Harley I Kornblum

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Induction of brain derived neurotrophic factor mRNA by seizures in neonatal and juvenile rat brain
    H I Kornblum
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Brain Res Mol Brain Res 44:219-28. 1997
  2. ncbi request reprint Prenatal ontogeny of the epidermal growth factor receptor and its ligand, transforming growth factor alpha, in the rat brain
    H I Kornblum
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine 90095, USA
    J Comp Neurol 380:243-61. 1997
  3. ncbi request reprint Abnormal astrocyte development and neuronal death in mice lacking the epidermal growth factor receptor
    H I Kornblum
    Department of Molecular and Medical Pharmacology, Brain Research Institute, University of California, Los Angeles School of Medicine, 90095, USA
    J Neurosci Res 53:697-717. 1998
  4. ncbi request reprint Multiple trophic actions of heparin-binding epidermal growth factor (HB-EGF) in the central nervous system
    H I Kornblum
    Department of Molecular and Medical Pharmacology, Brain Research Institute, University of California, Los Angeles School of Medicine 90095, USA
    Eur J Neurosci 11:3236-46. 1999
  5. ncbi request reprint Expression of the EGF receptor family members ErbB2, ErbB3, and ErbB4 in germinal zones of the developing brain and in neurosphere cultures containing CNS stem cells
    H I Kornblum
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, Calif, USA
    Dev Neurosci 22:16-24. 2000
  6. ncbi request reprint A multipronged approach to the identification and study of an important oncogene in GBM
    Harley I Kornblum
    Intellectual and Developmental Disabilities Research Center and Department of Psychiatry, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Cancer Cell 17:417-8. 2010
  7. doi request reprint Methods for analysis of brain tumor stem cell and neural stem cell self-renewal
    Ichiro Nakano
    Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Methods Mol Biol 568:37-56. 2009
  8. pmc Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation
    Ichiro Nakano
    Department of Pharmacology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Cell Biol 170:413-27. 2005
  9. ncbi request reprint Patterns of Jagged1, Jagged2, Delta-like 1 and Delta-like 3 expression during late embryonic and postnatal brain development suggest multiple functional roles in progenitors and differentiated cells
    Dwain K Irvin
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California, USA
    J Neurosci Res 75:330-43. 2004
  10. ncbi request reprint Phenotypic and functional heterogeneity of GFAP-expressing cells in vitro: differential expression of LeX/CD15 by GFAP-expressing multipotent neural stem cells and non-neurogenic astrocytes
    Tetsuya Imura
    Department of Neurobiology, University of California, Los Angeles, California 90095 1763, USA
    Glia 53:277-93. 2006

Detail Information

Publications47

  1. ncbi request reprint Induction of brain derived neurotrophic factor mRNA by seizures in neonatal and juvenile rat brain
    H I Kornblum
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Brain Res Mol Brain Res 44:219-28. 1997
    ..Furthermore, BDNF may be capable of playing a role in the development of seizure susceptibility in the immature brain...
  2. ncbi request reprint Prenatal ontogeny of the epidermal growth factor receptor and its ligand, transforming growth factor alpha, in the rat brain
    H I Kornblum
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine 90095, USA
    J Comp Neurol 380:243-61. 1997
    ..These data indicate that TGF alpha and EGF-R are positioned to have a role in the genesis, differentiation, migration, or survival of numerous cell populations in the embryonic brain...
  3. ncbi request reprint Abnormal astrocyte development and neuronal death in mice lacking the epidermal growth factor receptor
    H I Kornblum
    Department of Molecular and Medical Pharmacology, Brain Research Institute, University of California, Los Angeles School of Medicine, 90095, USA
    J Neurosci Res 53:697-717. 1998
    ..These data demonstrate that EGF-R expression is critical for the maintenance of large portions of the postnatal mouse forebrain as well as the normal development of astrocytes...
