Gary Koretzky

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Differential requirement for adapter proteins Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa and adhesion- and degranulation-promoting adapter protein in FcepsilonRI signaling and mast cell function
    Jennifer N Wu
    Abramson Family Cancer Research Institute and Department of Laboratory Medicine and Pathology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 172:6768-74. 2004
  2. pmc Conditional deletion reveals a cell-autonomous requirement of SLP-76 for thymocyte selection
    Jonathan S Maltzman
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Exp Med 202:893-900. 2005
  3. pmc Impaired degranulation but enhanced cytokine production after Fc epsilonRI stimulation of diacylglycerol kinase zeta-deficient mast cells
    Benjamin A Olenchock
    The Signal Transduction Program, The Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Exp Med 203:1471-80. 2006
  4. pmc Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo
    Natalie A Bezman
    Leonard and Madlyn Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Exp Med 205:1775-88. 2008
  5. pmc Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling
    Barbi A Judd
    Program in Molecular Biology, University of Iowa, Iowa City, IA 52242, USA
    J Exp Med 195:705-17. 2002
  6. pmc The Role of SH2 Domain-containing Leukocyte Phosphoprotein of 76 kDa in the Regulation of Immune Cell Development and Function
    Gary A Koretzky
    Department of Pathology and Laboratory Medicine and Department of Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA
    Immune Netw 9:75-83. 2009
  7. pmc Diacylglycerol kinases: regulated controllers of T cell activation, function, and development
    Rohan P Joshi
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Int J Mol Sci 14:6649-73. 2013
  8. pmc The legacy of the Philadelphia chromosome
    Gary A Koretzky
    Abramson Family Cancer Research Institute, University of Pennsylvania Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Clin Invest 117:2030-2. 2007
  9. ncbi request reprint T cell activation I: proximal events
    Gary A Koretzky
    Department of Pathology and Laboratory Medicine, Signal Transduction Program, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Immunol Rev 191:5-6. 2003
  10. ncbi request reprint SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond
    Gary A Koretzky
    Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania, 415 BRBII III, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Immunol 6:67-78. 2006

Collaborators

Detail Information

Publications63

  1. ncbi request reprint Differential requirement for adapter proteins Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa and adhesion- and degranulation-promoting adapter protein in FcepsilonRI signaling and mast cell function
    Jennifer N Wu
    Abramson Family Cancer Research Institute and Department of Laboratory Medicine and Pathology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 172:6768-74. 2004
    ..Thus, failure to bind ADAP does not underlie the functional defects exhibited by SLP-76 SH2 domain mutant-expressing mast cells...
  2. pmc Conditional deletion reveals a cell-autonomous requirement of SLP-76 for thymocyte selection
    Jonathan S Maltzman
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Exp Med 202:893-900. 2005
    ..These studies show for the first time that SLP-76 is required for signal transduction through the mature alphabeta TCR in primary cells of the T lineage...
  3. pmc Impaired degranulation but enhanced cytokine production after Fc epsilonRI stimulation of diacylglycerol kinase zeta-deficient mast cells
    Benjamin A Olenchock
    The Signal Transduction Program, The Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Exp Med 203:1471-80. 2006
    ..Our data demonstrate dissociation between cytokine production and degranulation in mast cells and reveal the importance of DGK activity during IgE sensitization for proper attenuation of Fc epsilonRI signals...
  4. pmc Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo
    Natalie A Bezman
    Leonard and Madlyn Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Exp Med 205:1775-88. 2008
    ..Using genetic complementation, we further demonstrate that all three phosphorylatable tyrosines are required within the same SLP76 molecule to support platelet activation by GPVI...
  5. pmc Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling
    Barbi A Judd
    Program in Molecular Biology, University of Iowa, Iowa City, IA 52242, USA
    J Exp Med 195:705-17. 2002
    ....
  6. pmc The Role of SH2 Domain-containing Leukocyte Phosphoprotein of 76 kDa in the Regulation of Immune Cell Development and Function
    Gary A Koretzky
    Department of Pathology and Laboratory Medicine and Department of Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA
    Immune Netw 9:75-83. 2009
    ....
