Laura Koutsky

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Chapter 13: Current findings from prophylactic HPV vaccine trials
    Laura A Koutsky
    Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA 98195, USA
    Vaccine 24:S3/114-21. 2006
  2. doi request reprint The epidemiology behind the HPV vaccine discovery
    Laura Koutsky
    Department of Epidemiology, School of Public Health, University of Washington, 155 NE 100th St, Seattle, WA 98125
    Ann Epidemiol 19:239-44. 2009
  3. ncbi request reprint A controlled trial of a human papillomavirus type 16 vaccine
    Laura A Koutsky
    Department of Epidemiology, University of Washington, Seattle, USA
    N Engl J Med 347:1645-51. 2002
  4. ncbi request reprint Cigarette smoking, oncogenic human papillomavirus, Ki-67 antigen, and cervical intraepithelial neoplasia
    Tiffany G Harris
    Department of Epidemiology, University of Washington, Seattle, WA, USA
    Am J Epidemiol 159:834-42. 2004
  5. ncbi request reprint Evaluation of human papillomavirus testing in primary screening for cervical abnormalities: comparison of sensitivity, specificity, and frequency of referral
    Shalini L Kulasingam
    Department of Epidemiology, University of Washington, Seattle, WA, USA
    JAMA 288:1749-57. 2002
  6. ncbi request reprint Acquisition and natural history of human papillomavirus type 16 variant infection among a cohort of female university students
    Long Fu Xi
    Department of Pathology, School of Medicine, University of Washington, Seattle, Washington 98103, USA
    Cancer Epidemiol Biomarkers Prev 11:343-51. 2002
  7. ncbi request reprint Genital human papillomavirus infection: incidence and risk factors in a cohort of female university students
    Rachel L Winer
    Department of Epidemiology, University of Washington, Seattle, WA 98103, USA
    Am J Epidemiol 157:218-26. 2003
  8. ncbi request reprint Characterization of IgA response among women with incident HPV 16 infection
    Takashi Onda
    Program in Cancer Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Virology 312:213-21. 2003
  9. ncbi request reprint Liquid-based Papanicolaou smears without a transformation zone component: should clinicians worry?
    Atar Baer
    Department of Epidemiology, University of Washington, Seattle, Washington 98103, USA
    Obstet Gynecol 99:1053-9. 2002
  10. doi request reprint Persistence of genital human papillomavirus infection in a long-term follow-up study of female university students
    Laura K Sycuro
    Departments of Epidemiology, University of Washington, Seattle, WA 98103, USA
    J Infect Dis 198:971-8. 2008

Research Grants

Detail Information

Publications72

  1. ncbi request reprint Chapter 13: Current findings from prophylactic HPV vaccine trials
    Laura A Koutsky
    Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA 98195, USA
    Vaccine 24:S3/114-21. 2006
    ..Both vaccines have the potential to substantially reduce HPV-related morbidity and mortality. This review focuses on published data from clinical trials of these two vaccines...
  2. doi request reprint The epidemiology behind the HPV vaccine discovery
    Laura Koutsky
    Department of Epidemiology, School of Public Health, University of Washington, 155 NE 100th St, Seattle, WA 98125
    Ann Epidemiol 19:239-44. 2009
    ..Presented below is one epidemiologist's perspective on events that contributed to these scientific achievements...
  3. ncbi request reprint A controlled trial of a human papillomavirus type 16 vaccine
    Laura A Koutsky
    Department of Epidemiology, University of Washington, Seattle, USA
    N Engl J Med 347:1645-51. 2002
    ..Although most infections are benign, some progress to anogenital cancer. A vaccine that reduces the incidence of HPV-16 infection may provide important public health benefits...
  4. ncbi request reprint Cigarette smoking, oncogenic human papillomavirus, Ki-67 antigen, and cervical intraepithelial neoplasia
    Tiffany G Harris
    Department of Epidemiology, University of Washington, Seattle, WA, USA
    Am J Epidemiol 159:834-42. 2004
    ..Since smoking was associated with both CIN1 and >/= CIN2-3, cigarette by-products may affect the early evolution of HPV-related lesions, possibly by increasing the rate of cell turnover...
  5. ncbi request reprint Evaluation of human papillomavirus testing in primary screening for cervical abnormalities: comparison of sensitivity, specificity, and frequency of referral
    Shalini L Kulasingam
    Department of Epidemiology, University of Washington, Seattle, WA, USA
    JAMA 288:1749-57. 2002
    ..Whether HPV DNA testing alone is useful in primary screening remains to be determined...
