed expected patterns. This approach to scale development may have applications for other neuropsychological assessment problems...
  13. ncbi request reprint Profiles of neuropsychological impairment in autopsy-defined Alzheimer's disease and cerebrovascular disease
    Bruce R Reed
    University of California, Davis, CA, USA
    Brain 130:731-9. 2007
    ....
  14. ncbi request reprint Discriminant validity and neuroanatomical correlates of rule monitoring in frontotemporal dementia and Alzheimer's disease
    Catherine L Carey
    Department of Psychiatry, University of California, San Francisco Medical Center, United States
    Neuropsychologia 46:1081-7. 2008
    ..Findings are consistent with literature implicating the frontal lobes in performance monitoring and highlight the importance of characterizing the component processes of performance failures in the cognitive assessment of FTD and AD...
  15. pmc Patterns of structural complexity in Alzheimer's disease and frontotemporal dementia
    Karl Young
    Department of Radiology, University of California San Francisco, and VA Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Hum Brain Mapp 30:1667-77. 2009
    ....
  16. pmc Oculomotor function in frontotemporal lobar degeneration, related disorders and Alzheimer's disease
    Siobhan Garbutt
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143 1207, USA
    Brain 131:1268-81. 2008
    ..These data suggest that oculomotor assessment may aid in the diagnosis of FTLD and related disorders...
  17. ncbi request reprint Potential mechanisms for chemotherapy-induced impairments in cognitive function
    Catherine Jansen
    Kaiser Permanente Medical Center in San Francisco, University of California, USA
    Oncol Nurs Forum 32:1151-63. 2005
    ....
  18. pmc Longitudinal changes in white matter disease and cognition in the first year of the Alzheimer disease neuroimaging initiative
    Owen Carmichael
    Department of Neurology, School of Medicine, University of California, Davis, CA, USA
    Arch Neurol 67:1370-8. 2010
    ....
  19. ncbi request reprint Subtype of mild cognitive impairment and progression to dementia and death
    Kristine Yaffe
    Department of Psychiatry, University of California, San Francisco, CA 94121, USA
    Dement Geriatr Cogn Disord 22:312-9. 2006
    ..We determined the longitudinal course of subtypes of MCI and assessed the rate of progression to dementia and to death...
  20. pmc Development of methodology for conducting clinical trials in frontotemporal lobar degeneration
    David S Knopman
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Brain 131:2957-68. 2008
    ..There are several candidate outcome measures -- including the FTLD-CDR and the cognitive composites -- that could be used in clinical trials across the spectrum of FTLD...
  21. pmc Longitudinal changes in memory and executive functioning are associated with longitudinal change in instrumental activities of daily living in older adults
    Sarah Tomaszewski Farias
    Department of Neurology, School of Medicine, University of California, Davis, CA, USA
    Clin Neuropsychol 23:446-61. 2009
    ..Findings indicate that declines in MEM and EXEC over time make unique and independent contributions to declines in older adults' ability to function in daily life...
  22. ncbi request reprint Fresh blood and aged stored blood are equally efficacious in immediately reversing anemia-induced brain oxygenation deficits in humans
    Richard B Weiskopf
    Department of Anesthesia and Cardiovascular Research Institute, University of California, San Francisco, USA
    Anesthesiology 104:911-20. 2006
    ..The authors tested the hypothesis that erythrocytes stored for 3 weeks are as effective in supplying oxygen to human tissues as are erythrocytes stored for less than 5 h...
  23. pmc Subcortical lacunes are associated with executive dysfunction in cognitively normal elderly
    Catherine L Carey
    Department of Psychiatry, University of California, San Diego, 150 W Washington, 2nd Floor San Diego, CA 92103, USA
    Stroke 39:397-402. 2008
    ..We therefore hypothesized that MRI markers of SIVD would be selectively associated with worse executive functioning...
  24. ncbi request reprint Clinical and neuropsychological features in autopsy-defined vascular dementia
    Bruce R Reed
    Alzheimer s Disease Center, University of California, Davis 94553, USA
    Clin Neuropsychol 18:63-74. 2004
    ..A illustrative case example is included. We conclude that the profile of cognitive impairment in IVD is highly variable, but that in clinical settings neuropsychological readings may contribute to the differential diagnosis of dementia...
