Research Topics
Species | Joel H KramerSummaryAffiliation: University of California Country: USA Publications
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Publications
Developmental sex differences in verbal learningJ H Kramer
Department of Psychiatry, University of California, Medical Center, San Francisco 94143, USA
Neuropsychology 11:577-84. 1997..Because boys had higher mean scores on Wechsler Intelligence Scale for Children--Revised Vocabulary, the observed female superiority in verbal learning could not be attributed to sex differences in overall word knowledge...
Dissociations in hippocampal and frontal contributions to episodic memory performanceJoel H Kramer
Department of Neurology, University of California, San Francisco Medical Center, San Francisco, CA 94143, USA
Neuropsychology 19:799-805. 2005....
Age and gender interactions on verbal memory performanceJoel H Kramer
University of California, San Francisco Medical Center, 94143, USA
J Int Neuropsychol Soc 9:97-102. 2003..The role of estrogen on cognition in normal aging warrants further study...
Multiple cognitive deficits in amnestic mild cognitive impairmentJoel H Kramer
San Francisco Medical Center, University of California, San Francisco, CA 94143, USA
Dement Geriatr Cogn Disord 22:306-11. 2006..To determine if more widespread cognitive deficits are present in a narrowly defined group of patients with the amnestic form of mild cognitive impairment (MCI)...
Executive dysfunction in subcortical ischaemic vascular diseaseJ H Kramer
San Francisco Medical Center, University of California, 401 Parnassus Avenue, San Francisco, CA 94143, USA
J Neurol Neurosurg Psychiatry 72:217-20. 2002..Executive dysfunction has been reported in patients with subcortical-frontal pathology, even in the absence of dementia...
Forgetting in dementia with and without subcortical lacunesJoel H Kramer
San Francisco Medical Center, University of California, CA 94143, USA
Clin Neuropsychol 18:32-40. 2004..Three SIVD patients with rapid forgetting followed to autopsy all had AD pathology, further supporting the link between memory patterns and AD...
Hippocampal volume and retention in Alzheimer's diseaseJoel H Kramer
Department of Neurology, University of California at San Francisco, 94143, USA
J Int Neuropsychol Soc 10:639-43. 2004..Results suggest that the role of the hippocampus is relatively specific to the consolidation of new memories...
Distinctive neuropsychological patterns in frontotemporal dementia, semantic dementia, and Alzheimer diseaseJoel H Kramer
University of California Medical Center, San Francisco, California 94143, USA
Cogn Behav Neurol 16:211-8. 2003..To assess the ability of a brief neuropsychological bedside screening battery to discriminate between Alzheimer disease, frontotemporal dementia, and semantic dementia...
Configural errors on WISC-III block designJ H Kramer
University of California, San Francisco Medical Center, USA
J Int Neuropsychol Soc 5:518-24. 1999..Broken configurations are also made more frequently by children whose perception is less influenced by the global properties of spatial stimuli...
The role of perceptual bias in complex figure recallJoel H Kramer
San Francisco Medical Center, University of California, San Francisco, CA 94143, USA
J Clin Exp Neuropsychol 26:838-45. 2004....
Neuropathological basis of magnetic resonance images in aging and dementiaWilliam J Jagust
School of Public Health and Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720 3190, USA
Ann Neurol 63:72-80. 2008..Magnetic resonance (MR) imaging is used widely for assessment of patients with cognitive impairment, but the pathological correlates are unclear, especially when multiple pathologies are present...
Influences of lobar gray matter and white matter lesion load on cognition and moodSusanne G Mueller
Center for Imaging of Neurodegenerative Diseases, VAMC University of California San Francisco, 4150 Clement Street, San Francisco, CA, 94121, USA
Psychiatry Res 181:90-6. 2010..Cognitive function is associated with GM atrophy and depressed mood is associated with frontal WML. This indicates that although both often occur together, depressed mood and cognitive impairment have different pathological correlates...
Cerebral blood flow in ischemic vascular dementia and Alzheimer's disease, measured by arterial spin-labeling magnetic resonance imagingNorbert Schuff
Department of Veterans Affairs Medical Center, University of California at San Francisco, USA
Alzheimers Dement 5:454-62. 2009....
