Hyun Koo

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint Effect of a new variety of Apis mellifera propolis on mutans Streptococci
    H Koo
    Department of Physiological Sciences, Faculty of Dentistry of Piracicaba, State University of Campinas, Caixa Postal 52, Piracicaba, 13414 900, SP, Brazil
    Curr Microbiol 41:192-6. 2000
  2. ncbi request reprint Effects of apigenin and tt-farnesol on glucosyltransferase activity, biofilm viability and caries development in rats
    H Koo
    Center for Oral Biology and Eastman Department of Dentistry, University of Rochester Medical Center, NY 14642, USA
    Oral Microbiol Immunol 17:337-43. 2002
  3. pmc Dynamics of Streptococcus mutans transcriptome in response to starch and sucrose during biofilm development
    Marlise I Klein
    Center for Oral Biology and Eastman Department of Dentistry, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 5:e13478. 2010
  4. pmc The exopolysaccharide matrix modulates the interaction between 3D architecture and virulence of a mixed-species oral biofilm
    Jin Xiao
    Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS Pathog 8:e1002623. 2012
  5. pmc Natural products in caries research: current (limited) knowledge, challenges and future perspective
    J G Jeon
    Department of Preventive Dentistry, BK 21 Program, School of Dentistry and Institute of Oral Bioscience, Chonbuk National University, Jeonju, Republic of Korea
    Caries Res 45:243-63. 2011
  6. pmc Antimicrobial and antiproliferative activities of stingless bee Melipona scutellaris geopropolis
    Marcos Guilherme da Cunha
    Department of Physiological Sciences, Piracicaba Dental School, University of Campinas UNICAMP, Av, Limeira 901, 13414 903 Piracicaba, SP, Brazil
    BMC Complement Altern Med 13:23. 2013
  7. ncbi request reprint Strategies to enhance the biological effects of fluoride on dental biofilms
    H Koo
    Eastman Department of Dentistry and Center for Oral Biology, University of Rochester Medical Center, Rochester, NY 14620, USA
    Adv Dent Res 20:17-21. 2008
  8. pmc Influence of apigenin on gtf gene expression in Streptococcus mutans UA159
    Hyun Koo
    Eastman Department of Dentistry and Center for Oral Biology, University of Rochester Medical Center, 625 Elmwood Ave, Box 683, Rochester, NY 14620, USA
    Antimicrob Agents Chemother 50:542-6. 2006
  9. ncbi request reprint Influence of cranberry juice on glucan-mediated processes involved in Streptococcus mutans biofilm development
    H Koo
    Center for Oral Biology and Eastman Department of Dentistry, 601 Elmwood Avenue, Box 611, University of Rochester Medical Center, Rochester, NY 14642, USA
    Caries Res 40:20-7. 2006
  10. pmc Apigenin and tt-farnesol with fluoride effects on S. mutans biofilms and dental caries
    H Koo
    Center for Oral Biology and Eastman Dept of Dentistry, University of Rochester Medical Center, 625 Elmwood Avenue, Box 683, Rochester, NY 14620, USA
    J Dent Res 84:1016-20. 2005

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Effect of a new variety of Apis mellifera propolis on mutans Streptococci
    H Koo
    Department of Physiological Sciences, Faculty of Dentistry of Piracicaba, State University of Campinas, Caixa Postal 52, Piracicaba, 13414 900, SP, Brazil
    Curr Microbiol 41:192-6. 2000
    ....
  2. ncbi request reprint Effects of apigenin and tt-farnesol on glucosyltransferase activity, biofilm viability and caries development in rats
    H Koo
    Center for Oral Biology and Eastman Department of Dentistry, University of Rochester Medical Center, NY 14642, USA
    Oral Microbiol Immunol 17:337-43. 2002
    ..The incidence of smooth-surface caries was significantly reduced by apigenin +tt-farnesol (60%), fluoride (70%), and chlorhexidine (72%) treatments compared to control (P < 0.05)...
  3. pmc Dynamics of Streptococcus mutans transcriptome in response to starch and sucrose during biofilm development
    Marlise I Klein
    Center for Oral Biology and Eastman Department of Dentistry, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 5:e13478. 2010
    ..Our data show complex remodeling of S. mutans-transcriptome in response to changing environmental conditions in situ, which could modulate the dynamics of biofilm development and pathogenicity...
  4. pmc The exopolysaccharide matrix modulates the interaction between 3D architecture and virulence of a mixed-species oral biofilm
    Jin Xiao
    Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS Pathog 8:e1002623. 2012
    ..These observations may have relevance beyond the mouth, as matrix is inherent to all biofilms...