  6. ncbi request reprint Acquisition and natural history of human papillomavirus type 16 variant infection among a cohort of female university students
    Long Fu Xi
    Department of Pathology, School of Medicine, University of Washington, Seattle, Washington 98103, USA
    Cancer Epidemiol Biomarkers Prev 11:343-51. 2002
    ....
  7. ncbi request reprint Genital human papillomavirus infection: incidence and risk factors in a cohort of female university students
    Rachel L Winer
    Department of Epidemiology, University of Washington, Seattle, WA 98103, USA
    Am J Epidemiol 157:218-26. 2003
    ..The data show that the incidence of HPV associated with acquisition of a new sex partner is high and that nonpenetrative sexual contact is a plausible route of transmission in virgins...
  8. ncbi request reprint Characterization of IgA response among women with incident HPV 16 infection
    Takashi Onda
    Program in Cancer Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Virology 312:213-21. 2003
    ..6 months for serum IgA, whereas approximately 20% of women with serum IgG antibodies reverted within 36 months. Thus, the duration of IgA in cervical secretions and sera was shorter than the duration of serum IgG (P = 0.007 and 0.001)...
  9. ncbi request reprint Liquid-based Papanicolaou smears without a transformation zone component: should clinicians worry?
    Atar Baer
    Department of Epidemiology, University of Washington, Seattle, Washington 98103, USA
    Obstet Gynecol 99:1053-9. 2002
    ..To evaluate whether ThinPrep smears without versus those with a transformation zone component were more likely to have falsely negative cytology findings...
  10. doi request reprint Persistence of genital human papillomavirus infection in a long-term follow-up study of female university students
    Laura K Sycuro
    Departments of Epidemiology, University of Washington, Seattle, WA 98103, USA
    J Infect Dis 198:971-8. 2008
    ..Little is known about the epidemiology of human papillomavirus (HPV) infections that persist for more than a few years...
  11. ncbi request reprint Genital human papillomavirus infection in men: incidence and risk factors in a cohort of university students
    Jeffrey M Partridge
    Department of Epidemiology, University of Washington, Seattle, WA 98103, USA
    J Infect Dis 196:1128-36. 2007
    ..In contrast to the wealth of data on human papillomavirus (HPV) infections in women, much less is known about HPV in men...
  12. doi request reprint Evaluation of an ELISA for p16INK4a as a screening test for cervical cancer
    Akhila Balasubramanian
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Cancer Epidemiol Biomarkers Prev 18:3008-17. 2009
    ..The low sensitivity of cytology and low specificity of human papillomavirus testing prompts searching for more accurate cervical cancer screening strategies. Our goal was to evaluate an ELISA-based test for p16(INK4a)...
  13. pmc Age of diagnosis of squamous cell cervical carcinoma and early sexual experience
    Zoe R Edelstein
    University of Washington, HPV Research Group, Seattle, WA 98103, USA
    Cancer Epidemiol Biomarkers Prev 18:1070-6. 2009
    ....
  14. ncbi request reprint Clinical findings among young women with genital human papillomavirus infection
    Constance Mao
    Department of Obstetrics and Gynecology, University of Washington, Seattle, USA
    Am J Obstet Gynecol 188:677-84. 2003
    ..The purpose of this study was to identify clinical signs and symptoms associated with detection of human papillomavirus (HPV) DNA in the female genital tract...
  15. ncbi request reprint Factors that are associated with parental acceptance of human papillomavirus vaccines: a randomized intervention study of written information about HPV
    Amanda F Dempsey
    Robert Wood Johnson Clinical Scholars Program, University of Washington, Seattle, Washington, USA
    Pediatrics 117:1486-93. 2006
    ....
  16. ncbi request reprint The effect of vaginal speculum lubrication on the rate of unsatisfactory cervical cytology diagnosis
    Anne Marie E Amies
    Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Obstet Gynecol 100:889-92. 2002
    ..We wanted to see if application of water-soluble gel lubricant to the plastic vaginal speculum would change the unsatisfactory cervical cytology diagnosis rate...
  17. pmc Antibody responses in oral fluid after administration of prophylactic human papillomavirus vaccines
    Ali Rowhani-Rahbar
    Department of Epidemiology, University of Washington, Seattle, WA 98125, USA
    J Infect Dis 200:1452-5. 2009
    ..6% (95% confidence interval [CI], 42.0%-57.3%) before and 100% (95% CI, 92.0%-100%) after administration of the quadrivalent vaccine. Oral fluid may have the potential to be used for monitoring of prophylactic HPV vaccines in the future...