Neuropsychological correlates of dominance, warmth, and extraversion in neurodegenerative diseaseMarc Sollberger
Memory and Aging Center, UCSF Department of Neurology, University of California San Francisco, 350 Parnassus Avenue, San Francisco, CA 94143 1207, USA
Cortex 48:674-82. 2012..In this study, we hypothesized that different combinations of cognitive, neuropsychiatric, and emotional measures would predict different interpersonal traits in patients with neurodegenerative diseases...
Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementiaAn Tao Du
Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
Brain 130:1159-66. 2007..In conclusion, the characteristic patterns of cortical thinning in Alzheimer's disease and FTD suggest that cortical thickness may be a useful surrogate marker for these types of dementia...
Profiles of neuropsychological impairment in autopsy-defined Alzheimer's disease and cerebrovascular diseaseBruce R Reed
University of California, Davis, CA, USA
Brain 130:731-9. 2007....
Longitudinal MRI and cognitive change in healthy elderlyJoel H Kramer
Department of Neurology, San Francisco Medical Center, University of California, San Francisco, CA 94143, USA
Neuropsychology 21:412-8. 2007..The association between WMSH and EXEC further highlights the cognitive sequealae associated with cerebrovascular disease in normal elderly...
The MRI brain correlates of depressed mood, anhedonia, apathy, and anergia in older adults with and without cognitive impairment or dementiaHelen Lavretsky
Department of Psychiatry, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Int J Geriatr Psychiatry 23:1040-50. 2008..We examined the magnetic resonance imaging (MRI) correlates of depressed mood, apathy, anhedonia, and anergia in older adults with and without cognitive impairment or dementia...
Frontal paralimbic network atrophy in very mild behavioral variant frontotemporal dementiaWilliam W Seeley
UCSF Memory and Aging Center, University of California San Francisco, 350 Parnassus Avenue, San Francisco, CA 94143 1207, USA
Arch Neurol 65:249-55. 2008..Behavioral variant frontotemporal dementia (bvFTD) strikes hardest at the frontal lobes, but the sites of earliest injury remain unclear...
Effects of Alzheimer disease on fronto-parietal brain N-acetyl aspartate and myo-inositol using magnetic resonance spectroscopic imagingXiaoping Zhu
Department of Radiology, VA Medical Center, University of California, San Francisco, CA 94121, USA
Alzheimer Dis Assoc Disord 20:77-85. 2006..However, the NAA and mI changes are not correlated with each other, suggesting that they represent different processes that might help staging of AD...
Association of depressed mood and mortality in older adults with and without cognitive impairment in a prospective naturalistic studyHelen Lavretsky
Department of Psychiatry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Am J Psychiatry 167:589-97. 2010....
Neuroanatomical correlates of impaired recognition of emotion in dementiaHoward J Rosen
University of California at San Francisco Department of Neurology, Memory and Aging Center, 350 Parnassus Avenue, Suite 706, Box 1207, San Francisco, CA 94143 1207, USA
Neuropsychologia 44:365-73. 2006....
Rule violation errors are associated with right lateral prefrontal cortex atrophy in neurodegenerative diseaseKatherine L Possin
Department of Neurology, University of California San Francisco, San Francisco, California, USA
J Int Neuropsychol Soc 15:354-64. 2009..These data underscore the importance of right lateral PFC in behavioral monitoring and highlight the potential of RV error assessment for identifying patients with damage to this region...
White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophyAn-Tao Du
Magnetic Resonance Unit (114M, Department of Veterans Affairs Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA
Neurobiol Aging 26:553-9. 2005..Further, AD pathology and subcortical vascular disease may independently affect cortical atrophy...
Baseline predictors of clinical progression among patients with dysexecutive mild cognitive impairmentJulene K Johnson
Institute for Health and Aging, University of California, San Francisco, USA
Dement Geriatr Cogn Disord 30:344-51. 2010..The purpose of this study was to evaluate baseline predictors of clinical progression after 2 years for patients with dysexecutive MCI (dMCI), a single-domain non-amnestic MCI subgroup...
Subcortical lacunes are associated with executive dysfunction in cognitively normal elderlyCatherine L Carey
Department of Psychiatry, University of California, San Diego, 150 W Washington, 2nd Floor San Diego, CA 92103, USA
Stroke 39:397-402. 2008..We therefore hypothesized that MRI markers of SIVD would be selectively associated with worse executive functioning...
