L N Kolonel

Summary

Affiliation: University of Hawaii
Country: USA

Publications

  1. pmc Association between breast cancer susceptibility loci and mammographic density: the Multiethnic Cohort
    Christy G Woolcott
    Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Breast Cancer Res 11:R10. 2009
  2. pmc The association of mammographic density with ductal carcinoma in situ of the breast: the Multiethnic Cohort
    Jasmeet K Gill
    Cancer Research Center of Hawaii, Honolulu, Hawaii, USA
    Breast Cancer Res 8:R30. 2006
  3. pmc Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA
    BMC Cancer 9:43. 2009
  4. ncbi request reprint Dietary fat and prostate cancer: current status
    L N Kolonel
    Cancer Etiology Program, Cancer Research Center, University of Hawaii, Honolulu 96813, USA
    J Natl Cancer Inst 91:414-28. 1999
  5. ncbi request reprint The multiethnic cohort study: exploring genes, lifestyle and cancer risk
    Laurence N Kolonel
    Cancer Research Center, University of Hawaii, Honolulu, Hawaii 96813, USA
    Nat Rev Cancer 4:519-27. 2004
  6. ncbi request reprint Body mass index and physical activity as risk factors for pancreatic cancer: the Multiethnic Cohort Study
    Ute Nöthlings
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI, USA
    Cancer Causes Control 18:165-75. 2007
  7. ncbi request reprint B-vitamin intake, metabolic genes, and colorectal cancer risk (United States)
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu 96813, USA
    Cancer Causes Control 13:239-48. 2002
  8. ncbi request reprint Well-done red meat, metabolic phenotypes and colorectal cancer in Hawaii
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street Suite 407, Honolulu, HI 96813, USA
    Mutat Res 506:205-14. 2002
  9. ncbi request reprint Aggregation of ovarian cancer with breast, ovarian, colorectal, and prostate cancer in first-degree relatives
    Ko Hui Tung
    Cancer Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Am J Epidemiol 159:750-8. 2004
  10. pmc Meat and heterocyclic amine intake, smoking, NAT1 and NAT2 polymorphisms, and colorectal cancer risk in the multiethnic cohort study
    Ute Nöthlings
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 18:2098-106. 2009

Research Grants

  1. Multiethnic Cohort Study of Diet and Cancer
    Laurence Kolonel; Fiscal Year: 2007
  2. MULTIETHNIC/MINORITY COHORT STUDY OF DIET AND CANCER
    Laurence Kolonel; Fiscal Year: 2002
  3. MULTIETHNIC MINORITY COHORT STUDY OF DIET AND CANCER
    Laurence Kolonel; Fiscal Year: 1993