  25. pmc Concordance and discordance between brain perfusion and atrophy in frontotemporal dementia
    Soichiro Shimizu
    Center for Imaging of Neurodegenerative Diseases, Veterans Affairs Medical Center, Department of Radiology and Biomedical Imaging, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121, USA
    Brain Imaging Behav 4:46-54. 2010
    ..Detection of discordance between brain perfusion and structure in FTD might aid diagnosis and staging of the disease...
  26. pmc Off-label medication use in frontotemporal dementia
    - Bei Hu
    Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA
    Am J Alzheimers Dis Other Demen 25:128-33. 2010
    ..We sought to determine the most commonly used drugs used to treat behavioral variant FTD (bvFTD) in specialized dementia clinics...
  27. ncbi request reprint Early features in frontotemporal dementia
    Ana María Villamizar Caycedo
    Memory and Aging Center, Department of Neurology, UCSF, USA
    Curr Alzheimer Res 6:337-40. 2009
    ..Treatment is currently focused around symptoms but disease-modifying therapies seem feasible...
  28. pmc White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI
    Yu Zhang
    Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Brain 132:2579-92. 2009
    ..Taken together, the results suggest that white matter degradation measured with DTI may improve the diagnostic differentiation between FTD and Alzheimer's disease...
  29. pmc ASL perfusion MRI predicts cognitive decline and conversion from MCI to dementia
    Linda L Chao
    Center for Imaging of Neurodegenerative Disease, San Francisco, CA, USA
    Alzheimer Dis Assoc Disord 24:19-27. 2010
    ..03). These results suggest that hypoperfusion as detected by ASL-MRI can predict subsequent clinical, functional, and cognitive decline and may be useful for identifying candidates for future Alzheimer disease treatment trials...
  30. pmc Gray matter correlates of set-shifting among neurodegenerative disease, mild cognitive impairment, and healthy older adults
    Judy Pa
    Alzheimer Disease Research Center, Dept of Neurology, University of California, San Francisco, California, USA
    J Int Neuropsychol Soc 16:640-50. 2010
    ..Overall, these findings highlight the neuroanatomical correlates of set-shifting and the importance of controlling for component processes when investigating complex cognitive tasks...
  31. pmc The early neuropsychological and behavioral characteristics of frontotemporal dementia
    Dana Wittenberg
    Memory and Aging Center, University of California San Francisco Medical Center, San Francisco, CA, USA
    Neuropsychol Rev 18:91-102. 2008
    ..As this review underscores, frontotemporal dementia remains a powerful model for studying brain-behavior relationships...
  32. pmc Rule violation errors are associated with right lateral prefrontal cortex atrophy in neurodegenerative disease
    Katherine L Possin
    Department of Neurology, University of California San Francisco, San Francisco, California, USA
    J Int Neuropsychol Soc 15:354-64. 2009
    ..These data underscore the importance of right lateral PFC in behavioral monitoring and highlight the potential of RV error assessment for identifying patients with damage to this region...
  33. pmc Baseline predictors of clinical progression among patients with dysexecutive mild cognitive impairment
    Julene K Johnson
    Institute for Health and Aging, University of California, San Francisco, USA
    Dement Geriatr Cogn Disord 30:344-51. 2010
    ..The purpose of this study was to evaluate baseline predictors of clinical progression after 2 years for patients with dysexecutive MCI (dMCI), a single-domain non-amnestic MCI subgroup...
  34. ncbi request reprint Diagnostic criteria for the behavioral variant of frontotemporal dementia (bvFTD): current limitations and future directions
    Katya Rascovsky
    Memory and Aging Center, University of California, San Francisco, CA 94117, USA
    Alzheimer Dis Assoc Disord 21:S14-8. 2007
    ..In this article, we discuss the limitations of current diagnostic criteria and propose the establishment of an international consortium to revise diagnostic and research criteria for the behavioral variant of frontotemporal dementia...
