Research Topics
Genomes and GenesSpecies | Gary KoretzkySummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Differential requirement for adapter proteins Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa and adhesion- and degranulation-promoting adapter protein in FcepsilonRI signaling and mast cell functionJennifer N Wu
Abramson Family Cancer Research Institute and Department of Laboratory Medicine and Pathology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 172:6768-74. 2004..Thus, failure to bind ADAP does not underlie the functional defects exhibited by SLP-76 SH2 domain mutant-expressing mast cells...
Diacylglycerol kinases: regulated controllers of T cell activation, function, and developmentRohan P Joshi
Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
Int J Mol Sci 14:6649-73. 2013..This review summarizes the available knowledge of the function and regulation of DGK isoforms in signal transduction with a particular focus on T lymphocytes...- Positive and negative regulation of T-cell activation by adaptor proteinsG A Koretzky
Abramson Family Cancer Research Institute and Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Nat Rev Immunol 1:95-107. 2001..This review will focus on a number of adaptors that are important for lymphocyte function and emphasize the various ways in which these proteins carry out their essential roles... 
The legacy of the Philadelphia chromosomeGary A Koretzky
Abramson Family Cancer Research Institute, University of Pennsylvania Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
J Clin Invest 117:2030-2. 2007..The legacy of the Philadelphia chromosome now serves as a paradigm for how basic science discoveries can lead to effective new approaches for the treatment of human disease...- T cell activation I: proximal eventsGary A Koretzky
Department of Pathology and Laboratory Medicine, Signal Transduction Program, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Immunol Rev 191:5-6. 2003 - SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyondGary A Koretzky
Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania, 415 BRBII III, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
Nat Rev Immunol 6:67-78. 2006..In this Review, we discuss the role of SLP76 and SLP65 in several signalling pathways in haematopoietic cells, with an emphasis on recent studies that provide insight into their mechanisms of action... - Control of T cell function by positive and negative regulatorsAndrew L Singer
The Abramson Family Cancer Research Institute, Department of Laboratory Medicine and Pathology, University of Pennsylvania, Philadelphia, PA 19104, USA
Science 296:1639-40. 2002..Understanding the mechanisms that regulate T cell responsiveness will aid in the development of therapeutic agents to treat infection, cancer, and autoimmune disease and immune deficiency... - Stimulation and inhibition of immune responses: an intricate balancing actGary Koretzky
Department of Pathology, Signal Transduction Program, Abramson Family Cancer Research Institute, 415 BRBII/III, 421 Curie Boulevard, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Clin Invest 109:7-8. 2002 - The adapter protein SLP-76 mediates "outside-in" integrin signaling and function in T cellsR G Baker
Abramson Family Cancer Research Institute, University of Pennsylvania, 415 BRB 421 Curie Blvd, Philadelphia, PA 19104, USA
Mol Cell Biol 29:5578-89. 2009.... - Coupling of the TCR to integrin activation by Slap-130/FybE J Peterson
The Abramson Family Cancer Research Institute, Department of Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA
Science 293:2263-5. 2001..These data indicate that SLAP-130/Fyb is important for coupling TCR-mediated actin cytoskeletal rearrangement with activation of integrin function, and for T cells to respond fully to activating signals... - Differential requirement for SLP-76 domains in T cell development and functionP S Myung
Graduate Program in Immunology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Immunity 15:1011-26. 2001.... - RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activationGael Menasche
Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 415 BRBII III, 421 Curie Blvd, Philadelphia, PA 19104 6160, USA
Mol Cell Biol 27:4070-81. 2007..These results describe for the first time a link between ADAP/SKAP-55 and the Rap1/RIAM complex and provide a potential new mechanism for TCR-mediated integrin activation... - Akt1 and Akt2 promote peripheral B-cell maturation and survivalMarco Calamito
Department of Pathology and Laboratory of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
Blood 115:4043-50. 2010..Altogether, these studies show that Akt signaling plays a key role in peripheral B-cell maturation and survival... - Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cellsD Allman
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
J Exp Med 194:99-106. 2001.... - The role of the adapter molecule SLP-76 in platelet functionB A Judd
Signal Transduction Program, Abramson Family Cancer Research Institute University of Pennsylvania, Philadelphia, PA 19104, USA
