Research Topics
| Benjamin D KozowerSummaryAffiliation: University of Virginia Country: USA Publications
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Detail Information
Publications
Gene transfer of tumor necrosis factor inhibitor improves the function of lung allograftsTsutomu Tagawa
Department of Surgery, Division of Cardiothoracic Surgery, Washington University School of Medicine, Barnes- Jewish Hospital, St Louis, MO 63110, USA
J Thorac Cardiovasc Surg 127:1558-63. 2004..CONCLUSIONS: Recipient intramuscular Ad.sTNF-RI-Ig gene transfer improves allograft function in a well-established model of acute rejection. Maximum benefit was observed when transfection occurred 24 hours before transplantation...
The relationship between hospital lung cancer resection volume and patient mortality riskBenjamin D Kozower
Department of Surgery, University of Virginia Health System, Charlottesville, VA 22908 0679, USA
Ann Surg 254:1032-7. 2011..To evaluate the volume-outcome relationship after lung cancer resection using 3 alternative measures of the effect of volume...- Lung cancer resection volume: is procedure volume really an indicator of quality?Benjamin D Kozower
Department of Surgery, University of Virginia Health System, Charlottesville, Virginia 22908 0679, USA
Semin Thorac Cardiovasc Surg 24:93-8. 2012..Careful examination of the literature demonstrates that lung cancer resection volume is not strongly associated with mortality and should not be used as a proxy measure for quality... - Hospital procedure volume should not be used as a measure of surgical qualityDamien J LaPar
Departments of Surgery and Public Health Sciences, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
Ann Surg 256:606-15. 2012..However, controversy exists regarding the strength and validity of the evidence for the volume-outcome association. The purpose of this study was to reevaluate the volume-outcome relationship for these procedures... - Hospital esophageal cancer resection volume does not predict patient mortality riskBenjamin D Kozower
Department of Surgery, University of Virginia Health System, Charlottesville, Virginia Department of Public Health Sciences, University of Virginia Health System, Charlottesville, Virginia, USA
Ann Thorac Surg 93:1690-6; discussion 1696-8. 2012..The purpose of this study was to evaluate the volume-outcome relationship for esophageal cancer resection in a large population dataset and to compare 3alternative techniques for measuring the effect of volume... - Does positron emission tomography prevent nontherapeutic pulmonary resections for clinical stage IA lung cancer?Benjamin D Kozower
Department of Surgery, University of Virginia Health System, Charlottesville, Virginia 22908 0679, USA
Ann Thorac Surg 85:1166-9; discussion 1169-70. 2008..This study evaluates whether PET prevents nontherapeutic pulmonary resections in clinical stage IA patients by finding advanced disease or by declaring a nodule as benign... - The impact of the lung allocation score on short-term transplantation outcomes: a multicenter studyBenjamin D Kozower
Department of Surgery, University of Virginia Health System, Charlottesville 22908 0679, USA
J Thorac Cardiovasc Surg 135:166-71. 2008..The purpose of this study was to evaluate the impact of the lung allocation score on short-term outcomes after lung transplantation... - A thoracic surgeon-directed tobacco cessation interventionBenjamin D Kozower
Department of Surgery, University of Virginia Health System, Charlottesville, Virginia 22908 0679, USA
Ann Thorac Surg 89:926-30; discussion 930. 2010..The purpose of this study was to prospectively evaluate a brief tobacco cessation intervention offered by surgeons in an outpatient thoracic surgery clinic... - STS database risk models: predictors of mortality and major morbidity for lung cancer resectionBenjamin D Kozower
Department of Surgery, University of Virginia Health System, Charlottesville, Virginia 22908 0679, USA
Ann Thorac Surg 90:875-81; discussion 881-3. 2010..The aim of this study is to create models for perioperative risk of lung cancer resection using the STS GTDB (Society of Thoracic Surgeons General Thoracic Database)... 
