H Korkaya

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi Platelet-derived growth factor stimulates Src-dependent mRNA stabilization of specific early genes in fibroblasts
    Paul A Bromann
    Laboratory of Signal Regulation and Cancer, Van Andel Research Institute, 333 Bostwick NE, Grand Rapids, Michigan 49503, USA
    J Biol Chem 280:10253-63. 2005
  2. ncbi Selective targeting of cancer stem cells: a new concept in cancer therapeutics
    Hasan Korkaya
    University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA
    BioDrugs 21:299-310. 2007
  3. doi HER2 and breast cancer stem cells: more than meets the eye
    Hasan Korkaya
    University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109, USA
    Cancer Res 73:3489-93. 2013
  4. doi Breast cancer stem cells: we've got them surrounded
    Hasan Korkaya
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Clin Cancer Res 19:511-3. 2013
  5. pmc Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population
    Hasan Korkaya
    Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109 5942, USA
    Mol Cell 47:570-84. 2012
  6. pmc HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion
    H Korkaya
    Department of Internal Medicine, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
    Oncogene 27:6120-30. 2008
  7. pmc Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling
    Hasan Korkaya
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    PLoS Biol 7:e1000121. 2009
  8. ncbi [The cancer stem cell: the breast cancer driver]
    Christophe Ginestier
    University of Michigan Medical Center, Comprehensive Cancer Center, Int Med Hematology Oncology, 1500 E Medical Center Drive, Ann Arbor, MI, USA
    Med Sci (Paris) 23:1133-9. 2007

Collaborators

Detail Information

Publications8

  1. ncbi Platelet-derived growth factor stimulates Src-dependent mRNA stabilization of specific early genes in fibroblasts
    Paul A Bromann
    Laboratory of Signal Regulation and Cancer, Van Andel Research Institute, 333 Bostwick NE, Grand Rapids, Michigan 49503, USA
    J Biol Chem 280:10253-63. 2005
    ..Our data suggest that PDGF regulates gene expression through an SFK-specific pathway that is distinct from the Ras-MAPK and PI3K pathways, and that SFKs signal gene expression by enhancing mRNA stability...
  2. ncbi Selective targeting of cancer stem cells: a new concept in cancer therapeutics
    Hasan Korkaya
    University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA
    BioDrugs 21:299-310. 2007
    ....
  3. doi HER2 and breast cancer stem cells: more than meets the eye
    Hasan Korkaya
    University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109, USA
    Cancer Res 73:3489-93. 2013
    ..Furthermore, these studies suggest that effective adjuvant therapies may need to target the CSC population...
  4. doi Breast cancer stem cells: we've got them surrounded
    Hasan Korkaya
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Clin Cancer Res 19:511-3. 2013
    ..New evidence suggests that an important interaction between the interleukin (IL)-8 receptor CXCR1/2 and HER2 is involved in this regulation. Simultaneous targeting of these pathways provides a novel therapeutic approach...
  5. pmc Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population
    Hasan Korkaya
    Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109 5942, USA
    Mol Cell 47:570-84. 2012
    ..These studies demonstrate that trastuzumab resistance may be mediated by an IL6 inflammatory loop and suggest that blocking this loop may provide alternative strategy to overcome trastuzumab resistance...
  6. pmc HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion
    H Korkaya
    Department of Internal Medicine, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
    Oncogene 27:6120-30. 2008
    ..Furthermore, the clinical efficacy of trastuzumab may relate to its ability to target the cancer stem cell population in HER2-amplified tumors...
  7. pmc Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling
    Hasan Korkaya
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    PLoS Biol 7:e1000121. 2009
    ....
  8. ncbi [The cancer stem cell: the breast cancer driver]
    Christophe Ginestier
    University of Michigan Medical Center, Comprehensive Cancer Center, Int Med Hematology Oncology, 1500 E Medical Center Drive, Ann Arbor, MI, USA
    Med Sci (Paris) 23:1133-9. 2007
    ..This model has fundamental implications for breast cancer treatment. The development of specific therapeutics that target this population is an important focus for the future...