  4. ncbi request reprint Multiple trophic actions of heparin-binding epidermal growth factor (HB-EGF) in the central nervous system
    H I Kornblum
    Department of Molecular and Medical Pharmacology, Brain Research Institute, University of California, Los Angeles School of Medicine 90095, USA
    Eur J Neurosci 11:3236-46. 1999
    ..These findings indicate that HB-EGF may be an important trophic factor in the developing CNS and is a useful candidate molecule for brain repair strategies...
  5. ncbi request reprint Expression of the EGF receptor family members ErbB2, ErbB3, and ErbB4 in germinal zones of the developing brain and in neurosphere cultures containing CNS stem cells
    H I Kornblum
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, Calif, USA
    Dev Neurosci 22:16-24. 2000
    ..Overall, our results indicate that ErbB2, ErbB3 and ErbB4 may play important and distinct roles in the genesis of the CNS. However, our in vitro data do not support a role for neuregulins in proliferation, per se, of CNS stem cells...
  6. ncbi request reprint A multipronged approach to the identification and study of an important oncogene in GBM
    Harley I Kornblum
    Intellectual and Developmental Disabilities Research Center and Department of Psychiatry, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Cancer Cell 17:417-8. 2010
    ..provide strong evidence that PLAGL2 serves as an oncogene in GBM. They demonstrate that PLAGL2 inhibits differentiation and promotes a persistent, self-renewing state, at least in part because of activation of Wnt signaling...
  7. doi request reprint Methods for analysis of brain tumor stem cell and neural stem cell self-renewal
    Ichiro Nakano
    Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Methods Mol Biol 568:37-56. 2009
    ..Utilizing our studies with MELK as an example, this chapter describes methods to culture NSC and BT stem cells, and to analyze the pathways, which regulate self-renewal of those cells...
  8. pmc Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation
    Ichiro Nakano
    Department of Pharmacology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Cell Biol 170:413-27. 2005
    ..These findings indicate that MELK is necessary for proliferation of embryonic and postnatal MNP and suggest that it regulates the transition from GFAP-expressing progenitors to rapid amplifying progenitors in the postnatal brain...
  9. ncbi request reprint Patterns of Jagged1, Jagged2, Delta-like 1 and Delta-like 3 expression during late embryonic and postnatal brain development suggest multiple functional roles in progenitors and differentiated cells
    Dwain K Irvin
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California, USA
    J Neurosci Res 75:330-43. 2004
    ..Taken together, these results support multiple and differing roles for the various ligands during and after central nervous system (CNS) development...
  10. ncbi request reprint Phenotypic and functional heterogeneity of GFAP-expressing cells in vitro: differential expression of LeX/CD15 by GFAP-expressing multipotent neural stem cells and non-neurogenic astrocytes
    Tetsuya Imura
    Department of Neurobiology, University of California, Los Angeles, California 90095 1763, USA
    Glia 53:277-93. 2006
    ..The findings provide evidence that GFAP-expressing NSCs are phenotypically and functionally distinct from non-neurogenic astrocytes...
  11. ncbi request reprint Developmental expression of glial fibrillary acidic protein mRNA in mouse forebrain germinal zones--implications for stem cell biology
    Irina J Fox
    UCLA Interdepartmental Program in Molecular, Cellular, and Integrative Physiology, David Geffen School of Medicine, Los Angeles, CA 90095, USA
    Brain Res Dev Brain Res 153:121-5. 2004
    ..The current findings indicate that while some GFAP-expressing cells in the GZ may be NSCs, most are not likely to function in a neurogenic capacity...
  12. ncbi request reprint Phosphoserine phosphatase is expressed in the neural stem cell niche and regulates neural stem and progenitor cell proliferation
    Ichiro Nakano
    Department of Neurological Surgery, UCLA, Los Angeles, CA 90095 1769, USA
    Stem Cells 25:1975-84. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  13. ncbi request reprint Extrinsic and intrinsic factors governing cell fate in cortical progenitor cultures
    Dwain K Irvin
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, Calif 90095, USA
    Dev Neurosci 25:162-72. 2003
    ..These data suggest that both extrinsic and intrinsic factors differentially regulate cell fate choices of progenitors during cortical development...