  5. pmc Natural products in caries research: current (limited) knowledge, challenges and future perspective
    J G Jeon
    Department of Preventive Dentistry, BK 21 Program, School of Dentistry and Institute of Oral Bioscience, Chonbuk National University, Jeonju, Republic of Korea
    Caries Res 45:243-63. 2011
    ..This review focuses on gaps in the current knowledge and presents a model for investigating the use of natural products in anticaries chemotherapy...
  6. pmc Antimicrobial and antiproliferative activities of stingless bee Melipona scutellaris geopropolis
    Marcos Guilherme da Cunha
    Department of Physiological Sciences, Piracicaba Dental School, University of Campinas UNICAMP, Av, Limeira 901, 13414 903 Piracicaba, SP, Brazil
    BMC Complement Altern Med 13:23. 2013
    ....
  7. ncbi request reprint Strategies to enhance the biological effects of fluoride on dental biofilms
    H Koo
    Eastman Department of Dentistry and Center for Oral Biology, University of Rochester Medical Center, Rochester, NY 14620, USA
    Adv Dent Res 20:17-21. 2008
  8. pmc Influence of apigenin on gtf gene expression in Streptococcus mutans UA159
    Hyun Koo
    Eastman Department of Dentistry and Center for Oral Biology, University of Rochester Medical Center, 625 Elmwood Ave, Box 683, Rochester, NY 14620, USA
    Antimicrob Agents Chemother 50:542-6. 2006
    ..The data show that apigenin modulates the genetic expression of virulence factors in S. mutans...
  9. ncbi request reprint Influence of cranberry juice on glucan-mediated processes involved in Streptococcus mutans biofilm development
    H Koo
    Center for Oral Biology and Eastman Department of Dentistry, 601 Elmwood Avenue, Box 611, University of Rochester Medical Center, Rochester, NY 14642, USA
    Caries Res 40:20-7. 2006
    ..05). Our data show that cranberry juice inhibited glucan-mediated biofilm development and acid production, and holds promise as a natural product to prevent biofilm-related oral diseases...
  10. pmc Apigenin and tt-farnesol with fluoride effects on S. mutans biofilms and dental caries
    H Koo
    Center for Oral Biology and Eastman Dept of Dentistry, University of Rochester Medical Center, 625 Elmwood Avenue, Box 683, Rochester, NY 14620, USA
    J Dent Res 84:1016-20. 2005
    ..Results from these studies showed that apigenin and tt-farnesol may enhance the cariostatic effectiveness of fluoride...
  11. pmc Effects of compounds found in propolis on Streptococcus mutans growth and on glucosyltransferase activity
    Hyun Koo
    Center for Oral Biology and Eastman Department of Dentistry, University of Rochester Medical Center, Rochester, New York 14642, USA
    Antimicrob Agents Chemother 46:1302-9. 2002
    ..Several of the compounds identified in propolis inhibit GTF activities and bacterial growth. Apigenin is a novel and potent inhibitor of GTF activity, and tt-farnesol was found to be an effective antibacterial agent...
  12. ncbi request reprint Inhibition of Streptococcus mutans biofilm accumulation and polysaccharide production by apigenin and tt-farnesol
    H Koo
    Eastman Department of Dentistry, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Antimicrob Chemother 52:782-9. 2003
    ..We investigated the influence of apigenin and tt-farnesol, alone and in combination, on the accumulation, polysaccharide composition and viability of S. mutans UA159 biofilms...
  13. pmc The specific degree-of-polymerization of A-type proanthocyanidin oligomers impacts Streptococcus mutans glucan-mediated adhesion and transcriptome responses within biofilms
    Guoping Feng
    Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA
    Biofouling 29:629-40. 2013
    ..This study identified putative molecular targets of A-type cranberry PACs in S. mutans while demonstrating that PAC oligomers with a specific DP may be effective in disrupting the assembly of cariogenic biofilms. ..
  14. pmc Novel antibiofilm chemotherapy targets exopolysaccharide synthesis and stress tolerance in Streptococcus mutans to modulate virulence expression in vivo
    Megan L Falsetta
    Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA
    Antimicrob Agents Chemother 56:6201-11. 2012
    ..These observations may have relevance for development of enhanced therapies against other biofilm-dependent infections...
  15. ncbi request reprint The influence of a novel propolis on mutans streptococci biofilms and caries development in rats
    Simone Duarte
    Eastman Department of Dentistry and Center for Oral Biology, University of Rochester Medical Center, NY 14620, USA
    Arch Oral Biol 51:15-22. 2006
    ....
