Alexei V Korennykh

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc The unfolded protein response signals through high-order assembly of Ire1
    Alexei V Korennykh
    Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California 94158, USA
    Nature 457:687-93. 2009
  2. pmc Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1
    Alexei V Korennykh
    Howard Hughes Medical Institute, University of California, San Francisco, 600 16th Street, Room S272, Box 0724, San Francisco, CA 94158, USA
    BMC Biol 9:48. 2011
  3. pmc Structural and functional basis for RNA cleavage by Ire1
    Alexei V Korennykh
    Howard Hughes Medical Institute, University of California, San Francisco, Genentech Hall, 600 16th Street, San Francisco, CA 94158, USA
    BMC Biol 9:47. 2011
  4. pmc Messenger RNA targeting to endoplasmic reticulum stress signalling sites
    TOMAS ARAGON
    Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California 94158 2517, USA
    Nature 457:736-40. 2009
  5. pmc Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering
    Han Li
    Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 107:16113-8. 2010

Detail Information

Publications5

  1. pmc The unfolded protein response signals through high-order assembly of Ire1
    Alexei V Korennykh
    Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California 94158, USA
    Nature 457:687-93. 2009
    ..Activation of Ire1 through oligomerization expands the mechanistic repertoire of kinase-based signalling receptors...
  2. pmc Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1
    Alexei V Korennykh
    Howard Hughes Medical Institute, University of California, San Francisco, 600 16th Street, Room S272, Box 0724, San Francisco, CA 94158, USA
    BMC Biol 9:48. 2011
    ..In this study, we investigated how the binding of cofactors to the kinase domain of Ire1 modulates its RNase activity...
  3. pmc Structural and functional basis for RNA cleavage by Ire1
    Alexei V Korennykh
    Howard Hughes Medical Institute, University of California, San Francisco, Genentech Hall, 600 16th Street, San Francisco, CA 94158, USA
    BMC Biol 9:47. 2011
    ..Here, we experimentally define the active site of Ire1 RNase and quantitatively evaluate the contribution of the key active site residues to catalysis...
  4. pmc Messenger RNA targeting to endoplasmic reticulum stress signalling sites
    TOMAS ARAGON
    Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California 94158 2517, USA
    Nature 457:736-40. 2009
    ..Translational repression afforded by the intron fulfils this requirement for HAC1 mRNA. Recruitment of mRNA to signalling centres provides a new paradigm for the control of eukaryotic gene expression...
  5. pmc Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering
    Han Li
    Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 107:16113-8. 2010
    ..Thus IRE1 activity is governed by a timer that may be important in switching the UPR from the initially cytoprotective phase to the apoptotic mode...