Vyacheslav A Korshunov

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. doi request reprint Smooth muscle apoptosis and vascular remodeling
    Vyacheslav A Korshunov
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14586, USA
    Curr Opin Hematol 15:250-4. 2008
  2. pmc Axl-dependent signalling: a clinical update
    Vyacheslav A Korshunov
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Clin Sci (Lond) 122:361-8. 2012
  3. pmc Genetic modifier loci linked to intima formation induced by low flow in the mouse carotid
    Vyacheslav A Korshunov
    Aab Cardiovascular Research Institute, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 29:47-53. 2009
  4. ncbi request reprint Axl mediates vascular remodeling induced by deoxycorticosterone acetate-salt hypertension
    Vyacheslav A Korshunov
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester, NY 14642, USA
    Hypertension 50:1057-62. 2007
  5. ncbi request reprint Vascular remodeling: hemodynamic and biochemical mechanisms underlying Glagov's phenomenon
    Vyacheslav A Korshunov
    Cardiovascular Research Institute and Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 27:1722-8. 2007
  6. ncbi request reprint Axl, a receptor tyrosine kinase, mediates flow-induced vascular remodeling
    Vyacheslav A Korshunov
    Cardiovascular Research Institute, Department of Medicine, University of Rochester, NY, USA
    Circ Res 98:1446-52. 2006
  7. pmc Role of Axl in early kidney inflammation and progression of salt-dependent hypertension
    Sri N Batchu
    Department of Medicine and Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Hypertension 62:302-9. 2013
  8. ncbi request reprint Strain-dependent vascular remodeling: the "Glagov phenomenon" is genetically determined
    Vyacheslav A Korshunov
    Center for Cardiovascular Research and Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    Circulation 110:220-6. 2004
  9. ncbi request reprint Angiotensin II type 2 receptor expression after vascular injury: differing effects of angiotensin-converting enzyme inhibition and angiotensin receptor blockade
    Thomas A Barker
    Cardiovascular Research Institute, University of Rochester, Rochester, NY, USA
    Hypertension 48:942-9. 2006
  10. ncbi request reprint Interleukin-18 and macrophage migration inhibitory factor are associated with increased carotid intima-media thickening
    Vyacheslav A Korshunov
    Cardiovascular Research Institute, Department of Medicine, University of Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 26:295-300. 2006

