K L Kotloff

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Human challenge studies with infectious agents
    Karen L Kotloff
    Center for Vaccine Development, Division of Infections Disease and Tropical Pediatrics, Department of Pediatrics, University of Maryland School of Medicine, 685 W Baltimore Street, HSF 480, Baltimore, MD 21201, USA
    J Investig Med 51:S6-11. 2003
  2. doi request reprint Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study
    Karen L Kotloff
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD, USA
    Lancet 382:209-22. 2013
  3. pmc The Global Enteric Multicenter Study (GEMS) of diarrheal disease in infants and young children in developing countries: epidemiologic and clinical methods of the case/control study
    Karen L Kotloff
    Department of Pediatrics, University of Maryland School of Medicine, Center for Vaccine Development, 685 W Baltimore St, HSF 480, Baltimore, MD 21201, USA
    Clin Infect Dis 55:S232-45. 2012
  4. ncbi request reprint Safety and immunogenicity of a recombinant multivalent group a streptococcal vaccine in healthy adults: phase 1 trial
    Karen L Kotloff
    Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore 21201, USA
    JAMA 292:709-15. 2004
  5. ncbi request reprint Deletion in the Shigella enterotoxin genes further attenuates Shigella flexneri 2a bearing guanine auxotrophy in a phase 1 trial of CVD 1204 and CVD 1208
    Karen L Kotloff
    Division of Infectious Disease and Tropical Pediatrics, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Infect Dis 190:1745-54. 2004
  6. pmc Clinical and microbiological responses of volunteers to combined intranasal and oral inoculation with a Streptococcus gordonii carrier strain intended for future use as a group A streptococcus vaccine
    Karen L Kotloff
    Department of Pediatrics, School of Medicine, University of Maryland, 685 West Baltimore St, HSF 480, Baltimore, MD 21201, USA
    Infect Immun 73:2360-6. 2005
  7. ncbi request reprint Safety and immunogenicity of CVD 1208S, a live, oral DeltaguaBA Deltasen Deltaset Shigella flexneri 2a vaccine grown on animal-free media
    Karen L Kotloff
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Hum Vaccin 3:268-75. 2007
  8. pmc Phase I evaluation of delta virG Shigella sonnei live, attenuated, oral vaccine strain WRSS1 in healthy adults
    Karen L Kotloff
    Division of Infectious Disease and Tropical Pediatrics, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Infect Immun 70:2016-21. 2002
  9. pmc Safety and immunogenicity of oral inactivated whole-cell Helicobacter pylori vaccine with adjuvant among volunteers with or without subclinical infection
    K L Kotloff
    Division of Infectious Disease and Tropical Pediatrics, Department of Pediatrics, University of Maryland School of Medicine, Baltimore 21201, USA
    Infect Immun 69:3581-90. 2001
  10. pmc Safety, immunogenicity, and transmissibility in humans of CVD 1203, a live oral Shigella flexneri 2a vaccine candidate attenuated by deletions in aroA and virG
    K L Kotloff
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, USA
    Infect Immun 64:4542-8. 1996

Detail Information

Publications33

  1. ncbi request reprint Human challenge studies with infectious agents
    Karen L Kotloff
    Center for Vaccine Development, Division of Infections Disease and Tropical Pediatrics, Department of Pediatrics, University of Maryland School of Medicine, 685 W Baltimore Street, HSF 480, Baltimore, MD 21201, USA
    J Investig Med 51:S6-11. 2003
    ....
  2. doi request reprint Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study
    Karen L Kotloff
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD, USA
    Lancet 382:209-22. 2013
    ..We designed the Global Enteric Multicenter Study (GEMS) to identify the aetiology and population-based burden of paediatric diarrhoeal disease in sub-Saharan Africa and south Asia...
  3. pmc The Global Enteric Multicenter Study (GEMS) of diarrheal disease in infants and young children in developing countries: epidemiologic and clinical methods of the case/control study
    Karen L Kotloff
    Department of Pediatrics, University of Maryland School of Medicine, Center for Vaccine Development, 685 W Baltimore St, HSF 480, Baltimore, MD 21201, USA
    Clin Infect Dis 55:S232-45. 2012
    ....
