Research Topics
| Hyun KooSummaryAffiliation: University of Rochester Country: USA Publications
Research Grants
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Detail Information
Publications
Effect of a new variety of Apis mellifera propolis on mutans StreptococciH Koo
Department of Physiological Sciences, Faculty of Dentistry of Piracicaba, State University of Campinas, Caixa Postal 52, Piracicaba, 13414 900, SP, Brazil
Curr Microbiol 41:192-6. 2000....- Effects of apigenin and tt-farnesol on glucosyltransferase activity, biofilm viability and caries development in ratsH Koo
Center for Oral Biology and Eastman Department of Dentistry, University of Rochester Medical Center, NY 14642, USA
Oral Microbiol Immunol 17:337-43. 2002..The incidence of smooth-surface caries was significantly reduced by apigenin +tt-farnesol (60%), fluoride (70%), and chlorhexidine (72%) treatments compared to control (P < 0.05)... 
Apigenin and tt-farnesol with fluoride effects on S. mutans biofilms and dental cariesH Koo
Center for Oral Biology and Eastman Dept of Dentistry, University of Rochester Medical Center, 625 Elmwood Avenue, Box 683, Rochester, NY 14620, USA
J Dent Res 84:1016-20. 2005..Results from these studies showed that apigenin and tt-farnesol may enhance the cariostatic effectiveness of fluoride...- Effects of compounds found in propolis on Streptococcus mutans growth and on glucosyltransferase activityHyun Koo
Center for Oral Biology and Eastman Department of Dentistry, University of Rochester Medical Center, Rochester, New York 14642, USA
Antimicrob Agents Chemother 46:1302-9. 2002..Several of the compounds identified in propolis inhibit GTF activities and bacterial growth. Apigenin is a novel and potent inhibitor of GTF activity, and tt-farnesol was found to be an effective antibacterial agent... - Strategies to enhance the biological effects of fluoride on dental biofilmsH Koo
Eastman Department of Dentistry and Center for Oral Biology, University of Rochester Medical Center, Rochester, NY 14620, USA
Adv Dent Res 20:17-21. 2008 - Influence of cranberry juice on glucan-mediated processes involved in Streptococcus mutans biofilm developmentH Koo
Center for Oral Biology and Eastman Department of Dentistry, 601 Elmwood Avenue, Box 611, University of Rochester Medical Center, Rochester, NY 14642, USA
Caries Res 40:20-7. 2006..05). Our data show that cranberry juice inhibited glucan-mediated biofilm development and acid production, and holds promise as a natural product to prevent biofilm-related oral diseases... - Inhibition of Streptococcus mutans biofilm accumulation and polysaccharide production by apigenin and tt-farnesolH Koo
Eastman Department of Dentistry, University of Rochester Medical Center, Rochester, NY 14642, USA
J Antimicrob Chemother 52:782-9. 2003..We investigated the influence of apigenin and tt-farnesol, alone and in combination, on the accumulation, polysaccharide composition and viability of S. mutans UA159 biofilms... - Influence of apigenin on gtf gene expression in Streptococcus mutans UA159Hyun Koo
Eastman Department of Dentistry and Center for Oral Biology, University of Rochester Medical Center, 625 Elmwood Ave, Box 683, Rochester, NY 14620, USA
Antimicrob Agents Chemother 50:542-6. 2006..The data show that apigenin modulates the genetic expression of virulence factors in S. mutans... - Novel antibiofilm chemotherapy targets exopolysaccharide synthesis and stress tolerance in Streptococcus mutans to modulate virulence expression in vivoMegan L Falsetta
Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA
Antimicrob Agents Chemother 56:6201-11. 2012..These observations may have relevance for development of enhanced therapies against other biofilm-dependent infections... - The influence of a novel propolis on mutans streptococci biofilms and caries development in ratsSimone Duarte
Eastman Department of Dentistry and Center for Oral Biology, University of Rochester Medical Center, NY 14620, USA
Arch Oral Biol 51:15-22. 2006.... - Influence of cranberry proanthocyanidins on formation of biofilms by Streptococcus mutans on saliva-coated apatitic surface and on dental caries development in vivoH Koo
