Ulla C Kopp

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi Impaired responsiveness of renal mechanosensory nerves in heart failure: role of endogenous angiotensin
    Ulla C Kopp
    Department of Internal Medicine, Department of Veterans Affairs Medical Center, and University of Iowa Roy J and Lucille Carver College of Medicine, Iowa City, Iowa 52242, USA
    Am J Physiol Regul Integr Comp Physiol 284:R116-24. 2003
  2. ncbi Renal substance P-containing neurons and substance P receptors impaired in hypertension
    U C Kopp
    Department of Internal Medicine, University of Iowa College of Medicine, and Department of Veterans Affairs Medical Center, Iowa City 52242, USA
    Hypertension 31:815-22. 1998
  3. ncbi Angiotensin blocks substance P release from renal sensory nerves by inhibiting PGE2-mediated activation of cAMP
    Ulla C Kopp
    Dept of Internal Medicine, Medical Center, University of Iowa Roy J and Lucille Carver College of Medicine, Iowa City 52242, USA
    Am J Physiol Renal Physiol 285:F472-83. 2003
  4. ncbi PGE2 increases substance P release from renal pelvic sensory nerves via activation of N-type calcium channels
    U C Kopp
    Department of Internal Medicine, Department of Veterans Affairs Medical Center and University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Physiol 276:R1241-8. 1999
  5. ncbi Cyclooxygenase-2 involved in stimulation of renal mechanosensitive neurons
    U C Kopp
    Department of Internal Medicine, Department of Veterans Affairs Medical Center and University of Iowa College of Medicine, Iowa City 52242, USA
    Hypertension 35:373-8. 2000
  6. ncbi Activation of renal mechanosensitive neurons involves bradykinin, protein kinase C, PGE(2), and substance P
    U C Kopp
    Departments of Internal Medicine, Department of Veterans Affairs Medical Center, and University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Physiol Regul Integr Comp Physiol 278:R937-46. 2000
  7. ncbi Endogenous angiotensin modulates PGE(2)-mediated release of substance P from renal mechanosensory nerve fibers
    Ulla C Kopp
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Physiol Regul Integr Comp Physiol 282:R19-30. 2002
  8. ncbi PGE(2) increases release of substance P from renal sensory nerves by activating the cAMP-PKA transduction cascade
    Ulla C Kopp
    Department of Internal Medicine, Department of Veterans Affairs Medical Center, Iowa City 52246, USA
    Am J Physiol Regul Integr Comp Physiol 282:R1618-27. 2002
  9. ncbi Dietary sodium modulates the interaction between efferent renal sympathetic nerve activity and afferent renal nerve activity: role of endothelin
    Ulla C Kopp
    Department of Internal Medicine, Department of Veterans Affairs Medical Center and University of Iowa Carver College of Medicine, Iowa City, Iowa 52246, USA
    Am J Physiol Regul Integr Comp Physiol 297:R337-51. 2009
  10. ncbi Activation of endothelin-a receptors contributes to angiotensin-induced suppression of renal sensory nerve activation
    Ulla C Kopp
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, USA
    Hypertension 49:141-7. 2007

Detail Information

Publications25

  1. ncbi Impaired responsiveness of renal mechanosensory nerves in heart failure: role of endogenous angiotensin
    Ulla C Kopp
    Department of Internal Medicine, Department of Veterans Affairs Medical Center, and University of Iowa Roy J and Lucille Carver College of Medicine, Iowa City, Iowa 52242, USA
    Am J Physiol Regul Integr Comp Physiol 284:R116-24. 2003
    ..In conclusion, the responsiveness of renal mechanosensory nerves is impaired in CHF rats due to ANG II inhibiting PGE(2)-mediated release of substance P from renal pelvic nerves...
