Douglas J Kominsky

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. pmc An endogenously anti-inflammatory role for methylation in mucosal inflammation identified through metabolite profiling
    Douglas J Kominsky
    Department of Anesthesiology and Perioperative Medicine, University of Colorado Health Science Center, Aurora, CO 80045, USA
    J Immunol 186:6505-14. 2011
  2. doi request reprint Abnormalities in glucose uptake and metabolism in imatinib-resistant human BCR-ABL-positive cells
    Douglas J Kominsky
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO, USA
    Clin Cancer Res 15:3442-50. 2009
  3. pmc Metabolic characteristics of imatinib resistance in chronic myeloid leukaemia cells
    Jelena Klawitter
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO 80045, USA
    Br J Pharmacol 158:588-600. 2009
  4. pmc Resolvin E1-induced intestinal alkaline phosphatase promotes resolution of inflammation through LPS detoxification
    Eric L Campbell
    Mucosal Inflammation Program, Department of Medicine, University of Colorado, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 107:14298-303. 2010
  5. pmc Anti-inflammatory actions of adrenomedullin through fine tuning of HIF stabilization
    Christopher F MacManus
    Department of Medicine, University of Colorado Health Sciences Center, Aurora, Colorado, USA
    FASEB J 25:1856-64. 2011
  6. doi request reprint IFN-γ attenuates hypoxia-inducible factor (HIF) activity in intestinal epithelial cells through transcriptional repression of HIF-1β
    Louise E Glover
    Mucosal Inflammation Program, Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    J Immunol 186:1790-8. 2011
  7. doi request reprint IFN-γ-Mediated Induction of an Apical IL-10 Receptor on Polarized Intestinal Epithelia
    Douglas J Kominsky
    Department of Anesthesiology and Perioperative Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045
    J Immunol 192:1267-76. 2014
  8. pmc HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium
    Tobias Eckle
    Organ Protection Program, Department of Anesthesiology, University of Colorado School of Medicine, Denver, Colorado, United States of America
    PLoS Biol 11:e1001665. 2013
  9. doi request reprint Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation
    Eric L Campbell
    Mucosal Inflammation Program, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA Electronic address
    Immunity 40:66-77. 2014
  10. pmc Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis
    Louise E Glover
    Mucosal Inflammation Program, Department of Medicine, Department of Anesthesiology and Perioperative Medicine, and Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045
    Proc Natl Acad Sci U S A 110:19820-5. 2013

