Hema Kothari

Summary

Affiliation: University of Texas Health Center
Country: USA

Publications

  1. pmc Mycobacterium tuberculosis infection and tissue factor expression in macrophages
    Hema Kothari
    Department of Cellular and Molecular Biology, The University of Texas Health Science Center, Tyler, TX, USA
    PLoS ONE 7:e45700. 2012
  2. pmc 4-Hydroxy-2-nonenal enhances tissue factor activity in human monocytic cells via p38 mitogen-activated protein kinase activation-dependent phosphatidylserine exposure
    Rit Vatsyayan
    Department of Cellular and Molecular Biology, The University of Texas Health Science Center, Tyler, TX 75708, USA
    Arterioscler Thromb Vasc Biol 33:1601-11. 2013
  3. pmc Role of tissue factor in Mycobacterium tuberculosis-induced inflammation and disease pathogenesis
    Hema Kothari
    Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, United States of America
    PLoS ONE 9:e114141. 2014
  4. pmc Tissue factor encryption and decryption: facts and controversies
    L Vijaya Mohan Rao
    Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, TX, USA
    Thromb Res 129:S13-7. 2012
  5. pmc Tissue factor: mechanisms of decryption
    L Vijaya Mohan Rao
    Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA
    Front Biosci (Elite Ed) 4:1513-27. 2012
  6. pmc Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection
    Prosenjit Sen
    Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, TX, USA
    Blood 117:3199-208. 2011
  7. pmc Inactivation of factor VIIa by antithrombin in vitro, ex vivo and in vivo: role of tissue factor and endothelial cell protein C receptor
    Rit Vatsyayan
    Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas, United States of America
    PLoS ONE 9:e103505. 2014
  8. pmc Cystine 186-cystine 209 disulfide bond is not essential for the procoagulant activity of tissue factor or for its de-encryption
    Hema Kothari
    Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
    Blood 115:4273-83. 2010

Collaborators

Detail Information

Publications8

  1. pmc Mycobacterium tuberculosis infection and tissue factor expression in macrophages
    Hema Kothari
    Department of Cellular and Molecular Biology, The University of Texas Health Science Center, Tyler, TX, USA
    PLoS ONE 7:e45700. 2012
    ..The importance of TF in granuloma formation and containment of Mtb is discussed...
  2. pmc 4-Hydroxy-2-nonenal enhances tissue factor activity in human monocytic cells via p38 mitogen-activated protein kinase activation-dependent phosphatidylserine exposure
    Rit Vatsyayan
    Department of Cellular and Molecular Biology, The University of Texas Health Science Center, Tyler, TX 75708, USA
    Arterioscler Thromb Vasc Biol 33:1601-11. 2013
    ..The objective of the present study is to investigate the effect of HNE on tissue factor (TF) procoagulant activity expressed on cell surfaces...
  3. pmc Role of tissue factor in Mycobacterium tuberculosis-induced inflammation and disease pathogenesis
    Hema Kothari
    Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, United States of America
    PLoS ONE 9:e114141. 2014
    ..Our data indicate, in contrast to that observed in acute bacterial infections, that TF-mediated coagulation and/or signaling does not appear to contribute to the host-defense in experimental tuberculosis. ..
  4. pmc Tissue factor encryption and decryption: facts and controversies
    L Vijaya Mohan Rao
    Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, TX, USA
    Thromb Res 129:S13-7. 2012
    ....
  5. pmc Tissue factor: mechanisms of decryption
    L Vijaya Mohan Rao
    Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA
    Front Biosci (Elite Ed) 4:1513-27. 2012
    ..In this article, we critically review literature on TF encryption/decryption with specific emphasis on recently published data and provide our perspective on this subject...
  6. pmc Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection
    Prosenjit Sen
    Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, TX, USA
    Blood 117:3199-208. 2011
    ..These findings are novel and of great clinical significance, because FVIIa is used clinically for the prevention of bleeding in hemophilia and other bleeding disorders...
  7. pmc Inactivation of factor VIIa by antithrombin in vitro, ex vivo and in vivo: role of tissue factor and endothelial cell protein C receptor
    Rit Vatsyayan
    Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas, United States of America
    PLoS ONE 9:e103505. 2014
    ..However, TF's role in AT inactivation of FVIIa appears to be minor and other factor(s) present in plasma, on blood cells or vascular endothelium may play a predominant role in this process...
  8. pmc Cystine 186-cystine 209 disulfide bond is not essential for the procoagulant activity of tissue factor or for its de-encryption
    Hema Kothari
    Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
    Blood 115:4273-83. 2010
    ..Our data provide clear evidence that TF lacking the Cys186-Cys209 bond is coagulantly active once it is complexed with FVIIa, and TF de-encryption does not require Cys186-Cys209 disulfide bond formation...