DANIEL KOSMAN

Summary

Affiliation: University at Buffalo
Country: USA

Publications

  1. doi request reprint Illustrating the steady-state condition and the single-molecule kinetic method with the NMDA receptor
    Daniel J Kosman
    Department of Biochemistry, The University at Buffalo, Buffalo, New York 14214
    Biochem Mol Biol Educ 37:333-8. 2009
  2. ncbi request reprint Molecular mechanisms of iron uptake in fungi
    Daniel J Kosman
    Department of Biochemistry, 140 Farber Hall, The University at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, NY 14214, USA
    Mol Microbiol 47:1185-97. 2003
  3. pmc Redox cycling in iron uptake, efflux, and trafficking
    Daniel J Kosman
    Department of Biochemistry, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York 14214, USA
    J Biol Chem 285:26729-35. 2010
  4. doi request reprint Multicopper oxidases: a workshop on copper coordination chemistry, electron transfer, and metallophysiology
    Daniel J Kosman
    Department of Biochemistry, The University at Buffalo, NY 14214, USA
    J Biol Inorg Chem 15:15-28. 2010
  5. ncbi request reprint Assembly, activation, and trafficking of the Fet3p.Ftr1p high affinity iron permease complex in Saccharomyces cerevisiae
    Arvinder Singh
    Department of Biochemistry, School of Medicine and Biomedical Sciences, The University at Buffalo, Buffalo, New York 14214, USA
    J Biol Chem 281:13355-64. 2006
  6. ncbi request reprint Structure-function analysis of the cuprous oxidase activity in Fet3p from Saccharomyces cerevisiae
    Christopher S Stoj
    Department of Biochemistry, School of Medicine and Biomedical Sciences, The University at Buffalo, Buffalo, New York 14214, USA
    J Biol Chem 282:7862-8. 2007
  7. ncbi request reprint The metalloreductase Fre6p in Fe-efflux from the yeast vacuole
    Arvinder Singh
    Department of Biochemistry, School of Medicine and Biomedical Sciences, The University at Buffalo, Buffalo, New York 14214, USA
    J Biol Chem 282:28619-26. 2007
  8. pmc The Ftr1p iron permease in the yeast plasma membrane: orientation, topology and structure-function relationships
    Scott Severance
    Department of Biochemistry, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14214, USA
    Biochem J 380:487-96. 2004
  9. ncbi request reprint Targeted suppression of the ferroxidase and iron trafficking activities of the multicopper oxidase Fet3p from Saccharomyces cerevisiae
    Tzu Pin Wang
    Department of Biochemistry, The University at Buffalo, 140 Farber Hall, Buffalo, NY 14214, USA
    J Biol Inorg Chem 8:611-20. 2003
  10. ncbi request reprint FET3P, ceruloplasmin, and the role of copper in iron metabolism
    Daniel J Kosman
    Department of Biochemistry, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York 14214, USA
    Adv Protein Chem 60:221-69. 2002

Collaborators

  • Edward I Solomon
  • Navjot Kaur
  • James Kronstad
  • Liliana Quintanar
  • Christopher S Stoj
  • Anthony J Augustine
  • Scott Severance
  • Arvinder Singh
  • Christopher Stoj
  • Tzu Pin Wang
  • Alexander B Taylor
  • Alaina Terzulli
  • Alaina J Terzulli
  • Won Hee Jung
  • Ernest Y Kwok
  • P John Hart
  • Xiaoli Shi
  • Amy E Palmer
  • Ritimukta Sarangi
  • Anita Sham
  • Tianshun Lian
  • Keith O Hodgson
  • Mads Emil Kragh
  • Satoshi Fujii
  • Barry D Liboiron
  • Britt Hedman
  • William Wiltsie
  • Lynn Zeigler
  • Lynn Ziegler
  • Satadipta Chakraborty
  • Mark Gebhard
  • Zhiwu Zhu
  • Annette Romeo