  18. ncbi request reprint Risk of cervical intraepithelial neoplasia grade 2 or 3 after loop electrosurgical excision procedure associated with human papillomavirus type 16 variants
    Long Fu Xi
    Department of Pathology, School of Medicine, University of Washington, Seattle, WA 98103, USA
    J Infect Dis 195:1340-4. 2007
    ..1 (95% confidence interval, 1.1-8.9) was associated with HPV16 non-European, compared with European, variants, a finding that is consistent with the variant-related risk of prevalent/incident high-grade CIN...
  19. ncbi request reprint Evaluation of a new p16(INK4A) ELISA test and a high-risk HPV DNA test for cervical cancer screening: results from proof-of-concept study
    Constance Mao
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98104 2499, USA
    Int J Cancer 120:2435-8. 2007
    ..These findings support proceeding with a larger study with samples from a population of women presenting for routine cytology screening...
  20. ncbi request reprint Risk for high-grade cervical intraepithelial neoplasia associated with variants of human papillomavirus types 16 and 18
    Long Fu Xi
    Department of Pathology, School of Medicine, University of Washington, Seattle, Washington 98103, USA
    Cancer Epidemiol Biomarkers Prev 16:4-10. 2007
    ..Although the variant lineages of human papillomavirus (HPV) types 16 and 18 are well established, their individual associations with high-grade cervical intraepithelial neoplasia (CIN) have not been extensively evaluated...
  21. ncbi request reprint Concordance of self-collected and clinician-collected swab samples for detecting human papillomavirus DNA in women 18 to 32 years of age
    Rachel L Winer
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Sex Transm Dis 34:371-7. 2007
    ..The objective of this study was to determine whether self- and clinician-collected samples are comparable for human papillomavirus (HPV) detection...
  22. pmc Human papillomavirus type 16 variants in paired enrollment and follow-up cervical samples: implications for a proper understanding of type-specific persistent infections
    Long Fu Xi
    Department of Pathology, School of Medicine, University of Washington, Seattle 98104, USA
    J Infect Dis 202:1667-70. 2010
    ..11). These results suggest the possibility that rare misclassification of transient infections as persistent infections occurs in natural history studies of type-specific HPV infections...
  23. pmc Longer term efficacy of a prophylactic monovalent human papillomavirus type 16 vaccine
    Ali Rowhani-Rahbar
    Department of Epidemiology, University of Washington, Seattle, WA 98125, USA
    Vaccine 27:5612-9. 2009
    ..The results suggest that this monovalent HPV-16 vaccine remains efficacious through 8.5 years after its administration...
  24. pmc Detection of genital HPV types in fingertip samples from newly sexually active female university students
    Rachel L Winer
    University of Washington HPV Research Group, Box 359933, 325 9th Avenue, Seattle, WA 98104, USA
    Cancer Epidemiol Biomarkers Prev 19:1682-5. 2010
    ..The study objectives were to determine the presence of genital HPV types in fingertip samples and the agreement between fingertip and genital samples for detecting HPV...
  25. pmc Risk of female human papillomavirus acquisition associated with first male sex partner
    Rachel L Winer
    Department of Epidemiology, University of Washington, Seattle, WA 98103, USA
    J Infect Dis 197:279-82. 2008
    ..6%-38.6%) and increased to almost 50% by 3 years. The risk was increased when the first male partner was sexually experienced. Our results indicate a high risk of HPV infection in young women who have had just 1 male sex partner...
  26. doi request reprint Evaluation of primary cervical cancer screening with an oncogenic human papillomavirus DNA test and cervical cytologic findings among women who attended family planning clinics in the United States
    Janet G Baseman
    Department of Epidemiology, University of Washington, Seattle, WA, USA
    Am J Obstet Gynecol 199:26.e1-8. 2008
    ....
  27. pmc Effect of cervical cytologic status on the association between human papillomavirus type 16 DNA load and the risk of cervical intraepithelial neoplasia grade 3
    Long Fu Xi
    Department of Pathology, School of Medicine, University of Washington, Seattle, Washington 98103, USA
    J Infect Dis 198:324-31. 2008
    ....
  28. pmc Relationship between cigarette smoking and human papilloma virus types 16 and 18 DNA load
    Long Fu Xi
    Department of Pathology, University of Washington, Seattle, USA
    Cancer Epidemiol Biomarkers Prev 18:3490-6. 2009
    ..Although cigarette smoking has been associated with increased human papilloma virus (HPV) detection, its impact on HPV DNA load is unknown...
  29. pmc Development and evaluation of a liquid bead microarray assay for genotyping genital human papillomaviruses
    Qinghua Feng
    Department of Pathology, University of Washington, School of Public Health and Community Medicine, Seattle, Washington 98109, USA
    J Clin Microbiol 47:547-53. 2009
    ..The repeat test reproducibility for 100 samples was 99.1% (kappa=0.92; 95% CI, 0.90 to 0.95). We conclude that the new LBMA assay will be useful for clinical and epidemiological research...