Collaborators

Detail Information

Publications20

  1. pmc An endogenously anti-inflammatory role for methylation in mucosal inflammation identified through metabolite profiling
    Douglas J Kominsky
    Department of Anesthesiology and Perioperative Medicine, University of Colorado Health Science Center, Aurora, CO 80045, USA
    J Immunol 186:6505-14. 2011
    ..Taken together, these results identify a global change in methylation, which during inflammation, translates to an overall protective role in mucosal epithelia...
  2. doi request reprint Abnormalities in glucose uptake and metabolism in imatinib-resistant human BCR-ABL-positive cells
    Douglas J Kominsky
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO, USA
    Clin Cancer Res 15:3442-50. 2009
    ..In summary, elevated glucose uptake and nonoxidative glycolytic metabolic phenotype can be used as sensitive markers for early detection of imatinib resistance in BCR-ABL-positive cells...
  3. pmc Metabolic characteristics of imatinib resistance in chronic myeloid leukaemia cells
    Jelena Klawitter
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO 80045, USA
    Br J Pharmacol 158:588-600. 2009
    ..Early detection of resistance development is crucial for imatinib-based treatment in chronic myeloid leukaemia (CML) patients. We aimed to distinguish metabolic markers of cell resistance to imatinib...
  4. pmc Resolvin E1-induced intestinal alkaline phosphatase promotes resolution of inflammation through LPS detoxification
    Eric L Campbell
    Mucosal Inflammation Program, Department of Medicine, University of Colorado, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 107:14298-303. 2010
    ..Together, these data implicate a previously unappreciated role for ALPI in RvE1-mediated inflammatory resolution...
  5. pmc Anti-inflammatory actions of adrenomedullin through fine tuning of HIF stabilization
    Christopher F MacManus
    Department of Medicine, University of Colorado Health Sciences Center, Aurora, Colorado, USA
    FASEB J 25:1856-64. 2011
    ..Taken together, these results identify ADM as an endogenously generated vascular mediator that functions as a mucosal protective factor through fine tuning of HIF activity...
  6. doi request reprint IFN-γ attenuates hypoxia-inducible factor (HIF) activity in intestinal epithelial cells through transcriptional repression of HIF-1β
    Louise E Glover
    Mucosal Inflammation Program, Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    J Immunol 186:1790-8. 2011
    ..These observations are relevant to the pathophysiology of colitis (i.e., that loss of HIF signaling during active inflammation may exacerbate disease pathogenesis)...
  7. doi request reprint IFN-γ-Mediated Induction of an Apical IL-10 Receptor on Polarized Intestinal Epithelia
    Douglas J Kominsky
    Department of Anesthesiology and Perioperative Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045
    J Immunol 192:1267-76. 2014
    ..Together, these results provide novel insight into the crucial and underappreciated role of epithelial IL-10 signaling in the maintenance and restitution of epithelial barrier and of the temporal regulation of these pathways by IFN-γ. ..
  8. pmc HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium
    Tobias Eckle
    Organ Protection Program, Department of Anesthesiology, University of Colorado School of Medicine, Denver, Colorado, United States of America
    PLoS Biol 11:e1001665. 2013
    ..Therefore, we hypothesized that mechanical ventilation and concomitant stretch-exposure of pulmonary epithelia could activate endogenous pathways important in lung protection...
  9. doi request reprint Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation
    Eric L Campbell
    Mucosal Inflammation Program, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA Electronic address
    Immunity 40:66-77. 2014
    ..In conclusion, transcriptional imprinting by infiltrating neutrophils modulates the host response to inflammation, via localized O2 depletion, resulting in microenvironmental hypoxia and effective inflammatory resolution. ..
  10. pmc Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis
    Louise E Glover
    Mucosal Inflammation Program, Department of Medicine, Department of Anesthesiology and Perioperative Medicine, and Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045
    Proc Natl Acad Sci U S A 110:19820-5. 2013
    ..These findings establish a role for HIF-regulated CK in epithelial homeostasis and reveal a fundamental link between cellular bioenergetics and mucosal barrier. ..
  11. pmc Central role for endothelial human deneddylase-1/SENP8 in fine-tuning the vascular inflammatory response
    Stefan F Ehrentraut
    Mucosal Inflammation Program, Department of Medicine and Immunology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    J Immunol 190:392-400. 2013
    ..Moreover, our findings provide feasibility for therapeutic targeting of the Culs during inflammation...
  12. doi request reprint Contributions of neutrophils to resolution of mucosal inflammation
    Sean P Colgan
    Department of Medicine and the Mucosal Inflammation Program, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Immunol Res 55:75-82. 2013
    ..Here, we highlight several recent examples of how PMN coordinate the resolution of ongoing inflammation, with a particular focus on the gastrointestinal mucosa...
  13. doi request reprint Metabolic shifts in immunity and inflammation
    Douglas J Kominsky
    Department of Anesthesiology, University of Colorado Denver Health Sciences Center, Aurora, CO 80045, USA
    J Immunol 184:4062-8. 2010
    ..Such phenotypic shifts can imprint fundamental changes to tissue metabolism. In this study, we review recent work addressing metabolic changes and metabolic control of inflammation and immunity...
  14. doi request reprint Enhanced leukocyte HIF-1alpha and HIF-1 DNA binding in humans after rapid ascent to 4300 m
    Martha C Tissot van Patot
    Department of Anesthesiology, University of Colorado at Denver School of Medicine, Aurora, CO 80045, USA
    Free Radic Biol Med 46:1551-7. 2009
    ..001), as were urinary 15-F(2t)-isoprostanes (p=0.037). HIF-1 DNA binding and HIF-1alpha were elevated in vivo in leukocytes of healthy human subjects exposed to 12% oxygen, in association with plasma and urinary markers of hypoxic stress...
  15. doi request reprint Use of the 1-mm micro-probe for metabolic analysis on small volume biological samples
    Natalie J Serkova
    Biomedical MRI MRS Cancer Center Core, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Cell Mol Med 13:1933-41. 2009
    ..In this study, the use of the Bruker 1-mm micro-probe provides a convenient way to measure and quantify endogenous metabolic profiles of samples with a very low volume/weight/cell count...
  16. pmc Increased susceptibility of natural killer T-cell-deficient mice to acetaminophen-induced liver injury
    Brittany V Martin-Murphy
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
    Hepatology 57:1575-84. 2013
    ..Compared to WT mice, starvation of NKT cell-deficient mice induced a higher increase of ketone bodies, which up-regulate CYP2E1 through protein stabilization...
  17. pmc Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia
    Tobias Eckle
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, Aurora, USA
    Nat Med 18:774-82. 2012
    ....
  18. ncbi request reprint Glutamine-mediated attenuation of cellular metabolic dysfunction and cell death after injury is dependent on heat shock factor-1 expression
    Zhi Yong Peng
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, 80262, USA
    JPEN J Parenter Enteral Nutr 30:373-8; discussion 379. 2006
    ..We hypothesize that GLN's attenuation of cellular metabolic dysfunction is dependent on presence of heat shock factor-1 (HSF-1)...
  19. pmc Defective leukocyte GM-CSF receptor (CD116) expression and function in inflammatory bowel disease
    Jonathan I Goldstein
    Mucosal Inflammation Program, Division of Gastroenterology and Hepatology, University of Colorado Denver, Aurora, Colorado 80045, USA
    Gastroenterology 141:208-16. 2011
    ..In this regard, there is much interest in therapies that activate innate immunity (eg, recombinant granulocyte-macrophage colony-stimulating factor)...
  20. ncbi request reprint Metabolic regulation in the lactating mammary gland: a lipid synthesizing machine
    Michael C Rudolph
    Department of Physiology and Biophysics, University of Colorado Health Sciences Center at Fitzsimmons, Aurora, Colorado 80045, USA
    Physiol Genomics 28:323-36. 2007
    ..They also implicate the transcription factor SREBP-1c in regulation of part of the pathway...