Cognitive impact of subcortical vascular and Alzheimer's disease pathologyHelena C Chui
Department of Neurology, University of Southern California, Los Angeles, USA
Ann Neurol 60:677-87. 2006..To assess the interactions among three types of pathology (ie, cerebrovascular disease, hippocampal sclerosis [HS], and Alzheimer's disease [AD]), cognitive status, and apolipoprotein E genotype...
The frontal-anatomic specificity of design fluency repetitions and their diagnostic relevance for behavioral variant frontotemporal dementiaKatherine L Possin
Department of Neurology, University of California, San Francisco, San Francisco, California 94143 1207, USA
J Int Neuropsychol Soc 18:834-44. 2012..These results highlight the frontal-anatomic specificity of design fluency repetitions. In addition, the results indicate that the propensity to make these errors supports the diagnosis of bvFTD. (JINS, 2012, 18, 1-11)...
Age effects on atrophy rates of entorhinal cortex and hippocampusAn-Tao Du
Magnetic Resonance Unit (114M, Department of Veterans Affairs Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA
Neurobiol Aging 27:733-40. 2006..In conclusion, age and presence of lacunes should be taken into consideration in imaging studies of CN subjects and AD patients to predict AD progression and assess the response to treatment trials...
Double dissociation in the anatomy of socioemotional disinhibition and executive functioning in dementiaCasey E Krueger
Memory and Aging Center, Department of Neurology, University of California, San Francisco, USA
Neuropsychology 25:249-59. 2011....
Development of methodology for conducting clinical trials in frontotemporal lobar degenerationDavid S Knopman
Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Brain 131:2957-68. 2008..There are several candidate outcome measures -- including the FTLD-CDR and the cognitive composites -- that could be used in clinical trials across the spectrum of FTLD...
Normative data in women aged 85 and older: verbal fluency, digit span, and the CVLT-II short formEric M Fine
Department of Neurology, University of California, San Francisco, CA, USA
Clin Neuropsychol 26:18-30. 2012..Findings from the present normative study are discussed within the context of "robust" longitudinal normative data...
Predicting regional neurodegeneration from the healthy brain functional connectomeJuan Zhou
Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA
Neuron 73:1216-27. 2012..Molecular pathological approaches may help clarify what makes each epicenter vulnerable to its targeting disease and how toxic protein species travel between networked brain structures...
C-reactive protein is related to memory and medial temporal brain volume in older adultsBrianne Magouirk Bettcher
Department of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, CA, USA
Brain Behav Immun 26:103-8. 2012..These findings underscore a potential role for inflammation in cognitive aging as a modifiable risk factor...
White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRIYu Zhang
Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
Brain 132:2579-92. 2009..Taken together, the results suggest that white matter degradation measured with DTI may improve the diagnostic differentiation between FTD and Alzheimer's disease...
Magnetic resonance imaging correlates of set shiftingJoel H Kramer
Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA
J Int Neuropsychol Soc 13:386-92. 2007..Follow-up analyses indicated that frontal contributions to shifting were not related to working memory. Results highlight the importance of carefully controlling for component cognitive processes when studying executive functioning...
Longitudinal changes in memory and executive functioning are associated with longitudinal change in instrumental activities of daily living in older adultsSarah Tomaszewski Farias
Department of Neurology, School of Medicine, University of California, Davis, CA, USA
Clin Neuropsychol 23:446-61. 2009..Findings indicate that declines in MEM and EXEC over time make unique and independent contributions to declines in older adults' ability to function in daily life...
Atrophy in two attention networks is associated with performance on a Flanker task in neurodegenerative diseaseTracy L Luks
Department of Radiology and Biomedical Imaging, University of California San Francisco, CA 94143, USA
Neuropsychologia 48:165-70. 2010....
Discriminant validity and neuroanatomical correlates of rule monitoring in frontotemporal dementia and Alzheimer's diseaseCatherine L Carey
Department of Psychiatry, University of California, San Francisco Medical Center, United States
Neuropsychologia 46:1081-7. 2008..Findings are consistent with literature implicating the frontal lobes in performance monitoring and highlight the importance of characterizing the component processes of performance failures in the cognitive assessment of FTD and AD...
