Research Topics
Species | Maranke I KosterSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
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Detail Information
Publications
Epidermal differentiation: transgenic/knockout mouse models reveal genes involved in stem cell fate decisions and commitment to differentiationMaranke I Koster
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
J Investig Dermatol Symp Proc 7:41-5. 2002..In this review, we discuss transgenic/knockout mouse models that have provided evidence linking c-Myc and p63 to different stages of epidermal development and differentiation...
Sorting out the p63 signaling networkMaranke I Koster
Department of Dermatology and Charles C Gates Regenerative Medicine and Stem Cell Biology Program, University of Colorado Denver, Aurora, Colorado 80045, USA
J Invest Dermatol 128:1617-9. 2008..In this issue, Antonini et al., describe a novel p63 target gene whose evolutionary conservation suggests a critical role for this gene in the epidermis...- Mechanisms regulating epithelial stratificationMaranke I Koster
Department of Dermatology and Charles C Gates Program in Regenerative Medicine and Stem Cell Biology, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80010, USA
Annu Rev Cell Dev Biol 23:93-113. 2007..In this review we summarize the current advances that have been made in understanding the molecular mechanisms that regulate epidermal morphogenesis... - DeltaNp63 knockdown mice: A mouse model for AEC syndromeMaranke I Koster
Department of Dermatology and Charles C Gates Regenerative Medicine and Stem Cell Biology Program, University of Colorado Denver, Aurora, CO 80045, USA
Am J Med Genet A 149:1942-7. 2009..c) 2009 Wiley-Liss, Inc... - p63 in skin development and ectodermal dysplasiasMaranke I Koster
Department of Dermatology, Charles C Gates Regenerative Medicine and Stem Cell Biology Program, University of Colorado Denver, Aurora, Colorado 80045, USA
J Invest Dermatol 130:2352-8. 2010..This review summarizes the current understanding of the role of p63 in normal development and ectodermal dysplasias... - Making an epidermisMaranke I Koster
Department of Dermatology and Charles C Gates Regenerative Medicine and Stem Cell Biology Program, University of Colorado Denver, Aurora, Colorado 80045, USA
Ann N Y Acad Sci 1170:7-10. 2009..This review summarizes our current understanding of the mechanisms that control proliferation and differentiation of epidermal stem cells, and thus addresses fundamental processes that control epidermal morphogenesis and function... - Cross-regulation between Notch and p63 in keratinocyte commitment to differentiationBach Cuc Nguyen
Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA, and Department of Biochemistry, University of Lausanne, Switzerland
Genes Dev 20:1028-42. 2006..Thus, a complex cross-talk between Notch and p63 is involved in the balance between keratinocyte self-renewal and differentiation... - Conflicting roles for p63 in skin development and carcinogenesisMaranke I Koster
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Cell Cycle 6:269-73. 2007..In this review, we discuss these conflicting findings and provide evidence for various roles of p63 in the epidermis under normal and pathological conditions... - p63 induces key target genes required for epidermal morphogenesisMaranke I Koster
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 104:3255-60. 2007..Our data provide insights into the role of DeltaNp63alpha in epidermal morphogenesis and homeostasis, and may contribute to our understanding of the pathogenic mechanisms underlying disorders caused by p63 mutations... - P63 deficiency: a failure of lineage commitment or stem cell maintenance?Maranke I Koster
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
J Investig Dermatol Symp Proc 10:118-23. 2005..In this review, we discuss evidence suggesting that p63 is required for the commitment to stratification, making p63 the earliest known gene expressed in the developing epidermis that is specific for the keratinocyte lineage... - p63 is the molecular switch for initiation of an epithelial stratification programMaranke I Koster
Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
Genes Dev 18:126-31. 2004..Our data demonstrate that p63 plays a dual role: initiating epithelial stratification during development and maintaining proliferative potential of basal keratinocytes in mature epidermis... - The role of p63 in development and differentiation of the epidermisMaranke I Koster
Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
J Dermatol Sci 34:3-9. 2004..In this review, we discuss recent evidence supporting this dual role for p63 and place it in the context of our increasing knowledge of epidermal development and differentiation... - p63 and epithelial appendage developmentMaranke I Koster
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Differentiation 72:364-70. 2004..In this review, we will discuss the current knowledge of the developmental role of p63 and the implications for epithelial appendage development... - Genes involved in stem cell fate decisions and commitment to differentiation play a role in skin diseaseKimberly A Honeycutt
Departments of Molecular and Cellular Biology, Houston, Texas 77030, USA
J Investig Dermatol Symp Proc 9:261-8. 2004..In this review, we will discuss recent data implicating a role for both c-Myc and p63 in human skin diseases... - Transgenic mouse models provide new insights into the role of p63 in epidermal developmentMaranke I Koster
Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Cell Cycle 3:411-3. 2004..These data demonstrate that TA- and DeltaNp63 isoforms have fundamentally different roles during epidermal development and provide new insight into the molecular events required for normal epidermal morphogenesis... - TAp63alpha induces AP-2gamma as an early event in epidermal morphogenesisMaranke I Koster
Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
Dev Biol 289:253-61. 2006..Our data identify AP-2gamma as the first in vivo target gene of TAp63alpha, and provide novel insights into the molecular mechanisms associated with early events in epidermal morphogenesis... - Roles of TGFbeta signaling in epidermal/appendage developmentAllen G Li
Department of Dermatology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Cytokine Growth Factor Rev 14:99-111. 2003..Future studies will be instrumental in defining the precise roles for TGFbeta superfamily signaling in epidermal/appendage development... - Disruption of epidermal specific gene expression and delayed skin development in AP-2 gamma mutant miceJillian Guttormsen
Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA
Dev Biol 317:187-95. 2008..These results document an important role for AP-2 gamma in skin development, and reveal the existence of regulatory factors that can compensate for AP-2 gamma in its absence... - Double-inducible gene activation system for caspase 3 and 9 in epidermisViraj R Shah
Center for Molecular Development and Disease, Texas A and M University Health Science Center, Institute of Biosciences and Technology, Houston, Texas 77030, USA
Genesis 45:194-9. 2007..This Double-Inducible Gene Activation System generates two barriers for the target gene expression and protein activation thereby minimizing leakage... - p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumorsWilliam M Keyes
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
Proc Natl Acad Sci U S A 103:8435-40. 2006..These findings demonstrate that, in agreement with data from human tumors, p63 plays a markedly different biological role in cancer than p53... - Genetic pathways required for epidermal morphogenesisMaranke I Koster
Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
Eur J Cell Biol 83:625-9. 2004..In this review, we summarize the involvement of several signaling pathways in different stages of epidermal morphogenesis... - Asymmetric cell division in skin development: a new look at an old observationMaranke I Koster
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Dev Cell 9:444-6. 2005..A recent article by Lechler and Fuchs in Nature (Lechler and Fuchs, 2005) suggests that these events are triggered by asymmetric cell division... - Reactivation of developmentally expressed p63 isoforms predisposes to tumor development and progressionMaranke I Koster
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Cancer Res 66:3981-6. 2006..Thus, as observed for other developmental pathways, aberrant reactivation of TAp63 predisposes to tumor development and progression...