  30. pmc Human papillomavirus type 18 DNA load and 2-year cumulative diagnoses of cervical intraepithelial neoplasia grades 2-3
    Long Fu Xi
    Department of Pathology, School of Medicine, University of Washington, 1914 North 34th St, Suite 300, Seattle, WA 98103, USA
    J Natl Cancer Inst 101:153-61. 2009
    ..The clinical relevance of the amount of human papillomavirus type 18 (HPV18) DNA in cervical tissue (ie, HPV18 DNA load) is unknown...
  31. pmc Quantitative human papillomavirus 16 and 18 levels in incident infections and cervical lesion development
    Rachel L Winer
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    J Med Virol 81:713-21. 2009
    ..05, 95% CI = 1.09-92.56) and increased HPV DNA (VLR = 16.80, 95% CI = 1.46-193.01). In newly detected HPV-16 infections, increasing levels of E7 mRNA appear to be associated with an increased risk of developing cervical pre-cancer...
  32. pmc Human Papillomavirus (HPV) type 16 and type 18 DNA Loads at Baseline and Persistence of Type-Specific Infection during a 2-year follow-up
    Long Fu Xi
    Department of Pathology, School of Medicine, University of Washington, Seattle, USA
    J Infect Dis 200:1789-97. 2009
    ..Studies of viral load-associated persistence of human papillomavirus (HPV) infection are rare, with inconsistent results reported...
  33. pmc Depot-medroxyprogesterone acetate and combined oral contraceptive use and cervical neoplasia among women with oncogenic human papillomavirus infection
    Tiffany G Harris
    Department of Epidemiology, University of Washington School of Public Health and Community Medicine, Seattle, WA, USA
    Am J Obstet Gynecol 200:489.e1-8. 2009
    ..The objective of the study was to examine the relationship of depot-medroxyprogesterone acetate (DMPA) and combined oral contraceptive (COC) use with cervical intraepithelial neoplasia (CIN)...
  34. ncbi request reprint Condom use and the risk of genital human papillomavirus infection in young women
    Rachel L Winer
    Department of Epidemiology, University of Washington, Seattle, USA
    N Engl J Med 354:2645-54. 2006
    ....
  35. ncbi request reprint Characterization of vaginal flora and bacterial vaginosis in women who have sex with women
    Jeanne M Marrazzo
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Infect Dis 185:1307-13. 2002
    ..These data support the hypothesis that sexual exchange of vaginal secretions is a possible mechanism for acquisition of BV...
  36. ncbi request reprint The epidemiology of human papillomavirus infections
    Janet G Baseman
    UW HPV Research Group, Lake Union Place, Suite 300, 1914 N 34th Street, Seattle, WA 98103, USA
    J Clin Virol 32:S16-24. 2005
    ..Finally, we discuss strategies for preventing HPV infection...
  37. ncbi request reprint Evaluation of genital sites and sampling techniques for detection of human papillomavirus DNA in men
    Bethany A Weaver
    Center for AIDS and STD Research, Department of Medicine, University of Washington, Harborview Medical Center, 325 9th Avenue, Box 359931, Seattle, WA 98104 USA
    J Infect Dis 189:677-85. 2004
    ..The HPV prevalence was similar for circumcised and uncircumcised men. Testing multiple sites increased the number of men for whom HPV DNA was detected...
  38. ncbi request reprint Should liquid-based cytology be repeated at the time of colposcopy?
    Constance Mao
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA
    J Low Genit Tract Dis 9:82-8. 2005
    ..To evaluate the usefulness of repeated liquid cytology at the time of colposcopy...
  39. ncbi request reprint p16(INK4a) expression correlates with degree of cervical neoplasia: a comparison with Ki-67 expression and detection of high-risk HPV types
    S Nicholas Agoff
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    Mod Pathol 16:665-73. 2003
    ..Although expression of p16(INK4a) in endometrial epithelium may be problematic in terms of screening, the potential of p16(INK4a) as a screening test warrants investigation...
  40. ncbi request reprint Do condoms prevent genital HPV infection, external genital warts, or cervical neoplasia? A meta-analysis
    Lisa E Manhart
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Sex Transm Dis 29:725-35. 2002
    ..Although condoms most likely prevent HIV infection, evidence of their effectiveness against other sexually transmitted diseases is mixed...
  41. ncbi request reprint Human papillomavirus type 16 and 18 variants: race-related distribution and persistence
    Long Fu Xi
    Department of Pathology, School of Medicine, University of Washington, Seattle, WA, USA
    J Natl Cancer Inst 98:1045-52. 2006
    ....