Gray matter correlates of set-shifting among neurodegenerative disease, mild cognitive impairment, and healthy older adultsJudy Pa
Alzheimer Disease Research Center, Dept of Neurology, University of California, San Francisco, California, USA
J Int Neuropsychol Soc 16:640-50. 2010..Overall, these findings highlight the neuroanatomical correlates of set-shifting and the importance of controlling for component processes when investigating complex cognitive tasks...
Coronary artery disease is associated with cognitive decline independent of changes on magnetic resonance imaging in cognitively normal elderly adultsLing Zheng
Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
J Am Geriatr Soc 60:499-504. 2012..To examine in cognitively normal elderly adults whether vascular factors predict cognitive decline and whether these associations are mediated by magnetic resonance imaging (MRI) measures of subclinical vascular brain injury...
Executive functions and the down-regulation and up-regulation of emotionAnett Gyurak
Departments of Psychiatry and Psychology, Stanford University, San Francisco, CA, USA
Cogn Emot 26:103-18. 2012..These findings contribute to our understanding of emotion-cognition interaction, suggesting a link between emotion-regulatory abilities and individual differences in complex executive functions...
Patterns of cerebral hypoperfusion in amnestic and dysexecutive MCILinda L Chao
Center for Imaging of Neurodegenerative Diseases, San Francisco VA Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
Alzheimer Dis Assoc Disord 23:245-52. 2009..These data further suggest that cognitive impairment in MCI is related to cerebral hypoperfusion...
Concordance and discordance between brain perfusion and atrophy in frontotemporal dementiaSoichiro Shimizu
Center for Imaging of Neurodegenerative Diseases, Veterans Affairs Medical Center, Department of Radiology and Biomedical Imaging, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121, USA
Brain Imaging Behav 4:46-54. 2010..Detection of discordance between brain perfusion and structure in FTD might aid diagnosis and staging of the disease...
Emotion comprehension in the temporal variant of frontotemporal dementiaHoward J Rosen
Department of Neurology, Memory and Aging Center, University of California at San Francisco, 350 Parnassus Avenue, Suite 800, Box 1207, San Francisco, CA 94143 1207, USA
Brain 125:2286-95. 2002..These results have implications both for the clinical presentation in tvFTD patients and for the study of the neuroanatomical basis of emotion...
Do tests of executive functioning predict ability to downregulate emotions spontaneously and when instructed to suppress?Anett Gyurak
Institute of Personality and Social Research, Department of Psychology, University of California, Berkeley, California 94720 5050, USA
Cogn Affect Behav Neurosci 9:144-52. 2009....
ASL perfusion MRI predicts cognitive decline and conversion from MCI to dementiaLinda L Chao
Center for Imaging of Neurodegenerative Disease, San Francisco, CA, USA
Alzheimer Dis Assoc Disord 24:19-27. 2010..03). These results suggest that hypoperfusion as detected by ASL-MRI can predict subsequent clinical, functional, and cognitive decline and may be useful for identifying candidates for future Alzheimer disease treatment trials...
Distinct neuroanatomical substrates and cognitive mechanisms of figure copy performance in Alzheimer's disease and behavioral variant frontotemporal dementiaKatherine L Possin
University of California, 350 Parnassus Ste 905, San Francisco, CA 94143 1207, United States
Neuropsychologia 49:43-8. 2011..Alternative methods of visual spatial assessment for dementia evaluations are proposed...
Cognitive and neuroimaging predictors of instrumental activities of daily livingDeborah A Cahn-Weiner
Department of Neurology, University of California, San Francisco, California 94143 0138, USA
J Int Neuropsychol Soc 13:747-57. 2007..Perhaps executive function is particularly important with respect to maintaining IADLs. Alternatively, executive dysfunction may be a sentinel event indicating widespread cortical involvement and poor prognosis...
Patterns of white matter atrophy in frontotemporal lobar degenerationLinda L Chao
Center for Imaging of Neurodegenerative Diseases, San Francisco Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
Arch Neurol 64:1619-24. 2007..Structural magnetic resonance imaging (MRI) has been used to investigate the in vivo pathology of frontotemporal lobar degeneration. However, few neuroimaging studies have focused on white matter (WM) alterations in this disease...
Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer's diseaseJuan Zhou
Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94117, USA
Brain 133:1352-67. 2010..Further developed, intrinsic connectivity network signatures may provide simple, inexpensive, and non-invasive biomarkers for dementia differential diagnosis and disease monitoring...