  35. pmc Mild cognitive impairment, dementia, and their subtypes in oldest old women
    Kristine Yaffe
    Department of Psychiatry, University of California at San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    Arch Neurol 68:631-6. 2011
    ..The population of oldest old is increasing, but the prevalence of cognitive impairment is not well characterized in this group...
  36. pmc Frontal paralimbic network atrophy in very mild behavioral variant frontotemporal dementia
    William W Seeley
    UCSF Memory and Aging Center, University of California San Francisco, 350 Parnassus Avenue, San Francisco, CA 94143 1207, USA
    Arch Neurol 65:249-55. 2008
    ..Behavioral variant frontotemporal dementia (bvFTD) strikes hardest at the frontal lobes, but the sites of earliest injury remain unclear...
  37. pmc Influences of lobar gray matter and white matter lesion load on cognition and mood
    Susanne G Mueller
    Center for Imaging of Neurodegenerative Diseases, VAMC University of California San Francisco, 4150 Clement Street, San Francisco, CA, 94121, USA
    Psychiatry Res 181:90-6. 2010
    ..Cognitive function is associated with GM atrophy and depressed mood is associated with frontal WML. This indicates that although both often occur together, depressed mood and cognitive impairment have different pathological correlates...
  38. pmc Spontaneous social behaviors discriminate behavioral dementias from psychiatric disorders and other dementias
    Katherine P Rankin
    Department of Neurology, University of California, San Francisco 94143 1207, USA
    J Clin Psychiatry 69:60-73. 2008
    ..The object of this study was to improve screening for behavioral dementias in primary care and mental health settings by quantifying spontaneous social behaviors specific to FTLD...
  39. pmc Neonatal watershed brain injury on magnetic resonance imaging correlates with verbal IQ at 4 years
    Kyle J Steinman
    MAS, University of California, Division of Child Neurology, 350 Parnassus Ave, Suite 609, San Francisco, CA 94117, USA
    Pediatrics 123:1025-30. 2009
    ....
  40. pmc Atrophy in two attention networks is associated with performance on a Flanker task in neurodegenerative disease
    Tracy L Luks
    Department of Radiology and Biomedical Imaging, University of California San Francisco, CA 94143, USA
    Neuropsychologia 48:165-70. 2010
    ....
  41. pmc Longitudinal rates of lobar atrophy in frontotemporal dementia, semantic dementia, and Alzheimer's disease
    Casey E Krueger
    UCSF Department of Neurology, San Francisco, CA, USA
    Alzheimer Dis Assoc Disord 24:43-8. 2010
    ..Measuring specific regions of cerebral volume changes by serial neuroimaging may serve as a useful biomarker outcome measure for clinical trials in neurodegenerative diseases...
  42. pmc Computer-based cognitive training for mild cognitive impairment: results from a pilot randomized, controlled trial
    Deborah E Barnes
    Department of Psychiatry, University of California San Francisco, 4150 Clement Street 151R, San Francisco, CA 94121, USA
    Alzheimer Dis Assoc Disord 23:205-10. 2009
    ..We conclude that intensive, computer-based mental activity is feasible in subjects with mild cognitive impairment and that larger trials are warranted...
  43. pmc Patterns of cerebral hypoperfusion in amnestic and dysexecutive MCI
    Linda L Chao
    Center for Imaging of Neurodegenerative Diseases, San Francisco VA Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Alzheimer Dis Assoc Disord 23:245-52. 2009
    ..These data further suggest that cognitive impairment in MCI is related to cerebral hypoperfusion...
  44. pmc Cerebral blood flow in ischemic vascular dementia and Alzheimer's disease, measured by arterial spin-labeling magnetic resonance imaging
    Norbert Schuff
    Department of Veterans Affairs Medical Center, University of California at San Francisco, USA
    Alzheimers Dement 5:454-62. 2009
    ....
  45. pmc Cognitive and neuropsychiatric profile of the synucleinopathies: Parkinson disease, dementia with Lewy bodies, and multiple system atrophy
    Aimee W Kao
    Department of Neurology, University of California San Francisco, 94143, USA
    Alzheimer Dis Assoc Disord 23:365-70. 2009
    ..PD, MSA, and DLB groups have similar neuropsychiatric profiles of increased depression and anxiety. Similar underlying alpha-synuclein pathology may contribute to these shared features...
  46. pmc Neuroanatomical correlates of cognitive self-appraisal in neurodegenerative disease
    Howard J Rosen
    Department of Neurology, University of California at San Francisco, San Francisco, CA, USA
    Neuroimage 49:3358-64. 2010
    ..We hypothesize that emotional/physiological processing carried out by vmPFC is an important factor mediating self-appraisal accuracy in dementia...
  47. pmc Patterns of white matter atrophy in frontotemporal lobar degeneration
    Linda L Chao
    Center for Imaging of Neurodegenerative Diseases, San Francisco Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Arch Neurol 64:1619-24. 2007
    ..Structural magnetic resonance imaging (MRI) has been used to investigate the in vivo pathology of frontotemporal lobar degeneration. However, few neuroimaging studies have focused on white matter (WM) alterations in this disease...
  48. ncbi request reprint Neuropsychological and functional measures of severity in Alzheimer disease, frontotemporal dementia, and semantic dementia
    Howard J Rosen
    Department of Neurology, Memory and Aging Center, University of California at San Francisco, San Francisco, California 94143 1207, USA
    Alzheimer Dis Assoc Disord 18:202-7. 2004
    ..Thus, in FTD the CDR reveals functional impairments in a wide variety of domains that are more severe than those seen in AD or SD patients with an equivalent Mini-Mental State Examination...
  49. ncbi request reprint Emotion comprehension in the temporal variant of frontotemporal dementia
    Howard J Rosen
    Department of Neurology, Memory and Aging Center, University of California at San Francisco, 350 Parnassus Avenue, Suite 800, Box 1207, San Francisco, CA 94143 1207, USA
    Brain 125:2286-95. 2002
    ..These results have implications both for the clinical presentation in tvFTD patients and for the study of the neuroanatomical basis of emotion...
  50. ncbi request reprint Patterns of cognitive and emotional empathy in frontotemporal lobar degeneration
    Katherine P Rankin
    Memory and Aging Center, University of California San Francisco, California 94145 1203, USA
    Cogn Behav Neurol 18:28-36. 2005
    ..To examine the relationship between empathy and cognition in frontotemporal lobar degeneration (FTLD)...
  51. pmc Double dissociation of social functioning in frontotemporal dementia
    Katherine P Rankin
    University of California San Francisco, USA
    Neurology 60:266-71. 2003
    ..Efforts to characterize changes in social functioning in frontotemporal dementia (FTD) have failed to elicit clear dissociation between frontal and temporal variants of the disease based on behavioral measures...
  52. pmc Forgetting in dementia with and without subcortical lacunes
    Joel H Kramer
    San Francisco Medical Center, University of California, CA 94143, USA
    Clin Neuropsychol 18:32-40. 2004
    ..Three SIVD patients with rapid forgetting followed to autopsy all had AD pathology, further supporting the link between memory patterns and AD...
  53. ncbi request reprint Age and gender interactions on verbal memory performance
    Joel H Kramer
    University of California, San Francisco Medical Center, 94143, USA
    J Int Neuropsychol Soc 9:97-102. 2003
    ..The role of estrogen on cognition in normal aging warrants further study...
  54. ncbi request reprint Challenging the clinical utility of the 14-3-3 protein for the diagnosis of sporadic Creutzfeldt-Jakob disease
    Michael D Geschwind
    Department of Neurology, University of California, San Francisco Medical Center, San Francisco, CA 94143, USA
    Arch Neurol 60:813-6. 2003
    ..Previous studies have suggested that, in the proper clinical context, the 14-3-3 protein in cerebrospinal fluid is a reliable marker for sporadic CJD...
  55. ncbi request reprint The role of perceptual bias in complex figure recall
    Joel H Kramer
    San Francisco Medical Center, University of California, San Francisco, CA 94143, USA
    J Clin Exp Neuropsychol 26:838-45. 2004
    ....
  56. pmc Hippocampal volume and retention in Alzheimer's disease
    Joel H Kramer
    Department of Neurology, University of California at San Francisco, 94143, USA
    J Int Neuropsychol Soc 10:639-43. 2004
    ..Results suggest that the role of the hippocampus is relatively specific to the consolidation of new memories...
  57. pmc Right and left medial orbitofrontal volumes show an opposite relationship to agreeableness in FTD
    Katherine P Rankin
    University of California San Francisco, San Francisco, Calif, USA
    Dement Geriatr Cogn Disord 17:328-32. 2004
    ..These data support the hypothesis that regulation of agreeableness arises from a balanced, mutually inhibitory circuit involving both hemispheres...
  58. ncbi request reprint Recognition of emotion in the frontal and temporal variants of frontotemporal dementia
    Howard J Rosen
    Department of Neurology, University of California, Memory and Aging Center, San Francisco, Calif, USA
    Dement Geriatr Cogn Disord 17:277-81. 2004
    ..These results suggest that damage to frontal lobe regions in FTD may lead to more profound impairment in recognition of emotion than when damage is more limited to the temporal lobe...
  59. ncbi request reprint Distinctive neuropsychological patterns in frontotemporal dementia, semantic dementia, and Alzheimer disease
    Joel H Kramer
    University of California Medical Center, San Francisco, California 94143, USA
    Cogn Behav Neurol 16:211-8. 2003
    ..To assess the ability of a brief neuropsychological bedside screening battery to discriminate between Alzheimer disease, frontotemporal dementia, and semantic dementia...
  60. ncbi request reprint Patterns of autobiographical memory loss in dementia
    Craig E Hou
    UCSF Memory and Aging Center, Department of Neurology, University of California at San Francisco, 350 Parnassus Avenue, Box 1207 San Francisco, CA 94143, USA
    Int J Geriatr Psychiatry 20:809-15. 2005
    ..Several studies have found impaired recall of remote autobiographical memories relative to recent memories in semantic dementia (SD), a pattern opposite to that in Alzheimer's disease (AD)...
  61. ncbi request reprint Neuroanatomical correlates of impaired recognition of emotion in dementia
    Howard J Rosen
    University of California at San Francisco Department of Neurology, Memory and Aging Center, 350 Parnassus Avenue, Suite 706, Box 1207, San Francisco, CA 94143 1207, USA
    Neuropsychologia 44:365-73. 2006
    ....
  62. ncbi request reprint Patterns of cerebral atrophy in primary progressive aphasia
    Howard J Rosen
    Department of Neurology, Memory and Aging Center, University of California at San Francisco, CA 94143 1207, USA
    Am J Geriatr Psychiatry 10:89-97. 2002
    ..Different clinical syndromes in PPA are associated with different patterns of atrophy. In the future, combined analysis of imaging and clinical characteristics may allow more accurate etiologic diagnosis...
  63. pmc Cognitive and neuroimaging predictors of instrumental activities of daily living
    Deborah A Cahn-Weiner
    Department of Neurology, University of California, San Francisco, California 94143 0138, USA
    J Int Neuropsychol Soc 13:747-57. 2007
    ..Perhaps executive function is particularly important with respect to maintaining IADLs. Alternatively, executive dysfunction may be a sentinel event indicating widespread cortical involvement and poor prognosis...
  64. ncbi request reprint Response bias and aging on a recognition memory task
    Terri J Huh
    Department of Psychiatry, Memory and Aging Center, University of California San Francisco, California 94143, USA
    J Int Neuropsychol Soc 12:1-7. 2006
    ..In the light of reported relationships between frontal regions and both aging and response bias, we hypothesize that frontal changes may be the underlying mechanism explaining the increase in liberal response bias with age...
  65. ncbi request reprint Continuum of frontal lobe impairment in amyotrophic lateral sclerosis
    Jennifer M Murphy
    Department of Neurology, ALS Center, University of California, San Francisco, CA 94117, USA
    Arch Neurol 64:530-4. 2007
    ..To identify the nature and prevalence of cognitive and behavioral abnormalities in patients with amyotrophic lateral sclerosis (ALS)...