  2. ncbi Renal substance P-containing neurons and substance P receptors impaired in hypertension
    U C Kopp
    Department of Internal Medicine, University of Iowa College of Medicine, and Department of Veterans Affairs Medical Center, Iowa City 52242, USA
    Hypertension 31:815-22. 1998
    ..These findings demonstrate that the impaired afferent renal nerve activity response to increased renal pelvic pressure is related to decreased release of substance P and/or impaired activation of substance P receptors...
  3. ncbi Angiotensin blocks substance P release from renal sensory nerves by inhibiting PGE2-mediated activation of cAMP
    Ulla C Kopp
    Dept of Internal Medicine, Medical Center, University of Iowa Roy J and Lucille Carver College of Medicine, Iowa City 52242, USA
    Am J Physiol Renal Physiol 285:F472-83. 2003
    ..In conclusion, renal pelvic ANG II modulates the responsiveness of renal sensory nerves by suppressing PGE2-mediated activation of adenylyl cyclase via a PTX-sensitive mechanism...
  4. ncbi PGE2 increases substance P release from renal pelvic sensory nerves via activation of N-type calcium channels
    U C Kopp
    Department of Internal Medicine, Department of Veterans Affairs Medical Center and University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Physiol 276:R1241-8. 1999
    ..1 microM) but was unaffected by verapamil. In conclusion, PGE2 increases the release of substance P from renal pelvic sensory nerves by a calcium-dependent mechanism that requires influx of calcium via N-type calcium channels...
  5. ncbi Cyclooxygenase-2 involved in stimulation of renal mechanosensitive neurons
    U C Kopp
    Department of Internal Medicine, Department of Veterans Affairs Medical Center and University of Iowa College of Medicine, Iowa City 52242, USA
    Hypertension 35:373-8. 2000
    ..We conclude that cyclooxygenase-2 is expressed in the renal pelvic wall and that the activation of cyclooxygenase-2 contributes to the stimulation of renal mechanosensitive neurons in the pelvic wall...
  6. ncbi Activation of renal mechanosensitive neurons involves bradykinin, protein kinase C, PGE(2), and substance P
    U C Kopp
    Departments of Internal Medicine, Department of Veterans Affairs Medical Center, and University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Physiol Regul Integr Comp Physiol 278:R937-46. 2000
    ..We conclude that bradykinin contributes to the activation of renal pelvic mechanosensitive neurons by activating PKC. PKC increases ARNA via a PGE(2)-induced release of substance P...
  7. ncbi Endogenous angiotensin modulates PGE(2)-mediated release of substance P from renal mechanosensory nerve fibers
    Ulla C Kopp
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Physiol Regul Integr Comp Physiol 282:R19-30. 2002
    ..Losartan had no effect on SP release in rats fed normal- and high-sodium diets. ANG II modulates the responsiveness of renal pelvic mechanosensory nerves by inhibiting PGE2-mediated SP release from renal pelvic nerve fibers...
  8. ncbi PGE(2) increases release of substance P from renal sensory nerves by activating the cAMP-PKA transduction cascade
    Ulla C Kopp
    Department of Internal Medicine, Department of Veterans Affairs Medical Center, Iowa City 52246, USA
    Am J Physiol Regul Integr Comp Physiol 282:R1618-27. 2002
    ..s, was blocked by DDA. In conclusion, PGE(2) activates the cAMP-PKA pathway leading to a release of SP and activation of renal pelvic mechanosensory nerve fibers...
  9. ncbi Dietary sodium modulates the interaction between efferent renal sympathetic nerve activity and afferent renal nerve activity: role of endothelin
    Ulla C Kopp
    Department of Internal Medicine, Department of Veterans Affairs Medical Center and University of Iowa Carver College of Medicine, Iowa City, Iowa 52246, USA
    Am J Physiol Regul Integr Comp Physiol 297:R337-51. 2009
    ....