Longitudinal volumetric MRI change and rate of cognitive declineD Mungas
Department of Neurology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
Neurology 65:565-71. 2005..To examine how baseline and change of volumetric MRI relate to cognitive decline in older individuals...
Anti-saccade performance predicts executive function and brain structure in normal eldersJacob B Mirsky
Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94143, USA
Cogn Behav Neurol 24:50-8. 2011..To assess the neuropsychological and anatomical correlates of anti-saccade (AS) task performance in normal elders...
Response bias and aging on a recognition memory taskTerri J Huh
Department of Psychiatry, Memory and Aging Center, University of California San Francisco, California 94143, USA
J Int Neuropsychol Soc 12:1-7. 2006..In the light of reported relationships between frontal regions and both aging and response bias, we hypothesize that frontal changes may be the underlying mechanism explaining the increase in liberal response bias with age...
Neuropsychological and functional measures of severity in Alzheimer disease, frontotemporal dementia, and semantic dementiaHoward J Rosen
Department of Neurology, Memory and Aging Center, University of California at San Francisco, San Francisco, California 94143 1207, USA
Alzheimer Dis Assoc Disord 18:202-7. 2004..Thus, in FTD the CDR reveals functional impairments in a wide variety of domains that are more severe than those seen in AD or SD patients with an equivalent Mini-Mental State Examination...
Fresh blood and aged stored blood are equally efficacious in immediately reversing anemia-induced brain oxygenation deficits in humansRichard B Weiskopf
Department of Anesthesia and Cardiovascular Research Institute, University of California, San Francisco, USA
Anesthesiology 104:911-20. 2006..The authors tested the hypothesis that erythrocytes stored for 3 weeks are as effective in supplying oxygen to human tissues as are erythrocytes stored for less than 5 h...
Recognition of emotion in the frontal and temporal variants of frontotemporal dementiaHoward J Rosen
Department of Neurology, University of California, Memory and Aging Center, San Francisco, Calif, USA
Dement Geriatr Cogn Disord 17:277-81. 2004..These results suggest that damage to frontal lobe regions in FTD may lead to more profound impairment in recognition of emotion than when damage is more limited to the temporal lobe...
Mental flexibility: age effects on switchingNancy S Wecker
San Francisco, CA 94131, USA
Neuropsychology 19:345-52. 2005..The results are discussed in terms of theories of executive control and neurologic correlates across the adult life span...
Longitudinal rates of lobar atrophy in frontotemporal dementia, semantic dementia, and Alzheimer's diseaseCasey E Krueger
UCSF Department of Neurology, San Francisco, CA, USA
Alzheimer Dis Assoc Disord 24:43-8. 2010..Measuring specific regions of cerebral volume changes by serial neuroimaging may serve as a useful biomarker outcome measure for clinical trials in neurodegenerative diseases...
Right and left medial orbitofrontal volumes show an opposite relationship to agreeableness in FTDKatherine P Rankin
University of California San Francisco, San Francisco, Calif, USA
Dement Geriatr Cogn Disord 17:328-32. 2004..These data support the hypothesis that regulation of agreeableness arises from a balanced, mutually inhibitory circuit involving both hemispheres...
Clinical and neuropsychological features in autopsy-defined vascular dementiaBruce R Reed
Alzheimer s Disease Center, University of California, Davis 94553, USA
Clin Neuropsychol 18:63-74. 2004..A illustrative case example is included. We conclude that the profile of cognitive impairment in IVD is highly variable, but that in clinical settings neuropsychological readings may contribute to the differential diagnosis of dementia...
Neonatal watershed brain injury on magnetic resonance imaging correlates with verbal IQ at 4 yearsKyle J Steinman
MAS, University of California, Division of Child Neurology, 350 Parnassus Ave, Suite 609, San Francisco, CA 94117, USA
Pediatrics 123:1025-30. 2009....
Let's inhibit our excitement: the relationships between Stroop, behavioral disinhibition, and the frontal lobesLara H Heflin
Department of Neurology, Memory and Aging Center, University of California, San Francisco Medical Center, USA
Neuropsychology 25:655-65. 2011..This study tested those interpretations by examining relationships between Stroop performance, behavioral disinhibition, and frontal lobe atrophy...
