Andrea A Kovacs

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. pmc HIV/HCV co-infection: pathogenesis, clinical complications, treatment, and new therapeutic technologies
    Eva A Operskalski
    Maternal Child and Adolescent Center for Infectious Diseases and Virology, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, 90033, USA
    Curr HIV/AIDS Rep 8:12-22. 2011
  2. pmc CD8(+) T cell activation in women coinfected with human immunodeficiency virus type 1 and hepatitis C virus
    Andrea Kovacs
    Department of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    J Infect Dis 197:1402-7. 2008
  3. ncbi request reprint Immune reconstitution after receipt of highly active antiretroviral therapy in children with advanced or progressive HIV disease and complete or partial viral load response
    Andrea Kovacs
    Maternal Child and Adolescent Center for Infectious Disease and Virology, University of Southern California Keck School of Medicine, Los Angeles 90033, USA
    J Infect Dis 192:296-302. 2005
  4. ncbi request reprint Pharmacokinetics of didanosine and drug resistance mutations in infants exposed to zidovudine during gestation or postnatally and treated with didanosine or zidovudine in the first three months of life
    Andrea Kovacs
    Maternal, Child and Adolescent Center for Infectious Diseases and Virology, University of Southern California, Keck School of Medicine, Los Angeles, 90033, USA
    Pediatr Infect Dis J 24:503-9. 2005
  5. pmc Activation of CD8 T cells predicts progression of HIV infection in women coinfected with hepatitis C virus
    Andrea Kovacs
    Maternal, Child, and Adolescent, Center for Infectious Diseases and Virology, University of Southern California, Keck School of Medicine, HRA 300, 1640 Marengo St, Los Angeles, CA 90033, USA
    J Infect Dis 201:823-34. 2010
  6. ncbi request reprint HIV-1 and immune control: can we change the course of HIV-1?
    Andrea Kovacs
    Maternal, Child and Adolescent Center for Infectious Disease and Virology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Lancet 363:833-4. 2004
  7. pmc HCV viremia is associated with drug use in young HIV-1 and HCV coinfected pregnant and non-pregnant women
    Georgia B Nikolopoulou
    Maternal, Child and Adolescent Center for Infectious Diseases and Virology, Los Angeles County and University of Southern California Medical Center, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Addiction 100:626-35. 2005
  8. doi request reprint Pharmacokinetics and safety of nelfinavir when used in combination with zidovudine and lamivudine in HIV-infected pregnant women: Pediatric AIDS Clinical Trials Group (PACTG) Protocol 353
    Y J Bryson
    David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1752, USA
    HIV Clin Trials 9:115-25. 2008
  9. ncbi request reprint CYP2B6 genetic variants are associated with nevirapine pharmacokinetics and clinical response in HIV-1-infected children
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, California 92093 0672, USA
    AIDS 21:2191-9. 2007
  10. pmc Virologic and immunologic correlates with the magnitude of antibody responses to the hepatitis A vaccine in HIV-infected children on highly active antiretroviral treatment
    Adriana Weinberg
    Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA
    J Acquir Immune Defic Syndr 52:17-24. 2009

Research Grants

  1. HCV and Progression of HIV and HAART Response in Women
    Andrea Kovacs; Fiscal Year: 2005
  2. HCV and HIV Progression in Women on HAART
    Andrea Kovacs; Fiscal Year: 2009
  3. HCV and HIV Progression in Women on HAART
    Andrea A Kovacs; Fiscal Year: 2010
  4. HCV and HIV Progression in Women on HAART
    Andrea Kovacs; Fiscal Year: 2009
  5. HCV and HIV Progression in Women on HAART
    Andrea A Kovacs; Fiscal Year: 2010

