CATHERINE KOTZ

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Brain orexin promotes obesity resistance
    CATHERINE KOTZ
    Department of Veterans Affairs, GRECC and Research Service, Minneapolis, Minnesota 55417, USA
    Ann N Y Acad Sci 1264:72-86. 2012
  2. ncbi request reprint Neuroregulation of nonexercise activity thermogenesis and obesity resistance
    Catherine M Kotz
    Veterans Affairs Medical Center, GRECC 11G One Veterans Drive, Minneapolis, MN 55417, USA
    Am J Physiol Regul Integr Comp Physiol 294:R699-710. 2008
  3. ncbi request reprint Orexin A mediation of time spent moving in rats: neural mechanisms
    C M Kotz
    Veterans Affairs Medical Center, Geriatric Research, Education and Clinical Care 11G, One Veterans Drive, Minneapolis, MN 55417, USA
    Neuroscience 142:29-36. 2006
  4. ncbi request reprint Integration of feeding and spontaneous physical activity: role for orexin
    Catherine M Kotz
    Veterans Affairs Medical Center, One Veterans Drive, GRECC 11G, Minneapolis, MN 55417, USA
    Physiol Behav 88:294-301. 2006
  5. ncbi request reprint Urocortin in the hypothalamic PVN increases leptin and affects uncoupling proteins-1 and -3 in rats
    Catherine M Kotz
    Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    Am J Physiol Regul Integr Comp Physiol 282:R546-51. 2002
  6. ncbi request reprint Diminished feeding responsiveness to orexin A (hypocretin 1) in aged rats is accompanied by decreased neuronal activation
    Catherine M Kotz
    Veterans Affairs Medical Center, GRECC 11G, One Veterans Drive, Minneapolis, MN 55417, USA
    Am J Physiol Regul Integr Comp Physiol 289:R359-R366. 2005
  7. ncbi request reprint Weight and body mass index in Parkinson's disease patients after deep brain stimulation surgery
    Paul J Tuite
    Department of Neurology, Fairview University Medical Center, University of Minnesota, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Parkinsonism Relat Disord 11:247-52. 2005
  8. ncbi request reprint Age-related changes in brain proDynorphin gene expression in the rat
    Catherine M Kotz
    Veterans Affairs Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA
    Neurobiol Aging 25:1343-7. 2004
  9. ncbi request reprint Feeding and activity induced by orexin A in the lateral hypothalamus in rats
    Catherine M Kotz
    Veterans Affairs Medical Center, One Veterans Drive, Research Service 151, Minneapolis, MN 55417, USA
    Regul Pept 104:27-32. 2002
  10. ncbi request reprint Urocortin in the lateral septal area modulates feeding induced by orexin A in the lateral hypothalamus
    Chuanfeng Wang
    Veterans Affairs Medical Center, Geriatric, Research, Education and Clinical Center and Research Service, Minneapolis 55417, USA
    Am J Physiol Regul Integr Comp Physiol 283:R358-67. 2002

Research Grants

  1. Spontaneous physical activity in obesity
    Catherine M Kotz; Fiscal Year: 2010
  2. HYPOTHALAMIC HYPOCRETIN PATHWAYS MODULATING FEEDING
    CATHERINE KOTZ; Fiscal Year: 2004
  3. Spontaneous physical activity in obesity
    Catherine M Kotz; Fiscal Year: 2010

