HELMUT KRAMER

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins
    J H Walenta
    Center for Basic Neuroscience and Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Cell Biol 152:923-34. 2001
  2. pmc Mutations in the Drosophila hook gene inhibit endocytosis of the boss transmembrane ligand into multivesicular bodies
    H Kramer
    Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, Dallas 75235 9111, USA
    J Cell Biol 133:1205-15. 1996
  3. ncbi request reprint Sorting out signals in fly endosomes
    HELMUT KRAMER
    Center for Basic Neuroscience, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9111, USA
    Traffic 3:87-91. 2002
  4. ncbi request reprint RIPping notch apart: a new role for endocytosis in signal transduction?
    H Kramer
    Center for Basic Neuroscience and Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75235 9111, USA
    Sci STKE 2000:pe1. 2000
  5. pmc The ups and downs of life in an epithelium
    H Kramer
    Center for Basic Neuroscience and Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Cell Biol 151:F15-8. 2000
  6. pmc Genetic analysis of hook, a gene required for endocytic trafficking in drosophila
    H Kramer
    Center for Basic Neuroscience, Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9111, USA
    Genetics 151:675-84. 1999
  7. pmc The SM protein Car/Vps33A regulates SNARE-mediated trafficking to lysosomes and lysosome-related organelles
    Mohammed A Akbar
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Mol Biol Cell 20:1705-14. 2009
  8. pmc Drosophila acinus encodes a novel regulator of endocytic and autophagic trafficking
    Adam S Haberman
    Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Development 137:2157-66. 2010
  9. ncbi request reprint Drosophila Vps16A is required for trafficking to lysosomes and biogenesis of pigment granules
    Suprabha Pulipparacharuvil
    Center for Basic Neuroscience, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9111, USA
    J Cell Sci 118:3663-73. 2005
  10. pmc The full-of-bacteria gene is required for phagosome maturation during immune defense in Drosophila
    Mohammed Ali Akbar
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Cell Biol 192:383-90. 2011