Oncogene 20:6291-9. 2001..Because many parallels exist between signal transduction pathways in platelets and lymphocytes, we will also review the function of SLP-76 in coordinating signal transduction pathways following antigen bind to the T cell receptor... - Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strengthD J Izon
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Immunity 14:253-64. 2001.... - Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76Martha S Jordan
Cancer Biology, Abramson Family Cancer Research Institute, 427 BRBII III, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA
Immunity 28:359-69. 2008..Thus, the N-terminal tyrosines of SLP76 are required for thymocyte selection but can function on separate molecules to support TCR signaling... - The SLP-76 family of adapter proteinsJennifer N Wu
Department of Laboratory Medicine and Pathology, School of Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania, 415 BRB II/III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
Semin Immunol 16:379-93. 2004.... - Disruption of SLP-76 interaction with Gads inhibits dynamic clustering of SLP-76 and FcepsilonRI signaling in mast cellsMichael A Silverman
Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Mol Cell Biol 26:1826-38. 2006.... - Persistence of cooperatively stabilized signaling clusters drives T-cell activationStephen C Bunnell
Laboratory of Cellular and Molecular Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland, USA
Mol Cell Biol 26:7155-66. 2006..These data indicate that multivalent cooperative interactions stabilize these persistent signaling clusters, which may correspond to the functional complexes predicted by kinetic proofreading models of T-cell activation... - Syk and Slp-76 mutant mice reveal a cell-autonomous hematopoietic cell contribution to vascular developmentEric Sebzda
Department of Medicine, University of Pennsylvania, Philadelphia, 19104, USA
Dev Cell 11:349-61. 2006..These studies provide genetic evidence for hematopoietic contribution to vascular development and suggest that hematopoietic tissue can provide a source of vascular endothelial progenitor cells throughout life... - The actin cloud induced by LFA-1-mediated outside-in signals lowers the threshold for T-cell activationJun ichiro Suzuki
Department of Molecular Genetics, Graduate School of Medicine, Chiba University, Japan
Blood 109:168-75. 2007..The formation of the actin cloud lowers the threshold for subsequent T-cell activation. Thus, the actin cloud induced by LFA-1 engagement may serve as a possible platform for LFA-1-mediated costimulatory function for T-cell activation... - Loss of SLP-76 expression within myeloid cells confers resistance to neutrophil-mediated tissue damage while maintaining effective bacterial killingRegina A Clemens
Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA
J Immunol 178:4606-14. 2007..aureus but reduction in LPS-induced tissue damage and vascular injury... - Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivoNatalie A Bezman
Leonard and Madlyn Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Exp Med 205:1775-88. 2008..Using genetic complementation, we further demonstrate that all three phosphorylatable tyrosines are required within the same SLP76 molecule to support platelet activation by GPVI... - In vivo disruption of T cell development by expression of a dominant-negative polypeptide designed to abolish the SLP-76/Gads interactionMartha S Jordan
Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
Eur J Immunol 37:2961-72. 2007..These data provide evidence for the in vivo function of a dominant-negative peptide based upon the biology of SLP-76 action and suggest the possibility of therapeutic potential of targeting the SLP-76/Gads interaction... - Inactivation of c-Cbl reverses neonatal lethality and T cell developmental arrest of SLP-76-deficient miceY Jeffrey Chiang
Experimental Immunology Branch, Building 10, Room 4B36, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 200:25-34. 2004.... - Regulation of hematopoietic cell development and activation by adapter proteinsGary A Koretzky
Abramson Family Cancer Research Institute, Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Immunol Res 27:357-66. 2003.... - Adaptors as central mediators of signal transduction in immune cellsMartha S Jordan
Signal Transduction Program, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia 19104, USA
Nat Immunol 4:110-6. 2003..Here we focus on T lymphocytes as a model to illustrate the critical roles adaptors play as regulators of cellular activation... - Macrophage activation and Fcgamma receptor-mediated signaling do not require expression of the SLP-76 and SLP-65 adaptorsKim E Nichols
Pediatric Oncology, Children s Hospital of Philadelphia, PA 19104, USA
J Leukoc Biol 75:541-52. 2004..Taken together, these data suggest that neither SLP-76 nor SLP-65 is required during FcgammaR-dependent signaling and functional events in macrophages... - Roles of the proline-rich domain in SLP-76 subcellular localization and T cell functionAndrew L Singer
