ULLA KOPP

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi request reprint Endogenous angiotensin modulates PGE(2)-mediated release of substance P from renal mechanosensory nerve fibers
    Ulla C Kopp
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Physiol Regul Integr Comp Physiol 282:R19-30. 2002
  2. pmc Renal sensory and sympathetic nerves reinnervate the kidney in a similar time-dependent fashion after renal denervation in rats
    Jan Mulder
    Science for Life Laboratory, Karolinska Institute, Stockholm, Sweden
    Am J Physiol Regul Integr Comp Physiol 304:R675-82. 2013
  3. doi request reprint Endothelin in the control of renal sympathetic nerve activity
    Ulla C Kopp
    Department of Internal Medicine, University of Iowa Carver, College of Medicine and Department of Veterans Affairs Medical Center, Iowa City, Iowa, USA
    Contrib Nephrol 172:107-19. 2011
  4. doi request reprint Impaired interaction between efferent and afferent renal nerve activity in SHR involves increased activation of alpha2-adrenoceptors
    Ulla C Kopp
    Department of Internal Medicine, University of Iowa Carver College of Medicine, VA Medical Center, Iowa City, IA 52246
    Hypertension 57:640-7. 2011
  5. pmc Dietary sodium modulates the interaction between efferent and afferent renal nerve activity by altering activation of α2-adrenoceptors on renal sensory nerves
    Ulla C Kopp
    Dept of Internal Medicine, Department of Veterans Affairs Medical Center, Bldg 41, Highway 6W, Iowa City, IA 52246, USA
    Am J Physiol Regul Integr Comp Physiol 300:R298-310. 2011
  6. pmc Activation of endothelin A receptors contributes to impaired responsiveness of renal mechanosensory nerves in congestive heart failure
    Ulla C Kopp
    Department of Internal Medicine, Department of Veterans Affairs Medical Center, and University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Can J Physiol Pharmacol 88:622-9. 2010
  7. pmc Dietary sodium modulates the interaction between efferent renal sympathetic nerve activity and afferent renal nerve activity: role of endothelin
    Ulla C Kopp
    Department of Internal Medicine, Department of Veterans Affairs Medical Center and University of Iowa Carver College of Medicine, Iowa City, Iowa 52246, USA
    Am J Physiol Regul Integr Comp Physiol 297:R337-51. 2009
  8. pmc Afferent renal denervation impairs baroreflex control of efferent renal sympathetic nerve activity
    Ulla C Kopp
    Department of Internal Medicine, Department of Veterans Affairs Medical Center, Bldg 41, Rm 124, Highway 6W, Iowa City, IA 52246, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1882-90. 2008
  9. doi request reprint Impaired responsiveness of renal sensory nerves in streptozotocin-treated rats and obese Zucker diabetic fatty rats: role of angiotensin
    Ulla C Kopp
    Department of Internal Medicine, Department of Veterans Affairs Medical Center, Bldg 41, Rm 124, Highway 6W, Iowa City, IA 52246, USA
    Am J Physiol Regul Integr Comp Physiol 294:R858-66. 2008
  10. ncbi request reprint Renal sympathetic nerve activity modulates afferent renal nerve activity by PGE2-dependent activation of alpha1- and alpha2-adrenoceptors on renal sensory nerve fibers
    Ulla C Kopp
    Dept of Internal Medicine, VA Medical Center, Bldg 41, Rm 124, Highway 6W, Iowa City, IA 52246, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1561-72. 2007

Research Grants

  1. RENORENAL REFLEXES
    ULLA KOPP; Fiscal Year: 2004
  2. RENORENAL REFLEXES
    ULLA KOPP; Fiscal Year: 2007
  3. RENORENAL REFLEXES
    ULLA KOPP; Fiscal Year: 2009
  4. RENORENAL REFLEXES
    Ulla C Kopp; Fiscal Year: 2010