Collaborators

Detail Information

Publications27

  1. doi request reprint Smooth muscle apoptosis and vascular remodeling
    Vyacheslav A Korshunov
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14586, USA
    Curr Opin Hematol 15:250-4. 2008
    ..In normal blood vessels apoptosis counteracts cell division, whereas apoptosis is especially crucial for regulating vascular remodeling during cardiovascular diseases...
  2. pmc Axl-dependent signalling: a clinical update
    Vyacheslav A Korshunov
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Clin Sci (Lond) 122:361-8. 2012
    ....
  3. pmc Genetic modifier loci linked to intima formation induced by low flow in the mouse carotid
    Vyacheslav A Korshunov
    Aab Cardiovascular Research Institute, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 29:47-53. 2009
    ..We hypothesized that a few genes control intima formation in response to low flow. A C3H/F and SJL backcross resulted in broad range of N2 intima phenotypes...
  4. ncbi request reprint Axl mediates vascular remodeling induced by deoxycorticosterone acetate-salt hypertension
    Vyacheslav A Korshunov
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester, NY 14642, USA
    Hypertension 50:1057-62. 2007
    ..Finally, increased vascular apoptosis in the Axl(-/-) DOCA mice suggests a likely mechanism for Axl-dependent effects on hypertension. These data strengthen the pathogenic role for Axl in salt-sensitive hypertension...
  5. ncbi request reprint Vascular remodeling: hemodynamic and biochemical mechanisms underlying Glagov's phenomenon
    Vyacheslav A Korshunov
    Cardiovascular Research Institute and Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 27:1722-8. 2007
    ..More comprehensive analyses of the specific molecular pathways in the vessels that determine constant flow may provide new therapeutic approaches to regulate vascular remodeling...
  6. ncbi request reprint Axl, a receptor tyrosine kinase, mediates flow-induced vascular remodeling
    Vyacheslav A Korshunov
    Cardiovascular Research Institute, Department of Medicine, University of Rochester, NY, USA
    Circ Res 98:1446-52. 2006
    ..These data demonstrate an important role for Axl in flow-dependent remodeling by regulating vascular apoptosis and vascular inflammation...
  7. pmc Role of Axl in early kidney inflammation and progression of salt-dependent hypertension
    Sri N Batchu
    Department of Medicine and Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Hypertension 62:302-9. 2013
    ..However, Axl in both hematopoietic and nonhematopoietic lineages contributes to the late phase of hypertension...
  8. ncbi request reprint Strain-dependent vascular remodeling: the "Glagov phenomenon" is genetically determined
    Vyacheslav A Korshunov
    Center for Cardiovascular Research and Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    Circulation 110:220-6. 2004
    ..Atherosclerosis of the carotid artery, called intima-media thickening (IMT), is a form of vascular remodeling that is an important predictor for cardiovascular events and has a strong genetic component...
  9. ncbi request reprint Angiotensin II type 2 receptor expression after vascular injury: differing effects of angiotensin-converting enzyme inhibition and angiotensin receptor blockade
    Thomas A Barker
    Cardiovascular Research Institute, University of Rochester, Rochester, NY, USA
    Hypertension 48:942-9. 2006
    ..Results suggest that AT2R expression and increased cGMP represent a molecular mechanism that differentiates AT1R blockers, such as valsartan, from angiotensin-converting enzyme inhibitors like benazepril...
  10. ncbi request reprint Interleukin-18 and macrophage migration inhibitory factor are associated with increased carotid intima-media thickening
    Vyacheslav A Korshunov
    Cardiovascular Research Institute, Department of Medicine, University of Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 26:295-300. 2006
    ..Because the SJL strain is prone to autoimmune diseases, we hypothesized that inflammation contributed to IMT in SJL mice...
  11. pmc Gas6-Axl pathway: the role of redox-dependent association of Axl with nonmuscle myosin IIB
    Megan E Cavet
    Aab Cardiovascular Research Institute, University of Rochester, Box 679, Rochester, NY 14642, USA
    Hypertension 56:105-11. 2010
    ..This interaction provides a direct link between Axl and molecular motors crucial for directed cell migration, which may mediate increased migration in vascular dysfunction...
  12. ncbi request reprint Impaired vasorelaxation in inbred mice is associated with alterations in both nitric oxide and super oxide pathways
    Chun Chen
    Cardiovascular Research Institute, Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    J Vasc Res 44:504-12. 2007
    ..In summary, relatively small alterations in redox (SOD-2) and NO pathways (eNOS and PKG) may contribute to significantly impaired vasorelaxation in SJL mice...
  13. pmc Identification of a genetic locus on chromosome 11 that regulates leukocyte infiltration in mouse carotid artery
    Elaine M Smolock
    University of Rochester, Aab Cardiovascular Research Institute, 601 Elmwood Ave, Box CVRI, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 33:1014-9. 2013
    ..We hypothesized that the extent of inflammation associated with intima-media thickening is a genetically regulated trait...