Detail Information

Publications24

  1. doi request reprint Illustrating the steady-state condition and the single-molecule kinetic method with the NMDA receptor
    Daniel J Kosman
    Department of Biochemistry, The University at Buffalo, Buffalo, New York 14214
    Biochem Mol Biol Educ 37:333-8. 2009
    ..The article emphasizes the advantages of collecting the mean behavior of a single molecule over time in comparison to the mean behavior of a large collection of independent molecules at a single time point...
  2. ncbi request reprint Molecular mechanisms of iron uptake in fungi
    Daniel J Kosman
    Department of Biochemistry, 140 Farber Hall, The University at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, NY 14214, USA
    Mol Microbiol 47:1185-97. 2003
    ..The integration of these multiple uptake mechanisms and their regulation into over-all iron homeostasis in yeast concludes this brief review...
  3. pmc Redox cycling in iron uptake, efflux, and trafficking
    Daniel J Kosman
    Department of Biochemistry, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York 14214, USA
    J Biol Chem 285:26729-35. 2010
    ..As a transition metal ion, iron can be "metabolized" only by this redox cycling, which is catalyzed in aerobes by the coupled activities of ferric iron reductases (ferrireductases) and ferrous iron oxidases (ferroxidases)...
  4. doi request reprint Multicopper oxidases: a workshop on copper coordination chemistry, electron transfer, and metallophysiology
    Daniel J Kosman
    Department of Biochemistry, The University at Buffalo, NY 14214, USA
    J Biol Inorg Chem 15:15-28. 2010
    ..These enzymes, in particular the ferroxidases found in all fungi and metazoans, play critical roles in the metal metabolism of the expressing organism...
  5. ncbi request reprint Assembly, activation, and trafficking of the Fet3p.Ftr1p high affinity iron permease complex in Saccharomyces cerevisiae
    Arvinder Singh
    Department of Biochemistry, School of Medicine and Biomedical Sciences, The University at Buffalo, Buffalo, New York 14214, USA
    J Biol Chem 281:13355-64. 2006
    ..The results are consistent with a (minimal) heterodimer model of the Fet3p.Ftr1p complex that supports the trafficking of iron from Fet3p to Ftr1p for iron permeation across the yeast PM...
  6. ncbi request reprint Structure-function analysis of the cuprous oxidase activity in Fet3p from Saccharomyces cerevisiae
    Christopher S Stoj
    Department of Biochemistry, School of Medicine and Biomedical Sciences, The University at Buffalo, Buffalo, New York 14214, USA
    J Biol Chem 282:7862-8. 2007
    ..These kinetic defects render the Fet3pM345A unable to support wild type cellular copper resistance, suggesting that there is a finely tuned copper redox balance at the yeast plasma membrane...
  7. ncbi request reprint The metalloreductase Fre6p in Fe-efflux from the yeast vacuole
    Arvinder Singh
    Department of Biochemistry, School of Medicine and Biomedical Sciences, The University at Buffalo, Buffalo, New York 14214, USA
    J Biol Chem 282:28619-26. 2007
    ..Demonstrating a role for a vacuolar metalloreductase in Fe-efflux supports the model that iron is stored in the vacuole in the ferric state...
  8. pmc The Ftr1p iron permease in the yeast plasma membrane: orientation, topology and structure-function relationships
    Scott Severance
    Department of Biochemistry, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14214, USA
    Biochem J 380:487-96. 2004
    ..Deletion or substitution of this residue led to a 70% loss of iron-uptake activity. Ile369 was the only residue identified in this domain that made such a major contribution to iron uptake by the Fet3p-Ftr1p complex...
  9. ncbi request reprint Targeted suppression of the ferroxidase and iron trafficking activities of the multicopper oxidase Fet3p from Saccharomyces cerevisiae
    Tzu Pin Wang
    Department of Biochemistry, The University at Buffalo, 140 Farber Hall, Buffalo, NY 14214, USA
    J Biol Inorg Chem 8:611-20. 2003
    ..These results suggest that E185 contributes to Fe(2+ )binding to Fet3p and to the subsequent trafficking of the Fe(3+) produced to Ftr1p...
  10. ncbi request reprint FET3P, ceruloplasmin, and the role of copper in iron metabolism
    Daniel J Kosman
    Department of Biochemistry, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York 14214, USA
    Adv Protein Chem 60:221-69. 2002
  11. ncbi request reprint Evidence for iron channeling in the Fet3p-Ftr1p high-affinity iron uptake complex in the yeast plasma membrane
    Ernest Y Kwok
    Department of Biochemistry, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Biochemistry 45:6317-27. 2006
    ..By analogy to the Fe(III) trafficking that leads to the mineralization of the ferritin core, we propose that ferric iron channeling is a conserved feature of iron homeostasis in aerobic organisms...
  12. ncbi request reprint Structural basis of the ferrous iron specificity of the yeast ferroxidase, Fet3p
    Christopher S Stoj
    Department of Biochemistry, School of Medicine and Biological Sciences, State University of New York, Buffalo, New York 14214, USA
    Biochemistry 45:12741-9. 2006
    ..Indeed, this double mutant functions kinetically better as a laccase, albeit a relatively inefficient one...
  13. ncbi request reprint Cuprous oxidase activity of yeast Fet3p and human ceruloplasmin: implication for function
    Christopher Stoj
    Department of Biochemistry, School of Medicine and Biomedical Sciences, State University of New York, 140 Farber Hall, 3435 Main St, Buffalo, NY 14214, USA
    FEBS Lett 554:422-6. 2003
    ..These two ferroxidases are fully competent kinetically to play a major role in maintaining the cuprous-cupric redox balance in aerobic organisms...
  14. pmc Analysis of the high-affinity iron uptake system at the Chlamydomonas reinhardtii plasma membrane
    Alaina Terzulli
    Department of Biochemistry, The University at Buffalo, 140 Farber Hall, 3435 Main St, Buffalo, NY 14214, USA
    Eukaryot Cell 9:815-26. 2010
    ..Last, recombinant FOX1 (rFOX1) has been isolated in a partially holo form that exhibits the UV-visible absorbance spectrum of a multicopper oxidase and the catalytic activity of a ferroxidase...
  15. pmc The Fox1 ferroxidase of Chlamydomonas reinhardtii: a new multicopper oxidase structural paradigm
    Alaina J Terzulli
    Department of Biochemistry, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14214, USA
    J Biol Inorg Chem 14:315-25. 2009
    ..These diverse structures suggest alternative mechanisms for intramolecular electron transfer and require a new trajectory for the evolution of the MCO superfamily...
  16. pmc The copper-iron connection in biology: structure of the metallo-oxidase Fet3p
    Alexander B Taylor
    Department of Biochemistry and the X ray Crystallography Core Laboratory, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Proc Natl Acad Sci U S A 102:15459-64. 2005
    ..The findings are correlated with biochemical and physiological data to cross-validate the elements of Fet3p that define it as both a ferroxidase and cuprous oxidase...
  17. pmc Iron source preference and regulation of iron uptake in Cryptococcus neoformans
    Won Hee Jung
    The Michael Smith Laboratories, Department of Microbiology and Immunology, and Faculty of Land and Food Systems, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS Pathog 4:e45. 2008
    ..Overall, these results indicate that C. neoformans utilizes iron sources within the host (e.g., holo-transferrin) that require Cft1 and a reductive iron uptake system...
  18. doi request reprint Spectroscopic studies of perturbed T1 Cu sites in the multicopper oxidases Saccharomyces cerevisiae Fet3p and Rhus vernicifera laccase: allosteric coupling between the T1 and trinuclear Cu sites
    Anthony J Augustine
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    Biochemistry 47:2036-45. 2008
    ..These changes in the side chain and backbone provide a possible mechanism for regulating intramolecular T1 to TNC ET in NI and partially reduced enzyme forms for efficient turnover...
  19. ncbi request reprint Ferrous binding to the multicopper oxidases Saccharomyces cerevisiae Fet3p and human ceruloplasmin: contributions to ferroxidase activity
    Liliana Quintanar
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 126:6579-89. 2004
    ....
  20. ncbi request reprint Role of aspartate 94 in the decay of the peroxide intermediate in the multicopper oxidase Fet3p
    Liliana Quintanar
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    Biochemistry 44:6081-91. 2005
    ..These studies provide new insight into the role of D94 and proton involvement in the reductive cleavage of the O-O bond...
  21. ncbi request reprint Spectroscopic characterization and O2 reactivity of the trinuclear Cu cluster of mutants of the multicopper oxidase Fet3p
    Amy E Palmer
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    Biochemistry 41:6438-48. 2002
    ..This change in the pH dependence provides new insight into the mechanism of intermediate decay involving reductive cleavage of the O-O bond...
  22. pmc Spectroscopic and kinetic studies of perturbed trinuclear copper clusters: the role of protons in reductive cleavage of the O-O bond in the multicopper oxidase Fet3p
    Anthony J Augustine
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    J Am Chem Soc 129:13118-26. 2007
    ..A mechanism is developed where these second sphere residues participate in the proton assisted reductive cleavage of the O-O bond at the TNC...
  23. ncbi request reprint Shall we dance? How a multicopper oxidase chooses its electron transfer partner
    Liliana Quintanar
    Centro de Investigacion y de Estudios Avanzados, Mexico, D F, Mexico
    Acc Chem Res 40:445-52. 2007
    ....
  24. ncbi request reprint Fre1p Cu2+ reduction and Fet3p Cu1+ oxidation modulate copper toxicity in Saccharomyces cerevisiae
    Xiaoli Shi
    Department of Environmental Toxicology, University of California, Santa Cruz, California 95064, USA
    J Biol Chem 278:50309-15. 2003
    ..Its functional homologs, e.g. ceruloplasmin and hephaestin, could play a similar role in mammals...

Research Grants33

  1. Iron Trafficking to Ribonucleotide Reductases
    DANIEL KOSMAN; Fiscal Year: 2006
    ..This work should provide new insight into the assembly of a critical iron prosthetic group in vivo and evidence that this process can be a target for intervention in a viral infection. ..
  2. Fet3 (Ferroxidase) and Ftrl (Permease) in Iron Uptake
    DANIEL KOSMAN; Fiscal Year: 2007
    ..This structure-function characterization of the Fet3p, Ftr1p system will provide significant new understanding of eukaryotic iron trafficking. ..
  3. Managing Ionic Iron: Molecular Architecture and Mechanism of Cell Iron Metabolism
    DANIEL KOSMAN; Fiscal Year: 2007
    ..An understanding of how cells suppress this chemistry would make a significant contribution to our eventual elucidation of the molecular basis for the multitude of human pathologies often attributed in part to mismanaged ionic iron. ..
  4. Production of Recombinant Eukaryotic Ferroxidases as Protein Therapeutics
    DANIEL KOSMAN; Fiscal Year: 2007
    ..The long-term goals of this research are to determine what is defective in the patients' ceruloplasmin protein and to develop a protein-based drug that can supplement the ceruloplasmin activity that the patients lack. ..
  5. Ferroxidase (Fet3) and Permease (Ftr1) in Iron Uptake
    DANIEL KOSMAN; Fiscal Year: 2009
    ....
  6. Managing Ionic Iron: Molecular Architecture and Mechanism of Cell Iron Metabolism
    DANIEL KOSMAN; Fiscal Year: 2009
    ..An understanding of how cells suppress this chemistry would make a significant contribution to our eventual elucidation of the molecular basis for the multitude of human pathologies often attributed in part to mismanaged ionic iron. ..
  7. Managing Ionic Iron: Molecular Architecture and Mechanism of Cell Iron Metabolism
    Daniel J Kosman; Fiscal Year: 2010
    ..An understanding of how cells suppress this chemistry would make a significant contribution to our eventual elucidation of the molecular basis for the multitude of human pathologies often attributed in part to mismanaged ionic iron. ..
  8. Ferroxidase (Fet3) and Permease (Ftr1) in Iron Uptake
    Daniel J Kosman; Fiscal Year: 2010
    ....
  9. COPPER METALLO-BIOCHEMISTRY IN SACCHAROMYCES CEREVISIAE
    DANIEL KOSMAN; Fiscal Year: 1993
    ..Most of the reagents needed to begin this work have been prepared. The details of copper metallobiochemistry which emerge from these studies will provide a paradigm for possible mechanisms of Cu-handling in higher eukaryotes...
  10. FET3P (FERROXIDASE) AND FTR1P (PERMEASE) IN IRON UPTAKE
    DANIEL KOSMAN; Fiscal Year: 2002
    ..abstract_text> ..
  11. COPPER METALLOBIOCHEMISTRY IN SACCHAROMYCES CEREVISAE
    DANIEL KOSMAN; Fiscal Year: 2002
    ..Thus, elucidation of the function and modulation of Mac1p in yeast will be broadly relevant to eukaryotic copper and iron metabolism in general. ..
  12. Managing Ionic Iron: Molecular Architecture and Mechanism of Cell Iron Metabolism
    DANIEL KOSMAN; Fiscal Year: 2009
    ..An understanding of how cells suppress this chemistry would make a significant contribution to our eventual elucidation of the molecular basis for the multitude of human pathologies often attributed in part to mismanaged ionic iron. ..