  42. ncbi request reprint Human papillomavirus infection among sexually active young women in the United States: Implications for developing a vaccination strategy
    Lisa E Manhart
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Sex Transm Dis 33:502-8. 2006
    ..Population-level data on prevalence and distribution of human papillomavirus (HPV) types in the United States are necessary to guide optimal vaccination strategies...
  43. ncbi request reprint Development and duration of human papillomavirus lesions, after initial infection
    Rachel L Winer
    Department of Epidemiology, University of Washington, Seattle, Washington 98103, USA
    J Infect Dis 191:731-8. 2005
    ..To determine the potential value of human papillomavirus (HPV) vaccines, information concerning the incidence and duration of clinically important lesions is needed...
  44. ncbi request reprint Comparison of incident cervical and vulvar/vaginal human papillomavirus infections in newly sexually active young women
    Rachel L Winer
    Department of Epidemiology, University of Washington, Seattle 98103, USA
    J Infect Dis 199:815-8. 2009
    ..03). Site-by-species differences were not statistically significant. Our results suggest that low- or undetermined-risk HPV types preferentially infect vaginal epithelium...
  45. pmc Evaluation of transported dry and wet cervical exfoliated samples for detection of human papillomavirus infection
    Qinghua Feng
    Department of Pathology, School of Medicine, University of Washington, 815 Mercer St, UW Medicine Box 358050, Seattle, WA 98109, USA
    J Clin Microbiol 48:3068-72. 2010
    ..6 times lower than those in matched STM samples. We concluded that exfoliated cervical cells could be collected as dry swab samples for HPV detection...
  46. ncbi request reprint Efficacy of human papillomavirus-16 vaccine to prevent cervical intraepithelial neoplasia: a randomized controlled trial
    Constance Mao
    Department of Obstetrics and Gynecology and Epidemiology, University of Washington, Seattle, Washington 98104 2499, USA
    Obstet Gynecol 107:18-27. 2006
    ..Whether protection lasts longer than 18 months and, thus, impacts rates of cervical intraepithelial neoplasia (CIN) 2-3 has not yet been established. We present results from an HPV16 L1 VLP vaccine trial through 48 months...
  47. ncbi request reprint The theoretical population-level impact of a prophylactic human papilloma virus vaccine
    James P Hughes
    Department of Biostatistics, University of Washington, Seattle, WA 98195, USA
    Epidemiology 13:631-9. 2002
    ..The ongoing development of a vaccine against human papillomavirus (HPV) raises important questions about the impact of various vaccination strategies...
  48. pmc Humoral immune response recognizes a complex set of epitopes on human papillomavirus type 6 l1 capsomers
    Johnnie J Orozco
    Program in Cancer Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Virol 79:9503-14. 2005
    ..Reactivity in two sera was not eliminated even with all six regions swapped. The patterns of epitope recognition did not change over time in women whose sera were examined 9 years after their first-seropositive visit...
  49. pmc Sequence variation of human papillomavirus type 16 and measurement of viral integration by quantitative PCR
    Mingjun Jiang
    Department of Pathology, School of Medicine, University of Washington, Seattle, Washington, USA
    J Clin Microbiol 47:521-6. 2009
    ....
  50. ncbi request reprint Genital human papillomavirus infection in men
    Jeffrey M Partridge
    Department of Epidemiology, University of Washington HPV Research Group, University of Washington, Seattle, WA 98103, USA
    Lancet Infect Dis 6:21-31. 2006
    ....
  51. pmc Accuracy and cost-effectiveness of cervical cancer screening by high-risk human papillomavirus DNA testing of self-collected vaginal samples
    Akhila Balasubramanian
    Department of Epidemiology, University of Washington, Seattle, WA, USA
    J Low Genit Tract Dis 14:185-95. 2010
    ..Estimate the accuracy and cost-effectiveness of cervical cancer screening strategies based on high-risk human papillomavirus (HPV) DNA testing of self-collected vaginal samples...
  52. doi request reprint Development of genital warts after incident detection of human papillomavirus infection in young men
    Yuzo Arima
    Departments of 1Epidemiology, and 6Harborview Medical Center, University of Washington, Seattle, WA 98104, USA
    J Infect Dis 202:1181-4. 2010
    ..7% (95% CI, 0.2%-2.8%) among 331 men who tested negative for HPV. Our results suggest that genital warts are common after HPV-6 or HPV-11 infection in young men...
  53. pmc Identification of human papillomavirus type 16 L1 surface loops required for neutralization by human sera
    Joseph J Carter
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N MSC 015, P O Box 19024, Seattle, WA 98109 1024, USA
    J Virol 80:4664-72. 2006
    ..These observations are consistent with the existence of multiple neutralizing epitopes on the HPV virion surface...