Donor factors are associated with bronchiolitis obliterans syndrome after lung transplantationSara A Hennessy
Department of Surgery, University of Virginia, Charlottesville, Virginia, USA
Ann Thorac Surg 89:1555-62. 2010..Recipient and perioperative risk factors have been investigated in BOS, but less is known about donor factors. Therefore, we investigated what donor factors are important in the development of BOS...- Fluorodeoxyglucose positron emission tomography and tumor marker expression in non-small cell lung cancerMatthew D Taylor
Department of Surgery, University of Virginia, Charlottesville, VA 22908 0679, USA
J Thorac Cardiovasc Surg 137:43-8. 2009..However, there are limited data correlating FDG-PET with tumor markers. The purpose of this study was to determine the correlation of tumor marker expression with FDG-PET maximal standardized uptake values in NSCLC... - Bronchiolitis obliterans syndrome occurs earlier in the post-lung allocation score eraAbbas Emaminia
Department of Surgery, University of Virginia, Charlottesville, VA 22908 0679, USA
J Thorac Cardiovasc Surg 141:1278-82. 2011..The objective of this study was to evaluate the impact of LAS on the development of bronchiolitis obliterans syndrome as well as on overall 3-year and bronchiolitis obliterans syndrome-related survival... - Pulmonary resections performed at hospitals with thoracic surgery residency programs have superior outcomesCastigliano M Bhamidipati
Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA 22908 0679, USA
J Thorac Cardiovasc Surg 145:60-6, 67.e1-2; discussion 66-7. 2013..We hypothesize that morbidity and mortality for these procedures are different between hospitals and that operations performed at TR teaching hospitals have superior results... - The effect of surgeon volume on mortality for off-pump coronary artery bypass graftingDamien J LaPar
Division of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, VA, USA
J Thorac Cardiovasc Surg 143:854-63. 2012..However, the true effect of surgeon volume on outcomes after OPCAB remains unknown. The purpose of this study was to examine the effect of surgeon volume on risk-adjusted mortality after OPCAB... - Differences in reported esophageal cancer resection outcomes between national clinical and administrative databasesDamien J LaPar
Division of Thoracic and Cardiovascular Surgery, University of Virginia School of Medicine, Charlottesville, VA, USA
J Thorac Cardiovasc Surg 144:1152-7. 2012..The purpose of the present study was to determine whether the GTSD esophagectomy outcomes are representative of nationwide outcomes by comparing them with other national clinical and administrative databases... - Tumor recurrence after complete resection for non-small cell lung cancerMatthew D Taylor
Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Virginia, Charlottesville, Virginia 22908 0679, USA
Ann Thorac Surg 93:1813-20; discussion 1820-1. 2012..The purpose of this study was to identify independent perioperative and pathologic variables that are associated with NSCLC recurrence after complete surgical resection... - Gender, race, and socioeconomic status affects outcomes after lung cancer resections in the United StatesDamien J LaPar
Department of Surgery, Division of Thoracic and Cardiovascular Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
Ann Thorac Surg 92:434-9. 2011..We hypothesized that risk-adjusted outcomes for lung cancer resections would not be influenced by these factors... - Predicted risk of mortality models: surgeons need to understand limitations of the University HealthSystem Consortium modelsBenjamin D Kozower
Department of Surgery, University of Virginia Health System, Charlottesville, VA, USA
J Am Coll Surg 209:551-6. 2009.... - Effects of induction immunosuppression regimen on acute rejection, bronchiolitis obliterans, and survival after lung transplantationGorav Ailawadi
Department of Surgery, University of Virginia, Charlottesville, VA 22908 0679, USA
J Thorac Cardiovasc Surg 135:594-602. 2008..We hypothesized that daclizumab results in less acute rejection and bronchiolitis obliterans and better survival than antithymocyte globulin... - Geographic distance between donor and recipient does not influence outcomes after lung transplantationSara A Hennessy
Department of Surgery, University of Virginia, Charlottesville, Virginia, USA
Ann Thorac Surg 92:1847-53. 2011..Expanding the donor pool would be beneficial. We investigated the importance of geographic distance between the donor and recipient and hypothesized that it would not be a critical determinant of outcomes after lung transplantation... - Radiotracer-guided thoracoscopic resection is a cost-effective technique for the evaluation of subcentimeter pulmonary nodulesEric L Grogan
Department of Surgery, Division of Thoracic and Cardiovascular Surgery, University of Virginia School of Medicine, Charlottesville, Virginia, USA
Ann Thorac Surg 86:934-40; discussion 934-40. 2008..Decision analysis, used to model cost and effectiveness, is useful to compare treatment options. We hypothesize that RGTR strategy is more cost-effective compared with thoracotomy for subcentimeter pulmonary nodules... - Seasonal variation influences outcomes following lung cancer resectionsDamien J LaPar
Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Virginia Health System, Charlottesville, VA, USA