  16. pmc Influences of naturally occurring agents in combination with fluoride on gene expression and structural organization of Streptococcus mutans in biofilms
    Jae Gyu Jeon
    Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, USA
    BMC Microbiol 9:228. 2009
    ..mutans within biofilms and their structural organization using real-time PCR and confocal fluorescence microscopy...
  17. pmc Influences of trans-trans farnesol, a membrane-targeting sesquiterpenoid, on Streptococcus mutans physiology and survival within mixed-species oral biofilms
    Jae Gyu Jeon
    Department of Preventive Dentistry, School of Dentistry, Chonbuk National University, Jeonju 561756, Republic of Korea
    Int J Oral Sci 3:98-106. 2011
    ..This naturally occurring terpenoid could be a potentially useful adjunctive agent to the current anti-biofilm/anti-caries chemotherapeutic strategies...
  18. pmc Streptococcus mutans protein synthesis during mixed-species biofilm development by high-throughput quantitative proteomics
    Marlise I Klein
    Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, USA
    PLoS ONE 7:e45795. 2012
    ..This reflects the intricate physiological processes linked to expression of virulence by this bacterium within complex biofilms...
  19. pmc Influence of cranberry proanthocyanidins on formation of biofilms by Streptococcus mutans on saliva-coated apatitic surface and on dental caries development in vivo
    H Koo
    Eastman Department of Dentistry, University of Rochester Medical Center, Rochester, NY 14620, USA hyun_koo urmc rochester edu
    Caries Res 44:116-26. 2010
    ..Our data show that cranberry PAC reduced the formation of biofilms by S. mutans in vitro and dental caries development in vivo, which may be attributed to the presence of specific bioactive A-type dimers and oligomers...
  20. ncbi request reprint Inhibitory effects of cranberry polyphenols on formation and acidogenicity of Streptococcus mutans biofilms
    Simone Duarte
    Eastman Department of Dentistry Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA
    FEMS Microbiol Lett 257:50-6. 2006
    ..The flavonols are comprised of mostly quercetin glycosides, and the PAC are largely A-type oligomers of epicatechin. Our data show that proanthocyanidins and flavonols are the active constituents of cranberry against S. mutans...
  21. pmc Human common salivary protein 1 (CSP-1) promotes binding of Streptococcus mutans to experimental salivary pellicle and glucans formed on hydroxyapatite surface
    Kiran S Ambatipudi
    Departments of Pharmacology and Physiology, Rochester Proteomics Center, University of Rochester Medical Center, Rochester, New York 14642, United States
    J Proteome Res 9:6605-14. 2010
    ..Thus, our data demonstrate that the host salivary protein CSP-1 binds to S. mutans cells and may influence the initial colonization of this pathogenic bacterium onto the tooth surface...
  22. pmc Role of Clp proteins in expression of virulence properties of Streptococcus mutans
    Jessica K Kajfasz
    Center for Oral Biology, University of Rochester Medical Center, NY 14642, USA
    J Bacteriol 191:2060-8. 2009
    ..mutans and indicates that the underlying mechanisms by which ClpXP affect virulence traits are associated with the accumulation of two Spx orthologues...
  23. pmc Symbiotic relationship between Streptococcus mutans and Candida albicans synergizes virulence of plaque biofilms in vivo
    Megan L Falsetta
    Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, USA
    Infect Immun 82:1968-81. 2014
    ..Altogether, we demonstrate a novel mutualistic bacterium-fungus relationship that occurs at a clinically relevant site to amplify the severity of a ubiquitous infectious disease. ..
  24. pmc Protocols to study the physiology of oral biofilms
    JOSE A LEMOS
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA
    Methods Mol Biol 666:87-102. 2010
    ..In this chapter, we use oral streptococci as examples for studying the physiology of oral biofilms...
  25. pmc Elevated incidence of dental caries in a mouse model of cystic fibrosis
    Marcelo A Catalán
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 6:e16549. 2011
    ..Given the close relationship between pH and caries development, we hypothesized that caries incidence might be elevated in the mouse CF model...
  26. pmc Streptococcus mutans: a new Gram-positive paradigm?
    JOSE A LEMOS
    Center for Oral Biology and Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Microbiology 159:436-45. 2013
    ..In this article, we provide an argument that places S. mutans, an organism that evolved in close association with the human host, as a novel Gram-positive model organism...
