Thomas Kornberg

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Spatial regulation of engrailed expression in the Drosophila embryo
    M P Weir
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143
    Genes Dev 2:1194-203. 1988
  2. pmc Expression profiling of Drosophila imaginal discs
    Ansgar Klebes
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
    Genome Biol 3:RESEARCH0038. 2002
  3. ncbi request reprint Pictures in cell biology. Cytonemes
    T Kornberg
    Dept of Biochemistry and Biophysics, University of California School of Medicine, San Francisco, CA 94143, USA
    Trends Cell Biol 9:434. 1999
  4. pmc Another arrow in the Drosophila quiver
    Thomas Kornberg
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 99:9607-8. 2002
  5. pmc Understanding morphogen gradients: a problem of dispersion and containment
    Thomas B Kornberg
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, United States
    Curr Opin Genet Dev 17:264-71. 2007
  6. ncbi request reprint Patterns of engrailed protein in early Drosophila embryos
    T L Karr
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143
    Development 105:605-12. 1989
  7. pmc A screen for modifiers of hedgehog signaling in Drosophila melanogaster identifies swm and mts
    David J Casso
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Genetics 178:1399-413. 2008
  8. pmc The C-terminal tail of the Hedgehog receptor Patched regulates both localization and turnover
    Xingwu Lu
    Department of Biochemistry and Biophysics, University of California at San Francisco, 94143, USA
    Genes Dev 20:2539-51. 2006
  9. pmc Smoothened regulates activator and repressor functions of Hedgehog signaling via two distinct mechanisms
    Stacey K Ogden
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH 03755, USA
    J Biol Chem 281:7237-43. 2006
  10. ncbi request reprint Dependence of Drosophila wing imaginal disc cytonemes on Decapentaplegic
    Frank Hsiung
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143, USA
    Nature 437:560-3. 2005

Research Grants

Collaborators

  • Makoto Sato
  • Ansgar Klebes
  • David J Casso
  • Arjun Guha
  • Stacey K Ogden
  • Songmei Liu
  • D David Iwaki
  • Xingwu Lu
  • Frank Hsiung
  • Brian Biehs
  • Li Lin
  • Manuel Ascano
  • David J Robbins
  • Mark M Yore
  • Soichi Tanda
  • Felipe Andrès Ramirez-Weber
  • Anne Sustar
  • Katherina Kechris
  • Gerold Schubiger
  • Bruno Martoglio
  • Hao Li
  • Francisco Cifuentes
  • M P Weir
  • T L Karr
  • B A Edgar
  • Z Ali
  • G Schubiger

