Douglas J Kominsky

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. ncbi An endogenously anti-inflammatory role for methylation in mucosal inflammation identified through metabolite profiling
    Douglas J Kominsky
    Department of Anesthesiology and Perioperative Medicine, University of Colorado Health Science Center, Aurora, CO 80045, USA
    J Immunol 186:6505-14. 2011
  2. ncbi Abnormalities in glucose uptake and metabolism in imatinib-resistant human BCR-ABL-positive cells
    Douglas J Kominsky
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO, USA
    Clin Cancer Res 15:3442-50. 2009
  3. ncbi Resolvin E1-induced intestinal alkaline phosphatase promotes resolution of inflammation through LPS detoxification
    Eric L Campbell
    Mucosal Inflammation Program, Department of Medicine, University of Colorado, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 107:14298-303. 2010
  4. ncbi Metabolic characteristics of imatinib resistance in chronic myeloid leukaemia cells
    Jelena Klawitter
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO 80045, USA
    Br J Pharmacol 158:588-600. 2009
  5. ncbi Anti-inflammatory actions of adrenomedullin through fine tuning of HIF stabilization
    Christopher F MacManus
    Department of Medicine, University of Colorado Health Sciences Center, Aurora, Colorado, USA
    FASEB J 25:1856-64. 2011
  6. ncbi IFN-γ attenuates hypoxia-inducible factor (HIF) activity in intestinal epithelial cells through transcriptional repression of HIF-1β
    Louise E Glover
    Mucosal Inflammation Program, Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    J Immunol 186:1790-8. 2011
  7. ncbi Central role for endothelial human deneddylase-1/SENP8 in fine-tuning the vascular inflammatory response
    Stefan F Ehrentraut
    Mucosal Inflammation Program, Department of Medicine and Immunology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    J Immunol 190:392-400. 2013
  8. ncbi Contributions of neutrophils to resolution of mucosal inflammation
    Sean P Colgan
    Department of Medicine and the Mucosal Inflammation Program, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Immunol Res 55:75-82. 2013
  9. ncbi Metabolic shifts in immunity and inflammation
    Douglas J Kominsky
    Department of Anesthesiology, University of Colorado Denver Health Sciences Center, Aurora, CO 80045, USA
    J Immunol 184:4062-8. 2010
  10. ncbi Enhanced leukocyte HIF-1alpha and HIF-1 DNA binding in humans after rapid ascent to 4300 m
    Martha C Tissot van Patot
    Department of Anesthesiology, University of Colorado at Denver School of Medicine, Aurora, CO 80045, USA
    Free Radic Biol Med 46:1551-7. 2009