  14. pmc PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry
    Matthias Groszer
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 103:111-6. 2006
    ..Therefore, loss of PTEN leads to cell physiological changes, which collectively are sufficient to increase the pool of self-renewing neural stem cells and promote their escape from the homeostatic mechanisms of proliferation control...
  15. ncbi request reprint Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells
    Ichiro Nakano
    Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Neurosci Res 86:48-60. 2008
    ..These results demonstrate a critical role for MELK in the proliferation of brain tumors, including their stem cells, and suggest that MELK may be a compelling molecular target for treatment of high-grade brain tumors...
  16. pmc A molecular screening approach to identify and characterize inhibitors of glioblastoma stem cells
    Koppany Visnyei
    Intellectual and Developmental Disabilities Research Center, Department of Psychiatry, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Mol Cancer Ther 10:1818-28. 2011
    ..These studies show that our screening strategy provides potential candidates and a blueprint for lead compound identification in larger scale screens or screens involving other cancer types...
  17. pmc Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis
    Caroline Gregorian
    Department of Molecular and Medical Pharmacology, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 29:1874-86. 2009
    ....
  18. ncbi request reprint Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations
    Mathew C Easterday
    Interdepartmental Program for Neuroscience, UCLA, School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Dev Biol 264:309-22. 2003
    ..Taken together, these studies identify many genes not previously associated with neural progenitor cell biology and also provide a rational scheme for stratification of microarray data for functional analysis...
  19. doi request reprint Clinical outcome in pediatric glial and embryonal brain tumors correlates with in vitro multi-passageable neurosphere formation
    Eduard H Panosyan
    Department of Pediatrics, University of California Los Angeles UCLA, Los Angeles, California 90095, USA
    Pediatr Blood Cancer 55:644-51. 2010
    ..Renewable neurosphere formation has clinical predictive value in adult malignant gliomas, yet its prognostic role for pediatric brain tumors is unknown...
  20. pmc A microfluidic platform for systems pathology: multiparameter single-cell signaling measurements of clinical brain tumor specimens
    Jing Sun
    Crump Institute for Molecular Imaging, University of California at Los Angeles, Los Angeles, California 90095, USA
    Cancer Res 70:6128-38. 2010
    ..Together with bioinformatic analysis, the MIC platform represents a robust, enabling in vitro molecular diagnostic technology for systems pathology analysis and personalized medicine...
  21. ncbi request reprint Neural progenitor implantation restores metabolic deficits in the brain following striatal quinolinic acid lesion
    Koppany Visnyei
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Exp Neurol 197:465-74. 2006
    ..These data demonstrate that progenitor cell implantation results in enhanced metabolic function and sparing of neuron number, but that these functions do not necessarily result in the restoration of complex circuitry...
  22. ncbi request reprint Developmental profile of ErbB receptors in murine central nervous system: implications for functional interactions
    Irina J Fox
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095, USA
    J Neurosci Res 79:584-97. 2005
    ..Together, these findings suggest that ErbB receptors might mediate multiple functions in central nervous system development, some of which may be initiated by EGFR/ErbB4 heterodimers in vivo...
  23. pmc Identification of retinol binding protein 1 promoter hypermethylation in isocitrate dehydrogenase 1 and 2 mutant gliomas
    Arthur P Chou
    Department of Neurology, David Geffen School of Medicine at the University of California Los Angeles, 90095, USA
    J Natl Cancer Inst 104:1458-69. 2012
    ....
  24. pmc Autocrine endothelin-3/endothelin receptor B signaling maintains cellular and molecular properties of glioblastoma stem cells
    Yue Liu
    Department of Surgery Surgical Oncology, University of California Los Angeles, Los Angeles, California 90095, USA
    Mol Cancer Res 9:1668-85. 2011
    ..Incorporating END3/EDNRB-targeted therapies into conventional cancer treatments may have clinical implication for the prevention of tumor recurrence...