Detail Information

Publications30

  1. pmc HIV/HCV co-infection: pathogenesis, clinical complications, treatment, and new therapeutic technologies
    Eva A Operskalski
    Maternal Child and Adolescent Center for Infectious Diseases and Virology, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, 90033, USA
    Curr HIV/AIDS Rep 8:12-22. 2011
    ....
  2. pmc CD8(+) T cell activation in women coinfected with human immunodeficiency virus type 1 and hepatitis C virus
    Andrea Kovacs
    Department of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    J Infect Dis 197:1402-7. 2008
    ..Because CD8(+) T cell activation is related to HIV-1 disease progression, these data may have implications for the medical management of patients coinfected with HIV-1 and HCV...
  3. ncbi request reprint Immune reconstitution after receipt of highly active antiretroviral therapy in children with advanced or progressive HIV disease and complete or partial viral load response
    Andrea Kovacs
    Maternal Child and Adolescent Center for Infectious Disease and Virology, University of Southern California Keck School of Medicine, Los Angeles 90033, USA
    J Infect Dis 192:296-302. 2005
    ..For VL rebounders still in the study, CD4 cell counts remained increased for 32 weeks after VL rebound. Sustained immunologic benefits can be achieved even with partial VL response in children with advanced disease...
  4. ncbi request reprint Pharmacokinetics of didanosine and drug resistance mutations in infants exposed to zidovudine during gestation or postnatally and treated with didanosine or zidovudine in the first three months of life
    Andrea Kovacs
    Maternal, Child and Adolescent Center for Infectious Diseases and Virology, University of Southern California, Keck School of Medicine, Los Angeles, 90033, USA
    Pediatr Infect Dis J 24:503-9. 2005
    ..There are limited numbers of drugs that are available in formulations that are appropriate for neonates and few studies assessing resistance among infants born to human immunodeficiency virus (HIV)-infected women...
  5. pmc Activation of CD8 T cells predicts progression of HIV infection in women coinfected with hepatitis C virus
    Andrea Kovacs
    Maternal, Child, and Adolescent, Center for Infectious Diseases and Virology, University of Southern California, Keck School of Medicine, HRA 300, 1640 Marengo St, Los Angeles, CA 90033, USA
    J Infect Dis 201:823-34. 2010
    ....
  6. ncbi request reprint HIV-1 and immune control: can we change the course of HIV-1?
    Andrea Kovacs
    Maternal, Child and Adolescent Center for Infectious Disease and Virology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Lancet 363:833-4. 2004
  7. pmc HCV viremia is associated with drug use in young HIV-1 and HCV coinfected pregnant and non-pregnant women
    Georgia B Nikolopoulou
    Maternal, Child and Adolescent Center for Infectious Diseases and Virology, Los Angeles County and University of Southern California Medical Center, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Addiction 100:626-35. 2005
    ..In this study we assessed clinical and demographic factors associated with HCV viremia in a cohort of young pregnant and non-pregnant mothers coinfected with HIV-1...
  8. doi request reprint Pharmacokinetics and safety of nelfinavir when used in combination with zidovudine and lamivudine in HIV-infected pregnant women: Pediatric AIDS Clinical Trials Group (PACTG) Protocol 353
    Y J Bryson
    David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1752, USA
    HIV Clin Trials 9:115-25. 2008
    ..We studied the safety, antiviral effect, and pharmacokinetics of NFV and its M8 metabolite with two dosing regimens in combination with zidovudine (ZDV) and lamivudine (3TC) in HIV-infected pregnant women...
  9. ncbi request reprint CYP2B6 genetic variants are associated with nevirapine pharmacokinetics and clinical response in HIV-1-infected children
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, California 92093 0672, USA
    AIDS 21:2191-9. 2007
    ....
  10. pmc Virologic and immunologic correlates with the magnitude of antibody responses to the hepatitis A vaccine in HIV-infected children on highly active antiretroviral treatment
    Adriana Weinberg
    Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA
    J Acquir Immune Defic Syndr 52:17-24. 2009
    ..We sought to identify the immunologic and virologic factors associated with a robust response to hepatitis A virus (HAV) vaccine in children on highly active antiretroviral treatment...
  11. ncbi request reprint A randomized trial of directly administered antiretroviral therapy and adherence case management intervention
    Amy Rock Wohl
    HIV Epidemiology Program, Los Angeles County Department of Health Services, Los Angeles, CA 90005, USA
    Clin Infect Dis 42:1619-27. 2006
    ....
  12. pmc CYP2C19 genetic variants affect nelfinavir pharmacokinetics and virologic response in HIV-1-infected children receiving highly active antiretroviral therapy
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA
    J Acquir Immune Defic Syndr 54:285-9. 2010
    ....
  13. pmc Correlates of perinatal depression in HIV-infected women
    Suad Kapetanovic
    USC Keck School of Medicine, Department of Psychiatry and Behavioral Sciences, HRA Building, Suite 300, Los Angeles, CA 90033, USA
    AIDS Patient Care STDS 23:101-8. 2009
    ..We conclude that pregnant HIV-infected women should be routinely screened for PND. Prospective studies examining the bio-psycho-social markers of PND in HIV-infected women are indicated...
  14. pmc Using social networks to recruit an HIV vaccine preparedness cohort
    Thomas W Valente
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    J Acquir Immune Defic Syndr 52:514-23. 2009
    ..To evaluate a social network approach to develop an adolescent cohort for HIV vaccine preparedness and investigate characteristics that influence recruitment...
  15. pmc Voriconazole pharmacokinetics and pharmacodynamics in children
    Michael Neely
    Division of Pediatric Infectious Diseases, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Clin Infect Dis 50:27-36. 2010
    ..Voriconazole pharmacokinetic and pharmacodynamic data are lacking in children...
  16. pmc Factors associated with prevalent hepatitis C infection among HIV-infected women with no reported history of injection drug use: the Women's Interagency HIV Study (WIHS)
    Toni Frederick
