MALAK YS KOTB
Affiliation: University of Tennessee
- An immunogenetic and molecular basis for differences in outcomes of invasive group A streptococcal infectionsMalak Kotb
Veterans Affairs Medical Center, Research Service, Memphis, Tennessee, USA
Nat Med 8:1398-404. 2002..We propose that human leukocyte antigen class II allelic variation contributes to differences in severity of invasive streptococcal infections through their ability to regulate cytokine responses triggered by streptococcal superantigens...
- An unbiased systems genetics approach to mapping genetic loci modulating susceptibility to severe streptococcal sepsisNourtan F Abdeltawab
Mid South Center for Biodefense and Security, The University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
PLoS Pathog 4:e1000042. 2008..The association of GAS sepsis with multiple pathways underscores the complexity of traits modulating GAS sepsis and provides a powerful approach for analyzing interactive traits affecting outcomes of other infectious diseases...
- Association of human leukocyte antigen with outcomes of infectious diseases: the streptococcal experienceM Kotb
Veterans Affairs Medical Center, Research Service, Memphis, Tennessee 38163, USA
Scand J Infect Dis 35:665-9. 2003....
- Human islet graft function in NOD-SCID mice predicts clinical response in islet transplant recipientsA O Gaber
Department of Surgery, University of Tennessee, Memphis, 38103, USA
Transplant Proc 36:1108-10. 2004..8 ng/mL and insulin free until suffering a rejection episode 3 months later. We observed that human islet graft function in NOD-SCID mice correlated with clinical response in islet transplant recipients...
- Host variation in cytokine responses to superantigens determine the severity of invasive group A streptococcal infectionA Norrby-Teglund
Veterans Affairs Medical Center, Research Service, Memphis, TN, USA
Eur J Immunol 30:3247-55. 2000..We therefore conclude that host factors influence the magnitude of cytokine responses to superantigens and consequently the clinical outcome of the infection...
- Reciprocal, temporal expression of SpeA and SpeB by invasive M1T1 group a streptococcal isolates in vivoS U Kazmi
Research Service, Veterans Affairs Medical Center, Memphis, Tennessee 38104, USA
Infect Immun 69:4988-95. 2001..This underscores the role of the host-pathogen interaction in regulating the expression of streptococcal virulence factors in vivo. The model described here should facilitate such studies...