Laura L Koth

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Interferon-inducible chemokines reflect severity and progression in sarcoidosis
    Robert Su
    Division of Pulmonary, Critical Care, Sleep and Allergy, University of California San Francisco, 505 Parnassus Avenue, Box 0111, San Francisco, CA 94143, USA
    Respir Res 14:121. 2013
  2. pmc Sarcoidosis blood transcriptome reflects lung inflammation and overlaps with tuberculosis
    Laura L Koth
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA
    Am J Respir Crit Care Med 184:1153-63. 2011
  3. doi request reprint DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2
    Laura L Koth
    Division of Pulmonary and Critical Care Medicine, Lung Biology Center, University of California at San Francisco, San Francisco, CA 94143, USA
    J Immunol 184:6522-8. 2010
  4. pmc Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1
    Laura L Koth
    Lung Biology Center, Department of Medicine, San Francisco General Hospital, California, USA
    Am J Respir Cell Mol Biol 37:651-9. 2007
  5. pmc A distinctive alveolar macrophage activation state induced by cigarette smoking
    Prescott G Woodruff
    UCSF Mission Bay Rock Hall, Room 545, 1550 4th Street, San Francisco, CA 94158, USA
    Am J Respir Crit Care Med 172:1383-92. 2005
  6. pmc Alveolar macrophage recruitment and activation by chronic second hand smoke exposure in mice
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, Dept of Medicine and Cardiovascular Research Institute, UCSF, San Francisco, California 94143, USA
    COPD 6:86-94. 2009
  7. pmc T-helper type 2-driven inflammation defines major subphenotypes of asthma
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, CA 94143 0111, USA
    Am J Respir Crit Care Med 180:388-95. 2009
  8. pmc Invariant natural killer T (iNKT) cell exhaustion in sarcoidosis
    Jennifer E Snyder-Cappione
    Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Eur J Immunol 43:2194-205. 2013
  9. pmc Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2
    Laura L Koth
    Lung Biology Center, Department of Medicine, University of California, San Francisco, California, USA
    Respir Res 5:12. 2004
  10. ncbi request reprint Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
    Douglas A Kuperman
    Lung Biology Center, Department of Medicine and Cardiovascular Research Institute, University of California San Francisco School of Medicine, San Francisco, California, USA
    Nat Med 8:885-9. 2002