  66. pmc Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia
    An Tao Du
    Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Brain 130:1159-66. 2007
    ..In conclusion, the characteristic patterns of cortical thinning in Alzheimer's disease and FTD suggest that cortical thickness may be a useful surrogate marker for these types of dementia...
  67. pmc Multiple cognitive deficits in amnestic mild cognitive impairment
    Joel H Kramer
    San Francisco Medical Center, University of California, San Francisco, CA 94143, USA
    Dement Geriatr Cogn Disord 22:306-11. 2006
    ..To determine if more widespread cognitive deficits are present in a narrowly defined group of patients with the amnestic form of mild cognitive impairment (MCI)...
  68. ncbi request reprint Oxygen reverses deficits of cognitive function and memory and increased heart rate induced by acute severe isovolemic anemia
    Richard B Weiskopf
    Department of Anesthesia, University of California, San Francisco, California 94143 0648, USA
    Anesthesiology 96:871-7. 2002
    ....
  69. pmc Effects of Alzheimer disease on fronto-parietal brain N-acetyl aspartate and myo-inositol using magnetic resonance spectroscopic imaging
    Xiaoping Zhu
    Department of Radiology, VA Medical Center, University of California, San Francisco, CA 94121, USA
    Alzheimer Dis Assoc Disord 20:77-85. 2006
    ..However, the NAA and mI changes are not correlated with each other, suggesting that they represent different processes that might help staging of AD...
  70. pmc Dissociations in hippocampal and frontal contributions to episodic memory performance
    Joel H Kramer
    Department of Neurology, University of California, San Francisco Medical Center, San Francisco, CA 94143, USA
    Neuropsychology 19:799-805. 2005
    ....
  71. ncbi request reprint Very early-onset familial Alzheimer's disease: a novel presenilin 1 mutation
    Jill S Goldman
    UCSF Memory and Aging Center, San Francisco, CA 94143, USA
    Int J Geriatr Psychiatry 17:649-51. 2002
    ..Early-onset familial Alzheimer's disease (EOFAD) is linked to mutations in three autosomal dominant genes: PS1, PS2 and APP. The clinical presentation and age of onset of mutations is variable...
  72. pmc Distinct neuroanatomical substrates and cognitive mechanisms of figure copy performance in Alzheimer's disease and behavioral variant frontotemporal dementia
    Katherine L Possin
    University of California, 350 Parnassus Ste 905, San Francisco, CA 94143 1207, United States
    Neuropsychologia 49:43-8. 2011
    ..Alternative methods of visual spatial assessment for dementia evaluations are proposed...
  73. pmc Associations among vascular risk factors, carotid atherosclerosis, and cortical volume and thickness in older adults
    Valerie A Cardenas
    University of California, San Francisco, Department of Veterans Affairs Medical Center, 4150 Clement Street 114M, San Francisco, CA 94121, USA
    Stroke 43:2865-70. 2012
    ..The purpose of this study was to investigate whether the Framingham Cardiovascular Risk Profile and carotid artery intima-media thickness are associated with cortical volume and thickness...
  74. pmc The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier)
    Adam L Boxer
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA
    Alzheimers Dement 9:189-98. 2013
    ..We conclude that FTD research has reached sufficient maturity to pursue clinical development of specific FTD therapies...
  75. ncbi request reprint A metaanalysis of studies of the effects of cancer chemotherapy on various domains of cognitive function
    Catherine E Jansen
    Patient Care Services, Kaiser Permanente Medical Center, San Francisco, California 94115, USA
    Cancer 104:2222-33. 2005
    ..e., normative data, control group, or baseline data)...
  76. ncbi request reprint A componential analysis of proverb interpretation in patients with frontal lobe epilepsy and temporal lobe epilepsy: relationships with disease-related factors
    Carrie R McDonald
    Veterans Administration San Diego Healthcare System, USA
    Clin Neuropsychol 22:480-96. 2008
    ..Overall, FLE patients exhibit greater impairment than TLE patients in interpreting proverbs. However, the nature and disease-specific correlates of impaired performances in proverb interpretation differ between the groups...