Detail Information

Publications19

  1. ncbi request reprint Endogenous angiotensin modulates PGE(2)-mediated release of substance P from renal mechanosensory nerve fibers
    Ulla C Kopp
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Physiol Regul Integr Comp Physiol 282:R19-30. 2002
    ..Losartan had no effect on SP release in rats fed normal- and high-sodium diets. ANG II modulates the responsiveness of renal pelvic mechanosensory nerves by inhibiting PGE2-mediated SP release from renal pelvic nerve fibers...
  2. pmc Renal sensory and sympathetic nerves reinnervate the kidney in a similar time-dependent fashion after renal denervation in rats
    Jan Mulder
    Science for Life Laboratory, Karolinska Institute, Stockholm, Sweden
    Am J Physiol Regul Integr Comp Physiol 304:R675-82. 2013
    ..76). In conclusion, in normotensive rats, reinnervation of the renal sensory nerves occurs over the same time course as reinnervation of the renal sympathetic nerves, both being complete at 9 to 12 wk following renal denervation...
  3. doi request reprint Endothelin in the control of renal sympathetic nerve activity
    Ulla C Kopp
    Department of Internal Medicine, University of Iowa Carver, College of Medicine and Department of Veterans Affairs Medical Center, Iowa City, Iowa, USA
    Contrib Nephrol 172:107-19. 2011
    ..These findings suggest that the increased renal sympathetic nerve activity and salt-sensitive hypertension in ET-1/ET(B)-R-deficient subjects is, at least in part, related to suppressed interaction between RSNA and ARNA...
  4. doi request reprint Impaired interaction between efferent and afferent renal nerve activity in SHR involves increased activation of alpha2-adrenoceptors
    Ulla C Kopp
    Department of Internal Medicine, University of Iowa Carver College of Medicine, VA Medical Center, Iowa City, IA 52246
    Hypertension 57:640-7. 2011
    ..We conclude that increased activation of renal α(2)-ARs and angiotensin II type 1 receptors contributes to the impaired interaction between ERSNA and ARNA in SHR...
  5. pmc Dietary sodium modulates the interaction between efferent and afferent renal nerve activity by altering activation of α2-adrenoceptors on renal sensory nerves
    Ulla C Kopp
    Dept of Internal Medicine, Department of Veterans Affairs Medical Center, Bldg 41, Highway 6W, Iowa City, IA 52246, USA
    Am J Physiol Regul Integr Comp Physiol 300:R298-310. 2011
    ....
  6. pmc Activation of endothelin A receptors contributes to impaired responsiveness of renal mechanosensory nerves in congestive heart failure
    Ulla C Kopp
    Department of Internal Medicine, Department of Veterans Affairs Medical Center, and University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Can J Physiol Pharmacol 88:622-9. 2010
    ..In conclusion, activation of ETA receptors contributes to the impaired responsiveness of renal mechanosensory nerves in CHF rats by a mechanism(s) at the renal sensory nerve endings...
  7. pmc Dietary sodium modulates the interaction between efferent renal sympathetic nerve activity and afferent renal nerve activity: role of endothelin
    Ulla C Kopp
    Department of Internal Medicine, Department of Veterans Affairs Medical Center and University of Iowa Carver College of Medicine, Iowa City, Iowa 52246, USA
    Am J Physiol Regul Integr Comp Physiol 297:R337-51. 2009
    ....
  8. pmc Afferent renal denervation impairs baroreflex control of efferent renal sympathetic nerve activity
    Ulla C Kopp
    Department of Internal Medicine, Department of Veterans Affairs Medical Center, Bldg 41, Rm 124, Highway 6W, Iowa City, IA 52246, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1882-90. 2008
    ..Impaired arterial baroreflex function contributes to increased ERSNA, which would eventually lead to sodium retention and increased MAP in DRX rats fed high-sodium diet...
  9. doi request reprint Impaired responsiveness of renal sensory nerves in streptozotocin-treated rats and obese Zucker diabetic fatty rats: role of angiotensin
    Ulla C Kopp
    Department of Internal Medicine, Department of Veterans Affairs Medical Center, Bldg 41, Rm 124, Highway 6W, Iowa City, IA 52246, USA
    Am J Physiol Regul Integr Comp Physiol 294:R858-66. 2008
    ..We conclude that the mechanisms involved in the decreased responsiveness of the renal sensory nerves in STZ rats involve activation of the renin angiotensin system in STZ but not in obese ZDF rats...
  10. ncbi request reprint Renal sympathetic nerve activity modulates afferent renal nerve activity by PGE2-dependent activation of alpha1- and alpha2-adrenoceptors on renal sensory nerve fibers
    Ulla C Kopp
    Dept of Internal Medicine, VA Medical Center, Bldg 41, Rm 124, Highway 6W, Iowa City, IA 52246, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1561-72. 2007
    ..Norepinephrine-induced activation of the sensory nerves is dependent on renal pelvic synthesis/release of PGE(2)...
  11. ncbi request reprint Activation of endothelin-a receptors contributes to angiotensin-induced suppression of renal sensory nerve activation
    Ulla C Kopp
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, USA
    Hypertension 49:141-7. 2007
    ..In conclusion, stimulation of ETA-R plays an important contributory role to the Ang II-mediated suppression of the activation of renal mechanosensory nerves in conditions of low-sodium diet...
