K L Kotloff

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Shigella flexneri 2a strain CVD 1207, with specific deletions in virG, sen, set, and guaBA, is highly attenuated in humans
    K L Kotloff
    Division of Infectious Diseases, Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Infect Immun 68:1034-9. 2000
  2. pmc Safety, immunogenicity, and transmissibility in humans of CVD 1203, a live oral Shigella flexneri 2a vaccine candidate attenuated by deletions in aroA and virG
    K L Kotloff
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, USA
    Infect Immun 64:4542-8. 1996
  3. pmc Antigen-specific IgA B memory cell responses to Shigella antigens elicited in volunteers immunized with live attenuated Shigella flexneri 2a oral vaccine candidates
    J K Simon
    Division of Infectious Diseases and Tropical Pediatrics, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA
    Clin Immunol 139:185-92. 2011
  4. pmc Safety and immunogenicity of oral inactivated whole-cell Helicobacter pylori vaccine with adjuvant among volunteers with or without subclinical infection
    K L Kotloff
    Division of Infectious Disease and Tropical Pediatrics, Department of Pediatrics, University of Maryland School of Medicine, Baltimore 21201, USA
    Infect Immun 69:3581-90. 2001
  5. pmc Phase 2 clinical trial of attenuated Salmonella enterica serovar typhi oral live vector vaccine CVD 908-htrA in U.S. volunteers
    C O Tacket
    Center for Vaccine Development, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Infect Immun 68:1196-201. 2000
  6. pmc Antigen-specific B memory cell responses to lipopolysaccharide (LPS) and invasion plasmid antigen (Ipa) B elicited in volunteers vaccinated with live-attenuated Shigella flexneri 2a vaccine candidates
    J K Simon
    Division of Infectious Disease and Tropical Pediatrics, Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, United States
    Vaccine 27:565-72. 2009
  7. pmc Safety and immunogenicity of increasing doses of a Clostridium difficile toxoid vaccine administered to healthy adults
    K L Kotloff
    Division of Infectious Disease and Tropical Pediatrics, Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Infect Immun 69:988-95. 2001
  8. pmc Global burden of Shigella infections: implications for vaccine development and implementation of control strategies
    K L Kotloff
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore 21201, USA
    Bull World Health Organ 77:651-66. 1999
  9. pmc A single dose of live oral cholera vaccine CVD 103-HgR is safe and immunogenic in HIV-infected and HIV-noninfected adults in Mali
    R T Perry
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, USA
    Bull World Health Organ 76:63-71. 1998
  10. pmc Prevalence of antibodies to human papillomavirus (HPV) type 16 virus-like particles in relation to cervical HPV infection among college women
    R P Viscidi
    Eudowood Division of Infectious Diseases, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Diagn Lab Immunol 4:122-6. 1997

Detail Information

Publications10

  1. pmc Shigella flexneri 2a strain CVD 1207, with specific deletions in virG, sen, set, and guaBA, is highly attenuated in humans
    K L Kotloff
    Division of Infectious Diseases, Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Infect Immun 68:1034-9. 2000
    ..flexneri 2a by rational use of recombinant DNA technology that achieves a remarkable degree of attenuation compared with earlier recombinant strains, even when administered at high dosage...
  2. pmc Safety, immunogenicity, and transmissibility in humans of CVD 1203, a live oral Shigella flexneri 2a vaccine candidate attenuated by deletions in aroA and virG
    K L Kotloff
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, USA
    Infect Immun 64:4542-8. 1996
    ..We conclude that engineered deletions in virG and aroA markedly attenuate wild-type S. flexneri but preserve immunogenicity; however, less reactogenic vaccines are needed...
  3. pmc Antigen-specific IgA B memory cell responses to Shigella antigens elicited in volunteers immunized with live attenuated Shigella flexneri 2a oral vaccine candidates
    J K Simon
    Division of Infectious Diseases and Tropical Pediatrics, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA
    Clin Immunol 139:185-92. 2011
    ..These B(M) cell responses are likely play an important role in modulating the magnitude and longevity of the humoral response...
  4. pmc Safety and immunogenicity of oral inactivated whole-cell Helicobacter pylori vaccine with adjuvant among volunteers with or without subclinical infection
    K L Kotloff
    Division of Infectious Disease and Tropical Pediatrics, Department of Pediatrics, University of Maryland School of Medicine, Baltimore 21201, USA
    Infect Immun 69:3581-90. 2001
    ..There was no evidence that vaccination eradicated H. pylori in infected volunteers. These results suggest that it is possible to stimulate mucosal and systemic immune responses in humans to H. pylori antigens by using an HWC vaccine...
  5. pmc Phase 2 clinical trial of attenuated Salmonella enterica serovar typhi oral live vector vaccine CVD 908-htrA in U.S. volunteers
    C O Tacket
    Center for Vaccine Development, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Infect Immun 68:1196-201. 2000
    ..This phase 2 study supports the further development of CVD 908-htrA as a single-dose vaccine against typhoid fever and as a possible live vector for oral delivery of other vaccine antigens...
  6. pmc Antigen-specific B memory cell responses to lipopolysaccharide (LPS) and invasion plasmid antigen (Ipa) B elicited in volunteers vaccinated with live-attenuated Shigella flexneri 2a vaccine candidates
    J K Simon
    Division of Infectious Disease and Tropical Pediatrics, Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, United States
    Vaccine 27:565-72. 2009
    ..In sum, oral vaccination with live-attenuated S. flexneri 2a elicits B(M) cells to LPS and IpaB, suggesting that B(M) responses to Shigella antigens should be further studied as a suitable surrogate of protection in shigellosis...
  7. pmc Safety and immunogenicity of increasing doses of a Clostridium difficile toxoid vaccine administered to healthy adults
    K L Kotloff
    Division of Infectious Disease and Tropical Pediatrics, Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Infect Immun 69:988-95. 2001
    ..We concluded that the C. difficile toxoid vaccine is safe and immunogenic in healthy volunteers. Further development as a prophylactic vaccine or for producing C. difficile hyperimmune globulin is justified...
  8. pmc Global burden of Shigella infections: implications for vaccine development and implementation of control strategies
    K L Kotloff
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore 21201, USA
    Bull World Health Organ 77:651-66. 1999
    ..Innovative strategies, including development of vaccines against the most common serotypes, could provide substantial benefits...
  9. pmc A single dose of live oral cholera vaccine CVD 103-HgR is safe and immunogenic in HIV-infected and HIV-noninfected adults in Mali
    R T Perry
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, USA
    Bull World Health Organ 76:63-71. 1998
    ..These results encourage further evaluations of this single-dose, oral cholera vaccine in high-risk populations such as refugees in sub-Saharan Africa...
  10. pmc Prevalence of antibodies to human papillomavirus (HPV) type 16 virus-like particles in relation to cervical HPV infection among college women
    R P Viscidi
    Eudowood Division of Infectious Diseases, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Diagn Lab Immunol 4:122-6. 1997
    ..However, the assay appears to have adequate specificity and should be useful as an epidemiological marker of HPV-16 infection and sexual behavior...