  77. ncbi request reprint Longitudinal tracking of FTLD: toward developing clinical trial methodology
    David S Knopman
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Alzheimer Dis Assoc Disord 21:S58-63. 2007
    ..In addition, a multicenter trial is described in which some aspects of diagnosis and longitudinal measurement in the frontotemporal lobar degenerations are being specifically explored...
  78. ncbi request reprint The California Verbal Learning Test--second edition: test-retest reliability, practice effects, and reliable change indices for the standard and alternate forms
    Steven Paul Woods
    Department of Psychiatry 0847, University of California at San Diego, 150 W Washington Street, 2nd Floor, San Diego, CA 92103 2005, USA
    Arch Clin Neuropsychol 21:413-20. 2006
    ..Overall, findings from this study support the test-retest reliability of the standard and alternate forms of the CVLT-II in healthy adults and may enhance the usefulness of this test in longitudinal neuropsychological evaluations...
  79. ncbi request reprint Recall discriminability: utility of a new CVLT-II measure in the differential diagnosis of dementia
    Dean C Delis
    Psychology Service, Veterans Affairs San Diego Healthcare System, San Diego, California 92161, USA
    J Int Neuropsychol Soc 11:708-15. 2005
    ..Implications of these results for clinical practice and theories of memory disorder in dementia are discussed...
  80. pmc Age effects on atrophy rates of entorhinal cortex and hippocampus
    An Tao Du
    Magnetic Resonance Unit 114M, Department of Veterans Affairs Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA
    Neurobiol Aging 27:733-40. 2006
    ..In conclusion, age and presence of lacunes should be taken into consideration in imaging studies of CN subjects and AD patients to predict AD progression and assess the response to treatment trials...
  81. ncbi request reprint Visual attention in long-term survivors of leukemia receiving cranial radiation therapy
    Jeffrey Schatz
    Department of Psychology, University of South Carolina, Columbia, SC 29208, USA
    J Int Neuropsychol Soc 10:211-20. 2004
    ..The data are consistent with prior reports emphasizing attention deficits following CRT, and suggest that attention shifting may be particularly affected by CRT early in life...
  82. ncbi request reprint Effects of white matter lesions and lacunes on cortical function
    Bruce R Reed
    University of California Davis Alzheimer s Disease Center, Martinez, CA 94553, USA
    Arch Neurol 61:1545-50. 2004
    ..Whether small-vessel disease in fact predominantly affects the frontal lobes is not well documented...
  83. ncbi request reprint 17q-linked frontotemporal dementia-amyotrophic lateral sclerosis without tau mutations with tau and alpha-synuclein inclusions
    Kirk C Wilhelmsen
    Ernest Gallo Clinic and Research Center, Emeryville, CA, USA
    Arch Neurol 61:398-406. 2004
    ..The most common familial form of this condition is caused by mutations in the microtubule-associated protein tau gene (MAP tau) and is associated with neuronal or glial tau inclusions...
  84. ncbi request reprint Cognitive functioning in children with sickle cell disease: a meta-analysis
    Jeffrey Schatz
    Department of Psychology, University of South Carolina, Columbia, USA
    J Pediatr Psychol 27:739-48. 2002
    ..To establish whether sickle cell disease (SCD) affects cognitive functioning in children with no evidence of cerebral infarction...
  85. ncbi request reprint Reliability and validity of the Delis-Kaplan Executive Function System: an update
    Dean C Delis
    J Int Neuropsychol Soc 10:301-3. 2004

Research Grants7

  1. Attention and Executive Functioning in FTD
    Joel Kramer; Fiscal Year: 2007
    ..abstract_text> ..
  2. Mechanisms of Executive Decline in Normal Aging
    Joel Kramer; Fiscal Year: 2009
    ..The potential contribution to public health lies in the fact that some of these age-related changes might be influenced by improvements in physical health and lifestyle choices. ..
  3. Mechanisms of Executive Decline in Normal Aging
    Joel H Kramer; Fiscal Year: 2010
    ..The potential contribution to public health lies in the fact that some of these age-related changes might be influenced by improvements in physical health and lifestyle choices. ..