Eur J Cardiothorac Surg 40:83-90. 2011..We hypothesized that postoperative outcomes following surgical resection for lung cancer within the United States would not be impacted by operative season... - Correlations between selected tumor markers and fluorodeoxyglucose maximal standardized uptake values in esophageal cancerMatthew D Taylor
Department of Surgery, University of Virginia, Charlottesville, VA, USA
Eur J Cardiothorac Surg 35:699-705. 2009..The purpose of this study was to determine the correlation of tumor markers with FDG-PET SUVmax in esophageal cancer... - Does reperfusion injury still cause significant mortality after lung transplantation?Gorav Ailawadi
Department of Surgery, University of Virginia, Charlottesville, VA 22908 0679, USA
J Thorac Cardiovasc Surg 137:688-94. 2009..The purpose of this investigation was to identify whether our improved 1-year survival after lung transplantation is related to a change in reperfusion injury... - Transplant pneumonectomy in a patient with an acutely thrombosed allograftSara A Hennessy
Division of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, Virginia, USA
Ann Thorac Surg 89:975-7. 2010..She required an allograft pneumonectomy as treatment for this and was eventually discharged on bi-level nasal positive pressure at night and 3 L nasal cannula oxygen during the day... - The Society of Thoracic Surgeons General Thoracic Surgery Database: establishing generalizability to national lung cancer resection outcomesDamien J LaPar
Division of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, Virginia 22908, USA
Ann Thorac Surg 94:216-21; discussion 221. 2012..The purpose of this study was to establish the generalizability of the GTDB by comparing lung cancer resection results with those of the Nationwide Inpatient Sample (NIS), the largest all-payer inpatient database in the United States... - Size matters: a comparison of T1 and T2 peripheral non-small-cell lung cancers treated with stereotactic body radiation therapy (SBRT)Neal E Dunlap
Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA
J Thorac Cardiovasc Surg 140:583-9. 2010..The purpose of this study was to compare the outcomes and local control rates of patients with peripheral T1 and T2 non-small-cell lung cancer treated with stereotactic body radiation therapy... - Phase I trial of induction histone deacetylase and proteasome inhibition followed by surgery in non-small-cell lung cancerDavid R Jones
Department of Surgery, University of Virginia, Charlottesville, VA, USA
J Thorac Oncol 7:1683-90. 2012..On the basis of prior preclinical evaluations, we hypothesized that combined induction proteasome and histone deacetylase inhibitor therapy, followed by tumor resection, is feasible... - Pathologic lymph node ratio is a predictor of survival in esophageal cancerCastigliano M Bhamidipati
Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia
Ann Thorac Surg 94:1643-51. 2012..We sought to determine the prognostic value of lymph node ratio (LNR) compared with TNM and N stage using the seventh edition American Joint Commission on Cancer and International Union Against Cancer criteria... - A diagnostic consideration for all ages: pseudoachalasia in a 22-year-old maleMatthew L Stone
Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Virginia Health System, Charlottesville, Virginia 22908 0679, USA
Ann Thorac Surg 93:e11-2. 2012..This unfortunate presentation reinforces the importance of a careful preoperative workup for dysphagia irrespective of age... - Identification of small lung nodules: technique of radiotracer-guided thoracoscopic biopsyEric L Grogan
Department of Surgery, Division of Thoracic and Cardiovascular Surgery, University of Virginia School of Medicine, Charlottesville, Virginia, USA
Ann Thorac Surg 85:S772-7. 2008..This study describes a thoracoscopic technique to reliably locate and excise lung nodules that were not thought to be thoracoscopically visible or instrumentally palpable... - Rosai-Dorfman disease presenting as a pulmonary artery massDustin M Walters
Department of Surgery, University of Virginia, Charlottesville, Virginia 22908, USA
Ann Thorac Surg 89:300-2. 2010..We present a case of Rosai-Dorfman disease affecting the pulmonary arteries in a 22-year-old woman with severe, symptomatic right heart failure... - Fatal Mycobacterium tuberculosis infection in a lung transplant recipientRobyn L Boedefeld
Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908 0679, USA
J Heart Lung Transplant 27:1176-8. 2008..We report a case of fatal M tuberculosis infection that presented as a pericardial abscess in a lung transplant recipient and review the literature... - Potential for detrimental hyperinflation after lung transplantation with application of negative pleural pressure to undersized lung graftsBenjamin D Kozower
Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
J Thorac Cardiovasc Surg 125:430-2. 2003 - Quality of life following primary vs. redo transthoracic paraesophageal hernia repairsMatthew D Taylor
Department of Surgery, University of Virginia, Box 800679, Charlottesville, VA 22908 0679, USA
Interact Cardiovasc Thorac Surg 7:71-4. 2008..These differences, while statistically significant, have limited clinical relevance as the overall QOL was not different between groups and low GERD symptom scores were found in both groups... - Surgical spectrum in the management of empyemasMatthew D Taylor
Department of Surgery, University of Virginia, Box 800300, Charlottesville, VA 22908 0679, USA