  7. pmc Diacylglycerol kinases: regulated controllers of T cell activation, function, and development
    Rohan P Joshi
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Int J Mol Sci 14:6649-73. 2013
    ..This review summarizes the available knowledge of the function and regulation of DGK isoforms in signal transduction with a particular focus on T lymphocytes...
  8. pmc The legacy of the Philadelphia chromosome
    Gary A Koretzky
    Abramson Family Cancer Research Institute, University of Pennsylvania Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Clin Invest 117:2030-2. 2007
    ..The legacy of the Philadelphia chromosome now serves as a paradigm for how basic science discoveries can lead to effective new approaches for the treatment of human disease...
  9. ncbi request reprint T cell activation I: proximal events
    Gary A Koretzky
    Department of Pathology and Laboratory Medicine, Signal Transduction Program, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Immunol Rev 191:5-6. 2003
  10. ncbi request reprint SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond
    Gary A Koretzky
    Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania, 415 BRBII III, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Immunol 6:67-78. 2006
    ..In this Review, we discuss the role of SLP76 and SLP65 in several signalling pathways in haematopoietic cells, with an emphasis on recent studies that provide insight into their mechanisms of action...
  11. ncbi request reprint Positive and negative regulation of T-cell activation by adaptor proteins
    G A Koretzky
    Abramson Family Cancer Research Institute and Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Nat Rev Immunol 1:95-107. 2001
    ..This review will focus on a number of adaptors that are important for lymphocyte function and emphasize the various ways in which these proteins carry out their essential roles...
  12. ncbi request reprint Control of T cell function by positive and negative regulators
    Andrew L Singer
    The Abramson Family Cancer Research Institute, Department of Laboratory Medicine and Pathology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 296:1639-40. 2002
    ..Understanding the mechanisms that regulate T cell responsiveness will aid in the development of therapeutic agents to treat infection, cancer, and autoimmune disease and immune deficiency...
  13. pmc Stimulation and inhibition of immune responses: an intricate balancing act
    Gary Koretzky
    Department of Pathology, Signal Transduction Program, Abramson Family Cancer Research Institute, 415 BRBII III, 421 Curie Boulevard, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 109:7-8. 2002
  14. pmc Akt1 and Akt2 promote peripheral B-cell maturation and survival
    Marco Calamito
    Department of Pathology and Laboratory of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    Blood 115:4043-50. 2010
    ..Altogether, these studies show that Akt signaling plays a key role in peripheral B-cell maturation and survival...
  15. pmc RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation
    Gael Menasche
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 415 BRBII III, 421 Curie Blvd, Philadelphia, PA 19104 6160, USA
    Mol Cell Biol 27:4070-81. 2007
    ..These results describe for the first time a link between ADAP/SKAP-55 and the Rap1/RIAM complex and provide a potential new mechanism for TCR-mediated integrin activation...
  16. pmc The adapter protein SLP-76 mediates "outside-in" integrin signaling and function in T cells
    R G Baker
    Abramson Family Cancer Research Institute, University of Pennsylvania, 415 BRB 421 Curie Blvd, Philadelphia, PA 19104, USA
    Mol Cell Biol 29:5578-89. 2009
    ....
  17. ncbi request reprint Coupling of the TCR to integrin activation by Slap-130/Fyb
    E J Peterson
    The Abramson Family Cancer Research Institute, Department of Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA
    Science 293:2263-5. 2001
    ..These data indicate that SLAP-130/Fyb is important for coupling TCR-mediated actin cytoskeletal rearrangement with activation of integrin function, and for T cells to respond fully to activating signals...
  18. ncbi request reprint Differential requirement for SLP-76 domains in T cell development and function
    P S Myung
    Graduate Program in Immunology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Immunity 15:1011-26. 2001
    ....
  19. pmc ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists
    Ana Kasirer-Friede
    Department of Medicine, University of California San Diego, La Jolla 92093 0726, USA
    Blood 109:1018-25. 2007
    ..These studies establish ADAP as a component of inside-out signaling pathways that couple GP Ib-IX-V and other platelet agonist receptors to alphaIIbbeta3 activation...
  20. ncbi request reprint The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity
    David Artis
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 173:5626-34. 2004
    ..In addition, IL-27 directly suppressed CD4+ T cell proliferation and Th2 cytokine production. Together, these studies identify a novel role for IL-27/WSX-1 in limiting innate and adaptive components of type 2 immunity at mucosal sites...