Detail Information

Publications109 found, 100 shown here

  1. pmc Association between breast cancer susceptibility loci and mammographic density: the Multiethnic Cohort
    Christy G Woolcott
    Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Breast Cancer Res 11:R10. 2009
    ..Mammographic density is a strong risk factor for breast cancer. Our objective was to examine its association with polymorphisms identifying breast cancer susceptibility loci that were ascertained in recent genome-wide association studies...
  2. pmc The association of mammographic density with ductal carcinoma in situ of the breast: the Multiethnic Cohort
    Jasmeet K Gill
    Cancer Research Center of Hawaii, Honolulu, Hawaii, USA
    Breast Cancer Res 8:R30. 2006
    ..However, little research has been done on mammographic density and ductal carcinoma in situ (DCIS) of the breast, which is thought to be a precursor lesion to some invasive breast cancers...
  3. pmc Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA
    BMC Cancer 9:43. 2009
    ....
  4. ncbi request reprint Dietary fat and prostate cancer: current status
    L N Kolonel
    Cancer Etiology Program, Cancer Research Center, University of Hawaii, Honolulu 96813, USA
    J Natl Cancer Inst 91:414-28. 1999
    ..Some suggestions for further research are offered...
  5. ncbi request reprint The multiethnic cohort study: exploring genes, lifestyle and cancer risk
    Laurence N Kolonel
    Cancer Research Center, University of Hawaii, Honolulu, Hawaii 96813, USA
    Nat Rev Cancer 4:519-27. 2004
  6. ncbi request reprint Body mass index and physical activity as risk factors for pancreatic cancer: the Multiethnic Cohort Study
    Ute Nöthlings
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI, USA
    Cancer Causes Control 18:165-75. 2007
    ..To examine body mass index (BMI) and physical activity as risk factors for pancreatic cancer...
  7. ncbi request reprint B-vitamin intake, metabolic genes, and colorectal cancer risk (United States)
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu 96813, USA
    Cancer Causes Control 13:239-48. 2002
    ....
  8. ncbi request reprint Well-done red meat, metabolic phenotypes and colorectal cancer in Hawaii
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street Suite 407, Honolulu, HI 96813, USA
    Mutat Res 506:205-14. 2002
    ..An attempt to examine the risk associated with specific HAAs suggested that the main HAAs increase risk of rectal cancer in men and that they do not appreciably affect risk of rectal cancer in women or of colon cancer in either sex...
  9. ncbi request reprint Aggregation of ovarian cancer with breast, ovarian, colorectal, and prostate cancer in first-degree relatives
    Ko Hui Tung
    Cancer Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Am J Epidemiol 159:750-8. 2004
    ..Study findings suggest that ovarian cancer aggregates with several common cancers in family members...
  10. pmc Meat and heterocyclic amine intake, smoking, NAT1 and NAT2 polymorphisms, and colorectal cancer risk in the multiethnic cohort study
    Ute Nöthlings
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 18:2098-106. 2009
    ..We investigated the modifying effects of NAT1 and NAT2 polymorphisms on the association of meat consumption, heterocyclic amine intake, and smoking with colorectal cancer risk...
  11. ncbi request reprint Reproductive factors and epithelial ovarian cancer risk by histologic type: a multiethnic case-control study
    Ko Hui Tung
    Cancer Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu 96813, USA
    Am J Epidemiol 158:629-38. 2003
    ..Mucinous tumors, both borderline and invasive, were more common in Asian women than in Caucasian and other women. Our data suggest that histologic types of epithelial ovarian cancer are etiologically distinct...
  12. ncbi request reprint Vegetable intake and pancreatic cancer risk: the multiethnic cohort study
    Ute Nöthlings
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI, USA
    Am J Epidemiol 165:138-47. 2007
    ..In conclusion, the authors found no evidence for an inverse association between vegetable intake and pancreatic cancer overall, but inverse associations in high-risk persons suggest the need for further investigation...
  13. pmc Dietary patterns and risk for diabetes: the multiethnic cohort
    Eva Erber
    Cancer Research Center, University of Hawaii, Honolulu, Hawaii, USA
    Diabetes Care 33:532-8. 2010
    ..005) than in men (0.92 [0.83-1.02], P(trend) = 0.04). CONCLUSIONS Foods high in meat and fat appear to confer a higher diabetes risk in all ethnic groups, whereas the effects of other dietary patterns vary by sex and ethnicity...
  14. ncbi request reprint Nonsteroidal antiinflammatory drugs and breast cancer risk: the multiethnic cohort
    Jasmeet K Gill
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI, USA
    Am J Epidemiol 166:1150-8. 2007
    ..This study found duration of current other NSAID use to be protective against breast cancer risk...
  15. pmc Dietary fiber, magnesium, and glycemic load alter risk of type 2 diabetes in a multiethnic cohort in Hawaii
    Beth N Hopping
    Department of Epidemiology, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    J Nutr 140:68-74. 2010
    ..These findings suggest that protection against diabetes can be achieved through food choices after taking into account body weight, but, due to differences in commonly consumed foods, risk estimates may differ by ethnic group...
  16. ncbi request reprint Lifestyle factors and chronic diseases: application of a composite risk index
    L Meng
    Prevention and Control Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu 96813, USA
    Prev Med 29:296-304. 1999
    ..Therefore, we developed a chronic disease risk index (CDRI) and investigated its relation with chronic disease in a multiethnic cohort...
  17. pmc Soy consumption is not protective against diabetes in Hawaii: the Multiethnic Cohort
    Y Morimoto
    Department of Epidemiology, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Eur J Clin Nutr 65:279-82. 2011
    ..The current findings do not support a protective effect of modest levels of soy food consumption against diabetes...
  18. pmc Urinary phytoestrogen excretion and prostate cancer risk: a nested case-control study in the Multiethnic Cohort
    S Y Park
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Br J Cancer 101:185-91. 2009
    ..Phytoestrogens are of special interest in prostate cancer research because populations in Asia with a high consumption of phytoestrogens have a lower incidence of the disease than comparable populations in Western countries...
  19. ncbi request reprint Intake of flavonoids and lung cancer
    L Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu 96813, USA
    J Natl Cancer Inst 92:154-60. 2000
    ..To investigate the possible relationship between intake of flavonoids-powerful dietary antioxidants that may also inhibit P450 enzymes-and lung cancer risk, we conducted a population-based, case-control study in Hawaii...
  20. ncbi request reprint Case-control study of ovarian cancer and polymorphisms in genes involved in catecholestrogen formation and metabolism
    M T Goodman
    Cancer Etiology Program, Cancer Research Center, University of Hawaii, Honolulu 96813, USA
    Cancer Epidemiol Biomarkers Prev 10:209-16. 2001
    ..These findings suggest that the CYP1B1-Val allele and perhaps other genetic polymorphisms in combination with environmental or hormonal exposures are susceptibility factors for ovarian cancer...
  21. doi request reprint The effect of multiple mailings on recruitment: the Multiethnic Cohort
    Alana D Steffen
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96822, USA
    Cancer Epidemiol Biomarkers Prev 17:447-54. 2008
    ....
  22. doi request reprint Nutrient intake from multivitamin/mineral supplements is similar among users from five ethnic groups: the Multiethnic Cohort Study
    Song Yi Park
    Cancer Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala St, