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Genomes and Genes | Vyacheslav A KorshunovSummaryAffiliation: University of Rochester Country: USA Publications
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Publications
Axl mediates vascular remodeling induced by deoxycorticosterone acetate-salt hypertensionVyacheslav A Korshunov
Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester, NY 14642, USA
Hypertension 50:1057-62. 2007..Finally, increased vascular apoptosis in the Axl(-/-) DOCA mice suggests a likely mechanism for Axl-dependent effects on hypertension. These data strengthen the pathogenic role for Axl in salt-sensitive hypertension...
Genetic modifier loci linked to intima formation induced by low flow in the mouse carotidVyacheslav A Korshunov
Aab Cardiovascular Research Institute, 601 Elmwood Avenue, Rochester, NY 14642, USA
Arterioscler Thromb Vasc Biol 29:47-53. 2009..We hypothesized that a few genes control intima formation in response to low flow. A C3H/F and SJL backcross resulted in broad range of N2 intima phenotypes...
Smooth muscle apoptosis and vascular remodelingVyacheslav A Korshunov
Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14586, USA
Curr Opin Hematol 15:250-4. 2008..In normal blood vessels apoptosis counteracts cell division, whereas apoptosis is especially crucial for regulating vascular remodeling during cardiovascular diseases...- Vascular remodeling: hemodynamic and biochemical mechanisms underlying Glagov's phenomenonVyacheslav A Korshunov
Cardiovascular Research Institute and Department of Medicine, University of Rochester, Rochester, NY 14642, USA
Arterioscler Thromb Vasc Biol 27:1722-8. 2007..More comprehensive analyses of the specific molecular pathways in the vessels that determine constant flow may provide new therapeutic approaches to regulate vascular remodeling... - Axl, a receptor tyrosine kinase, mediates flow-induced vascular remodelingVyacheslav A Korshunov
Cardiovascular Research Institute, Department of Medicine, University of Rochester, NY, USA
Circ Res 98:1446-52. 2006..These data demonstrate an important role for Axl in flow-dependent remodeling by regulating vascular apoptosis and vascular inflammation... - Axl-dependent signalling: a clinical updateVyacheslav A Korshunov
Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Clin Sci (Lond) 122:361-8. 2012.... - Strain-dependent vascular remodeling: the "Glagov phenomenon" is genetically determinedVyacheslav A Korshunov
Center for Cardiovascular Research and Department of Medicine, University of Rochester, Rochester, NY 14642, USA
Circulation 110:220-6. 2004..CONCLUSIONS: The present study indicates that performing a genetic cross of these strains and total genome scan should identify genes that mediate vascular remodeling... - Interleukin-18 and macrophage migration inhibitory factor are associated with increased carotid intima-media thickeningVyacheslav A Korshunov
Cardiovascular Research Institute, Department of Medicine, University of Rochester, NY 14642, USA
Arterioscler Thromb Vasc Biol 26:295-300. 2006..Because the SJL strain is prone to autoimmune diseases, we hypothesized that inflammation contributed to IMT in SJL mice... - Angiotensin II type 2 receptor expression after vascular injury: differing effects of angiotensin-converting enzyme inhibition and angiotensin receptor blockadeThomas A Barker
Cardiovascular Research Institute, University of Rochester, Rochester, NY, USA
Hypertension 48:942-9. 2006..Results suggest that AT2R expression and increased cGMP represent a molecular mechanism that differentiates AT1R blockers, such as valsartan, from angiotensin-converting enzyme inhibitors like benazepril... - Impaired vasorelaxation in inbred mice is associated with alterations in both nitric oxide and super oxide pathwaysChun Chen
Cardiovascular Research Institute, Department of Medicine, University of Rochester, Rochester, NY 14642, USA
J Vasc Res 44:504-12. 2007..In summary, relatively small alterations in redox (SOD-2) and NO pathways (eNOS and PKG) may contribute to significantly impaired vasorelaxation in SJL mice... - Gas6-Axl pathway: the role of redox-dependent association of Axl with nonmuscle myosin IIBMegan E Cavet
Aab Cardiovascular Research Institute, University of Rochester, Box 679, Rochester, NY 14642, USA
Hypertension 56:105-11. 2010..This interaction provides a direct link between Axl and molecular motors crucial for directed cell migration, which may mediate increased migration in vascular dysfunction... - Ribosomal protein L17, RpL17, is an inhibitor of vascular smooth muscle growth and carotid intima formationElaine M Smolock
Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Circulation 126:2418-27. 2012..The purpose of this study was to identify candidate genes contributing to intima formation... - Genetic determinants of vascular remodellingBradford C Berk
Center for Cardiolovascular Research and Department of Medicine, University of Rochester, Rochester, New York 14642, USA
Can J Cardiol 22:6B-11B. 2006..This model should be useful to identify and characterize the role of genes that mediate vascular remodelling... - Plasminogen activator expression correlates with genetic differences in vascular remodelingVyacheslav A Korshunov
Center for Cardiovascular Research, Aab Institute of Biomedical Sciences and Department of Medicine, University of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA
J Vasc Res 41:481-90. 2004..In summary, flow-induced IMT of the carotid is genetically determined and correlates with t-PA and u-PA expression in 2 inbred mouse strains... - Bcr kinase activation by angiotensin II inhibits peroxisome-proliferator-activated receptor gamma transcriptional activity in vascular smooth muscle cellsJeffrey D Alexis
Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Circ Res 104:69-78. 2009.... - Genetic locus on mouse chromosome 7 controls elevated heart rateElaine M Smolock
Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Physiol Genomics 44:689-98. 2012..The peak association was observed for 17 SNPs that are localized within three GABA(A) receptor genes. In summary, we used a combined genetic approach to fine map a novel elevated HR locus on mouse chromosome 7... - Fibronectin is an important regulator of flow-induced vascular remodelingHou Yu Chiang
Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Arterioscler Thromb Vasc Biol 29:1074-9. 2009.... - Flow-induced vascular remodeling in the mouse: a model for carotid intima-media thickeningVyacheslav A Korshunov
Center for Cardiovascular Research, University of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA
Arterioscler Thromb Vasc Biol 23:2185-91. 2003..CONCLUSIONS: The mouse model described here may be useful to define genetic determinants of IMT and identify new targets for therapy based on vascular remodeling... - Hydrogen peroxide activates the Gas6-Axl pathway in vascular smooth muscle cellsAtsushi Konishi
Center for Cardiovascular Research, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Biol Chem 279:28766-70. 2004..In summary, Axl is an important signaling mediator for oxidative stress in cultured vascular smooth muscle cells and intact vessels and may represent an important therapeutic target for vascular remodeling and response to injury... - Role of Angiotensin-converting enzyme and neutral endopeptidase in flow-dependent remodelingVyacheslav A Korshunov
Center for Cardiovascular Research and Department of Medicine, University of Rochester, Rochester, NY 14642, USA
J Vasc Res 41:148-56. 2004..The results suggest that dual inhibition of NEP/ACE may have greater effects than ACE inhibition alone on vessel remodeling in hypertension... - Immune modulation of vascular resident cells by Axl orchestrates carotid intima-media thickeningJanice Gerloff
Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Am J Pathol 180:2134-43. 2012..Our data suggest that Axl contributes to carotid remodeling not only by inhibition of apoptosis but also via regulation of immune heterogeneity of vascular cells, cytokine/chemokine expression, and extracellular matrix remodeling... - Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survivalDavid J Nagel
Cardiovascular Research Institute, University of Rochester, New York, USA
Circ Res 98:777-84. 2006..These suggest that nuclear PDE1A is important in VSMC growth and survival and may contribute to the neointima formation in atherosclerosis and restenosis... - Identification of a genetic locus on chromosome 11 that regulates leukocyte infiltration in mouse carotid arteryElaine M Smolock
University of Rochester, Aab Cardiovascular Research Institute, 601 Elmwood Ave, Box CVRI, Rochester, NY 14642
Arterioscler Thromb Vasc Biol 33:1014-9. 2013..Importantly, this locus overlaps with our previously published Im2 locus on chr 11. Our study reveals a potential mechanistic relationship between leukocyte infiltration and intima-media thickening in response to decreased blood flow... - Novel tyrosine kinase signaling pathways: implications in vascular remodelingSri N Batchu
Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Curr Opin Nephrol Hypertens 21:122-7. 2012..This review summarizes the recent advances in molecular mechanisms by which five classes of receptor tyrosine kinases (RTKs) contribute to vascular remodeling... - G-protein-coupled receptor kinase interacting protein-1 mediates intima formation by regulating vascular smooth muscle proliferation, apoptosis, and migrationJinjiang Pang
Aab Cardiovascular Research Institute, University of Rochester, Box CVRI, 601 Elmwood Ave, Rochester, NY 14642
Arterioscler Thromb Vasc Biol 33:999-1005. 2013..CONCLUSIONS: GIT1 is a novel mediator of vascular remodeling by regulating VSMC proliferation, migration, and apoptosis through phospholipase Cγ and extracellular signal-regulated kinase 1/2 signaling pathways...