  21. pmc Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells
    D Allman
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    J Exp Med 194:99-106. 2001
    ....
  22. ncbi request reprint The role of the adapter molecule SLP-76 in platelet function
    B A Judd
    Signal Transduction Program, Abramson Family Cancer Research Institute University of Pennsylvania, Philadelphia, PA 19104, USA
    Oncogene 20:6291-9. 2001
    ..Because many parallels exist between signal transduction pathways in platelets and lymphocytes, we will also review the function of SLP-76 in coordinating signal transduction pathways following antigen bind to the T cell receptor...
  23. ncbi request reprint Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength
    D J Izon
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Immunity 14:253-64. 2001
    ....
  24. pmc Persistence of cooperatively stabilized signaling clusters drives T-cell activation
    Stephen C Bunnell
    Laboratory of Cellular and Molecular Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland, USA
    Mol Cell Biol 26:7155-66. 2006
    ..These data indicate that multivalent cooperative interactions stabilize these persistent signaling clusters, which may correspond to the functional complexes predicted by kinetic proofreading models of T-cell activation...
  25. pmc Disruption of SLP-76 interaction with Gads inhibits dynamic clustering of SLP-76 and FcepsilonRI signaling in mast cells
    Michael A Silverman
    Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 26:1826-38. 2006
    ....
  26. ncbi request reprint Syk and Slp-76 mutant mice reveal a cell-autonomous hematopoietic cell contribution to vascular development
    Eric Sebzda
    Department of Medicine, University of Pennsylvania, Philadelphia, 19104, USA
    Dev Cell 11:349-61. 2006
    ..These studies provide genetic evidence for hematopoietic contribution to vascular development and suggest that hematopoietic tissue can provide a source of vascular endothelial progenitor cells throughout life...
  27. ncbi request reprint The actin cloud induced by LFA-1-mediated outside-in signals lowers the threshold for T-cell activation
    Jun ichiro Suzuki
    Department of Molecular Genetics, Graduate School of Medicine, Chiba University, Japan
    Blood 109:168-75. 2007
    ..The formation of the actin cloud lowers the threshold for subsequent T-cell activation. Thus, the actin cloud induced by LFA-1 engagement may serve as a possible platform for LFA-1-mediated costimulatory function for T-cell activation...
  28. ncbi request reprint Loss of SLP-76 expression within myeloid cells confers resistance to neutrophil-mediated tissue damage while maintaining effective bacterial killing
    Regina A Clemens
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    J Immunol 178:4606-14. 2007
    ..aureus but reduction in LPS-induced tissue damage and vascular injury...
  29. ncbi request reprint In vivo disruption of T cell development by expression of a dominant-negative polypeptide designed to abolish the SLP-76/Gads interaction
    Martha S Jordan
    Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Eur J Immunol 37:2961-72. 2007
    ..These data provide evidence for the in vivo function of a dominant-negative peptide based upon the biology of SLP-76 action and suggest the possibility of therapeutic potential of targeting the SLP-76/Gads interaction...
  30. pmc Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76
    Martha S Jordan
    Cancer Biology, Abramson Family Cancer Research Institute, 427 BRBII III, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA
    Immunity 28:359-69. 2008
    ..Thus, the N-terminal tyrosines of SLP76 are required for thymocyte selection but can function on separate molecules to support TCR signaling...
  31. ncbi request reprint SLP-76 regulates Fcgamma receptor and integrin signaling in neutrophils
    Sally A Newbrough
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunity 19:761-9. 2003
    ..These results provide genetic evidence for a critical role of SLP-76 in the regulation of neutrophil function...
  32. ncbi request reprint Macrophage activation and Fcgamma receptor-mediated signaling do not require expression of the SLP-76 and SLP-65 adaptors
    Kim E Nichols
    Pediatric Oncology, Children s Hospital of Philadelphia, PA 19104, USA
    J Leukoc Biol 75:541-52. 2004
    ..Taken together, these data suggest that neither SLP-76 nor SLP-65 is required during FcgammaR-dependent signaling and functional events in macrophages...
  33. ncbi request reprint Regulation of hematopoietic cell development and activation by adapter proteins
    Gary A Koretzky
    Abramson Family Cancer Research Institute, Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Immunol Res 27:357-66. 2003
    ....