  10. ncbi Activation of endothelin-a receptors contributes to angiotensin-induced suppression of renal sensory nerve activation
    Ulla C Kopp
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, USA
    Hypertension 49:141-7. 2007
    ..In conclusion, stimulation of ETA-R plays an important contributory role to the Ang II-mediated suppression of the activation of renal mechanosensory nerves in conditions of low-sodium diet...
  11. ncbi Dietary sodium modulates the interaction between efferent and afferent renal nerve activity by altering activation of α2-adrenoceptors on renal sensory nerves
    Ulla C Kopp
    Dept of Internal Medicine, Department of Veterans Affairs Medical Center, Bldg 41, Highway 6W, Iowa City, IA 52246, USA
    Am J Physiol Regul Integr Comp Physiol 300:R298-310. 2011
    ....
  12. ncbi Impaired substance P release from renal sensory nerves in SHR involves a pertussis toxin-sensitive mechanism
    Ulla C Kopp
    Dept of Internal Medicine, VA Medical Center, Bldg 3, Rm 226, Highway 6W, Iowa City, IA 52246, USA
    Am J Physiol Regul Integr Comp Physiol 286:R326-33. 2004
    ..03 microM. In conclusion, the impaired responsiveness of renal sensory nerves in SHR involves endogenous ANG II suppressing the PGE2-mediated release of substance P via a PTX-sensitive mechanism...
  13. ncbi Activation of endothelin A receptors contributes to impaired responsiveness of renal mechanosensory nerves in congestive heart failure
    Ulla C Kopp
    Department of Internal Medicine, Department of Veterans Affairs Medical Center, and University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Can J Physiol Pharmacol 88:622-9. 2010
    ..In conclusion, activation of ETA receptors contributes to the impaired responsiveness of renal mechanosensory nerves in CHF rats by a mechanism(s) at the renal sensory nerve endings...
  14. ncbi Activation of EP4 receptors contributes to prostaglandin E2-mediated stimulation of renal sensory nerves
    Ulla C Kopp
    Department of Internal Medicine, Department of Veterans Affairs Medical Center and University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Am J Physiol Renal Physiol 287:F1269-82. 2004
    ..L-161,982 also blocked the ARNA response to increasing renal pelvic pressure 10 mmHg, 85 +/- 5%. In conclusion, PGE(2) increases renal pelvic release of SP and ARNA by activating EP4 receptors on renal sensory nerve fibers...
  15. ncbi Renal sympathetic nerve activity modulates afferent renal nerve activity by PGE2-dependent activation of alpha1- and alpha2-adrenoceptors on renal sensory nerve fibers
    Ulla C Kopp
    Dept of Internal Medicine, VA Medical Center, Bldg 41, Rm 124, Highway 6W, Iowa City, IA 52246, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1561-72. 2007
    ..Norepinephrine-induced activation of the sensory nerves is dependent on renal pelvic synthesis/release of PGE(2)...
  16. ncbi Differential effects of endothelin on activation of renal mechanosensory nerves: stimulatory in high-sodium diet and inhibitory in low-sodium diet
    Ulla C Kopp
    Dept of Internal Medicine, VA Medical Center, University of Iowa Carver College of Medicine, Bldg 3, Rm 226, Highway 6W, Iowa City, IA 52246, USA
    Am J Physiol Regul Integr Comp Physiol 291:R1545-56. 2006
    ..Impaired renorenal reflexes may contribute to the salt-sensitive hypertension in the ETBR-deficient rat...
  17. ncbi Impaired interaction between efferent and afferent renal nerve activity in SHR involves increased activation of alpha2-adrenoceptors
    Ulla C Kopp
    Department of Internal Medicine, University of Iowa Carver College of Medicine, VA Medical Center, Iowa City, IA 52246
    Hypertension 57:640-7. 2011
    ..We conclude that increased activation of renal α(2)-ARs and angiotensin II type 1 receptors contributes to the impaired interaction between ERSNA and ARNA in SHR...
