Research Topics
Genomes and GenesSpecies | Thomas KornbergSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Spatial regulation of engrailed expression in the Drosophila embryoM P Weir
Department of Biochemistry and Biophysics, University of California, San Francisco 94143
Genes Dev 2:1194-203. 1988..We suggest that products of known segmentation genes are the repressors that suppress engrailed expression in interbands...
Expression profiling of Drosophila imaginal discsAnsgar Klebes
Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
Genome Biol 3:RESEARCH0038. 2002..To identify genes that establish and express the different states of determination in discs and larval tissues, we used DNA microarrays to analyze mRNAs isolated from single imaginal discs...- Pictures in cell biology. CytonemesT Kornberg
Dept of Biochemistry and Biophysics, University of California School of Medicine, San Francisco, CA 94143, USA
Trends Cell Biol 9:434. 1999 - Another arrow in the Drosophila quiverThomas Kornberg
Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 99:9607-8. 2002 - Understanding morphogen gradients: a problem of dispersion and containmentThomas B Kornberg
Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, United States
Curr Opin Genet Dev 17:264-71. 2007..We argue that in the absence of constraining barriers, gradient-generating dispersion of morphogens cannot be achieved by passive diffusion and that other mechanisms for distribution must be considered... - Patterns of engrailed protein in early Drosophila embryosT L Karr
Department of Biochemistry and Biophysics, University of California, San Francisco 94143
Development 105:605-12. 1989..When localization of engrailed protein begins during cycle 14, engrailed expression was first present in broad anterior and posterior regions before the fourteen-stripe pattern appeared... - A screen for modifiers of hedgehog signaling in Drosophila melanogaster identifies swm and mtsDavid J Casso
Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
Genetics 178:1399-413. 2008..Characterization of newly isolated alleles indicates that swm is a negative regulator of Hh signaling and is essential for cell polarity... - The C-terminal tail of the Hedgehog receptor Patched regulates both localization and turnoverXingwu Lu
Department of Biochemistry and Biophysics, University of California at San Francisco, 94143, USA
Genes Dev 20:2539-51. 2006..These data show that degradation of Ptc is regulated at a step subsequent to endocytosis, although endocytosis is a likely prerequisite. We also show that the CTD of mouse Ptc regulates turnover... - Smoothened regulates activator and repressor functions of Hedgehog signaling via two distinct mechanismsStacey K Ogden
Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH 03755, USA
J Biol Chem 281:7237-43. 2006.... - Dependence of Drosophila wing imaginal disc cytonemes on DecapentaplegicFrank Hsiung
Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143, USA
Nature 437:560-3. 2005..We also show that the Dpp receptor, Thickveins (Tkv), is present in punctae that move along cytonemes. These observations are consistent with a role for cytonemes in signal transduction... - Regulation of cellular plasticity in Drosophila imaginal disc cells by the Polycomb group, trithorax group and lama genesAnsgar Klebes
Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
Development 132:3753-65. 2005..Our findings are likely to be relevant to the mechanisms that lead to disease when homologs of Wingless are expressed at abnormal levels and to the manifestation of pluripotency of stem cells... - Drosophila signal peptide peptidase is an essential protease for larval developmentDavid J Casso
Department of Biochemistry and Biophysics, University of California, San Francisco, 94143, USA
Genetics 170:139-48. 2005..Flies bearing mutations in conserved residues or carrying deficiencies for the Spp gene had defective tracheae and died as larvae... - FGF is an essential mitogen and chemoattractant for the air sacs of the drosophila tracheal systemMakoto Sato
Department of Biochemistry and Biophysics, University of California, San Francisco, 94143, USA
Dev Cell 3:195-207. 2002.... - Tracheal branch repopulation precedes induction of the Drosophila dorsal air sac primordiumArjun Guha
Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
Dev Biol 287:192-200. 2005.... 
Linear RNA amplification for the production of microarray hybridization probesAnsgar Klebes
Institut fü Biologie Genetik, Freie Universitä Berlin, Berlin, Germany
Methods Mol Biol 420:303-17. 2008..These smaller quantities can be isolated from a few 100 cells. Here, we present a linear amplification protocol designed to preserve both the relative abundance of transcripts as well as their sequence complexity...- Organ renewal and cell divisions by differentiated cells in DrosophilaArjun Guha
Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 105:10832-6. 2008..We report here that they reinitiate cell divisions during the third instar (L3) to increase the Tr2 population by approximately 10-fold with multipotent cells...
Research Grants
- GENETIC CONTROL OF THE YEAST SPORULATION PROGRAMThomas Kornberg; Fiscal Year: 2003..Learning about Ndt80 protein is likely to yield enormous insight on the decision to exit meiotic prophase and on the overall program of sporulation. ..
- THE DROSOPHILA DORSAL AIR SACS, A MODEL SYSTEM FOR LUNG DEVELOPMENTThomas Kornberg; Fiscal Year: 2007....