Eastman Department of Dentistry, University of Rochester Medical Center, Rochester, NY 14620, USA hyun_koo urmc rochester edu
Caries Res 44:116-26. 2010..Our data show that cranberry PAC reduced the formation of biofilms by S. mutans in vitro and dental caries development in vivo, which may be attributed to the presence of specific bioactive A-type dimers and oligomers... - Influences of naturally occurring agents in combination with fluoride on gene expression and structural organization of Streptococcus mutans in biofilmsJae Gyu Jeon
Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, USA
BMC Microbiol 9:228. 2009..mutans within biofilms and their structural organization using real-time PCR and confocal fluorescence microscopy... - Inhibitory effects of cranberry polyphenols on formation and acidogenicity of Streptococcus mutans biofilmsSimone Duarte
Eastman Department of Dentistry Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA
FEMS Microbiol Lett 257:50-6. 2006..The flavonols are comprised of mostly quercetin glycosides, and the PAC are largely A-type oligomers of epicatechin. Our data show that proanthocyanidins and flavonols are the active constituents of cranberry against S. mutans... - Human common salivary protein 1 (CSP-1) promotes binding of Streptococcus mutans to experimental salivary pellicle and glucans formed on hydroxyapatite surfaceKiran S Ambatipudi
Departments of Pharmacology and Physiology, Rochester Proteomics Center, University of Rochester Medical Center, Rochester, New York 14642, United States
J Proteome Res 9:6605-14. 2010..Thus, our data demonstrate that the host salivary protein CSP-1 binds to S. mutans cells and may influence the initial colonization of this pathogenic bacterium onto the tooth surface... - Role of Clp proteins in expression of virulence properties of Streptococcus mutansJessica K Kajfasz
Center for Oral Biology, University of Rochester Medical Center, NY 14642, USA
J Bacteriol 191:2060-8. 2009..mutans and indicates that the underlying mechanisms by which ClpXP affect virulence traits are associated with the accumulation of two Spx orthologues... - The exopolysaccharide matrix modulates the interaction between 3D architecture and virulence of a mixed-species oral biofilmJin Xiao
Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, United States of America
PLoS Pathog 8:e1002623. 2012..These observations may have relevance beyond the mouth, as matrix is inherent to all biofilms... - Elevated incidence of dental caries in a mouse model of cystic fibrosisMarcelo A Catalán
Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York, United States of America
PLoS ONE 6:e16549. 2011..Given the close relationship between pH and caries development, we hypothesized that caries incidence might be elevated in the mouse CF model... - Protocols to study the physiology of oral biofilmsJOSE A LEMOS
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA
Methods Mol Biol 666:87-102. 2010..In this chapter, we use oral streptococci as examples for studying the physiology of oral biofilms... - Streptococcus mutans protein synthesis during mixed-species biofilm development by high-throughput quantitative proteomicsMarlise I Klein
Center for Oral Biology, University of Rochester Medical Center, Rochester, New York, USA
PLoS ONE 7:e45795. 2012..This reflects the intricate physiological processes linked to expression of virulence by this bacterium within complex biofilms... - Adjunctive chemotherapeutic suppression of mutans streptococci in the setting of severe early childhood caries: an exploratory studyRobert J Berkowitz
University of Rochester Eastman Dental Center, 625 Elmwood Avenue, Rochester, NY 14620, USA
J Public Health Dent 69:163-7. 2009.... - Dynamics of Streptococcus mutans transcriptome in response to starch and sucrose during biofilm developmentMarlise I Klein
Center for Oral Biology and Eastman Department of Dentistry, University of Rochester Medical Center, Rochester, New York, United States of America