Thorac Surg Clin 22:431-40. 2012..Although management of chronic empyema remains a significant challenge, surgical intervention is usually successful in cleaning up the pleural space... - Intratracheal adenovirus-mediated gene transfer is optimal in experimental lung transplantationSamer A Kanaan
Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
J Thorac Cardiovasc Surg 124:1130-6. 2002..This delivery strategy has tremendous potential in experimental lung transplant models to reduce ischemia-reperfusion injury and acute allograft rejection and should be investigated further... - Living donor lobar grafts improve pediatric lung retransplantation survivalBenjamin D Kozower
Division of Cardiothoracic Surgery, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO 63110, USA
J Thorac Cardiovasc Surg 131:1142-7. 2006..This strategy offers significant benefit for this high-risk group and preserves the limited supply of donor lungs for other children at risk of dying while waiting for lung transplantation... - Recipient intramuscular cotransfection of transforming growth factor beta1 and interleukin 10 ameliorates acute lung graft rejectionTakashi Suda
Division of Cardiothoracic Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
J Thorac Cardiovasc Surg 129:926-31. 2005..This approach might be applied to the clinical setting because transplant recipients could be treated at the time of implantation... - Recipient intramuscular cotransfection of naked plasmid transforming growth factor beta1 and interleukin 10 ameliorates lung graft ischemia-reperfusion injuryNiccolo Daddi
Division of Cardiothoracic Surgery, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
J Thorac Cardiovasc Surg 124:259-69. 2002..In this study we analyzed whether recipient intramuscular naked plasmid cotransfection of transforming growth factor beta(1) and interleukin 10 would result in amelioration of lung graft ischemia-reperfusion injury... - Adenovirus encoding soluble tumor necrosis factor alpha receptor immunoglobulin prolongs gene expression of a cotransfected reporter gene in rat lungTakashi Suda
Division of Cardiothoracic Surgery, Washington University School of Medicine, One Barnes-Jewish Hospital Plaza, 3108 Queeny Tower, St Louis, MO 63110-1013, USA
J Thorac Cardiovasc Surg 126:1155-61. 2003..The cotransfection approach is feasible, but the increase of antiadenovirus antibodies might make repeated cotransfection unfeasible... - Immunotargeting of catalase to the pulmonary endothelium alleviates oxidative stress and reduces acute lung transplantation injuryBenjamin D Kozower
Division of Cardiothoracic Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA
Nat Biotechnol 21:392-8. 2003..Potential applications of this strategy include improving the outcome of clinical lung transplantation and treating a wide variety of endothelial disorders... - Tumor necrosis factor inhibitor gene transfer ameliorates lung graft ischemia-reperfusion injuryTsutomu Tagawa
Division of Cardiothoracic Surgery, Washington University School of Medicine, One Barnes-Jewish Hospital Plaza, 3108 Queeny Tower, St Louis, MO 63110-1013, USA
J Thorac Cardiovasc Surg 126:1147-54. 2003..However, donor endobronchial transfection required 500-fold less vector. Furthermore, at low vector doses, it does not create significant graft inflammation... - Recipient intramuscular administration of naked plasmid TGF-beta1 attenuates lung graft reperfusion injuryNiccolo Daddi
Division of Cardiothoracic Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
J Heart Lung Transplant 22:1323-34. 2003..We investigated whether recipient intramuscular (IM) naked plasmid gene transfer of transforming growth factor beta1-active (TGF-beta1-active) ameliorates lung graft ischemia-reperfusion injury... - Impact of complete revascularization on long-term survival after coronary artery bypass grafting in octogenariansBenjamin D Kozower
Division of Cardiothoracic Surgery, Washington University School of Medicine, St. Louis, Missouri 63110-1013, USA
Ann Thorac Surg 80:112-6; discussion 116-7. 2005..008). CONCLUSIONS: In octogenarians undergoing coronary artery bypass grafting, complete revascularization correlated with improved long-term survival, increasing mean survival by almost 25% compared with incomplete revascularization... - Clinical-pathologic conference in general thoracic surgery: malignant transformation of recurrent respiratory papillomatosisBenjamin D Kozower
Washington University School of Medicine, Department of Cardiothoracic Surgery, Barnes-Jewish Hospital, St Louis, MO 63105, USA
J Thorac Cardiovasc Surg 130:1190-3. 2005 - Clinical-pathologic conference in general thoracic surgery: carinal resection for endobronchial grade I neuroendocrine carcinomaBenjamin D Kozower
Washington University School of Medicine, Barnes-Jewish Hospital, Saint Louis, MO, USA
J Thorac Cardiovasc Surg 132:1219-22. 2006 - Low-dose endobronchial gene transfer to ameliorate lung graft ischemia-reperfusion injuryTsutomu Tagawa
Division of Cardiothoracic Surgery and the Department of Surgery, Washington University School of Medicine, Barnes Jewish Hospital, St Louis, Mo 63110 1013, USA
J Thorac Cardiovasc Surg 123:795-802. 2002..This study was undertaken to determine whether low-dose endobronchial transfer to the donor of the gene for human interleukin 10 would decrease ischemia-reperfusion injury in lung transplantation...