  25. pmc Endogenous Wnt signaling maintains neural progenitor cell potency
    Eric M Wexler
    Department of Psychiatry, The Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90024 1759, USA
    Stem Cells 27:1130-41. 2009
    ..In sum, this study establishes that autonomous Wnt signaling is a conserved feature of the neurogenic niche that preserves the delicate balance between NSC maintenance and differentiation...
  26. ncbi request reprint Developmental expression of OAP-1/Tspan-3, a member of the tetraspanin superfamily
    Seema K Tiwari-Woodruff
    Departments of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Neurosci Res 77:166-73. 2004
    ....
  27. pmc A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation
    Jonathan P Saxe
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Chem Biol 14:1019-30. 2007
    ..This work highlights the tremendous potential of developing effective small-molecule drugs for use in regenerative medicine or transplantation therapy...
  28. ncbi request reprint Global analysis of gene expression in neural progenitors reveals specific cell-cycle, signaling, and metabolic networks
    Stanislav L Karsten
    Department of Neurology, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    Dev Biol 261:165-82. 2003
    ..We propose a putative network of gene expression linking cell cycle control to cell fate pathways, providing a framework for further investigations of neural stem cell proliferation and differentiation...
  29. pmc Cell lineage and regional identity of cultured spinal cord neural stem cells and comparison to brain-derived neural stem cells
    Theresa K Kelly
    The Semel Institute for Neuroscience and Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    PLoS ONE 4:e4213. 2009
    ..Furthermore, there is a population of a LeX negative NSC that is present in neurospheres derived from the embryonic spinal cord but not the cortex...
  30. pmc Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant manner
    Janel E Le Belle
    NPI Semel Institute for Neuroscience and Human Behavior and Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Cell Stem Cell 8:59-71. 2011
    ..This study has identified a redox-mediated regulatory mechanism of NSC function that may have significant implications for brain injury, disease, and repair...
  31. pmc Neurosphere formation is an independent predictor of clinical outcome in malignant glioma
    Dan R Laks
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Stem Cells 27:980-7. 2009
    ..Furthermore, this study suggests that the ability to propagate brain tumor stem cells in vitro is associated with clinical outcome...
  32. doi request reprint BMPing off glioma stem cells
    Ichiro Nakano
    Department of Neurological Surgery, University of California, Los Angeles, School of Medicine, Los Angeles, CA 90095, USA
    Cancer Cell 13:3-4. 2008
    ..These findings document the importance of the BMP signaling system in BTSC as well as that of taking heterogeneity into account when studying BTSC as potential targets for therapy...
  33. pmc Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS
    Saravanan Karumbayaram
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Dis Model Mech 2:189-95. 2009
    ..These genetically manipulated hESC-derived motor neurons can facilitate and advance the study of disease-specific cellular pathways, and serve as a model system to test new therapeutic approaches...
  34. pmc Directed differentiation of human-induced pluripotent stem cells generates active motor neurons
    Saravanan Karumbayaram
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Stem Cells 27:806-11. 2009
    ..These findings demonstrate the feasibility of using iPS-derived motor neuron progenitors and motor neurons in regenerative medicine applications and in vitro modeling of motor neuron diseases...
  35. ncbi request reprint The predominant neural stem cell isolated from postnatal and adult forebrain but not early embryonic forebrain expresses GFAP
    Tetsuya Imura
    Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, California 90095 1763, USA
    J Neurosci 23:2824-32. 2003
    ....
  36. ncbi request reprint Evolution of diaschisis in a focal stroke model
    S Thomas Carmichael
    Department of Neurology, David Geffen School of Medicine at University of California at Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Stroke 35:758-63. 2004
    ..The sequential changes in diaschisis over time and the relationship of regions of diaschisis to functional cortical areas and regions of poststroke neuroplasticity have not been determined...