  54. ncbi request reprint Obtaining sensitive data through the Web: an example of design and methods
    Atar Baer
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA, USA
    Epidemiology 13:640-5. 2002
    ..We also discuss compliance, as well as methods for assuring appropriate security, confidentiality and privacy...
  55. ncbi request reprint Re: Specific antibody levels at the cervix during the menstrual cycle of women vaccinated with human papillomavirus 16 virus-like particles
    Eliav Barr
    J Natl Cancer Inst 96:412-3; author reply 413-4. 2004
  56. ncbi request reprint Comparison of oral fluid and serum ELISAs in the determination of IgG response to natural human papillomavirus infection in university women
    Farrel J Buchinsky
    Center for Genomic Sciences, Allegheny Singer Research Institute, 320 E North Avenue, Pittsburgh, PA 15212 4772, USA
    J Clin Virol 35:450-3. 2006
    ..Venipuncture (phlebotomy) is an obstacle to subject recruitment and ongoing participation in cohort studies investigating human papillomavirus (HPV) infection. Anti-HPV antibodies are not only detected in serum but also in oral fluid...
  57. ncbi request reprint Delivering reassurance to parents: perinatal human papillomavirus transmission is rare
    Rachel L Winer
    Sex Transm Dis 31:63-4. 2004
  58. ncbi request reprint Early assessment of the efficacy of a human papillomavirus type 16 L1 virus-like particle vaccine
    Darron R Brown
    Department of Medicine, Indiana University School of Medicine, Emerson Hall Room 435, 545 Barnhill Drive, Indianapolis 46022, USA
    Vaccine 22:2936-42. 2004
    ..These results support the institution of larger efficacy trials for HPV L1 VLP vaccines...
  59. ncbi request reprint Dose-ranging studies of the safety and immunogenicity of human papillomavirus Type 11 and Type 16 virus-like particle candidate vaccines in young healthy women
    Kenneth H Fife
    Department of Medicine, Indiana University School of Medicine, Indianapolis, USA
    Vaccine 22:2943-52. 2004
    ..Antibody to HPV11 and 16 was still present at Month 36 in 96.8 and 93.5% of vaccinees, respectively. Both vaccines were well tolerated and were associated with only mild to moderate injection-site reactions...
  60. ncbi request reprint Smokers at higher risk for undetected antibody for oncogenic human papillomavirus type 16 infection
    Dorothy J Wiley
    School of Nursing, University of California at Los Angeles, Los Angeles, CA 90095 6919, USA
    Cancer Epidemiol Biomarkers Prev 15:915-20. 2006
    ..Main Outcome Measure: HPV16-L1 antibody (anti-HPV16 antibody) detected from serum using RIA or ELISA...
  61. ncbi request reprint Potential impact of human papillomavirus vaccines on public STD clinic workloads and on opportunities to diagnose and treat other sexually transmitted diseases
    Amanda F Dempsey
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Sex Transm Dis 34:503-7. 2007
    ..Eradicating genital warts through HPV immunization could decrease STD clinic utilization but may result in missed opportunities to diagnose other STDs...
  62. pmc Noninferiority of antibody response to human papillomavirus type 16 in subjects vaccinated with monovalent and quadrivalent L1 virus-like particle vaccines
    Suzanne M Garland
    Microbiology and Infectious Diseases Department, Royal Women s Hospital, Carlton, University of Melbourne, Melbourne, Victoria, Australia
    Clin Vaccine Immunol 14:792-5. 2007
    ....
  63. ncbi request reprint Quadrivalent vaccine against human papillomavirus to prevent anogenital diseases
    Suzanne M Garland
    Microbiology and Infectious Diseases Department, Royal Women s Hospital, and the University of Melbourne, Melbourne, Australia
    N Engl J Med 356:1928-43. 2007
    ..A phase 3 trial was conducted to evaluate the efficacy of a prophylactic quadrivalent vaccine in preventing anogenital diseases associated with human papillomavirus (HPV) types 6, 11, 16, and 18...
  64. ncbi request reprint Efficacy of a quadrivalent prophylactic human papillomavirus (types 6, 11, 16, and 18) L1 virus-like-particle vaccine against high-grade vulval and vaginal lesions: a combined analysis of three randomised clinical trials
    Elmar A Joura
    Department of Gynecology and Obstetrics, Medical University of Vienna, Vienna, Austria
    Lancet 369:1693-702. 2007
    ..Our aim was to do a combined analysis of three randomised clinical trials to assess the effect of a prophylactic quadrivalent HPV vaccine on the incidence of these diseases...