  4. ncbi request reprint Safety and immunogenicity of a recombinant multivalent group a streptococcal vaccine in healthy adults: phase 1 trial
    Karen L Kotloff
    Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore 21201, USA
    JAMA 292:709-15. 2004
    ..Group A streptococcal infections and their sequelae represent a global health problem. Recent advances have allowed previous obstacles associated with group A streptococcal vaccine development to be overcome...
  5. ncbi request reprint Deletion in the Shigella enterotoxin genes further attenuates Shigella flexneri 2a bearing guanine auxotrophy in a phase 1 trial of CVD 1204 and CVD 1208
    Karen L Kotloff
    Division of Infectious Disease and Tropical Pediatrics, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Infect Dis 190:1745-54. 2004
    ....
  6. pmc Clinical and microbiological responses of volunteers to combined intranasal and oral inoculation with a Streptococcus gordonii carrier strain intended for future use as a group A streptococcus vaccine
    Karen L Kotloff
    Department of Pediatrics, School of Medicine, University of Maryland, 685 West Baltimore St, HSF 480, Baltimore, MD 21201, USA
    Infect Immun 73:2360-6. 2005
    ..The results of these clinical trials provide encouragement that the use of S. gordonii as a live mucosal vaccine vector is a feasible strategy...
  7. ncbi request reprint Safety and immunogenicity of CVD 1208S, a live, oral DeltaguaBA Deltasen Deltaset Shigella flexneri 2a vaccine grown on animal-free media
    Karen L Kotloff
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Hum Vaccin 3:268-75. 2007
    ....
  8. pmc Phase I evaluation of delta virG Shigella sonnei live, attenuated, oral vaccine strain WRSS1 in healthy adults
    Karen L Kotloff
    Division of Infectious Disease and Tropical Pediatrics, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Infect Immun 70:2016-21. 2002
    ..We conclude that WRSS1 vaccine is remarkably immunogenic in doses ranging from 10(3) to 10(6) CFU but elicits clinical reactions that must be assessed in further volunteer trials...
  9. pmc Safety and immunogenicity of oral inactivated whole-cell Helicobacter pylori vaccine with adjuvant among volunteers with or without subclinical infection
    K L Kotloff
    Division of Infectious Disease and Tropical Pediatrics, Department of Pediatrics, University of Maryland School of Medicine, Baltimore 21201, USA
    Infect Immun 69:3581-90. 2001
    ..There was no evidence that vaccination eradicated H. pylori in infected volunteers. These results suggest that it is possible to stimulate mucosal and systemic immune responses in humans to H. pylori antigens by using an HWC vaccine...
  10. pmc Safety, immunogenicity, and transmissibility in humans of CVD 1203, a live oral Shigella flexneri 2a vaccine candidate attenuated by deletions in aroA and virG
    K L Kotloff
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, USA
    Infect Immun 64:4542-8. 1996
    ..We conclude that engineered deletions in virG and aroA markedly attenuate wild-type S. flexneri but preserve immunogenicity; however, less reactogenic vaccines are needed...
  11. pmc Antigen-specific IgA B memory cell responses to Shigella antigens elicited in volunteers immunized with live attenuated Shigella flexneri 2a oral vaccine candidates
    J K Simon
    Division of Infectious Diseases and Tropical Pediatrics, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA
    Clin Immunol 139:185-92. 2011
    ..These B(M) cell responses are likely play an important role in modulating the magnitude and longevity of the humoral response...
  12. pmc Phase 2 clinical trial of attenuated Salmonella enterica serovar typhi oral live vector vaccine CVD 908-htrA in U.S. volunteers
    C O Tacket
    Center for Vaccine Development, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Infect Immun 68:1196-201. 2000
    ..This phase 2 study supports the further development of CVD 908-htrA as a single-dose vaccine against typhoid fever and as a possible live vector for oral delivery of other vaccine antigens...