Spontaneous social behaviors discriminate behavioral dementias from psychiatric disorders and other dementiasKatherine P Rankin
Department of Neurology, University of California, San Francisco 94143 1207, USA
J Clin Psychiatry 69:60-73. 2008..The object of this study was to improve screening for behavioral dementias in primary care and mental health settings by quantifying spontaneous social behaviors specific to FTLD...
Know thyself: real-world behavioral correlates of self-appraisal accuracyCasey E Krueger
Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Clin Neuropsychol 25:741-56. 2011....
Neuroanatomical correlates of cognitive self-appraisal in neurodegenerative diseaseHoward J Rosen
Department of Neurology, University of California at San Francisco, San Francisco, CA, USA
Neuroimage 49:3358-64. 2010..We hypothesize that emotional/physiological processing carried out by vmPFC is an important factor mediating self-appraisal accuracy in dementia...
Psychometrically matched measures of global cognition, memory, and executive function for assessment of cognitive decline in older personsDan Mungas
Department of Neurology, School of Medicine, University of California, Davis, Sacramento 95817, USA
Neuropsychology 17:380-92. 2003..Association of measures with quantitative structural magnetic resonance imaging variables followed expected patterns. This approach to scale development may have applications for other neuropsychological assessment problems...
Hemispheric dominance for emotions, empathy and social behaviour: evidence from right and left handers with frontotemporal dementiaR J Perry
Memory and Aging Center, Department of Neurology, University of California, San Francisco, California 94143, USA
Neurocase 7:145-60. 2001..The other left hander showed the opposite pattern of deficits, suggesting a novel presentation of anomalous dominance with reversed hemispheric specialization of semantic memory and emotional processing...
Emotional reactivity and emotion recognition in frontotemporal lobar degenerationK H Werner
Department of Psychology, University of California, Berkeley, CA 94720 1650, USA
Neurology 69:148-55. 2007....
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementiaKatya Rascovsky
Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, 3 West Gates, Philadelphia, PA 19104, USA
Brain 134:2456-77. 2011..Future studies will be needed to establish the reliability and specificity of these revised diagnostic guidelines...
Perioperative cognitive decline in the aging populationNiccolò Terrando
Department of Anesthesia and Perioperative Care, San Francisco, CA 94143 0648, USA
Mayo Clin Proc 86:885-93. 2011..A road map to further elucidate the mechanisms, diagnosis, risk factors, mitigation, and treatment of postoperative cognitive decline in the elderly is provided...
Computer-based cognitive training for mild cognitive impairment: results from a pilot randomized, controlled trialDeborah E Barnes
Department of Psychiatry, University of California San Francisco, 4150 Clement Street 151R, San Francisco, CA 94121, USA
Alzheimer Dis Assoc Disord 23:205-10. 2009..We conclude that intensive, computer-based mental activity is feasible in subjects with mild cognitive impairment and that larger trials are warranted...
Patterns of autobiographical memory loss in dementiaCraig E Hou
UCSF Memory and Aging Center, Department of Neurology, University of California at San Francisco, 350 Parnassus Avenue, Box 1207 San Francisco, CA 94143, USA
Int J Geriatr Psychiatry 20:809-15. 2005..Several studies have found impaired recall of remote autobiographical memories relative to recent memories in semantic dementia (SD), a pattern opposite to that in Alzheimer's disease (AD)...
Clinical and neuropsychological features of corticobasal degenerationNataliya Belfor
University of California San Francisco, Memory and Aging Center, 350 Parnassus Avenue, Suite 705, 94143, USA
Mech Ageing Dev 127:203-7. 2006..Increasing awareness of this disorder has led to the realization that specific cognitive and imaging changes are common with CBD degeneration and that these changes help with clinical diagnosis...
Cognitive and neuropsychiatric profile of the synucleinopathies: Parkinson disease, dementia with Lewy bodies, and multiple system atrophyAimee W Kao
Department of Neurology, University of California San Francisco, 94143, USA
Alzheimer Dis Assoc Disord 23:365-70. 2009..PD, MSA, and DLB groups have similar neuropsychiatric profiles of increased depression and anxiety. Similar underlying alpha-synuclein pathology may contribute to these shared features...
Volumetric MRI predicts rate of cognitive decline related to AD and cerebrovascular diseaseD Mungas
Department of Neurology, School of Medicine, University of California, Davis, USA
Neurology 59:867-73. 2002..To examine volumetric MRI correlates of longitudinal cognitive decline in normal aging, AD, and subcortical cerebrovascular brain injury (SCVBI)...