  65. ncbi request reprint Immunogenicity and reactogenicity of a novel vaccine for human papillomavirus 16: a 2-year randomized controlled clinical trial
    Gregory A Poland
    Division of General Internal Medicine, Mayo Vaccine Research Group, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 80:601-10. 2005
    ..To evaluate the immunogenicity, reactogenicity, and tolerability of a prototype human papillomavirus (HPV) 16 viruslike particle (VLP) vaccine directed against the L1 capsid protein...
  66. ncbi request reprint Human papillomavirus through the ages
    Rachel L Winer
    J Infect Dis 191:1787-9. 2005
  67. doi request reprint Using risk factors to predict human papillomavirus infection: implications for targeted vaccination strategies in young adult women
    Amanda F Dempsey
    Child Health Evaluation and Research Unit, Department of Pediatrics, University of Michigan, USA
    Vaccine 26:1111-7. 2008
    ..Our results support implementation of comprehensive HPV vaccination strategies...
  68. ncbi request reprint Human papillomavirus infection and cervical cytology in women screened for cervical cancer in the United States, 2003-2005
    S Deblina Datta
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Ann Intern Med 148:493-500. 2008
    ..Millions of women in the United States receive cervical screening in sexually transmitted disease (STD), family planning, and primary care clinical settings...
  69. ncbi request reprint Prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a randomised double-blind placebo-controlled multicentre phase II efficacy trial
    Luisa L Villa
    Department of Virology, Ludwig Institute for Cancer Research, Sao Paulo, Brazil
    Lancet Oncol 6:271-8. 2005
    ....
  70. ncbi request reprint Immunologic responses following administration of a vaccine targeting human papillomavirus Types 6, 11, 16, and 18
    Luisa L Villa
    Department of Virology, Ludwig Institute for Cancer Research, R Prof Antonio Prudente 109, 4th Floor, 01509 010 Sao Paulo, SP, Brazil
    Vaccine 24:5571-83. 2006
    ..Following an initial, similar sized decline, anti-HPV responses plateaued and remained stable through end-of-study (3.0 years). No vaccine-related serious adverse experiences were reported...
  71. doi request reprint National burden of genital warts: a first step in defining the problem
    Amanda F Dempsey
    Sex Transm Dis 35:361-2. 2008
  72. ncbi request reprint Men's perceptions and knowledge of human papillomavirus (HPV) infection and cervical cancer
    Tara S McPartland
    Yale University School of Medicine, Department of Pediatrics, New Haven, Connecticut 06520, USA
    J Am Coll Health 53:225-30. 2005
    ..The authors concluded that it is important to include men in HPV education and prevention efforts, especially within the context that HPV may lead to cervical cancer in female partners...

Research Grants38

  1. ACQUISITION & NATURAL HISTORY OF GENITAL HPV INFECTIONS
    Laura Koutsky; Fiscal Year: 2004
    ..Additionally, these data will provide investigators working on HPV vaccine development with information that is needed to guide the selection of appropriate target populations, outcome measures, and immunization strategies. ..
  2. ETIOLOGY AND NATURAL HISTORY OF CERVICAL NEOPLASIA
    Laura Koutsky; Fiscal Year: 2004
    ..The overall goal of this research is development of accurate and cost-effective cervical cancer prevention strategies that will improve the health of diverse populations. ..
  3. RNA Analysis of HPV Viral Loads
    Laura Koutsky; Fiscal Year: 2005
    ....
  4. Natural History of HPV Infections in Men
    Laura Koutsky; Fiscal Year: 2005
    ..Our long-term goal is development of cost-effective approaches to the prevention of HPV-related cancers. ..
  5. Acquisition and Natural History of Genital HPV Infection
    Laura Koutsky; Fiscal Year: 2005
    ..In summary, the long-range goal of this project is to improve the effectiveness of both vaccine-based and behavioral strategies for preventing HPV infection. ..
  6. ETIOLOGY AND NATURAL HISTORY OF CERVICAL NEOPLASIA
    Laura Koutsky; Fiscal Year: 2005
    ..Clear public health benefits will accrue from development of more accurate and less costly screening tests. ..
  7. Natural History of HPV Infections in Men
    Laura Koutsky; Fiscal Year: 2006
    ..Our long-term goal is development of cost-effective approaches to the prevention of HPV-related cancers. ..
  8. ETIOLOGY AND NATURAL HISTORY OF CERVICAL NEOPLASIA
    Laura Koutsky; Fiscal Year: 2006
    ..Clear public health benefits will accrue from development of more accurate and less costly screening tests. ..
  9. Acquisition and Natural History of Genital HPV Infection
    Laura Koutsky; Fiscal Year: 2006
    ..In summary, the long-range goal of this project is to improve the effectiveness of both vaccine-based and behavioral strategies for preventing HPV infection. ..