Signal Transduction Program, Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 279:15481-90. 2004..Furthermore, we provide direct evidence that SLP-76 localization and, in turn, function are dependent upon association with Gads... - SLP-76 regulates Fcgamma receptor and integrin signaling in neutrophilsSally A Newbrough
Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
Immunity 19:761-9. 2003..These results provide genetic evidence for a critical role of SLP-76 in the regulation of neutrophil function... - Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signalingBarbi A Judd
Program in Molecular Biology, University of Iowa, Iowa City, IA 52242, USA
J Exp Med 195:705-17. 2002.... - Role of the adapter protein SLP-76 in GPVI-dependent platelet procoagulant responses to collagenLorie Leo
Departments of Internal Medicine and Pediatrics, University of Iowa College of Medicine, and Veterans Affairs Medical Center, Iowa City, IA 52242, USA
Blood 100:2839-44. 2002..Thus, both GPVI-dependent and GPVI-independent pathways contribute to collagen-induced platelet procoagulant activity... - Enhanced T cell responses due to diacylglycerol kinase zeta deficiencyXiao Ping Zhong
The Signal Transduction Program, The Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania 19104, USA
Nat Immunol 4:882-90. 2003..These results demonstrate the importance of DGKzeta as a physiological negative regulator of TCR signaling and T cell activation... - Compartmentalization of ITAM and integrin signaling by adapter moleculesNatalie Bezman
Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
Immunol Rev 218:9-28. 2007..In this review, we discuss the mechanisms by which adapter proteins coordinate signal transduction with an emphasis on the role of subcellular compartmentalization in adapter function... - Antigen receptor signaling: the Tuscan connectionCosima T Baldari
Department of Evolutionary Biology, University of Siena, 53100 Siena, Italy
Nat Immunol 8:787-90. 2007 - Azathioprine: old drug, new actionsJonathan S Maltzman
Signal Transduction Program, Abramson Family Cancer Research Institute, Department of Medicine, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA
J Clin Invest 111:1122-4. 2003 - Phospholipase cbeta is critical for T cell chemotaxisTami L Bach
Department of Medicine, Abramson Family Cancer Research Institute, Philadelphia, PA, USA
J Immunol 179:2223-7. 2007..This study demonstrates that, in contrast to neutrophils, phospholipid second messengers generated by PLCbeta play a critical role in T lymphocyte chemotaxis... - Impaired thymic selection in mice expressing altered levels of the SLP-76 adaptor proteinKimberley Ramsey
Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
J Leukoc Biol 83:419-29. 2008.... - Differential requirement for the SAP-Fyn interaction during NK T cell development and functionSelene Nunez-Cruz
Division of Oncology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
J Immunol 181:2311-20. 2008..Thus, SAP appears to use differential signaling mechanisms in NKT cells, with optimal ontogeny requiring Fyn binding, while functional responses occur independently of this interaction... - Indirect involvement of allergen-captured mast cells in antigen presentationTaku Kambayashi
Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
Blood 111:1489-96. 2008..This mechanism may contribute to how mast cells impact the development of T-cell responses... - Critical roles of the PI3K/Akt signaling pathway in T cell developmentMarisa M Juntilla
Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
Immunol Lett 116:104-10. 2008..We provide new evidence that Akt-mediated survival is not solely due to the increased expression of Bcl-xL but also is a consequence of the role played by Akt to support metabolism in proliferating thymocytes... - Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and SykFarhad Abtahian
Signal Transduction Program, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
Science 299:247-51. 2003..These studies reveal a hematopoietic signaling pathway required for separation of the two major vascular networks in mammals... - Human CD8+ T cells do not require the polarization of lipid rafts for activation and proliferationBirgit Kovacs
Division of Rheumatology, Department of Pediatrics, Children's Hospital of Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 99:15006-11. 2002..It is possible that the lower stringency of CD8(+) T cell activation obviates a requirement for raft polarization... - Proximal signaling events in Fc epsilon RI-mediated mast cell activationTaku Kambayashi
Department of Pathology, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, USA
J Allergy Clin Immunol 119:544-52; quiz 553-4. 2007..Understanding the molecular mechanisms underlying mast cell activation ideally will provide insights into the development of novel therapeutics to control allergic disease... - PRAM-1 is required for optimal integrin-dependent neutrophil functionRegina A Clemens