Collaborators

Detail Information

Publications18

  1. pmc The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins
    J H Walenta
    Center for Basic Neuroscience and Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Cell Biol 152:923-34. 2001
    ..Because overexpression of Hook3 caused fragmentation of the Golgi complex, we propose that Hook3 participates in defining the architecture and localization of the mammalian Golgi complex...
  2. pmc Mutations in the Drosophila hook gene inhibit endocytosis of the boss transmembrane ligand into multivesicular bodies
    H Kramer
    Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, Dallas 75235 9111, USA
    J Cell Biol 133:1205-15. 1996
    ....
  3. ncbi request reprint Sorting out signals in fly endosomes
    HELMUT KRAMER
    Center for Basic Neuroscience, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9111, USA
    Traffic 3:87-91. 2002
    ..This review discusses some intriguing links between these findings, the sorting of proteins in endocytic trafficking, and the regulation of signaling pathways in Drosophila...
  4. ncbi request reprint RIPping notch apart: a new role for endocytosis in signal transduction?
    H Kramer
    Center for Basic Neuroscience and Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75235 9111, USA
    Sci STKE 2000:pe1. 2000
    ..This trans-endocytosis event contributes to the cleavage and release of the active Notch intracellular domain. The Perspective is accompanied by a movie illustrating the trans-endocytosis of Notch...
  5. pmc The ups and downs of life in an epithelium
    H Kramer
    Center for Basic Neuroscience and Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Cell Biol 151:F15-8. 2000
  6. pmc Genetic analysis of hook, a gene required for endocytic trafficking in drosophila
    H Kramer
    Center for Basic Neuroscience, Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9111, USA
    Genetics 151:675-84. 1999
    ..The importance of all three domains for Hook function was confirmed by their conservation between two Drosophila and two human Hook proteins...
  7. pmc The SM protein Car/Vps33A regulates SNARE-mediated trafficking to lysosomes and lysosome-related organelles
    Mohammed A Akbar
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Mol Biol Cell 20:1705-14. 2009
    ..Consistent with a role in Car-mediated fusion, dSyntaxin16 is not restricted to Golgi membranes but also present on lysosomes...
  8. pmc Drosophila acinus encodes a novel regulator of endocytic and autophagic trafficking
    Adam S Haberman
    Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Development 137:2157-66. 2010
    ..Taken together, our data show that dacn encodes a regulator of endosomal and autophagosomal dynamics, modulating developmental signaling and the cellular response to starvation...
  9. ncbi request reprint Drosophila Vps16A is required for trafficking to lysosomes and biogenesis of pigment granules
    Suprabha Pulipparacharuvil
    Center for Basic Neuroscience, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9111, USA
    J Cell Sci 118:3663-73. 2005
    ..Ubiquitous knockdown of dVps16A was lethal. Together, these findings demonstrate that Drosophila Vps16A is essential for lysosomal trafficking. Furthermore, metazoans have two types of Vps-C complexes with non-redundant functions...
  10. pmc The full-of-bacteria gene is required for phagosome maturation during immune defense in Drosophila
    Mohammed Ali Akbar
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Cell Biol 192:383-90. 2011
    ..These findings suggest that defects in phagosome maturation may contribute to symptoms of ARC patients including recurring infections...
  11. pmc Drosophila mauve mutants reveal a role of LYST homologs late in the maturation of phagosomes and autophagosomes
    Mokhlasur Rahman
    Department of Neuroscience, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9111, USA
    Traffic 13:1680-92. 2012
    ..Together these data suggest a model in which Mauve functions to restrict homotypic fusion of different pre-lysosomal organelles and LROs...
  12. pmc Hook2 contributes to aggresome formation
    Györgyi Szebenyi
    Center for Basic Neuroscience, University of Texas, Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    BMC Cell Biol 8:19. 2007
    ..Hook proteins have been proposed to serve as adaptors for the association of cargos with dynein for transport on microtubules. Hook2 was shown to localize to the centrosome, bind centriolin, and contribute to centrosomal function...
  13. pmc A mutation in dVps28 reveals a link between a subunit of the endosomal sorting complex required for transport-I complex and the actin cytoskeleton in Drosophila
    Evgueni A Sevrioukov
    Center for Basic Neuroscience and Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Mol Biol Cell 16:2301-12. 2005
    ....
  14. ncbi request reprint Hook2 localizes to the centrosome, binds directly to centriolin/CEP110 and contributes to centrosomal function
    Györgyi Szebenyi
    Center for Basic Neuroscience, University of Texas, Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390 9111, USA
    Traffic 8:32-46. 2007
    ..Thus, we propose that hook2 contributes to the establishment and maintenance of centrosomal structure and function...
  15. pmc Route to destruction: autophagosomes SNARE lysosomes
    HELMUT KRAMER
    Department of Neuroscience and 2 Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Cell Biol 201:495-7. 2013
    ..Three recent papers, including one by Takáts et al. (2013. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201211160), have taken different routes to discover a role for Syntaxin 17 in the maturation of autophagosomes...
  16. pmc Acinus: a nuclear regulator of autophagy and endocytic trafficking
    HELMUT KRAMER
    Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX, USA
    Autophagy 6:974-5. 2010
    ..The increase in autophagy upon Acinus overexpression and its location to the nucleus are consistent with Acinus being a novel regulator of autophagy...
  17. pmc Visual neurotransmission in Drosophila requires expression of Fic in glial capitate projections
    Mokhlasur Rahman
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Nat Neurosci 15:871-5. 2012
    ..These findings establish a previously unknown regulatory mechanism in visual neurotransmission and provide, to the best of our knowledge, the first evidence for a role of glial capitate projections in neurotransmitter recycling...
  18. pmc Dynamin-independent synaptic vesicle retrieval?
    HELMUT KRAMER
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Nat Neurosci 11:6-8. 2008
    ..A new study proposes that synaptic vesicle endocytosis at a large synaptic terminal is partly independent of dynamin and GTP hydrolysis, suggesting a new mechanism leading to vesicle fission and maintenance of neurotransmission...