A voxel-based morphometry study of patterns of brain atrophy in ALS and ALS/FTLDJ L Chang
Department of Neurology, University of California San Francisco, CA, USA
Neurology 65:75-80. 2005..This finding supports the idea of a clinical and anatomic continuum between ALS and frontotemporal lobar degeneration...
Joint assessment of structural, perfusion, and diffusion MRI in Alzheimer's disease and frontotemporal dementiaYu Zhang
Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs San Francisco VA, Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA
Int J Alzheimers Dis 2011:546871. 2011..Joint assessments of multimodal MRI have potential value to provide new imaging markers for improved differential diagnoses between FTD and AD...
The early neuropsychological and behavioral characteristics of frontotemporal dementiaDana Wittenberg
Memory and Aging Center, University of California San Francisco Medical Center, San Francisco, CA, USA
Neuropsychol Rev 18:91-102. 2008..As this review underscores, frontotemporal dementia remains a powerful model for studying brain-behavior relationships...
Longitudinal tracking of FTLD: toward developing clinical trial methodologyDavid S Knopman
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
Alzheimer Dis Assoc Disord 21:S58-63. 2007..In addition, a multicenter trial is described in which some aspects of diagnosis and longitudinal measurement in the frontotemporal lobar degenerations are being specifically explored...
Are amyotrophic lateral sclerosis patients cognitively normal?C Lomen-Hoerth
Department of Neurology, University of California at San Francisco, 94143, USA
Neurology 60:1094-7. 2003..In many instances, the frontal executive deficits represent the co-occurrence of frontotemporal lobar dementia (FTLD) and ALS...
Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's diseaseA T Du
Magnetic Resonance Unit, Department of Veterans Affairs Medical Center (114M, University of California, San Francisco 94121, USA
J Neurol Neurosurg Psychiatry 71:441-7. 2001..CONCLUSIONS: Volume reductions in the ERC and hippocampus may be early signs of AD pathology that can be measured using MRI...
Effects of subcortical ischemic vascular dementia and AD on entorhinal cortex and hippocampusA T Du
Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
Neurology 58:1635-41. 2002..CONCLUSIONS: The entorhinal cortex and hippocampus are less affected by subcortical ischemic vascular dementia than by AD...
Very early-onset familial Alzheimer's disease: a novel presenilin 1 mutationJill S Goldman
UCSF Memory and Aging Center, San Francisco, CA 94143, USA
Int J Geriatr Psychiatry 17:649-51. 2002..Early-onset familial Alzheimer's disease (EOFAD) is linked to mutations in three autosomal dominant genes: PS1, PS2 and APP. The clinical presentation and age of onset of mutations is variable...
Double dissociation of social functioning in frontotemporal dementiaKatherine P Rankin
University of California San Francisco, USA
Neurology 60:266-71. 2003..Efforts to characterize changes in social functioning in frontotemporal dementia (FTD) have failed to elicit clear dissociation between frontal and temporal variants of the disease based on behavioral measures...
Mild cognitive impairment, dementia, and their subtypes in oldest old womenKristine Yaffe
Department of Psychiatry, University of California at San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
Arch Neurol 68:631-6. 2011..The population of oldest old is increasing, but the prevalence of cognitive impairment is not well characterized in this group...
Oxygen reverses deficits of cognitive function and memory and increased heart rate induced by acute severe isovolemic anemiaRichard B Weiskopf
Department of Anesthesia, University of California, San Francisco, California 94143 0648, USA
Anesthesiology 96:871-7. 2002....
Patterns of cognitive and emotional empathy in frontotemporal lobar degenerationKatherine P Rankin
Memory and Aging Center, University of California San Francisco, California 94145 1203, USA
Cogn Behav Neurol 18:28-36. 2005..To examine the relationship between empathy and cognition in frontotemporal lobar degeneration (FTLD)...
Patterns of cerebral atrophy in primary progressive aphasiaHoward J Rosen
Department of Neurology, Memory and Aging Center, University of California at San Francisco, CA 94143 1207, USA
Am J Geriatr Psychiatry 10:89-97. 2002..Different clinical syndromes in PPA are associated with different patterns of atrophy. In the future, combined analysis of imaging and clinical characteristics may allow more accurate etiologic diagnosis...