Collaborators

Detail Information

Publications15

  1. ncbi An endogenously anti-inflammatory role for methylation in mucosal inflammation identified through metabolite profiling
    Douglas J Kominsky
    Department of Anesthesiology and Perioperative Medicine, University of Colorado Health Science Center, Aurora, CO 80045, USA
    J Immunol 186:6505-14. 2011
    ..Taken together, these results identify a global change in methylation, which during inflammation, translates to an overall protective role in mucosal epithelia...
  2. ncbi Abnormalities in glucose uptake and metabolism in imatinib-resistant human BCR-ABL-positive cells
    Douglas J Kominsky
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO, USA
    Clin Cancer Res 15:3442-50. 2009
    ..In summary, elevated glucose uptake and nonoxidative glycolytic metabolic phenotype can be used as sensitive markers for early detection of imatinib resistance in BCR-ABL-positive cells...
  3. ncbi Resolvin E1-induced intestinal alkaline phosphatase promotes resolution of inflammation through LPS detoxification
    Eric L Campbell
    Mucosal Inflammation Program, Department of Medicine, University of Colorado, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 107:14298-303. 2010
    ..Together, these data implicate a previously unappreciated role for ALPI in RvE1-mediated inflammatory resolution...
  4. ncbi Metabolic characteristics of imatinib resistance in chronic myeloid leukaemia cells
    Jelena Klawitter
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO 80045, USA
    Br J Pharmacol 158:588-600. 2009
    ..Early detection of resistance development is crucial for imatinib-based treatment in chronic myeloid leukaemia (CML) patients. We aimed to distinguish metabolic markers of cell resistance to imatinib...
  5. ncbi Anti-inflammatory actions of adrenomedullin through fine tuning of HIF stabilization
    Christopher F MacManus
    Department of Medicine, University of Colorado Health Sciences Center, Aurora, Colorado, USA
    FASEB J 25:1856-64. 2011
    ..Taken together, these results identify ADM as an endogenously generated vascular mediator that functions as a mucosal protective factor through fine tuning of HIF activity...
  6. ncbi IFN-γ attenuates hypoxia-inducible factor (HIF) activity in intestinal epithelial cells through transcriptional repression of HIF-1β
    Louise E Glover
    Mucosal Inflammation Program, Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    J Immunol 186:1790-8. 2011
    ..These observations are relevant to the pathophysiology of colitis (i.e., that loss of HIF signaling during active inflammation may exacerbate disease pathogenesis)...
  7. ncbi Central role for endothelial human deneddylase-1/SENP8 in fine-tuning the vascular inflammatory response
    Stefan F Ehrentraut
    Mucosal Inflammation Program, Department of Medicine and Immunology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    J Immunol 190:392-400. 2013
    ..Moreover, our findings provide feasibility for therapeutic targeting of the Culs during inflammation...
  8. ncbi Contributions of neutrophils to resolution of mucosal inflammation
    Sean P Colgan
    Department of Medicine and the Mucosal Inflammation Program, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Immunol Res 55:75-82. 2013
    ..Here, we highlight several recent examples of how PMN coordinate the resolution of ongoing inflammation, with a particular focus on the gastrointestinal mucosa...
  9. ncbi Metabolic shifts in immunity and inflammation
    Douglas J Kominsky
    Department of Anesthesiology, University of Colorado Denver Health Sciences Center, Aurora, CO 80045, USA
    J Immunol 184:4062-8. 2010
    ..Such phenotypic shifts can imprint fundamental changes to tissue metabolism. In this study, we review recent work addressing metabolic changes and metabolic control of inflammation and immunity...
  10. ncbi Enhanced leukocyte HIF-1alpha and HIF-1 DNA binding in humans after rapid ascent to 4300 m
    Martha C Tissot van Patot
    Department of Anesthesiology, University of Colorado at Denver School of Medicine, Aurora, CO 80045, USA
    Free Radic Biol Med 46:1551-7. 2009
    ..001), as were urinary 15-F(2t)-isoprostanes (p=0.037). HIF-1 DNA binding and HIF-1alpha were elevated in vivo in leukocytes of healthy human subjects exposed to 12% oxygen, in association with plasma and urinary markers of hypoxic stress...
  11. ncbi Use of the 1-mm micro-probe for metabolic analysis on small volume biological samples
    Natalie J Serkova
    Biomedical MRI MRS Cancer Center Core, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Cell Mol Med 13:1933-41. 2009
    ..In this study, the use of the Bruker 1-mm micro-probe provides a convenient way to measure and quantify endogenous metabolic profiles of samples with a very low volume/weight/cell count...
  12. ncbi Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia
    Tobias Eckle
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, Aurora, USA
    Nat Med 18:774-82. 2012
    ....
  13. ncbi Glutamine-mediated attenuation of cellular metabolic dysfunction and cell death after injury is dependent on heat shock factor-1 expression
    Zhi Yong Peng
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, 80262, USA
    JPEN J Parenter Enteral Nutr 30:373-8; discussion 379. 2006
    ..Thus, GLN's beneficial effect on cellular metabolic dysfunction and cell survival appears to be dependent on HSF-1 expression...
  14. ncbi Metabolic regulation in the lactating mammary gland: a lipid synthesizing machine
    Michael C Rudolph
    Department of Physiology and Biophysics, University of Colorado Health Sciences Center at Fitzsimmons, Aurora, Colorado 80045, USA
    Physiol Genomics 28:323-36. 2007
    ..They also implicate the transcription factor SREBP-1c in regulation of part of the pathway...
  15. ncbi Defective leukocyte GM-CSF receptor (CD116) expression and function in inflammatory bowel disease
    Jonathan I Goldstein
    Mucosal Inflammation Program, Division of Gastroenterology and Hepatology, University of Colorado Denver, Aurora, Colorado 80045, USA
    Gastroenterology 141:208-16. 2011
    ..In this regard, there is much interest in therapies that activate innate immunity (eg, recombinant granulocyte-macrophage colony-stimulating factor)...