  12. ncbi request reprint Differential effects of endothelin on activation of renal mechanosensory nerves: stimulatory in high-sodium diet and inhibitory in low-sodium diet
    Ulla C Kopp
    Dept of Internal Medicine, VA Medical Center, University of Iowa Carver College of Medicine, Bldg 3, Rm 226, Highway 6W, Iowa City, IA 52246, USA
    Am J Physiol Regul Integr Comp Physiol 291:R1545-56. 2006
    ..Impaired renorenal reflexes may contribute to the salt-sensitive hypertension in the ETBR-deficient rat...
  13. ncbi request reprint Activation of EP4 receptors contributes to prostaglandin E2-mediated stimulation of renal sensory nerves
    Ulla C Kopp
    Department of Internal Medicine, Department of Veterans Affairs Medical Center and University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Am J Physiol Renal Physiol 287:F1269-82. 2004
    ..L-161,982 also blocked the ARNA response to increasing renal pelvic pressure 10 mmHg, 85 +/- 5%. In conclusion, PGE(2) increases renal pelvic release of SP and ARNA by activating EP4 receptors on renal sensory nerve fibers...
  14. ncbi request reprint Impaired substance P release from renal sensory nerves in SHR involves a pertussis toxin-sensitive mechanism
    Ulla C Kopp
    Dept of Internal Medicine, VA Medical Center, Bldg 3, Rm 226, Highway 6W, Iowa City, IA 52246, USA
    Am J Physiol Regul Integr Comp Physiol 286:R326-33. 2004
    ..03 microM. In conclusion, the impaired responsiveness of renal sensory nerves in SHR involves endogenous ANG II suppressing the PGE2-mediated release of substance P via a PTX-sensitive mechanism...
  15. ncbi request reprint Dietary sodium loading increases arterial pressure in afferent renal-denervated rats
    Ulla C Kopp
    Department of Internal Medicine, Veterans Affairs Medical Center, and the Roy J and Lucille Carver College of Medicine, University of Iowa, Bldg 3, Room 226, Highway 6W, Iowa City, IA 52246, USA
    Hypertension 42:968-73. 2003
    ..In conclusion, when the afferent limb of the renorenal reflex is interrupted, a high sodium diet results in increased arterial pressure to facilitate the natriuresis and maintenance of sodium balance...
  16. ncbi request reprint Angiotensin blocks substance P release from renal sensory nerves by inhibiting PGE2-mediated activation of cAMP
    Ulla C Kopp
    Dept of Internal Medicine, Medical Center, University of Iowa Roy J and Lucille Carver College of Medicine, Iowa City 52242, USA
    Am J Physiol Renal Physiol 285:F472-83. 2003
    ..In conclusion, renal pelvic ANG II modulates the responsiveness of renal sensory nerves by suppressing PGE2-mediated activation of adenylyl cyclase via a PTX-sensitive mechanism...
  17. ncbi request reprint Impaired responsiveness of renal mechanosensory nerves in heart failure: role of endogenous angiotensin
    Ulla C Kopp
    Department of Internal Medicine, Department of Veterans Affairs Medical Center, and University of Iowa Roy J and Lucille Carver College of Medicine, Iowa City, Iowa 52242, USA
    Am J Physiol Regul Integr Comp Physiol 284:R116-24. 2003
    ..In conclusion, the responsiveness of renal mechanosensory nerves is impaired in CHF rats due to ANG II inhibiting PGE(2)-mediated release of substance P from renal pelvic nerves...
  18. ncbi request reprint PGE(2) increases release of substance P from renal sensory nerves by activating the cAMP-PKA transduction cascade
    Ulla C Kopp
    Department of Internal Medicine, Department of Veterans Affairs Medical Center, Iowa City 52246, USA
    Am J Physiol Regul Integr Comp Physiol 282:R1618-27. 2002
    ..s, was blocked by DDA. In conclusion, PGE(2) activates the cAMP-PKA pathway leading to a release of SP and activation of renal pelvic mechanosensory nerve fibers...
  19. ncbi request reprint Vitamin A deficiency promotes bronchial hyperreactivity in rats by altering muscarinic M(2) receptor function
    Stephen E McGowan
    Department of Veterans Affairs Research Service, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Physiol Lung Cell Mol Physiol 282:L1031-9. 2002
    ..Vitamin A (retinol) and its congeners (retinoids) may be required to regulate bronchial responsiveness in addition to maintaining a normal bronchial epithelium...

Research Grants8

  1. RENORENAL REFLEXES
    ULLA KOPP; Fiscal Year: 2004
    ..Identifying the mechanisms involved in the activation of the renal sensory neurons during changes in dietary Na+ in rats and mice may further our understanding of the renal mechanisms contributing to hypertension. ..
  2. RENORENAL REFLEXES
    ULLA KOPP; Fiscal Year: 2007
    ..Understanding the mechanisms involved in the ET-1-mediated activation of renal sensory nerves may further our understanding of the role of ET-1 in sodium balance, heart failure and hypertension. ..
  3. RENORENAL REFLEXES
    ULLA KOPP; Fiscal Year: 2009
    ..Understanding the mechanisms involved in the ET-1-mediated activation of renal sensory nerves may further our understanding of the role of ET-1 in sodium balance, heart failure and hypertension. ..
  4. RENORENAL REFLEXES
    Ulla C Kopp; Fiscal Year: 2010
    ..Understanding the mechanisms involved in the ET-1-mediated activation of renal sensory nerves may further our understanding of the role of ET-1 in sodium balance, heart failure and hypertension. ..