PLoS ONE 5:e13478. 2010..Our data show complex remodeling of S. mutans-transcriptome in response to changing environmental conditions in situ, which could modulate the dynamics of biofilm development and pathogenicity... - Co-operative inhibition by fluoride and zinc of glucosyl transferase production and polysaccharide synthesis by mutans streptococci in suspension cultures and biofilmsHyun Koo
Center for Oral Biology and Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642-8672, USA
FEMS Microbiol Lett 254:134-40. 2006..As insoluble glucans are important for virulence of mutans streptococci, the inhibitory actions of fluoride and zinc could significantly affect cariogenicity... - The putative autolysin regulator LytR in Streptococcus mutans plays a role in cell division and is growth-phase regulatedChrista H Chatfield
Center for Oral Biology, University of Rochester, Rochester, NY 14642, USA
Microbiology 151:625-31. 2005..No defect in cell-to-surface adherence or biofilm growth was seen in the LytR mutant. However, a connection between cell growth phase and transcription of lytR was found... - Influence of cranberry phenolics on glucan synthesis by glucosyltransferases and Streptococcus mutans acidogenicityS Gregoire
Department of Dentistry, University of Rochester Medical Center, Rochester, NY 14620, USA
J Appl Microbiol 103:1960-8. 2007..To investigate the influence of several phenolic compounds isolated from cranberry fruit (Vaccinium macrocarpon) on some of the virulence properties of Streptococcus mutans associated with glucan synthesis and acidogenicity... 
Influences of starch and sucrose on Streptococcus mutans biofilmsS Duarte
Eastman Department of Dentistry and Center for Oral Biology, University of Rochester Medical Center, Rochester, NY 14620, USA
Oral Microbiol Immunol 23:206-12. 2008..The aim of this study was to examine the influence of starch and sucrose, alone or in combinations, on formation, polysaccharide composition, gene expression, and acidogenicity of Streptococcus mutans biofilms...- Exopolysaccharides produced by Streptococcus mutans glucosyltransferases modulate the establishment of microcolonies within multispecies biofilmsH Koo
Center for Oral Biology, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
J Bacteriol 192:3024-32. 2010..mutans; these Gtf-mediated processes may enhance the competitiveness of S. mutans in the multispecies environment in biofilms on tooth surfaces... - Streptococcus mutans: a new Gram-positive paradigm?JOSE A LEMOS
Center for Oral Biology and Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Microbiology 159:436-45. 2013..In this article, we provide an argument that places S. mutans, an organism that evolved in close association with the human host, as a novel Gram-positive model organism... - Chemical characterization of red wine grape (Vitis vinifera and Vitis interspecific hybrids) and pomace phenolic extracts and their biological activity against Streptococcus mutansJoanne Thimothe
Eastman Department of Dentistry and Center for Oral Biology, University of Rochester Medical Center, Rochester, New York 14620, USA
J Agric Food Chem 55:10200-7. 2007..The results showed that grape phenolic extracts, especially from pomace, are highly effective against specific virulence traits of S. mutans despite major differences in their phenolic content... - Role of unsaturated fatty acid biosynthesis in virulence of Streptococcus mutansElizabeth M Fozo
Department of Microbiology and Immunology, Center for Oral Biology, Rochester, NY 14642, USA
Infect Immun 75:1537-9. 2007..In this study, the strain was shown to be poorly transmissible from host to host. Animals directly infected with the fabM strain exhibited fewer and less severe carious lesions than those observed in the wild-type strain... - Structural and molecular basis of the role of starch and sucrose in Streptococcus mutans biofilm developmentM I Klein
Eastman Department of Dentistry and Center for Oral Biology, University of Rochester Medical Center, New York 14620, USA
Appl Environ Microbiol 75:837-41. 2009.... - Interactions of Streptococcus mutans glucosyltransferase B with lysozyme in solution and on the surface of hydroxyapatiteH S Kho