Collaborators

Detail Information

Publications15

  1. doi request reprint Interferon-inducible chemokines reflect severity and progression in sarcoidosis
    Robert Su
    Division of Pulmonary, Critical Care, Sleep and Allergy, University of California San Francisco, 505 Parnassus Avenue, Box 0111, San Francisco, CA 94143, USA
    Respir Res 14:121. 2013
    ..The objective of this study was to determine whether proteins encoded by these transcripts were elevated in serum and identified patients with remitting vs. chronic progressive sarcoidosis longitudinally...
  2. pmc Sarcoidosis blood transcriptome reflects lung inflammation and overlaps with tuberculosis
    Laura L Koth
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA
    Am J Respir Crit Care Med 184:1153-63. 2011
    ..Sarcoidosis is a granulomatous disease of unknown etiology, although M. tuberculosis may play a role in the pathogenesis. The traditional view holds that inflammation in sarcoidosis is compartmentalized to involved organs...
  3. doi request reprint DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2
    Laura L Koth
    Division of Pulmonary and Critical Care Medicine, Lung Biology Center, University of California at San Francisco, San Francisco, CA 94143, USA
    J Immunol 184:6522-8. 2010
    ..These findings indicate that DAP12, possibly through association with TREM2, contributes to alveolar macrophage chemotaxis and recruitment to the lung and may mediate macrophage accumulation in lung diseases such as emphysema...
  4. pmc Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1
    Laura L Koth
    Lung Biology Center, Department of Medicine, San Francisco General Hospital, California, USA
    Am J Respir Cell Mol Biol 37:651-9. 2007
    ..These findings show that alphavbeta6 and TGF-beta1 regulate homeostasis of phospholipids and collectins in adult mouse lungs and may have implications for anti-fibrotic therapeutics that inhibit active TGF-beta in the lung...
  5. pmc A distinctive alveolar macrophage activation state induced by cigarette smoking
    Prescott G Woodruff
    UCSF Mission Bay Rock Hall, Room 545, 1550 4th Street, San Francisco, CA 94158, USA
    Am J Respir Crit Care Med 172:1383-92. 2005
    ..Macrophages are believed to play a central role in emphysema based largely on data from mouse models. However, the relevance of these models to smoking-related lung disease in humans is uncertain...
  6. pmc Alveolar macrophage recruitment and activation by chronic second hand smoke exposure in mice
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, Dept of Medicine and Cardiovascular Research Institute, UCSF, San Francisco, California 94143, USA
    COPD 6:86-94. 2009
    ..These findings indicate that second smoke exposure can cause macrophage recruitment and activation, providing a biological link between second-hand smoke exposure and the development of inflammatory processes linked to COPD...
  7. pmc T-helper type 2-driven inflammation defines major subphenotypes of asthma
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, CA 94143 0111, USA
    Am J Respir Crit Care Med 180:388-95. 2009
    ..However, clinical studies increasingly suggest that asthma is heterogeneous...
  8. pmc Invariant natural killer T (iNKT) cell exhaustion in sarcoidosis
    Jennifer E Snyder-Cappione
    Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Eur J Immunol 43:2194-205. 2013
    ..Programmed death-1 receptor antagonists may therefore be attractive therapeutic candidates for sarcoidosis and other iNKT-cell-mediated chronic diseases. ..
  9. pmc Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2
    Laura L Koth
    Lung Biology Center, Department of Medicine, University of California, San Francisco, California, USA
    Respir Res 5:12. 2004
    ..Furthermore, MCP-1-deficient mice have not previously been studied in models of experimental allergic asthma...
  10. ncbi request reprint Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
    Douglas A Kuperman
    Lung Biology Center, Department of Medicine and Cardiovascular Research Institute, University of California San Francisco School of Medicine, San Francisco, California, USA
    Nat Med 8:885-9. 2002
    ..These results demonstrate the importance of direct effects of IL-13 on epithelial cells in causing two central features of asthma...
  11. ncbi request reprint Hard metal interstitial lung disease: high-resolution computed tomography appearance
    Michael B Gotway
    Thoracic Imaging Section, Department of Radiology, San Francisco General Hospital, University of California, San Francisco, CA 94110, USA
    J Thorac Imaging 17:314-8. 2002
    ..This appearance, along with a consistent occupational exposure, should specifically suggest the diagnosis of HM-ILD...
  12. pmc Spotted long oligonucleotide arrays for human gene expression analysis
    Andrea Barczak
    Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    Genome Res 13:1775-85. 2003
    ..The approach described here involves far more gene expression measurements and provides a useful method for comparing existing and emerging techniques for genome-scale expression analysis...
  13. pmc A comprehensive ex vivo functional analysis of human NKT cells reveals production of MIP1-α and MIP1-β, a lack of IL-17, and a Th1-bias in males
    Jennifer E Snyder-Cappione
    Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 5:e15412. 2010
    ..In addition, the panoply of Th2 and Th17 cytokine secretion by NKT cells from healthy donors may not be as pronounced as previously believed. NKT cells may therefore contribute to the gender bias found in many diseases...
  14. pmc Undifferentiated connective tissue disease-associated interstitial lung disease: changes in lung function
    Brent W Kinder
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0564, USA
    Lung 188:143-9. 2010
    ..These findings demonstrate the clinical importance of identifying UCTD in patients presenting with an "idiopathic" interstitial pneumonia...
  15. ncbi request reprint Hypersensitivity pneumonitis reaction to Mycobacterium avium in household water
    Theodore K Marras
    Division of Respirology, Toronto Western Hospital, Edith Cavell 4 022, 399 Bathurst St, Toronto, ON, Canada M5T 2S8
    Chest 127:664-71. 2005
    ..Hypersensitivity pneumonitis has been described with exposure to aerosolized Mycobacterium avium complex (MAC) in indoor hot tubs (hot tub lung)...