  34. ncbi request reprint Roles of the proline-rich domain in SLP-76 subcellular localization and T cell function
    Andrew L Singer
    Signal Transduction Program, Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 279:15481-90. 2004
    ..Furthermore, we provide direct evidence that SLP-76 localization and, in turn, function are dependent upon association with Gads...
  35. ncbi request reprint Adaptors as central mediators of signal transduction in immune cells
    Martha S Jordan
    Signal Transduction Program, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia 19104, USA
    Nat Immunol 4:110-6. 2003
    ..Here we focus on T lymphocytes as a model to illustrate the critical roles adaptors play as regulators of cellular activation...
  36. pmc Inactivation of c-Cbl reverses neonatal lethality and T cell developmental arrest of SLP-76-deficient mice
    Y Jeffrey Chiang
    Experimental Immunology Branch, Building 10, Room 4B36, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 200:25-34. 2004
    ....
  37. ncbi request reprint The SLP-76 family of adapter proteins
    Jennifer N Wu
    Department of Laboratory Medicine and Pathology, School of Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania, 415 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Semin Immunol 16:379-93. 2004
    ....
  38. ncbi request reprint Role of the adapter protein SLP-76 in GPVI-dependent platelet procoagulant responses to collagen
    Lorie Leo
    Departments of Internal Medicine and Pediatrics, University of Iowa College of Medicine, and Veterans Affairs Medical Center, Iowa City, IA 52242, USA
    Blood 100:2839-44. 2002
    ..Thus, both GPVI-dependent and GPVI-independent pathways contribute to collagen-induced platelet procoagulant activity...
  39. pmc Differential requirement for the SAP-Fyn interaction during NK T cell development and function
    Selene Nunez-Cruz
    Division of Oncology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Immunol 181:2311-20. 2008
    ..Thus, SAP appears to use differential signaling mechanisms in NKT cells, with optimal ontogeny requiring Fyn binding, while functional responses occur independently of this interaction...
  40. ncbi request reprint Antigen receptor signaling: the Tuscan connection
    Cosima T Baldari
    Department of Evolutionary Biology, University of Siena, 53100 Siena, Italy
    Nat Immunol 8:787-90. 2007
  41. ncbi request reprint Enhanced T cell responses due to diacylglycerol kinase zeta deficiency
    Xiao Ping Zhong
    The Signal Transduction Program, The Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania 19104, USA
    Nat Immunol 4:882-90. 2003
    ..These results demonstrate the importance of DGKzeta as a physiological negative regulator of TCR signaling and T cell activation...
  42. pmc Phospholipase cbeta is critical for T cell chemotaxis
    Tami L Bach
    Department of Medicine, Abramson Family Cancer Research Institute, Philadelphia, PA, USA
    J Immunol 179:2223-7. 2007
    ..This study demonstrates that, in contrast to neutrophils, phospholipid second messengers generated by PLCbeta play a critical role in T lymphocyte chemotaxis...
  43. pmc Human CD8+ T cells do not require the polarization of lipid rafts for activation and proliferation
    Birgit Kovacs
    Division of Rheumatology, Department of Pediatrics, Children s Hospital of Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 99:15006-11. 2002
    ..It is possible that the lower stringency of CD8(+) T cell activation obviates a requirement for raft polarization...
  44. ncbi request reprint Impaired thymic selection in mice expressing altered levels of the SLP-76 adaptor protein
    Kimberley Ramsey
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    J Leukoc Biol 83:419-29. 2008
    ....
  45. pmc Indirect involvement of allergen-captured mast cells in antigen presentation
    Taku Kambayashi
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
    Blood 111:1489-96. 2008
    ..This mechanism may contribute to how mast cells impact the development of T-cell responses...
  46. pmc Critical roles of the PI3K/Akt signaling pathway in T cell development
    Marisa M Juntilla
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
    Immunol Lett 116:104-10. 2008
    ..We provide new evidence that Akt-mediated survival is not solely due to the increased expression of Bcl-xL but also is a consequence of the role played by Akt to support metabolism in proliferating thymocytes...