University of Rochester, Center for Oral Biology, Rochester, New York, N Y, USA
Caries Res 39:411-6. 2005..Therefore, the interaction of lysozyme and GtfB enzymes on HA surface may modulate the formation of glucan and dental plaque... - Role of glucosyltransferase B in interactions of Candida albicans with Streptococcus mutans and with an experimental pellicle on hydroxyapatite surfacesS Gregoire
Center for Oral Biology, University of Rochester, Rochester, NY 14642, USA
Appl Environ Microbiol 77:6357-67. 2011..Surface-bound GtfB promotes the formation of a glucan-rich matrix in situ and may enhance the accumulation of S. mutans on the tooth enamel surface, thereby modulating the development of virulent biofilms... - Inhibitory effects of 7-epiclusianone on glucan synthesis, acidogenicity and biofilm formation by Streptococcus mutansRamiro Mendonca Murata
Department of Physiological Sciences, State University of Campinas, SP, Brazil
FEMS Microbiol Lett 282:174-81. 2008..05). The data show that 7-epiclusianone disrupts the extracellular and intracellular sugar metabolism of S. mutans, and holds promise as a novel, naturally occurring compound to prevent biofilm-related oral diseases... - In vitro and in vivo effects of isolated fractions of Brazilian propolis on caries developmentMitsue F Hayacibara
Department of Physiological Sciences, Dentistry Faculty of Piracicaba, State University of Campinas, Av Limeira, 901 PIRACICABA SP, CEP 13414 903, Brazil
J Ethnopharmacol 101:110-5. 2005..The data suggest that the putative cariostatic compounds of propolis type-3 and -12 are mostly non-polar; and H-fr should be the fraction of choice for identifying further potentially novel anti-caries agents... - The influence of mutanase and dextranase on the production and structure of glucans synthesized by streptococcal glucosyltransferasesMitsue F Hayacibara
Faculty of Dentistry of Piracicaba, UNICAMP, Piracicaba, , Brazil
Carbohydr Res 339:2127-37. 2004..Our data have relevance for the formation of polysaccharide matrix of other biofilms... - Effect of a novel type of propolis and its chemical fractions on glucosyltransferases and on growth and adherence of mutans streptococciSimone Duarte
Department of Physiological Sciences, Dentistry School of Piracicaba, State University of Campinas Brazil, Sao Paulo
Biol Pharm Bull 26:527-31. 2003..The data showed that propolis type 6 remarkably reduced GTF activity and inhibited mutans streptococci growth and adherence; these biological activities are associated with its nonpolar components... - Extraction and purification of total RNA from Streptococcus mutans biofilmsJaime A Cury
Faculty of Dentistry of Piracicaba, State University of Campinas, Piracicaba, Sao Paulo, Brazil
Anal Biochem 365:208-14. 2007..The results demonstrated a method that yields high-quality RNA from biofilms of S. mutans in sufficient quantity for real-time RT-PCR analyses, and our data have relevance for isolation of RNA from other biofilm-forming microorganisms...
Research Grants
- Influence of Cranberry on Plaque-Related DiseasesHyun Koo; Fiscal Year: 2006..We also propose to examine the ability of cranberry to prevent or reduce caries in our well-proven rodent model and to investigate the effects of cranberry on plaque formation and gingivitis in vivo. ..
- Effects of Natural Agents with Fluoride on CariesHyun Koo; Fiscal Year: 2004....
- Evaluation of a Novel Anti-Caries Approach to Modulate Virulence of S. mutansHyun Koo; Fiscal Year: 2010..Our approach uses natural compounds, is highly effective without suppressing the resident oral flora (non-microbiocidal) and may decrease exposure to fluoride. ..
- Evaluation of a Novel Anti-Caries Approach to Modulate Virulence of S. mutansHyun Koo; Fiscal Year: 2009..Our approach uses natural compounds, is highly effective without suppressing the resident oral flora (non-microbiocidal) and may decrease exposure to fluoride. ..
- Molecular Basis for Caries Inhibiting Effects of Cranberry FlavonoidsHyun Koo; Fiscal Year: 2010....