  13. pmc Shigella flexneri 2a strain CVD 1207, with specific deletions in virG, sen, set, and guaBA, is highly attenuated in humans
    K L Kotloff
    Division of Infectious Diseases, Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Infect Immun 68:1034-9. 2000
    ..flexneri 2a by rational use of recombinant DNA technology that achieves a remarkable degree of attenuation compared with earlier recombinant strains, even when administered at high dosage...
  14. pmc Antigen-specific B memory cell responses to lipopolysaccharide (LPS) and invasion plasmid antigen (Ipa) B elicited in volunteers vaccinated with live-attenuated Shigella flexneri 2a vaccine candidates
    J K Simon
    Division of Infectious Disease and Tropical Pediatrics, Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, United States
    Vaccine 27:565-72. 2009
    ..In sum, oral vaccination with live-attenuated S. flexneri 2a elicits B(M) cells to LPS and IpaB, suggesting that B(M) responses to Shigella antigens should be further studied as a suitable surrogate of protection in shigellosis...
  15. pmc Safety and immunogenicity of increasing doses of a Clostridium difficile toxoid vaccine administered to healthy adults
    K L Kotloff
    Division of Infectious Disease and Tropical Pediatrics, Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Infect Immun 69:988-95. 2001
    ..We concluded that the C. difficile toxoid vaccine is safe and immunogenic in healthy volunteers. Further development as a prophylactic vaccine or for producing C. difficile hyperimmune globulin is justified...
  16. ncbi request reprint A voluntary serosurvey and behavioral risk assessment for human immunodeficiency virus infection among college students
    K L Kotloff
    Department of Pediatrics and Geographic Medicine, University of Maryland School of Medicine, Baltimore 21201
    Sex Transm Dis 18:223-7. 1991
    ....
  17. pmc A single dose of live oral cholera vaccine CVD 103-HgR is safe and immunogenic in HIV-infected and HIV-noninfected adults in Mali
    R T Perry
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, USA
    Bull World Health Organ 76:63-71. 1998
    ..These results encourage further evaluations of this single-dose, oral cholera vaccine in high-risk populations such as refugees in sub-Saharan Africa...
  18. pmc Global burden of Shigella infections: implications for vaccine development and implementation of control strategies
    K L Kotloff
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore 21201, USA
    Bull World Health Organ 77:651-66. 1999
    ..Innovative strategies, including development of vaccines against the most common serotypes, could provide substantial benefits...
  19. ncbi request reprint Invasive pneumococcal infections among hospitalized children in Bamako, Mali
    James D Campbell
    University of Maryland School of Medicine, Center for Vaccine Development, Baltimore, MD 21201, USA
    Pediatr Infect Dis J 23:642-9. 2004
    ..Prevention of invasive pneumococcal disease (IPD) in children is a global public health priority, and determination of the most common serotypes is crucial for vaccine development and implementation...
  20. ncbi request reprint Safety, reactogenicity and immunogenicity of a recombinant protective antigen anthrax vaccine given to healthy adults
    James D Campbell
    University of Maryland School of Medicine, Center for Vaccine Development, Baltimore, Maryland 21201, USA
    Hum Vaccin 3:205-11. 2007
    ..Although an anthrax vaccine is currently licensed in the USA, better vaccines are desirable for both pre- and post-exposure prophylaxis...
  21. pmc Clinical trials of Shigella vaccines: two steps forward and one step back on a long, hard road
    Myron M Levine
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Nat Rev Microbiol 5:540-53. 2007
    ....
  22. ncbi request reprint Measurement of tetanus antitoxin in oral fluid: a tool to conduct serosurveys
    Milagritos D Tapia
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Pediatr Infect Dis J 25:819-25. 2006
    ..Measurement of IgG tetanus antitoxin in oral fluid was investigated as a practical and noninvasive alternative to and correlate of serum antibodies...