  47. pmc Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk
    Farhad Abtahian
    Signal Transduction Program, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 299:247-51. 2003
    ..These studies reveal a hematopoietic signaling pathway required for separation of the two major vascular networks in mammals...
  48. pmc Azathioprine: old drug, new actions
    Jonathan S Maltzman
    Signal Transduction Program, Abramson Family Cancer Research Institute, Department of Medicine, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    J Clin Invest 111:1122-4. 2003
  49. ncbi request reprint Functional hierarchy of the N-terminal tyrosines of SLP-76
    Martha S Jordan
    Signal Transduction Program, Leonard and Madlyn Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Immunol 176:2430-8. 2006
    ..These studies show that Tyr(145) of SLP-76 is the most critical tyrosine for both T cell function in vitro and T cell development in vivo...
  50. pmc Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation
    Marisa M Juntilla
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 104:12105-10. 2007
    ..Our results show that Akt protects thymocytes from cell death during the beta-selection checkpoint...
  51. ncbi request reprint Regulation of NKT cell development by SAP, the protein defective in XLP
    Kim E Nichols
    Pediatric Oncology, Wood, 4th Floor, 3615 Civic Center Boulevard, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Nat Med 11:340-5. 2005
    ..Thus, SAP is a crucial regulator of NKT cell ontogeny in humans and in mice. The absence of NKT cells may contribute to the phenotypes of SAP deficiency, including abnormal antiviral and antitumor immunity and hypogammaglobulinemia...
  52. pmc PRAM-1 is required for optimal integrin-dependent neutrophil function
    Regina A Clemens
    Dept of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
    Mol Cell Biol 24:10923-32. 2004
    ..Together, these findings demonstrate the uncoupling of key integrin-dependent responses in the absence of PRAM-1 and show this adaptor to be critical for select integrin functions in neutrophils...
  53. ncbi request reprint Adhesion- and degranulation-promoting adapter protein is required for efficient thymocyte development and selection
    Jennifer N Wu
    Abramson Family Cancer Research Institute and Department of Laboratory Medicine and Pathology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 176:6681-9. 2006
    ..ADAP deficiency also impairs the ability of transgene-bearing DP thymocytes to form conjugates with Ag-loaded presenting cells. These findings suggest that ADAP is critical for thymocyte development and selection...
  54. pmc Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells
    Farhad Abtahian
    Signal Transduction Program, Abramson Family Cancer Research Institute, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Mol Cell Biol 26:6936-49. 2006
    ....
  55. pmc The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1
    Stefanie Kliche
    Institute of Immunology, Otto von Guericke University, 39120 Magdeburg, Germany
    Mol Cell Biol 26:7130-44. 2006
    ..However, it appears as if the ADAP/SKAP55 module can exert its signaling function outside of the classical raft fraction of the cell membrane...
  56. ncbi request reprint SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1
    Jennifer L Cannons
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 21:693-706. 2004
    ..SLAM engagement amplified PKC-theta recruitment in wt but not SAP- or Fyn-deficient cells, arguing that a SAP/Fyn-mediated pathway enhances PKC-theta/NF-kappaB1 activation and suggesting a role for this pathway in T(H)2 regulation...
  57. pmc PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization
    Tami L Bach
    Department of Medicine, University of Pennsylvania School of Medicine, and Department of Pathology, Children s Hospital of Philadelphia 19104, USA
    Blood 109:1147-55. 2007
    ....
  58. ncbi request reprint Disruption of diacylglycerol metabolism impairs the induction of T cell anergy
    Benjamin A Olenchock
    Signal Transduction Program, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nat Immunol 7:1174-81. 2006
    ..Our findings suggest that regulation of diacylglycerol metabolism is critical in determining whether activation or anergy ensues after T cell receptor stimulation...
  59. ncbi request reprint Integrins and ITAMs: more than just good neighbors
    Mark L Kahn
    Nat Immunol 7:1286-8. 2006
  60. pmc Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motif
    Bruce T Seet
    Centre for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    EMBO J 26:678-89. 2007
    ....
  61. ncbi request reprint Proximal signaling events in Fc epsilon RI-mediated mast cell activation
    Taku Kambayashi
    Department of Pathology, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, USA
    J Allergy Clin Immunol 119:544-52; quiz 553-4. 2007
    ..Understanding the molecular mechanisms underlying mast cell activation ideally will provide insights into the development of novel therapeutics to control allergic disease...