Detail Information

Publications16

  1. ncbi request reprint Spatial regulation of engrailed expression in the Drosophila embryo
    M P Weir
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143
    Genes Dev 2:1194-203. 1988
    ..We suggest that products of known segmentation genes are the repressors that suppress engrailed expression in interbands...
  2. pmc Expression profiling of Drosophila imaginal discs
    Ansgar Klebes
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
    Genome Biol 3:RESEARCH0038. 2002
    ..To identify genes that establish and express the different states of determination in discs and larval tissues, we used DNA microarrays to analyze mRNAs isolated from single imaginal discs...
  3. ncbi request reprint Pictures in cell biology. Cytonemes
    T Kornberg
    Dept of Biochemistry and Biophysics, University of California School of Medicine, San Francisco, CA 94143, USA
    Trends Cell Biol 9:434. 1999
  4. pmc Another arrow in the Drosophila quiver
    Thomas Kornberg
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 99:9607-8. 2002
  5. pmc Understanding morphogen gradients: a problem of dispersion and containment
    Thomas B Kornberg
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, United States
    Curr Opin Genet Dev 17:264-71. 2007
    ..We argue that in the absence of constraining barriers, gradient-generating dispersion of morphogens cannot be achieved by passive diffusion and that other mechanisms for distribution must be considered...
  6. ncbi request reprint Patterns of engrailed protein in early Drosophila embryos
    T L Karr
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143
    Development 105:605-12. 1989
    ..When localization of engrailed protein begins during cycle 14, engrailed expression was first present in broad anterior and posterior regions before the fourteen-stripe pattern appeared...
  7. pmc A screen for modifiers of hedgehog signaling in Drosophila melanogaster identifies swm and mts
    David J Casso
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Genetics 178:1399-413. 2008
    ..Characterization of newly isolated alleles indicates that swm is a negative regulator of Hh signaling and is essential for cell polarity...
  8. pmc The C-terminal tail of the Hedgehog receptor Patched regulates both localization and turnover
    Xingwu Lu
    Department of Biochemistry and Biophysics, University of California at San Francisco, 94143, USA
    Genes Dev 20:2539-51. 2006
    ..These data show that degradation of Ptc is regulated at a step subsequent to endocytosis, although endocytosis is a likely prerequisite. We also show that the CTD of mouse Ptc regulates turnover...
  9. pmc Smoothened regulates activator and repressor functions of Hedgehog signaling via two distinct mechanisms
    Stacey K Ogden
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH 03755, USA
    J Biol Chem 281:7237-43. 2006
    ....
  10. ncbi request reprint Dependence of Drosophila wing imaginal disc cytonemes on Decapentaplegic
    Frank Hsiung
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143, USA
    Nature 437:560-3. 2005
    ..We also show that the Dpp receptor, Thickveins (Tkv), is present in punctae that move along cytonemes. These observations are consistent with a role for cytonemes in signal transduction...
  11. ncbi request reprint Regulation of cellular plasticity in Drosophila imaginal disc cells by the Polycomb group, trithorax group and lama genes
    Ansgar Klebes
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
    Development 132:3753-65. 2005
    ..Our findings are likely to be relevant to the mechanisms that lead to disease when homologs of Wingless are expressed at abnormal levels and to the manifestation of pluripotency of stem cells...
  12. pmc Drosophila signal peptide peptidase is an essential protease for larval development
    David J Casso
    Department of Biochemistry and Biophysics, University of California, San Francisco, 94143, USA
    Genetics 170:139-48. 2005
    ..Flies bearing mutations in conserved residues or carrying deficiencies for the Spp gene had defective tracheae and died as larvae...
  13. ncbi request reprint FGF is an essential mitogen and chemoattractant for the air sacs of the drosophila tracheal system
    Makoto Sato
    Department of Biochemistry and Biophysics, University of California, San Francisco, 94143, USA
    Dev Cell 3:195-207. 2002
    ....
  14. ncbi request reprint Tracheal branch repopulation precedes induction of the Drosophila dorsal air sac primordium
    Arjun Guha
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
    Dev Biol 287:192-200. 2005
    ....
  15. doi request reprint Linear RNA amplification for the production of microarray hybridization probes
    Ansgar Klebes
    Institut fü Biologie Genetik, Freie Universitä Berlin, Berlin, Germany
    Methods Mol Biol 420:303-17. 2008
    ..These smaller quantities can be isolated from a few 100 cells. Here, we present a linear amplification protocol designed to preserve both the relative abundance of transcripts as well as their sequence complexity...
  16. pmc Organ renewal and cell divisions by differentiated cells in Drosophila
    Arjun Guha
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 105:10832-6. 2008
    ..We report here that they reinitiate cell divisions during the third instar (L3) to increase the Tr2 population by approximately 10-fold with multipotent cells...

Research Grants3

  1. GENETIC CONTROL OF THE YEAST SPORULATION PROGRAM
    Thomas Kornberg; Fiscal Year: 2003
    ..Learning about Ndt80 protein is likely to yield enormous insight on the decision to exit meiotic prophase and on the overall program of sporulation. ..
  2. THE DROSOPHILA DORSAL AIR SACS, A MODEL SYSTEM FOR LUNG DEVELOPMENT
    Thomas Kornberg; Fiscal Year: 2007
    ....