Collaborators

Detail Information

Publications34

  1. pmc Brain orexin promotes obesity resistance
    CATHERINE KOTZ
    Department of Veterans Affairs, GRECC and Research Service, Minneapolis, Minnesota 55417, USA
    Ann N Y Acad Sci 1264:72-86. 2012
    ..Greater activation of this SPA network leads to a lower propensity for fat mass gain and therefore may be an attractive target for obesity prevention and therapy...
  2. ncbi request reprint Neuroregulation of nonexercise activity thermogenesis and obesity resistance
    Catherine M Kotz
    Veterans Affairs Medical Center, GRECC 11G One Veterans Drive, Minneapolis, MN 55417, USA
    Am J Physiol Regul Integr Comp Physiol 294:R699-710. 2008
    ....
  3. ncbi request reprint Orexin A mediation of time spent moving in rats: neural mechanisms
    C M Kotz
    Veterans Affairs Medical Center, Geriatric Research, Education and Clinical Care 11G, One Veterans Drive, Minneapolis, MN 55417, USA
    Neuroscience 142:29-36. 2006
    ..This potential for conferring physical activity stimulation may be useful for inducing shifts in time spent moving, which has important implications for obesity...
  4. ncbi request reprint Integration of feeding and spontaneous physical activity: role for orexin
    Catherine M Kotz
    Veterans Affairs Medical Center, One Veterans Drive, GRECC 11G, Minneapolis, MN 55417, USA
    Physiol Behav 88:294-301. 2006
    ..This review focuses on how hypothalamic orexins participate in both feeding and spontaneous physical activity, and provides potential models for the integration of signals important to both...
  5. ncbi request reprint Urocortin in the hypothalamic PVN increases leptin and affects uncoupling proteins-1 and -3 in rats
    Catherine M Kotz
    Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    Am J Physiol Regul Integr Comp Physiol 282:R546-51. 2002
    ....
  6. ncbi request reprint Diminished feeding responsiveness to orexin A (hypocretin 1) in aged rats is accompanied by decreased neuronal activation
    Catherine M Kotz
    Veterans Affairs Medical Center, GRECC 11G, One Veterans Drive, Minneapolis, MN 55417, USA
    Am J Physiol Regul Integr Comp Physiol 289:R359-R366. 2005
    ..These data suggest that delayed and diminished feeding responses in old animals may be due to ineffective neural signaling and implicate the orexin A network as one feeding system affected by aging...
  7. ncbi request reprint Weight and body mass index in Parkinson's disease patients after deep brain stimulation surgery
    Paul J Tuite
    Department of Neurology, Fairview University Medical Center, University of Minnesota, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Parkinsonism Relat Disord 11:247-52. 2005
    ..This weight gain may be associated with decreased energy expenditure due to subsidence of chronic tremor. The magnitude of gain underscores the need for proactive management of body weight in PD patients undergoing DBS...
  8. ncbi request reprint Age-related changes in brain proDynorphin gene expression in the rat
    Catherine M Kotz
    Veterans Affairs Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA
    Neurobiol Aging 25:1343-7. 2004
    ..These data suggest an age-related decrease in the synthesis of dynorphin in two brain regions strongly associated with feeding behavior, and an increase in dynorphin synthesis in a brain region associated with learning and memory...
  9. ncbi request reprint Feeding and activity induced by orexin A in the lateral hypothalamus in rats
    Catherine M Kotz
    Veterans Affairs Medical Center, One Veterans Drive, Research Service 151, Minneapolis, MN 55417, USA
    Regul Pept 104:27-32. 2002
    ..These data show that LH orexin A stimulation of feeding is not always coincident with increased activity, suggesting that feeding induced by LH-injected orexin A is not consequent to enhanced arousal...
  10. ncbi request reprint Urocortin in the lateral septal area modulates feeding induced by orexin A in the lateral hypothalamus
    Chuanfeng Wang
    Veterans Affairs Medical Center, Geriatric, Research, Education and Clinical Center and Research Service, Minneapolis 55417, USA
    Am J Physiol Regul Integr Comp Physiol 283:R358-67. 2002
    ..These data define the LSi as an important site for UCN-induced anorexia and indicate that LSi UCN may influence orexin A feeding signals in the LH...
  11. ncbi request reprint Orexin A (hypocretin 1) injected into hypothalamic paraventricular nucleus and spontaneous physical activity in rats
    Kohji Kiwaki
    Endocrine Research Unit, Joseph 5 194, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN 55905, USA
    Am J Physiol Endocrinol Metab 286:E551-9. 2004
    ..Thus orexin A can act in PVN to increase nonfeeding-associated physical activity, suggesting that this neuropeptide might be a mediator of NEAT...
  12. ncbi request reprint Central orexin sensitivity, physical activity, and obesity in diet-induced obese and diet-resistant rats
    Colleen M Novak
    Endocrine Research Unit, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