  62. ncbi request reprint Transcriptional regulation of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa: dissection of key promoter elements
    Xiao Ping Zhong
    Signal Transduction Program, The Abramson Family Cancer Research Institute, and Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 171:6621-9. 2003
    ..The present study provides the first data to address the mechanisms controlling SLP-76 transcription by providing evidence for several key cis-regulatory elements in the promoter region...
  63. ncbi request reprint Compartmentalization of ITAM and integrin signaling by adapter molecules
    Natalie Bezman
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunol Rev 218:9-28. 2007
    ..In this review, we discuss the mechanisms by which adapter proteins coordinate signal transduction with an emphasis on the role of subcellular compartmentalization in adapter function...

Research Grants35

  1. Regulation of T Cell and Mast Cell Function by DGKzeta
    Gary A Koretzky; Fiscal Year: 2010
    ..We anticipate that this work will shed additional light on the complex regulation of T cell and mast cell function and will hopefully suggest novel approaches to modulate activity of these cell types. ..
  2. Regulation of T Cell and Mast Cell Function by DGKzeta
    Gary Koretzky; Fiscal Year: 2004
    ..We anticipate that this work will shed additional light on the complex regulation of T cell and mast cell function and will hopefully suggest novel approaches to modulate activity of these cell types. ..
  3. Regulation of PMN activation by SLP-76, PRAM-1 and ADAP
    Gary Koretzky; Fiscal Year: 2004
    ....
  4. Regulation of T Cell and Mast Cell Function by DGKzeta
    Gary Koretzky; Fiscal Year: 2005
    ..We anticipate that this work will shed additional light on the complex regulation of T cell and mast cell function and will hopefully suggest novel approaches to modulate activity of these cell types. ..
  5. 2005 Immunochemistry and Immunobiology Gordon Conference
    Gary Koretzky; Fiscal Year: 2005
    ..These talks will be selected from among the submitted abstracts. ..
  6. Regulation of T Cell and Mast Cell Function by DGKzeta
    Gary Koretzky; Fiscal Year: 2006
    ..We anticipate that this work will shed additional light on the complex regulation of T cell and mast cell function and will hopefully suggest novel approaches to modulate activity of these cell types. ..
  7. Lymphocyte Activation and Signaling
    Gary Koretzky; Fiscal Year: 2006
    ..abstract_text> ..
  8. Regulation of PMN activation by SLP-76, PRAM-1 and ADAP
    Gary Koretzky; Fiscal Year: 2006
    ....
  9. Regulation of PMN activation by SLP-76, PRAM-1 and ADAP
    Gary Koretzky; Fiscal Year: 2007
    ....
  10. Training Program Rheumatic Disease
    Gary Koretzky; Fiscal Year: 2007
    ..This program will help to provide the highly trained professionals who will use the insights from basic laboratories to help solve the long-standing mysteries of rheumatic diseases. ..
  11. Temporal & spatial organization of signaling complexes in T & B Cells
    Gary Koretzky; Fiscal Year: 2007
    ..We anticipate that our collective efforts will provide new insights into how signals are transduced leading to appropriate cellular responses and how these processes may go awry leading to pathologic consequences. ..
  12. NOVEL SUBSTRATES OF THE TCR KINASE
    Gary Koretzky; Fiscal Year: 2004
    ..We anticipate that collectively these studies will provide new insights into how this protein (and by extension other proteins with similar functional domains) may function in the regulation of cellular activation. ..
  13. THE ROLE OF SLP-76 IN PLATELET SIGNAL TRANSDUCTION
    Gary Koretzky; Fiscal Year: 2003
    ..It is anticipated that these studies collectively will provide new insights into the biology of SLP-76 as a regulator of signaling events in platelets. ..
  14. NOVEL SUBSTRATES OF THE TCR KINASE
    Gary Koretzky; Fiscal Year: 1999
    ..It is hoped that these studies will shed further light into the regulation of signal transduction in immune cells and provide data that will be useful in the treatment of diseases related to immune dysfunction. ..
