Joe N Kornegay

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Widespread muscle expression of an AAV9 human mini-dystrophin vector after intravenous injection in neonatal dystrophin-deficient dogs
    Joe N Kornegay
    Department of Pathology and Laboratory Medicine, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Ther 18:1501-8. 2010
  2. doi request reprint The paradox of muscle hypertrophy in muscular dystrophy
    Joe N Kornegay
    Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    Phys Med Rehabil Clin N Am 23:149-72, xii. 2012
  3. doi request reprint Canine models of Duchenne muscular dystrophy and their use in therapeutic strategies
    Joe N Kornegay
    Department of Pathology and Laboratory Medicine, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    Mamm Genome 23:85-108. 2012
  4. doi request reprint Golden retriever muscular dystrophy (GRMD): Developing and maintaining a colony and physiological functional measurements
    Joe N Kornegay
    Department of Pathology and Laboratory Medicine and The Gene Therapy Center, School of Medicine, University of North Carolina Chapel Hill, Chapel Hill, NC, USA
    Methods Mol Biol 709:105-23. 2011
  5. pmc A single intravenous injection of adeno-associated virus serotype-9 leads to whole body skeletal muscle transduction in dogs
    Yongping Yue
    Department of Molecular Microbiology and Immunology, School of Medicine, The University of Missouri, Columbia, Missouri 65212, USA
    Mol Ther 16:1944-52. 2008
  6. pmc Chronic administration of a leupeptin-derived calpain inhibitor fails to ameliorate severe muscle pathology in a canine model of duchenne muscular dystrophy
    Martin K Childers
    Department of Neurology, Wake Forest University Health Sciences Winston Salem, NC, USA
    Front Pharmacol 2:89. 2011
  7. ncbi request reprint Skinned single fibers from normal and dystrophin-deficient dogs incur comparable stretch-induced force deficits
    Martin K Childers
    Department of Physical Medicine and Rehabilitation, School of Medicine, University of Missouri Columbia, DCO 46 00, One Hospital Drive, Columbia, Missouri 65212, USA
    Muscle Nerve 31:768-71. 2005
  8. doi request reprint A computerized MRI biomarker quantification scheme for a canine model of Duchenne muscular dystrophy
    Jiahui Wang
    Department of Psychiatry, University of North Carolina, Chapel Hill, NC, 27599, USA
    Int J Comput Assist Radiol Surg 8:763-74. 2013
  9. pmc Polystyrene-coated micropallets for culture and separation of primary muscle cells
    David A Detwiler
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Anal Bioanal Chem 402:1083-91. 2012
  10. doi request reprint Two anatomic resources of canine pelvic limb muscles based on CT and MRI
    Sarena K Sunico
    College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA
    Vet Radiol Ultrasound 53:266-72. 2012

Research Grants

  1. Regional Biocontainment Laboratory
    Joe Kornegay; Fiscal Year: 2006

Collaborators

Detail Information

Publications11

  1. pmc Widespread muscle expression of an AAV9 human mini-dystrophin vector after intravenous injection in neonatal dystrophin-deficient dogs
    Joe N Kornegay
    Department of Pathology and Laboratory Medicine, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Ther 18:1501-8. 2010
    ..Use of the ubiquitous CMV promoter, extra-high vector dose, and marked expression of a human protein in canine muscles may have contributed to the pathologic changes seen in the pelvic limbs...
  2. doi request reprint The paradox of muscle hypertrophy in muscular dystrophy
    Joe N Kornegay
    Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    Phys Med Rehabil Clin N Am 23:149-72, xii. 2012
    ..Muscle hypertrophy can exaggerate postural instability and joint contractures. Deleterious consequences of muscle hypertrophy should be considered when developing treatments for muscular dystrophy...
  3. doi request reprint Canine models of Duchenne muscular dystrophy and their use in therapeutic strategies
    Joe N Kornegay
    Department of Pathology and Laboratory Medicine, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    Mamm Genome 23:85-108. 2012
    ..By correlating functional and mRNA profiling results, gene targets for therapy development can be identified...
  4. doi request reprint Golden retriever muscular dystrophy (GRMD): Developing and maintaining a colony and physiological functional measurements
    Joe N Kornegay
    Department of Pathology and Laboratory Medicine and The Gene Therapy Center, School of Medicine, University of North Carolina Chapel Hill, Chapel Hill, NC, USA
    Methods Mol Biol 709:105-23. 2011
    ..Key challenges in colony development (breeding, neonatal death, and the risk of inbreeding) and representative functional measurements (tibiotarsal joint angle and torque force; and eccentric contraction decrement) are discussed...
  5. pmc A single intravenous injection of adeno-associated virus serotype-9 leads to whole body skeletal muscle transduction in dogs
    Yongping Yue
    Department of Molecular Microbiology and Immunology, School of Medicine, The University of Missouri, Columbia, Missouri 65212, USA
    Mol Ther 16:1944-52. 2008
    ..In particular, cardiac muscle was barely transduced in dogs. Many muscular dystrophy patients can be identified by neonatal screening. The technology described here may lead to an effective early intervention in these patients...
  6. pmc Chronic administration of a leupeptin-derived calpain inhibitor fails to ameliorate severe muscle pathology in a canine model of duchenne muscular dystrophy
    Martin K Childers
    Department of Neurology, Wake Forest University Health Sciences Winston Salem, NC, USA
    Front Pharmacol 2:89. 2011
    ..Taken together, these data do not support the hypothesis that treatment with C101 mitigates progressive weakness or ameliorates severe muscle pathology observed in young dogs with GRMD...
  7. ncbi request reprint Skinned single fibers from normal and dystrophin-deficient dogs incur comparable stretch-induced force deficits
    Martin K Childers
    Department of Physical Medicine and Rehabilitation, School of Medicine, University of Missouri Columbia, DCO 46 00, One Hospital Drive, Columbia, Missouri 65212, USA
    Muscle Nerve 31:768-71. 2005
    ....
  8. doi request reprint A computerized MRI biomarker quantification scheme for a canine model of Duchenne muscular dystrophy
    Jiahui Wang
    Department of Psychiatry, University of North Carolina, Chapel Hill, NC, 27599, USA
    Int J Comput Assist Radiol Surg 8:763-74. 2013
    ....
  9. pmc Polystyrene-coated micropallets for culture and separation of primary muscle cells
    David A Detwiler
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Anal Bioanal Chem 402:1083-91. 2012
    ..This micropallet coating strategy is readily adaptable to optimize the array surface for other types of primary cells...
  10. doi request reprint Two anatomic resources of canine pelvic limb muscles based on CT and MRI
    Sarena K Sunico
    College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA
    Vet Radiol Ultrasound 53:266-72. 2012
    ..Both projects are hosted on an open-access website, http://3dvetanatomy.ncsu.edu/..
  11. pmc Regulation of the calpain and ubiquitin-proteasome systems in a canine model of muscular dystrophy
    Kristine M Wadosky
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    Muscle Nerve 44:553-62. 2011
    ..Previous studies have tested the hypothesis that calpain and/or proteasome inhibition is beneficial in Duchenne muscular dystrophy, based largely on evidence that calpain and proteasome activities are enhanced in the mdx mouse...

Research Grants2

  1. Regional Biocontainment Laboratory
    Joe Kornegay; Fiscal Year: 2006
    ..The facility will also be available and prepared to assist national, state, and local public health officials in the event of a bioterrorism emergency. ..