Challenging the clinical utility of the 14-3-3 protein for the diagnosis of sporadic Creutzfeldt-Jakob diseaseMichael D Geschwind
Department of Neurology, University of California, San Francisco Medical Center, San Francisco, CA 94143, USA
Arch Neurol 60:813-6. 2003..Previous studies have suggested that, in the proper clinical context, the 14-3-3 protein in cerebrospinal fluid is a reliable marker for sporadic CJD...
Continuum of frontal lobe impairment in amyotrophic lateral sclerosisJennifer M Murphy
Department of Neurology, ALS Center, University of California, San Francisco, CA 94117, USA
Arch Neurol 64:530-4. 2007..To identify the nature and prevalence of cognitive and behavioral abnormalities in patients with amyotrophic lateral sclerosis (ALS)...
Diagnostic criteria for the behavioral variant of frontotemporal dementia (bvFTD): current limitations and future directionsKatya Rascovsky
Memory and Aging Center, University of California, San Francisco, CA 94117, USA
Alzheimer Dis Assoc Disord 21:S14-8. 2007..In this article, we discuss the limitations of current diagnostic criteria and propose the establishment of an international consortium to revise diagnostic and research criteria for the behavioral variant of frontotemporal dementia...
Different patterns of N-acetylaspartate loss in subcortical ischemic vascular dementia and ADN Schuff
Magnetic Resonance Unit, DVA Medical Center San Francisco, CA 94121, USA
Neurology 61:358-64. 2003....
Focal right inferotemporal atrophy in AD with disproportionate visual constructive impairmentA L Boxer
Memory and Aging Center, Department of Neurology, University of California at San Francisco, 94143 1207, USA
Neurology 61:1485-91. 2003..To explore the structural neuroimaging correlates of visual constructive impairment in patients with mild to moderate Alzheimer disease (AD)...
Acute severe isovolemic anemia impairs cognitive function and memory in humansR B Weiskopf
Departments of Anesthesia, The Cardiovascular Research Institute, University of California, San Francisco, California 94143 0648, USA
Anesthesiology 92:1646-52. 2000..However, in those studies, sensitive, specific measures of critical organ function were not used. This study tested the hypothesis that acute severe decreases of hemoglobin concentration alters human cognitive function...
DHEA treatment of Alzheimer's disease: a randomized, double-blind, placebo-controlled studyO M Wolkowitz
Department of Psychiatry, Center for Neurobiology and Psychiatry, University of California San Francisco UCSF School of Medicine, USA
Neurology 60:1071-6. 2003..To compare the efficacy and tolerability of dehydroepiandrosterone (DHEA) vs placebo in AD...
Utility of clinical criteria in differentiating frontotemporal lobar degeneration (FTLD) from ADHoward J Rosen
Department of Neurology, Memory and Aging Center, University of California at San Francisco, 350 Parnassus Avenue, Suite 800, San Francisco, CA 94143 1207, USA
Neurology 58:1608-15. 2002..To assess the ability of the current diagnostic criteria for frontotemporal lobar degeneration (FTLD) to differentiate FTLD from AD...
Patterns of brain atrophy in frontotemporal dementia and semantic dementiaH J Rosen
Department of Neurology, UCSF Memory and Aging Center, Univeristy of California, San Francisco, 94143 1207, USA
Neurology 58:198-208. 2002..To identify and compare the patterns of cerebral atrophy associated with two clinical variants of frontotemporal lobar degeneration (FTLD): frontotemporal dementia (FTD) and semantic dementia (SemD)...
MRI predictors of cognition in subcortical ischemic vascular disease and Alzheimer's diseaseD Mungas
Department of Neurology, School of Medicine University of California, Davis 95817, USA
Neurology 57:2229-35. 2001....
Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer diseaseY Zhang
MR Unit 114M, VA Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA
Neurology 68:13-9. 2007..However, it is unclear whether these abnormalities also impact the cingulum fibers, which connect the medial temporal lobe and the posterior cingulate regions...
Evidence of neurodegeneration in brains of older adults who do not yet fulfill MCI criteriaL L Chao
Center for Imaging of Neurodegenerative Diseases, San Francisco VA Medical Center, San Francisco, CA 94121, USA
Neurobiol Aging 31:368-77. 2010....