    Maternal Child and Adolescent Center for Infectious Diseases and Virology, University of Southern California, Los Angeles, California, USA
    AIDS Patient Care STDS 23:915-23. 2009
    ..25). For HIV-positive women with no reported history of IDU, sex with an IDU male was independently associated with HCV suggesting that sexual transmission may be an important mode of HCV transmission for these high-risk women...
  17. pmc Factors associated with hepatitis C viremia in a large cohort of HIV-infected and -uninfected women
    Eva A Operskalski
    Maternal Child and Adolescent Center for Infectious Diseases and Virology, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Clin Virol 41:255-63. 2008
    ..Co-infection with hepatitis C virus (HCV) is common among HIV-infected women...
  18. pmc Reduced type 1 and type 2 cytokines in antiviral memory T helper function among women coinfected with HIV and HCV
    Maria C Villacres
    Maternal, Child and Adolescent Center for Infectious Diseases and Virology, Keck School of Medicine, University of Southern California, Los Angeles, CA 99033, USA
    J Clin Immunol 25:134-41. 2005
    ..The overall anti-viral profile was dominated by Th1 cytokines even in coinfected women but both type 1 and type 2 responses were reduced in HIV-infected women and more extensively in women with HCV/HIV coinfection...
  19. pmc Cervical shedding of HIV-1 RNA among women with low levels of viremia while receiving highly active antiretroviral therapy
    Michael N Neely
    Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Acquir Immune Defic Syndr 44:38-42. 2007
    ..Among women with low or undetectable quantities of HIV-1 RNA in plasma, factors associated with genital HIV-1 RNA shedding, including choice of treatment regimen, are poorly characterized...
  20. pmc Presence of hepatitis C virus (HCV) RNA in the genital tracts of HCV/HIV-1-coinfected women
    Marek J Nowicki
    Maternal Child and Adolescent Center for Infectious Diseases and Virology, University of Southern California, Los Angeles 90033, and Mayo Clinic, Scottsdale, USA
    J Infect Dis 192:1557-65. 2005
    ..Hepatitis C virus (HCV)-infected women--in particular, those coinfected with human immunodeficiency virus type 1 (HIV-1)--can transmit infection to their children and sex partners...
  21. ncbi request reprint Management of antiretroviral therapy in neonates, children, and adolescents
    Michael Neely
    Division of Pediatric Infectious Diseases, Keck School of Medicine, University of Southern California, Los Angeles, CA 90041, USA
    Curr HIV/AIDS Rep 1:97-104. 2004
    ....
  22. pmc Safety and immunogenicity of a quadrivalent human papillomavirus (types 6, 11, 16, and 18) vaccine in HIV-infected children 7 to 12 years old
    Myron J Levin
    Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, CO, USA
    J Acquir Immune Defic Syndr 55:197-204. 2010
    ..Quadrivalent human papillomavirus vaccine (QHPV) is > 95% effective in preventing infection with vaccine-type human papillomavirus. The safety and immunogenicity of QHPV are unknown in HIV-infected children...
  23. ncbi request reprint The feasibility of a community-based directly administered antiretroviral therapy program
    Amy Rock Wohl
    HIV Epidemiology Program, Los Angeles County Department of Health Services, Los Angeles, CA 90005, USA
    Clin Infect Dis 38:S388-92. 2004
    ..Effective communication between the DAART staff, the medical providers, and the pharmacy is essential for the successful implementation of this program...
  24. ncbi request reprint Risk of opportunistic infection in the HAART era among HIV-infected Latinos born in the United States compared to Latinos born in Mexico and Central America
    Amy Rock Wohl
    HIV Epidemiology Program, Los Angeles County Department of Health Services, Los Angeles, California 90005, USA
    AIDS Patient Care STDS 17:267-75. 2003
    ....
  25. pmc Incidence of noninfectious conditions in perinatally HIV-infected children and adolescents in the HAART era
    Sharon A Nachman
    Department of Pediatrics, Stony Brook University Medical Center, Stony Brook, NY 11794 8111, USA
    Arch Pediatr Adolesc Med 163:164-71. 2009
    ....
  26. pmc Psychosocial factors and substance use in high-risk youth living with HIV: a multi-site study
    Sylvie Naar-King
    Department of Pediatrics, Wayne State University, Detroit, MI, USA
    AIDS Care 22:475-82. 2010
    ..Social support and psychological distress were associated with TTM constructs. Interventions focusing on improving motivation and self-efficacy for healthy behaviors may reduce substance use in YLH...
  27. pmc Antiretroviral therapies associated with lipoatrophy in HIV-infected women
    Phyllis C Tien
    Department of Medicine, University of California, San Francisco, San Francisco, California, USA
    AIDS Patient Care STDS 21:297-305. 2007
    ..17, -0.26), and arm (-0.23 cm, 95% CI: -0.48, 0.03; p = 0.08). These prospective data suggest that fat loss continues to predominate in HIV-positive women and exposure to didanosine for at least 12 months may further worsen fat loss...
  28. pmc Epidemiology of Pneumocystis colonization in families
    LaShonda Spencer
    Maternal Child and Adolescent Center for Infectious Diseases and Virology, Division of Pulmonary and Critical Care Medicine and Will Rogers Institute Pulmonary Research Center, University of Southern California, Los Angeles, USA
    Clin Infect Dis 46:1237-40. 2008
    ..Using nested polymerase chain reaction of oropharyngeal or nasopharyngeal samples, we detected colonization in 11.4% of HIV-infected adults and in 3.3% of their children, but there was no evidence of clustering...
  29. pmc HIV type 1 and cytomegalovirus coinfection in the female genital tract
    Nell S Lurain
    Rush University Medical Center, Chicago, Illinois 60612, USA
    J Infect Dis 190:619-23. 2004
    ..More than 1 strain of CMV was detected in specimens from 2 patients. These results suggest mechanisms by which CMV coinfection could affect HIV-1 disease progression...
  30. pmc HIV-inducing factor in cervicovaginal secretions is associated with bacterial vaginosis in HIV-1-infected women
    Jonathan A Cohn
    Division of Infectious Diseases, Department of Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Acquir Immune Defic Syndr 39:340-6. 2005
    ..This activity, HIV-inducing factor (HIF), changes when CVL fluid is heated. We sought to confirm a previous observation that HIF was associated with bacterial vaginosis (BV)...

