Andrey A Komissarov

Summary

Affiliation: University of Texas Health Center
Country: USA

Publications

  1. pmc Active α-macroglobulin is a reservoir for urokinase after fibrinolytic therapy in rabbits with tetracycline-induced pleural injury and in human pleural fluids
    Andrey A Komissarov
    The Univ of Texas Health Science Center at Tyler, 11937 US Highway 271, Lab C 6, Tyler, TX 75708 or
    Am J Physiol Lung Cell Mol Physiol 305:L682-92. 2013
  2. pmc Regulation of intrapleural fibrinolysis by urokinase-alpha-macroglobulin complexes in tetracycline-induced pleural injury in rabbits
    Andrey A Komissarov
    Texas Lung Injury Institute of The University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA
    Am J Physiol Lung Cell Mol Physiol 297:L568-77. 2009
  3. pmc Effects of extracellular DNA on plasminogen activation and fibrinolysis
    Andrey A Komissarov
    Texas Lung Injury Institute, University of Texas Health Science Center at Tyler, Tyler, Texas 75708 3154, USA
    J Biol Chem 286:41949-62. 2011
  4. pmc Intrapleural adenoviral delivery of human plasminogen activator inhibitor-1 exacerbates tetracycline-induced pleural injury in rabbits
    Sophia Karandashova
    Texas Lung Injury Institute, University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
    Am J Respir Cell Mol Biol 48:44-52. 2013
  5. pmc Remarkable stabilization of plasminogen activator inhibitor 1 in a "molecular sandwich" complex
    Galina Florova
    Texas Lung Injury Institute, University of Texas Health Science Center at Tyler, 11937 U S Highway 271, Tyler, Texas 75708 3154, United States
    Biochemistry 52:4697-709. 2013
  6. pmc Wood bark smoke induces lung and pleural plasminogen activator inhibitor 1 and stabilizes its mRNA in porcine lung cells
    Krishna K Midde
    The Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
    Shock 36:128-37. 2011
  7. pmc Lipoprotein receptor-related protein 1 regulates collagen 1 expression, proteolysis, and migration in human pleural mesothelial cells
    Torry A Tucker
    The Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, 11937 US Highway 271, Biomedical Research Building, Lab C 5, Tyler, TX 75708, USA
    Am J Respir Cell Mol Biol 46:196-206. 2012
  8. pmc The urokinase receptor supports tumorigenesis of human malignant pleural mesothelioma cells
    Torry A Tucker
    The Texas Lung Injury Institute, University of Texas Health Science Center at Tyler, 11937 US Hwy 271, Biomedical Research Building, Lab C 5, Tyler, TX 75708, USA
    Am J Respir Cell Mol Biol 42:685-96. 2010
  9. pmc Novel aspects of urokinase function in the injured lung: role of α2-macroglobulin
    Andrey A Komissarov
    Texas Lung Injury Institute, University of Texas Health Science Center, Tyler, Texas, USA
    Am J Physiol Lung Cell Mol Physiol 303:L1037-45. 2012

Collaborators

Detail Information

Publications9

  1. pmc Active α-macroglobulin is a reservoir for urokinase after fibrinolytic therapy in rabbits with tetracycline-induced pleural injury and in human pleural fluids
    Andrey A Komissarov
    The Univ of Texas Health Science Center at Tyler, 11937 US Highway 271, Lab C 6, Tyler, TX 75708 or
    Am J Physiol Lung Cell Mol Physiol 305:L682-92. 2013
    ..This mechanism offers potential clinically relevant advantages that may enhance the bioavailability of intrapleural scuPA and may mitigate the risk of bleeding complications...
  2. pmc Regulation of intrapleural fibrinolysis by urokinase-alpha-macroglobulin complexes in tetracycline-induced pleural injury in rabbits
    Andrey A Komissarov
    Texas Lung Injury Institute of The University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA
    Am J Physiol Lung Cell Mol Physiol 297:L568-77. 2009
    ..These complexes promote uPA-mediated plasminogen activation in scuPA-treated rabbits with TCN-induced pleural injury...
  3. pmc Effects of extracellular DNA on plasminogen activation and fibrinolysis
    Andrey A Komissarov
    Texas Lung Injury Institute, University of Texas Health Science Center at Tyler, Tyler, Texas 75708 3154, USA
    J Biol Chem 286:41949-62. 2011
    ..Conversely, DNA could inhibit fibrinolysis by increasing the susceptibility of fibrinolytic enzymes to serpins...
  4. pmc Intrapleural adenoviral delivery of human plasminogen activator inhibitor-1 exacerbates tetracycline-induced pleural injury in rabbits
    Sophia Karandashova
    Texas Lung Injury Institute, University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
    Am J Respir Cell Mol Biol 48:44-52. 2013
    ..Therefore, active PAI-1 in PFs affects the outcome of IPFT, and may be both a biomarker of pleural injury and a molecular target for its treatment...
  5. pmc Remarkable stabilization of plasminogen activator inhibitor 1 in a "molecular sandwich" complex
    Galina Florova
    Texas Lung Injury Institute, University of Texas Health Science Center at Tyler, 11937 U S Highway 271, Tyler, Texas 75708 3154, United States
    Biochemistry 52:4697-709. 2013
    ..The stabilization of PAI-1 in MSCs in vivo may potentiate uncontrolled thrombosis or extravascular fibrin deposition, suggesting a new paradigm for using PAI-1 inhibitors and novel potential targets for therapy. ..
  6. pmc Wood bark smoke induces lung and pleural plasminogen activator inhibitor 1 and stabilizes its mRNA in porcine lung cells
    Krishna K Midde
    The Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
    Shock 36:128-37. 2011
    ....
  7. pmc Lipoprotein receptor-related protein 1 regulates collagen 1 expression, proteolysis, and migration in human pleural mesothelial cells
    Torry A Tucker
    The Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, 11937 US Highway 271, Biomedical Research Building, Lab C 5, Tyler, TX 75708, USA
    Am J Respir Cell Mol Biol 46:196-206. 2012
    ..These studies indicate that TNF-α and IL-1β regulate LRP-1 in PMCs and that LRP-1 thereby contributes to a range of pathophysiologically relevant responses of these cells...
  8. pmc The urokinase receptor supports tumorigenesis of human malignant pleural mesothelioma cells
    Torry A Tucker
    The Texas Lung Injury Institute, University of Texas Health Science Center at Tyler, 11937 US Hwy 271, Biomedical Research Building, Lab C 5, Tyler, TX 75708, USA
    Am J Respir Cell Mol Biol 42:685-96. 2010
    ....
  9. pmc Novel aspects of urokinase function in the injured lung: role of α2-macroglobulin
    Andrey A Komissarov
    Texas Lung Injury Institute, University of Texas Health Science Center, Tyler, Texas, USA
    Am J Physiol Lung Cell Mol Physiol 303:L1037-45. 2012
    ..Our findings indicate for the first time that the function of uPA in patients with ALI/ARDS may be modulated by α(2)-M and that the effects may include the regulation of the fibrinolytic and signaling activities of uPA...