  10. Acquisition and Natural History of Genital HPV Infection
    Laura Koutsky; Fiscal Year: 2007
    ..In summary, the long-range goal of this project is to improve the effectiveness of both vaccine-based and behavioral strategies for preventing HPV infection. ..
  11. Natural History of HPV Infections in Men
    Laura Koutsky; Fiscal Year: 2007
    ..Our long-term goal is development of cost-effective approaches to the prevention of HPV-related cancers. ..
  12. ETIOLOGY AND NATURAL HISTORY OF CERVICAL NEOPLASIA
    Laura Koutsky; Fiscal Year: 2007
    ..Clear public health benefits will accrue from development of more accurate and less costly screening tests. ..
  13. Natural History of HPV Infections in Men
    Laura Koutsky; Fiscal Year: 2009
    ..Our long-term goal is development of cost-effective approaches to the prevention of HPV-related cancers. ..
  14. Acquisition and Natural History of Genital HPV Infection
    Laura Koutsky; Fiscal Year: 2009
    ..In summary, the long-range goal of this project is to improve the effectiveness of both vaccine-based and behavioral strategies for preventing HPV infection. ..
  15. ETIOLOGY AND NATURAL HISTORY OF CERVICAL NEOPLASIA
    Laura Koutsky; Fiscal Year: 2004
    ..Clear public health benefits will accrue from development of more accurate and less costly screening tests. ..
  16. ACQUISITION & NATURAL HISTORY OF GENITAL HPV INFECTIONS
    Laura Koutsky; Fiscal Year: 2003
    ..Additionally, these data will provide investigators working on HPV vaccine development with information that is needed to guide the selection of appropriate target populations, outcome measures, and immunization strategies. ..
  17. ETIOLOGY AND NATURAL HISTORY OF CERVICAL NEOPLASIA
    Laura Koutsky; Fiscal Year: 1999
    ..The proposed studies are intended to contribute to understanding of the pathogenesis of cervical caner and to have important public health implications for cervical cancer control. ..
  18. ACQUISITION & NATURAL HISTORY OF GENITAL HPV INFECTIONS
    Laura Koutsky; Fiscal Year: 1999
    ..g., immunization, condoms, or sexual behavior change) and secondary prevention (e.g., screening and treatment) of cervical cancer and other HPV associated epithelial lesions. ..
  19. ETIOLOGY AND NATURAL HISTORY OF CERVICAL NEOPLASIA
    Laura Koutsky; Fiscal Year: 1993
    ....
  20. ACQUISITION & NATURAL HISTORY OF GENITAL HPV INFECTIONS
    Laura Koutsky; Fiscal Year: 2000
    ..Additionally, these data will provide investigators working on HPV vaccine development with information that is needed to guide the selection of appropriate target populations, outcome measures, and immunization strategies. ..
  21. ETIOLOGY AND NATURAL HISTORY OF CERVICAL NEOPLASIA
    Laura Koutsky; Fiscal Year: 2000
    ..The proposed studies are intended to contribute to understanding of the pathogenesis of cervical caner and to have important public health implications for cervical cancer control. ..
  22. ETIOLOGY AND NATURAL HISTORY OF CERVICAL NEOPLASIA
    Laura Koutsky; Fiscal Year: 2001
    ..The proposed studies are intended to contribute to understanding of the pathogenesis of cervical caner and to have important public health implications for cervical cancer control. ..
  23. ACQUISITION & NATURAL HISTORY OF GENITAL HPV INFECTIONS
    Laura Koutsky; Fiscal Year: 2001
    ..Additionally, these data will provide investigators working on HPV vaccine development with information that is needed to guide the selection of appropriate target populations, outcome measures, and immunization strategies. ..
  24. ACQUISITION & NATURAL HISTORY OF GENITAL HPV INFECTIONS
    Laura Koutsky; Fiscal Year: 2002
    ..Additionally, these data will provide investigators working on HPV vaccine development with information that is needed to guide the selection of appropriate target populations, outcome measures, and immunization strategies. ..
  25. HPV Testing--Self-Collected Samples for Cervical Cancer
    Laura Koutsky; Fiscal Year: 2003
    ....
  26. ETIOLOGY AND NATURAL HISTORY OF CERVICAL NEOPLASIA
    Laura Koutsky; Fiscal Year: 2003
    ..Clear public health benefits will accrue from development of more accurate and less costly screening tests. ..
  27. Natural History of HPV Infections in Men
    Laura Koutsky; Fiscal Year: 2009
    ..Our long-term goal is development of cost-effective approaches to the prevention of HPV-related cancers. ..