Dept of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
Mol Cell Biol 24:10923-32. 2004..Together, these findings demonstrate the uncoupling of key integrin-dependent responses in the absence of PRAM-1 and show this adaptor to be critical for select integrin functions in neutrophils... - Regulation of NKT cell development by SAP, the protein defective in XLPKim E Nichols
Pediatric Oncology, Wood, 4th Floor, 3615 Civic Center Boulevard, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Nat Med 11:340-5. 2005..Thus, SAP is a crucial regulator of NKT cell ontogeny in humans and in mice. The absence of NKT cells may contribute to the phenotypes of SAP deficiency, including abnormal antiviral and antitumor immunity and hypogammaglobulinemia... - Conditional deletion reveals a cell-autonomous requirement of SLP-76 for thymocyte selectionJonathan S Maltzman
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Exp Med 202:893-900. 2005..These studies show for the first time that SLP-76 is required for signal transduction through the mature alphabeta TCR in primary cells of the T lineage... - Functional hierarchy of the N-terminal tyrosines of SLP-76Martha S Jordan
Signal Transduction Program, Leonard and Madlyn Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
J Immunol 176:2430-8. 2006..These studies show that Tyr(145) of SLP-76 is the most critical tyrosine for both T cell function in vitro and T cell development in vivo... - Adhesion- and degranulation-promoting adapter protein is required for efficient thymocyte development and selectionJennifer N Wu
Abramson Family Cancer Research Institute and Department of Laboratory Medicine and Pathology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 176:6681-9. 2006..ADAP deficiency also impairs the ability of transgene-bearing DP thymocytes to form conjugates with Ag-loaded presenting cells. These findings suggest that ADAP is critical for thymocyte development and selection... - Impaired degranulation but enhanced cytokine production after Fc epsilonRI stimulation of diacylglycerol kinase zeta-deficient mast cellsBenjamin A Olenchock
The Signal Transduction Program, The Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Exp Med 203:1471-80. 2006..Our data demonstrate dissociation between cytokine production and degranulation in mast cells and reveal the importance of DGK activity during IgE sensitization for proper attenuation of Fc epsilonRI signals... - Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cellsFarhad Abtahian
Signal Transduction Program, Abramson Family Cancer Research Institute, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104, USA
Mol Cell Biol 26:6936-49. 2006.... - Transcriptional regulation of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa: dissection of key promoter elementsXiao Ping Zhong
Signal Transduction Program, The Abramson Family Cancer Research Institute, and Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 171:6621-9. 2003..The present study provides the first data to address the mechanisms controlling SLP-76 transcription by providing evidence for several key cis-regulatory elements in the promoter region... - The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1Stefanie Kliche
Institute of Immunology, Otto von Guericke University, 39120 Magdeburg, Germany
Mol Cell Biol 26:7130-44. 2006..However, it appears as if the ADAP/SKAP55 module can exert its signaling function outside of the classical raft fraction of the cell membrane... - SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1Jennifer L Cannons
National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
Immunity 21:693-706. 2004..SLAM engagement amplified PKC-theta recruitment in wt but not SAP- or Fyn-deficient cells, arguing that a SAP/Fyn-mediated pathway enhances PKC-theta/NF-kappaB1 activation and suggesting a role for this pathway in T(H)2 regulation... - PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganizationTami L Bach
Department of Medicine, University of Pennsylvania School of Medicine, and Department of Pathology, Children s Hospital of Philadelphia 19104, USA
Blood 109:1147-55. 2007.... - Disruption of diacylglycerol metabolism impairs the induction of T cell anergyBenjamin A Olenchock
Signal Transduction Program, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Nat Immunol 7:1174-81. 2006..Our findings suggest that regulation of diacylglycerol metabolism is critical in determining whether activation or anergy ensues after T cell receptor stimulation... - Integrins and ITAMs: more than just good neighborsMark L Kahn
Nat Immunol 7:1286-8. 2006 - Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motifBruce T Seet
Centre for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
EMBO J 26:678-89. 2007.... - Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiationMarisa M Juntilla
Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 104:12105-10. 2007..Our results show that Akt protects thymocytes from cell death during the beta-selection checkpoint...