  23. ncbi request reprint The causes of hospital admission and death among children in Bamako, Mali
    James D Campbell
    University of Maryland School of Medicine, Center for Vaccine Development, Baltimore, Maryland 21201, USA
    J Trop Pediatr 50:158-63. 2004
    ..Prospective surveillance using microbiological data is needed to delineate the organism-specific burdens...
  24. ncbi request reprint MRSA with progression from otitis media and sphenoid sinusitis to clival osteomyelitis, pachymeningitis and abducens nerve palsy in an immunocompetent 10-year-old patient
    Matthew B Laurens
    Department of Pediatrics, Division of Infectious Disease and Tropical Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Int J Pediatr Otorhinolaryngol 72:945-51. 2008
    ..This case exemplifies an aggressive MRSA intracranial infection that advanced despite antibiotic therapy...
  25. ncbi request reprint B cell responses in gastric antrum and duodenum following oral inactivated Helicobacter pylori whole cell (HWC) vaccine and LT(R192G) in H pylori seronegative individuals
    Genevieve A Losonsky
    Department of Pediatrics, Baltimore, MD 21201, USA
    Vaccine 21:562-5. 2003
    ..01 and P=0.05, respectively). These results provide the first evidence that specific gastric B cell responses can be induced in HP-non-infected individuals following oral immunization...
  26. pmc Identification by PCR of non-typhoidal Salmonella enterica serovars associated with invasive infections among febrile patients in Mali
    Sharon M Tennant
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD, USA
    PLoS Negl Trop Dis 4:e621. 2010
    ..Importantly, including data from Mali, three serovars, Salmonella enterica serovar Typhimurium, Salmonella Enteritidis and Salmonella Dublin, account for the majority of non-typhoidal Salmonella isolated from these patients...
  27. ncbi request reprint Progress in group A streptococcal vaccine development
    Karen L Kotloff
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD, USA
    Pediatr Infect Dis J 23:765-6. 2004
  28. pmc Prevalence of antibodies to human papillomavirus (HPV) type 16 virus-like particles in relation to cervical HPV infection among college women
    R P Viscidi
    Eudowood Division of Infectious Diseases, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Diagn Lab Immunol 4:122-6. 1997
    ..However, the assay appears to have adequate specificity and should be useful as an epidemiological marker of HPV-16 infection and sexual behavior...
  29. pmc PCR method to identify Salmonella enterica serovars Typhi, Paratyphi A, and Paratyphi B among Salmonella Isolates from the blood of patients with clinical enteric fever
    Haim Levy
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Clin Microbiol 46:1861-6. 2008
    ..Blinded testing of 664 Malian and Chilean Salmonella blood isolates demonstrated 100% sensitivity and specificity...
  30. ncbi request reprint Overview of vaccines and immunisation
    Myron M Levine
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Br Med Bull 62:1-13. 2002
  31. ncbi request reprint Epidemiology and clinical presentation of shigellosis in children less than five years of age in rural Mozambique
    Inacio Mandomando
    Centro de Investigação em Saúde da Manhiça, IDIBAPS Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Pediatr Infect Dis J 26:1059-61. 2007
    ..7% versus 0.4%, P = 0.004), and from dysentery than nondysenteric diarrhea (24.1% versus 3.5%, P < 0.001). Shigella flexneri 2a, S. sonnei, and S. flexneri 6, were the most prevalent serotypes...
  32. ncbi request reprint Burden of invasive disease caused by Haemophilus influenzae type b in Bamako, Mali: impetus for routine infant immunization with conjugate vaccine
    Samba O Sow
    Centre pour le Développement des Vaccins, Mali CVD Mali
    Pediatr Infect Dis J 24:533-7. 2005
    ..Population-based, bacteriologically confirmed disease burden data aid decision makers in African countries pondering whether to introduce Haemophilus influenzae type b (Hib) immunization for infants...
  33. pmc Clostridium difficile vaccine and serum immunoglobulin G antibody response to toxin A
    Samer Aboudola
    Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Infect Immun 71:1608-10. 2003
    ..These findings support the feasibility of using a vaccine to protect high-risk individuals against C. difficile-associated diarrhea and colitis...