ULLA KOPP

..Losartan had no effect on SP release in rats fed normal- and high-sodium diets. ANG II modulates the responsiveness of renal pelvic mechanosensory nerves by inhibiting PGE2-mediated SP release from renal pelvic nerve fibers...

..76). In conclusion, in normotensive rats, reinnervation of the renal sensory nerves occurs over the same time course as reinnervation of the renal sympathetic nerves, both being complete at 9 to 12 wk following renal denervation...

..These findings suggest that the increased renal sympathetic nerve activity and salt-sensitive hypertension in ET-1/ET(B)-R-deficient subjects is, at least in part, related to suppressed interaction between RSNA and ARNA...

..We conclude that increased activation of renal α(2)-ARs and angiotensin II type 1 receptors contributes to the impaired interaction between ERSNA and ARNA in SHR...

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..In conclusion, activation of ETA receptors contributes to the impaired responsiveness of renal mechanosensory nerves in CHF rats by a mechanism(s) at the renal sensory nerve endings...

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..Impaired arterial baroreflex function contributes to increased ERSNA, which would eventually lead to sodium retention and increased MAP in DRX rats fed high-sodium diet...

..We conclude that the mechanisms involved in the decreased responsiveness of the renal sensory nerves in STZ rats involve activation of the renin angiotensin system in STZ but not in obese ZDF rats...

..Norepinephrine-induced activation of the sensory nerves is dependent on renal pelvic synthesis/release of PGE(2)...

..In conclusion, stimulation of ETA-R plays an important contributory role to the Ang II-mediated suppression of the activation of renal mechanosensory nerves in conditions of low-sodium diet...

..Impaired renorenal reflexes may contribute to the salt-sensitive hypertension in the ETBR-deficient rat...

..L-161,982 also blocked the ARNA response to increasing renal pelvic pressure 10 mmHg, 85 +/- 5%. In conclusion, PGE(2) increases renal pelvic release of SP and ARNA by activating EP4 receptors on renal sensory nerve fibers...

..03 microM. In conclusion, the impaired responsiveness of renal sensory nerves in SHR involves endogenous ANG II suppressing the PGE2-mediated release of substance P via a PTX-sensitive mechanism...

..In conclusion, when the afferent limb of the renorenal reflex is interrupted, a high sodium diet results in increased arterial pressure to facilitate the natriuresis and maintenance of sodium balance...

..In conclusion, renal pelvic ANG II modulates the responsiveness of renal sensory nerves by suppressing PGE2-mediated activation of adenylyl cyclase via a PTX-sensitive mechanism...

..In conclusion, the responsiveness of renal mechanosensory nerves is impaired in CHF rats due to ANG II inhibiting PGE(2)-mediated release of substance P from renal pelvic nerves...

..s, was blocked by DDA. In conclusion, PGE(2) activates the cAMP-PKA pathway leading to a release of SP and activation of renal pelvic mechanosensory nerve fibers...

..Vitamin A (retinol) and its congeners (retinoids) may be required to regulate bronchial responsiveness in addition to maintaining a normal bronchial epithelium...

..Identifying the mechanisms involved in the activation of the renal sensory neurons during changes in dietary Na+ in rats and mice may further our understanding of the renal mechanisms contributing to hypertension. ..

..Understanding the mechanisms involved in the ET-1-mediated activation of renal sensory nerves may further our understanding of the role of ET-1 in sodium balance, heart failure and hypertension. ..

..Understanding the mechanisms involved in the ET-1-mediated activation of renal sensory nerves may further our understanding of the role of ET-1 in sodium balance, heart failure and hypertension. ..

..Understanding the mechanisms involved in the ET-1-mediated activation of renal sensory nerves may further our understanding of the role of ET-1 in sodium balance, heart failure and hypertension. ..