  14. pmc Ribosomal protein L17, RpL17, is an inhibitor of vascular smooth muscle growth and carotid intima formation
    Elaine M Smolock
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Circulation 126:2418-27. 2012
    ..The purpose of this study was to identify candidate genes contributing to intima formation...
  15. pmc Bcr kinase activation by angiotensin II inhibits peroxisome-proliferator-activated receptor gamma transcriptional activity in vascular smooth muscle cells
    Jeffrey D Alexis
    Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Circ Res 104:69-78. 2009
    ....
  16. ncbi request reprint Plasminogen activator expression correlates with genetic differences in vascular remodeling
    Vyacheslav A Korshunov
    Center for Cardiovascular Research, Aab Institute of Biomedical Sciences and Department of Medicine, University of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA
    J Vasc Res 41:481-90. 2004
    ..In summary, flow-induced IMT of the carotid is genetically determined and correlates with t-PA and u-PA expression in 2 inbred mouse strains...
  17. pmc Genetic determinants of vascular remodelling
    Bradford C Berk
    Center for Cardiolovascular Research and Department of Medicine, University of Rochester, Rochester, New York 14642, USA
    Can J Cardiol 22:6B-11B. 2006
    ..This model should be useful to identify and characterize the role of genes that mediate vascular remodelling...
  18. pmc Genetic locus on mouse chromosome 7 controls elevated heart rate
    Elaine M Smolock
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Physiol Genomics 44:689-98. 2012
    ..The peak association was observed for 17 SNPs that are localized within three GABA(A) receptor genes. In summary, we used a combined genetic approach to fine map a novel elevated HR locus on mouse chromosome 7...
  19. ncbi request reprint Flow-induced vascular remodeling in the mouse: a model for carotid intima-media thickening
    Vyacheslav A Korshunov
    Center for Cardiovascular Research, University of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 23:2185-91. 2003
    ..Vascular remodeling of the carotid artery with intima-media thickness (IMT) is an important predictive factor for human cardiovascular disease. We characterized a mouse model of vascular remodeling...
  20. pmc Fibronectin is an important regulator of flow-induced vascular remodeling
    Hou Yu Chiang
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 29:1074-9. 2009
    ....
  21. ncbi request reprint Hydrogen peroxide activates the Gas6-Axl pathway in vascular smooth muscle cells
    Atsushi Konishi
    Center for Cardiovascular Research, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Biol Chem 279:28766-70. 2004
    ..In summary, Axl is an important signaling mediator for oxidative stress in cultured vascular smooth muscle cells and intact vessels and may represent an important therapeutic target for vascular remodeling and response to injury...
  22. pmc G-protein-coupled receptor kinase interacting protein-1 mediates intima formation by regulating vascular smooth muscle proliferation, apoptosis, and migration
    Jinjiang Pang
    Aab Cardiovascular Research Institute, University of Rochester, Box CVRI, 601 Elmwood Ave, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 33:999-1005. 2013
    ..Because GIT1 regulates signaling by several vascular smooth muscle cell (VSMC) growth factors, we hypothesized that intima formation would be inhibited by GIT1 depletion...
  23. ncbi request reprint Role of Angiotensin-converting enzyme and neutral endopeptidase in flow-dependent remodeling
    Vyacheslav A Korshunov
    Center for Cardiovascular Research and Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    J Vasc Res 41:148-56. 2004
    ..The results suggest that dual inhibition of NEP/ACE may have greater effects than ACE inhibition alone on vessel remodeling in hypertension...
  24. ncbi request reprint Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival
    David J Nagel
    Cardiovascular Research Institute, University of Rochester, New York, USA
    Circ Res 98:777-84. 2006
    ..These suggest that nuclear PDE1A is important in VSMC growth and survival and may contribute to the neointima formation in atherosclerosis and restenosis...
  25. pmc Platelet factor 4 mediates vascular smooth muscle cell injury responses
    Guanfang Shi
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Blood 121:4417-27. 2013
    ..Our data indicate an important mechanistic role for platelets and PF4 in VSMC injury responses both in vitro and in vivo...
  26. pmc Immune modulation of vascular resident cells by Axl orchestrates carotid intima-media thickening
    Janice Gerloff
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Am J Pathol 180:2134-43. 2012
    ..Our data suggest that Axl contributes to carotid remodeling not only by inhibition of apoptosis but also via regulation of immune heterogeneity of vascular cells, cytokine/chemokine expression, and extracellular matrix remodeling...
  27. pmc Novel tyrosine kinase signaling pathways: implications in vascular remodeling
    Sri N Batchu
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Curr Opin Nephrol Hypertens 21:122-7. 2012
    ..This review summarizes the recent advances in molecular mechanisms by which five classes of receptor tyrosine kinases (RTKs) contribute to vascular remodeling...