    Am J Physiol Endocrinol Metab 290:E396-403. 2006
    ..A putative mechanism for changes in NEAT that accompany obesity is a decreased sensitivity to the NEAT-activating effects of neuropeptides such as orexin...
  13. ncbi request reprint Role of nonexercise activity thermogenesis (NEAT) in obesity
    Catherine M Kotz
    Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
    Minn Med 88:54-7. 2005
    ..This article reviews the evidence for NEAT and the impact of NEAT on obesity...
  14. ncbi request reprint Caloric restriction and physical activity in zebrafish (Danio rerio)
    Colleen M Novak
    Endocrine Research Unit, Mayo Clinic and Mayo Foundation, St Mary s Hospital, Rochester, MN 55905, USA
    Neurosci Lett 383:99-104. 2005
    ..Thus, the association between negative energy balance and reductions in PA occurs across genera in biology and is associated with predictable neurological changes in brain gene expression...
  15. ncbi request reprint Peptides that regulate food intake: regional, metabolic, and circadian specificity of lateral hypothalamic orexin A feeding stimulation
    Andrew J Thorpe
    Veterans Affairs Medical Center and Minnesota Obesity Center, Minneapolis 55417, USA
    Am J Physiol Regul Integr Comp Physiol 284:R1409-17. 2003
    ..These data suggest that the rostral LH is the only region of the LH sensitive to the injection of OX-A, and the metabolic status of the animal at the time of injection may influence the feeding response to OX-A...
  16. ncbi request reprint Neural basis of orexigenic effects of ghrelin acting within lateral hypothalamus
    Pawel K Olszewski
    Veterans Affairs Medical Center, Research Service 151, Minneapolis, MN 55417, USA
    Peptides 24:597-602. 2003
    ..Also, LH ghrelin induced Fos IR in LH orexin neurons. We conclude that the LH, as part of larger central circuitry, integrates orexigenic properties of ghrelin...
  17. pmc Predisposition to late-onset obesity in GIRK4 knockout mice
    Cydne A Perry
    Department of Pharmacology, University of Minnesota, 6 120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 105:8148-53. 2008
    ..These data implicate GIRK4-containing channels in signaling crucial to energy homeostasis and body weight...
  18. ncbi request reprint Functional opioid pathways are necessary for hypocretin-1 (orexin-A)-induced feeding
    Donald C Sweet
    Minnesota Obesity Center, Minneapolis, MN 55417, USA
    Peptides 25:307-14. 2004
    ..NTX suppressed Hcrt-1-induced feeding only when injected i.p., i.c.v., and in the AcbSh. These studies reveal the necessity for functional central opioidergic pathways involving the AcbSh, but not the LH in Hcrt-1-induced feeding...
  19. pmc Chronic administration of brain-derived neurotrophic factor in the hypothalamic paraventricular nucleus reverses obesity induced by high-fat diet
    Chuanfeng Wang
    Veterans Affairs Medical Center, Research Service 151, One Veterans Drive, Minneapolis, MN 55417, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1320-32. 2010
    ..These BDNF effects were greatest in the H body fat group. These data indicate that BDNF reduced HFD-induced obesity and metabolic syndrome-like measures, and the animals with the most body fat had the most significant response to BDNF...
  20. pmc Evaluation of a quantitative magnetic resonance imaging system for whole body composition analysis in rodents
    Joshua P Nixon
    Minnesota Craniofacial Research Training Program, School of Dentistry, University of Minnesota, Minneapolis, Minnesota, USA
    Obesity (Silver Spring) 18:1652-9. 2010
    ..Despite these caveats, we conclude that the EchoMRI QMR system offers a fast in vivo method of body composition analysis, well correlated to but with greater overall precision than CCA...
  21. pmc Nicotine self-administration in the rat: effects of hypocretin antagonists and changes in hypocretin mRNA
    Mark G LeSage
    Minneapolis Medical Research Foundation, 914 S 8th Street, Minneapolis, MN 55404, USA
    Psychopharmacology (Berl) 209:203-12. 2010
    ..The hypocretin (hcrt) system has been implicated in addiction-relevant effects of several drugs, but its role in nicotine dependence has been little studied...
  22. doi request reprint Brain-derived neurotrophic factor (BDNF) in the hypothalamic ventromedial nucleus increases energy expenditure
    Chuanfeng Wang
    Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    Brain Res 1336:66-77. 2010
    ..In conclusion, VMH BDNF reduces body weight by decreasing food intake and increasing EE consequent to increased SPA and RMR, suggesting that the VMH is an important site of BDNF action to influence energy balance...
  23. ncbi request reprint Brain-derived neurotrophic factor in the hypothalamic paraventricular nucleus reduces energy intake
    Chuanfeng Wang
    Veterans Affairs Medical Center, Research Service 151, One Veterans Drive, Minneapolis, MN 55417, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1003-12. 2007
    ..Furthermore, BDNF appears to interact with NPY in its anorectic actions, although a direct effect on NPY remains to be established...