  27. pmc Adjunctive chemotherapeutic suppression of mutans streptococci in the setting of severe early childhood caries: an exploratory study
    Robert J Berkowitz
    University of Rochester Eastman Dental Center, 625 Elmwood Avenue, Rochester, NY 14620, USA
    J Public Health Dent 69:163-7. 2009
    ....
  28. ncbi request reprint Co-operative inhibition by fluoride and zinc of glucosyl transferase production and polysaccharide synthesis by mutans streptococci in suspension cultures and biofilms
    Hyun Koo
    Center for Oral Biology and Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642 8672, USA
    FEMS Microbiol Lett 254:134-40. 2006
    ..As insoluble glucans are important for virulence of mutans streptococci, the inhibitory actions of fluoride and zinc could significantly affect cariogenicity...
  29. ncbi request reprint The putative autolysin regulator LytR in Streptococcus mutans plays a role in cell division and is growth-phase regulated
    Christa H Chatfield
    Center for Oral Biology, University of Rochester, Rochester, NY 14642, USA
    Microbiology 151:625-31. 2005
    ..No defect in cell-to-surface adherence or biofilm growth was seen in the LytR mutant. However, a connection between cell growth phase and transcription of lytR was found...
  30. ncbi request reprint Influence of cranberry phenolics on glucan synthesis by glucosyltransferases and Streptococcus mutans acidogenicity
    S Gregoire
    Department of Dentistry, University of Rochester Medical Center, Rochester, NY 14620, USA
    J Appl Microbiol 103:1960-8. 2007
    ..To investigate the influence of several phenolic compounds isolated from cranberry fruit (Vaccinium macrocarpon) on some of the virulence properties of Streptococcus mutans associated with glucan synthesis and acidogenicity...
  31. doi request reprint Influences of starch and sucrose on Streptococcus mutans biofilms
    S Duarte
    Eastman Department of Dentistry and Center for Oral Biology, University of Rochester Medical Center, Rochester, NY 14620, USA
    Oral Microbiol Immunol 23:206-12. 2008
    ..The aim of this study was to examine the influence of starch and sucrose, alone or in combinations, on formation, polysaccharide composition, gene expression, and acidogenicity of Streptococcus mutans biofilms...
  32. pmc Exopolysaccharides produced by Streptococcus mutans glucosyltransferases modulate the establishment of microcolonies within multispecies biofilms
    H Koo
    Center for Oral Biology, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    J Bacteriol 192:3024-32. 2010
    ..mutans; these Gtf-mediated processes may enhance the competitiveness of S. mutans in the multispecies environment in biofilms on tooth surfaces...
  33. ncbi request reprint Chemical characterization of red wine grape (Vitis vinifera and Vitis interspecific hybrids) and pomace phenolic extracts and their biological activity against Streptococcus mutans
    Joanne Thimothe
    Eastman Department of Dentistry and Center for Oral Biology, University of Rochester Medical Center, Rochester, New York 14620, USA
    J Agric Food Chem 55:10200-7. 2007
    ..The results showed that grape phenolic extracts, especially from pomace, are highly effective against specific virulence traits of S. mutans despite major differences in their phenolic content...
  34. pmc Role of unsaturated fatty acid biosynthesis in virulence of Streptococcus mutans
    Elizabeth M Fozo
    Department of Microbiology and Immunology, Center for Oral Biology, Rochester, NY 14642, USA
    Infect Immun 75:1537-9. 2007
    ..In this study, the strain was shown to be poorly transmissible from host to host. Animals directly infected with the fabM strain exhibited fewer and less severe carious lesions than those observed in the wild-type strain...
  35. pmc Structural and molecular basis of the role of starch and sucrose in Streptococcus mutans biofilm development
    M I Klein
    Eastman Department of Dentistry and Center for Oral Biology, University of Rochester Medical Center, New York 14620, USA
    Appl Environ Microbiol 75:837-41. 2009
    ....
  36. ncbi request reprint Interactions of Streptococcus mutans glucosyltransferase B with lysozyme in solution and on the surface of hydroxyapatite
    H S Kho
    University of Rochester, Center for Oral Biology, Rochester, New York, N Y, USA
    Caries Res 39:411-6. 2005
    ..Therefore, the interaction of lysozyme and GtfB enzymes on HA surface may modulate the formation of glucan and dental plaque...
  37. pmc Role of glucosyltransferase B in interactions of Candida albicans with Streptococcus mutans and with an experimental pellicle on hydroxyapatite surfaces
    S Gregoire
    Center for Oral Biology, University of Rochester, Rochester, NY 14642, USA
    Appl Environ Microbiol 77:6357-67. 2011
    ..Surface-bound GtfB promotes the formation of a glucan-rich matrix in situ and may enhance the accumulation of S. mutans on the tooth enamel surface, thereby modulating the development of virulent biofilms...