Research Grants
- SIGNAL TRANSDUCTION IN THE IMMUNE SYSTEM-FASEB CONF.Gary Koretzky; Fiscal Year: 2005..3) To continue a biannual forum for investigators interested in a comprehensive focus on signaling events in the immune system. ..
- 2005 Immunochemistry and Immunobiology Gordon ConferenceGary Koretzky; Fiscal Year: 2005..These talks will be selected from among the submitted abstracts. ..
- Lymphocyte Activation and SignalingGary Koretzky; Fiscal Year: 2006..abstract_text> ..
- NOVEL SUBSTRATES OF THE TCR KINASEGary Koretzky; Fiscal Year: 2007..It is hoped additionally that this work will provide new insights into how T cell responses may be modulated to help combat diseases characterized by defective or overexuberant immune cell function. ..
- Regulation of T Cell and Mast Cell Function by DGKzetaGary Koretzky; Fiscal Year: 2007..We anticipate that this work will shed additional light on the complex regulation of T cell and mast cell function and will hopefully suggest novel approaches to modulate activity of these cell types. ..
- Regulation of PMN activation by SLP-76, PRAM-1 and ADAPGary Koretzky; Fiscal Year: 2007....
- Training Program Rheumatic DiseaseGary Koretzky; Fiscal Year: 2007..This program will help to provide the highly trained professionals who will use the insights from basic laboratories to help solve the long-standing mysteries of rheumatic diseases. ..
- Temporal & spatial organization of signaling complexes in T & B CellsGary Koretzky; Fiscal Year: 2007..We anticipate that our collective efforts will provide new insights into how signals are transduced leading to appropriate cellular responses and how these processes may go awry leading to pathologic consequences. ..
- NOVEL SUBSTRATES OF THE TCR KINASEGary Koretzky; Fiscal Year: 2005..We anticipate that collectively these studies will provide new insights into how this protein (and by extension other proteins with similar functional domains) may function in the regulation of cellular activation. ..
- NOVEL SUBSTRATES OF THE TCR KINASEGary Koretzky; Fiscal Year: 2001..It is hoped that these studies will shed further light into the regulation of signal transduction in immune cells and provide data that will be useful in the treatment of diseases related to immune dysfunction. ..
- STRUCTURE/FUNCTION OF SH2 DOMAIN OF SLP 76Gary Koretzky; Fiscal Year: 2002..Collectively, we hope these studies will provide insights into the complex regulation of signaling by SLP-76 and LAT in T cell development and activation. ..
- SIGNAL TRANSDUCTION IN THE IMMUNE SYSTEM-FASEB CONF.Gary Koretzky; Fiscal Year: 2003..3) To continue a biannual forum for investigators interested in a comprehensive focus on signaling events in the immune system. ..
- THE ROLE OF SLP-76 IN PLATELET SIGNAL TRANSDUCTIONGary Koretzky; Fiscal Year: 2003..It is anticipated that these studies collectively will provide new insights into the biology of SLP-76 as a regulator of signaling events in platelets. ..
- Regulation of T Cell and Mast Cell Function by DGKzetaGary A Koretzky; Fiscal Year: 2010..We anticipate that this work will shed additional light on the complex regulation of T cell and mast cell function and will hopefully suggest novel approaches to modulate activity of these cell types. ..