  18. ncbi Impaired responsiveness of renal sensory nerves in streptozotocin-treated rats and obese Zucker diabetic fatty rats: role of angiotensin
    Ulla C Kopp
    Department of Internal Medicine, Department of Veterans Affairs Medical Center, Bldg 41, Rm 124, Highway 6W, Iowa City, IA 52246, USA
    Am J Physiol Regul Integr Comp Physiol 294:R858-66. 2008
    ..We conclude that the mechanisms involved in the decreased responsiveness of the renal sensory nerves in STZ rats involve activation of the renin angiotensin system in STZ but not in obese ZDF rats...
  19. ncbi Afferent renal denervation impairs baroreflex control of efferent renal sympathetic nerve activity
    Ulla C Kopp
    Department of Internal Medicine, Department of Veterans Affairs Medical Center, Bldg 41, Rm 124, Highway 6W, Iowa City, IA 52246, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1882-90. 2008
    ..Impaired arterial baroreflex function contributes to increased ERSNA, which would eventually lead to sodium retention and increased MAP in DRX rats fed high-sodium diet...
  20. ncbi Nitric oxide modulates renal sensory nerve fibers by mechanisms related to substance P receptor activation
    U C Kopp
    Department of Internal Medicine, Department of Veterans Affairs Medical Center, Iowa City; University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Physiol Regul Integr Comp Physiol 281:R279-90. 2001
    ..In conclusion: activation of NO may function as an inhibitory neurotransmitter regulating the activation of renal mechanosensory nerve fibers by mechanisms related to activation of substance P receptors...
  21. ncbi Endothelin in the control of renal sympathetic nerve activity
    Ulla C Kopp
    Department of Internal Medicine, University of Iowa Carver, College of Medicine and Department of Veterans Affairs Medical Center, Iowa City, Iowa, USA
    Contrib Nephrol 172:107-19. 2011
    ..These findings suggest that the increased renal sympathetic nerve activity and salt-sensitive hypertension in ET-1/ET(B)-R-deficient subjects is, at least in part, related to suppressed interaction between RSNA and ARNA...
  22. ncbi Dietary sodium loading increases arterial pressure in afferent renal-denervated rats
    Ulla C Kopp
    Department of Internal Medicine, Veterans Affairs Medical Center, and the Roy J and Lucille Carver College of Medicine, University of Iowa, Bldg 3, Room 226, Highway 6W, Iowa City, IA 52246, USA
    Hypertension 42:968-73. 2003
    ..In conclusion, when the afferent limb of the renorenal reflex is interrupted, a high sodium diet results in increased arterial pressure to facilitate the natriuresis and maintenance of sodium balance...
  23. ncbi Vitamin A deficiency promotes bronchial hyperreactivity in rats by altering muscarinic M(2) receptor function
    Stephen E McGowan
    Department of Veterans Affairs Research Service, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Physiol Lung Cell Mol Physiol 282:L1031-9. 2002
    ..Vitamin A (retinol) and its congeners (retinoids) may be required to regulate bronchial responsiveness in addition to maintaining a normal bronchial epithelium...
  24. ncbi Renal mechanoreceptor dysfunction: an intermediate phenotype in spontaneously hypertensive rats
    G F DiBona
    Departments of Internal Medicine and Physiology, University of Iowa College of Medicine, and the Veterans Administration Medical Center, Iowa City 52242, USA
    Hypertension 33:472-5. 1999
    ..This aspect of the complex quantitative trait of altered renal sympathetic neural control of renal function, ie, decreased renal mechanoreceptor responsiveness, is part of an intermediate phenotype in SHR...
  25. ncbi Facilitatory role of efferent renal nerve activity on renal sensory receptors
    U C Kopp
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242
    Am J Physiol 253:F767-77. 1987
    ..01) to renal MR stimulation. These results indicate that ERNA exerts a facilitatory effect on renal MR and CR and their afferent renal nerve fibers in the renorenal reflexes...