  15. THE ROLE OF SLP-76 IN PLATELET SIGNAL TRANSDUCTION
    Gary Koretzky; Fiscal Year: 2000
    ..It is anticipated that these studies collectively will provide new insights into the biology of SLP-76 as a regulator of signaling events in platelets. ..
  16. THE ROLE OF SLP-76 IN PLATELET SIGNAL TRANSDUCTION
    Gary Koretzky; Fiscal Year: 2001
    ..It is anticipated that these studies collectively will provide new insights into the biology of SLP-76 as a regulator of signaling events in platelets. ..
  17. NOVEL SUBSTRATES OF THE TCR KINASE
    Gary Koretzky; Fiscal Year: 2002
    ..We anticipate that collectively these studies will provide new insights into how this protein (and by extension other proteins with similar functional domains) may function in the regulation of cellular activation. ..
  18. STRUCTURE/FUNCTION OF SH2 DOMAIN OF SLP 76
    Gary Koretzky; Fiscal Year: 2002
    ..Collectively, we hope these studies will provide insights into the complex regulation of signaling by SLP-76 and LAT in T cell development and activation. ..
  19. THE ROLE OF SLP-76 IN PLATELET SIGNAL TRANSDUCTION
    Gary Koretzky; Fiscal Year: 2002
    ..It is anticipated that these studies collectively will provide new insights into the biology of SLP-76 as a regulator of signaling events in platelets. ..
  20. NOVEL SUBSTRATES OF THE TCR KINASE
    Gary Koretzky; Fiscal Year: 2000
    ..It is hoped that these studies will shed further light into the regulation of signal transduction in immune cells and provide data that will be useful in the treatment of diseases related to immune dysfunction. ..
  21. NOVEL SUBSTRATES OF THE TCR KINASE
    Gary Koretzky; Fiscal Year: 2003
    ..We anticipate that collectively these studies will provide new insights into how this protein (and by extension other proteins with similar functional domains) may function in the regulation of cellular activation. ..
  22. STRUCTURE/FUNCTION OF SH2 DOMAIN OF SLP 76
    Gary Koretzky; Fiscal Year: 2001
    ..Collectively, we hope these studies will provide insights into the complex regulation of signaling by SLP-76 and LAT in T cell development and activation. ..
  23. Regulation of T Cell and Mast Cell Function by DGKzeta
    Gary Koretzky; Fiscal Year: 2007
    ..We anticipate that this work will shed additional light on the complex regulation of T cell and mast cell function and will hopefully suggest novel approaches to modulate activity of these cell types. ..
  24. NOVEL SUBSTRATES OF THE TCR KINASE
    Gary Koretzky; Fiscal Year: 2007
    ..It is hoped additionally that this work will provide new insights into how T cell responses may be modulated to help combat diseases characterized by defective or overexuberant immune cell function. ..
  25. NOVEL SUBSTRATES OF THE TCR KINASE
    Gary Koretzky; Fiscal Year: 2001
    ..It is hoped that these studies will shed further light into the regulation of signal transduction in immune cells and provide data that will be useful in the treatment of diseases related to immune dysfunction. ..
  26. SIGNAL TRANSDUCTION IN THE IMMUNE SYSTEM-FASEB CONF.
    Gary Koretzky; Fiscal Year: 2005
    ..3) To continue a biannual forum for investigators interested in a comprehensive focus on signaling events in the immune system. ..
  27. Regulation of PMN activation by SLP-76, PRAM-1 and ADAP
    Gary Koretzky; Fiscal Year: 2005
    ....
  28. NOVEL SUBSTRATES OF THE TCR KINASE
    Gary Koretzky; Fiscal Year: 2005
    ..We anticipate that collectively these studies will provide new insights into how this protein (and by extension other proteins with similar functional domains) may function in the regulation of cellular activation. ..
  29. SIGNAL TRANSDUCTION IN THE IMMUNE SYSTEM-FASEB CONF.
    Gary Koretzky; Fiscal Year: 2003
    ..3) To continue a biannual forum for investigators interested in a comprehensive focus on signaling events in the immune system. ..
  30. THE ROLE OF SLP-76 IN PLATELET SIGNAL TRANSDUCTION
    Gary Koretzky; Fiscal Year: 1999
    ..It is anticipated that these studies collectively will provide new insights into the biology of SLP-76 as a regulator of signaling events in platelets. ..