  37. ncbi request reprint Introduction to neural stem cells
    Harley I Kornblum
    Semel Institute and Departments of Psychiatry, Pharmacology and Pediatrics, David Geffen School of Medicine at UCLA, Los Angles, CA, USA
    Stroke 38:810-6. 2007
    ..This brief review provides an introduction to neural stem cells and briefly describes some advances in neural stem-cell biology and biotechnology...
  38. pmc Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy
    Whitney B Pope
    Department of Radiological Sciences, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, USA
    J Neurooncol 107:197-205. 2012
    ..In addition to 2-HG, alterations in several other metabolites measured by MRS correlate with IDH1 mutation status...
  39. doi request reprint Hydrogel matrix to support stem cell survival after brain transplantation in stroke
    Jin Zhong
    David Geffen School of Medicine at UCLA, Los Angeles, CA 98895, USA
    Neurorehabil Neural Repair 24:636-44. 2010
    ..Stem cell transplantation into the infarct cavity within a pro-survival hydrogel matrix may provide a translational therapy for stroke recovery...
  40. ncbi request reprint Brain tumor stem cells
    Ichiro Nakano
    Departments of Psychiatry, David Geffen School of Medicine at University of California, Los Angeles, 90095, USA
    Pediatr Res 59:54R-8R. 2006
    ..In this review, we discuss the cellular and molecular relationships between brain tumor stem cells and normal neural stem cells, and also the possible clinical implications of brain tumor stem cells...
  41. ncbi request reprint Expression patterns of epidermal growth factor receptor and fibroblast growth factor receptor 1 mRNA in fetal human brain
    Lijuan Fu
    Department of Neurology, University of California, Los Angeles School of Medicine, Los Angeles, California 90095, USA
    J Comp Neurol 462:265-73. 2003
    ..The current study suggests that HEGFR and HFGFR1 are likely to play different roles during human brain development, but that these roles will be similar to those observed in the rodent brain...
  42. ncbi request reprint Report on the workshop "New Technologies in Stem Cell Research," Society for Pediatric Research, San Francisco, California, April 29, 2006
    Jerry C Cheng
    Division of Hematology Oncology, Department of Pediatrics, Gwynne Hazen Cherry Memorial Laboratories and Mattel Children s Hospital, Jonsson Comprehensive Cancer Center, Los Angeles, California, USA
    Stem Cells 25:1070-88. 2007
  43. ncbi request reprint Metabolic correlates of lesion-specific plasticity: an in vivo imaging study
    Halleh M Mir
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Brain Res 1002:28-34. 2004
    ....
  44. pmc Disruption of the PACAP gene promotes medulloblastoma in ptc1 mutant mice
    Vincent Lelievre
    Department of Psychiatry and Biobehavioral Research Mental Retardation Research Center, University of California at Los Angeles, CA 90095, USA
    Dev Biol 313:359-70. 2008
    ..The results provide genetic evidence that PACAP acts as a physiological factor that regulates the pathogenesis of Hh pathway-associated MB tumors...
  45. ncbi request reprint The RAS effector RIN1 modulates the formation of aversive memories
    Ajay Dhaka
    Molecular Biology Institute, University of California, Los Angeles School of Medicine, Los Angeles, California 90095 1737, USA
    J Neurosci 23:748-57. 2003
    ..These results indicate that RIN1 serves as an inhibitory modulator of neuronal plasticity in aversive memory formation...
  46. ncbi request reprint [Cancer stem cells in pediatric brain tumors]
    Ichiro Nakano
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    No Shinkei Geka 32:827-34. 2004
    ..In this review, we discuss the difference as well as the similarity between tumor and normal stem cells, and also the possible clinical implication of cancer stem cells...
  47. pmc Identification of differentially expressed proteins in murine embryonic and postnatal cortical neural progenitors
    Lorelei D Shoemaker
    Pasarow Mass Spectrometry Laboratory, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e9121. 2010
    ..The study of NSPC would be greatly facilitated by the identification of additional proteins that mediate their function and that would distinguish amongst different progenitor populations...