  24. ncbi request reprint Brain-derived neurotrophic factor in the hypothalamic paraventricular nucleus increases energy expenditure by elevating metabolic rate
    Chuanfeng Wang
    Veterans Affairs Medical Center, Research Service 151, One Veterans Drive, Minneapolis, MN 55417, USA
    Am J Physiol Regul Integr Comp Physiol 293:R992-1002. 2007
    ..These data suggest that the PVN is an important site of BDNF action to influence energy balance...
  25. ncbi request reprint Brain-derived neurotrophic factor in the ventromedial nucleus of the hypothalamus reduces energy intake
    Chuanfeng Wang
    Veterans Affairs Medical Center, Research Service 151 One Veterans Drive, Minneapolis, MN 55417, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1037-45. 2007
    ..Furthermore, the anorectic effects of BDNF in this site appear to be mediated by NPY. These data suggest that the VMH is an important site of action for BDNF in its effects on energy metabolism...
  26. ncbi request reprint Our journey with neuropeptide Y: effects on ingestive behaviors and energy expenditure
    Allen S Levine
    Minnesota Obesity Center, Veterans Affairs Medical Center, and Department of Psychology, University of Minnesota, Minneapolis 55455, USA
    Peptides 25:505-10. 2004
    ....
  27. ncbi request reprint Intra-amygdalar injection of DAMGO: effects on c-Fos levels in brain sites associated with feeding behavior
    Allen S Levine
    Minnesota Obesity Center, Minneapolis Veterans Affairs Medical Center and University of Minnesota, Research Service 151, One Veterans Drive, Minneapolis, MN 55417, USA
    Brain Res 1015:9-14. 2004
    ..Thus, intra-CeA administration of DAMGO may increase feeding, in part, by activating neurons in the shell of the nucleus accumbens and by inhibiting activity of selected neurons in the CeA...
  28. ncbi request reprint Sugars: hedonic aspects, neuroregulation, and energy balance
    Allen S Levine
    Minnesota Obesity Center, Minneapolis VA Medical Center, Minneapolis, MN 55417, USA
    Am J Clin Nutr 78:834S-842S. 2003
    ....
  29. ncbi request reprint Effect of opioid receptor ligands injected into the rostral lateral hypothalamus on c-fos and feeding behavior
    Dehong Li
    Research Service, Minneapolis Veterans Affairs Medical Center, MN 55417, USA
    Brain Res 1096:120-4. 2006
    ....
  30. ncbi request reprint Sugars and fats: the neurobiology of preference
    Allen S Levine
    Minnesota Obesity Center, Minneapolis VA Medical Center, 55417, USA
    J Nutr 133:831S-834S. 2003
    ..Such palatable substances may contribute to the observed increase in the body weight of populations from affluent societies during the past few decades...
  31. ncbi request reprint Opioid receptor blockade in rat nucleus tractus solitarius alters amygdala dynorphin gene expression
    Michael J Glass
    Weill Medical College, Cornell University, New York, NY 10021, USA
    Am J Physiol Regul Integr Comp Physiol 283:R161-7. 2002
    ..Thus chronic administration of naltrexone in the NTS increased dynorphin gene expression in the amygdala, further supporting an opioidergic feeding pathway between these two brain sites...
  32. ncbi request reprint Orexin-induced feeding requires NMDA receptor activation in the perifornical region of the lateral hypothalamus
    Dolores F Doane
    University of Illinois at Urbana Champaign, 1207 W Gregory Drive, Urbana, IL 61801, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1022-6. 2007
    ..2 +/- 0.5 g). There was no effect of d-AP5 alone on food intake. These data support glutamatergic systems in the LH/PFA mediating the feeding response to orexin-A through NMDA receptors...
  33. ncbi request reprint Novel peptide-peptide cooperation may transform feeding behavior
    Abba J Kastin
    Veterans Affairs Medical Center and Tulane University School of Medicine, 1601 Perdido Street, New Orleans, LA 70112 1262, USA
    Peptides 23:2189-96. 2002
    ..Such a novel interaction between two peptides at the BBB opens new approaches for general study of the dynamic regulatory role of the BBB in brain-body communication as well as the specific study of obesity...
  34. ncbi request reprint Rewired to be thin? When exercise hits the brain
    Catherine M Kotz
    Am J Physiol Regul Integr Comp Physiol 294:R288-9. 2008

Research Grants11

  1. Spontaneous physical activity in obesity
    Catherine M Kotz; Fiscal Year: 2010
    ..Underlying part of the problem is disordered regulation of physical activity, and a better understanding of the brain pathways important to this is necessary in developing treatments for obesity. ..
  2. HYPOTHALAMIC HYPOCRETIN PATHWAYS MODULATING FEEDING
    CATHERINE KOTZ; Fiscal Year: 2004
    ....
  3. Spontaneous physical activity in obesity
    Catherine M Kotz; Fiscal Year: 2010
    ..Underlying part of the problem is disordered regulation of physical activity, and a better understanding of the brain pathways important to this is necessary in developing treatments for obesity. ..