Research Grants9

  1. HCV and Progression of HIV and HAART Response in Women
    Andrea Kovacs; Fiscal Year: 2005
    ..These studies will contribute to our understanding of the interaction of these viruses in a clinical setting and help to delineate populations of women who may benefit from specific antiviral therapies. ..
  2. HCV and HIV Progression in Women on HAART
    Andrea Kovacs; Fiscal Year: 2009
    ..Further, we will longitudinally investigate the relationship of T cell activation/maturation and function with a) HCV quasispecies dynamics and extrahepatic reservoirs and b) HIV disease progression. ..
  3. HCV and HIV Progression in Women on HAART
    Andrea A Kovacs; Fiscal Year: 2010
    ..Further, we will longitudinally investigate the relationship of T cell activation/maturation and function with a) HCV quasispecies dynamics and extrahepatic reservoirs and b) HIV disease progression. ..
  4. HCV and HIV Progression in Women on HAART
    Andrea Kovacs; Fiscal Year: 2009
    ..Further, we will longitudinally investigate the relationship of T cell activation/maturation and function with a) HCV quasispecies dynamics and extrahepatic reservoirs and b) HIV disease progression. ..
  5. HCV and HIV Progression in Women on HAART
    Andrea A Kovacs; Fiscal Year: 2010
    ..Further, we will longitudinally investigate the relationship of T cell activation/maturation and function with a) HCV quasispecies dynamics and extrahepatic reservoirs and b) HIV disease progression. ..