  38. ncbi request reprint In vitro and in vivo effects of isolated fractions of Brazilian propolis on caries development
    Mitsue F Hayacibara
    Department of Physiological Sciences, Dentistry Faculty of Piracicaba, State University of Campinas, Av Limeira, 901 PIRACICABA SP, CEP 13414 903, Brazil
    J Ethnopharmacol 101:110-5. 2005
    ..The data suggest that the putative cariostatic compounds of propolis type-3 and -12 are mostly non-polar; and H-fr should be the fraction of choice for identifying further potentially novel anti-caries agents...
  39. ncbi request reprint The influence of mutanase and dextranase on the production and structure of glucans synthesized by streptococcal glucosyltransferases
    Mitsue F Hayacibara
    Faculty of Dentistry of Piracicaba, UNICAMP, Piracicaba, São Paulo 13414 018, Brazil
    Carbohydr Res 339:2127-37. 2004
    ..Our data have relevance for the formation of polysaccharide matrix of other biofilms...
  40. ncbi request reprint Effect of a novel type of propolis and its chemical fractions on glucosyltransferases and on growth and adherence of mutans streptococci
    Simone Duarte
    Department of Physiological Sciences, Dentistry School of Piracicaba, State University of Campinas Brazil, Sao Paulo
    Biol Pharm Bull 26:527-31. 2003
    ..The data showed that propolis type 6 remarkably reduced GTF activity and inhibited mutans streptococci growth and adherence; these biological activities are associated with its nonpolar components...
  41. pmc Inhibitory effects of 7-epiclusianone on glucan synthesis, acidogenicity and biofilm formation by Streptococcus mutans
    Ramiro Mendonca Murata
    Department of Physiological Sciences, State University of Campinas, SP, Brazil
    FEMS Microbiol Lett 282:174-81. 2008
    ..05). The data show that 7-epiclusianone disrupts the extracellular and intracellular sugar metabolism of S. mutans, and holds promise as a novel, naturally occurring compound to prevent biofilm-related oral diseases...
  42. ncbi request reprint Extraction and purification of total RNA from Streptococcus mutans biofilms
    Jaime A Cury
    Faculty of Dentistry of Piracicaba, State University of Campinas, Piracicaba, Sao Paulo, Brazil
    Anal Biochem 365:208-14. 2007
    ..The results demonstrated a method that yields high-quality RNA from biofilms of S. mutans in sufficient quantity for real-time RT-PCR analyses, and our data have relevance for isolation of RNA from other biofilm-forming microorganisms...

Research Grants8

  1. Influence of Cranberry on Plaque-Related Diseases
    Hyun Koo; Fiscal Year: 2006
    ..We also propose to examine the ability of cranberry to prevent or reduce caries in our well-proven rodent model and to investigate the effects of cranberry on plaque formation and gingivitis in vivo. ..
  2. Effects of Natural Agents with Fluoride on Caries
    Hyun Koo; Fiscal Year: 2004
    ....
  3. Evaluation of a Novel Anti-Caries Approach to Modulate Virulence of S. mutans
    Hyun Koo; Fiscal Year: 2010
    ..Our approach uses natural compounds, is highly effective without suppressing the resident oral flora (non-microbiocidal) and may decrease exposure to fluoride. ..
  4. Influence of Cranberry on Plaque-Related Diseases
    Hyun Koo; Fiscal Year: 2004
    ..We also propose to examine the ability of cranberry to prevent or reduce caries in our well-proven rodent model and to investigate the effects of cranberry on plaque formation and gingivitis in vivo. ..
  5. Influence of Cranberry on Plaque-Related Diseases
    Hyun Koo; Fiscal Year: 2005
    ..We also propose to examine the ability of cranberry to prevent or reduce caries in our well-proven rodent model and to investigate the effects of cranberry on plaque formation and gingivitis in vivo. ..
  6. Molecular Basis for Caries Inhibiting Effects of Cranberry Flavonoids
    Hyun Koo; Fiscal Year: 2010
    ....
  7. Evaluation of a Novel Anti-Caries Approach to Modulate Virulence of S. mutans
    Hyun Koo; Fiscal Year: 2009
    ..Our approach uses natural compounds, is highly effective without suppressing the resident oral flora (non-microbiocidal) and may decrease exposure to fluoride. ..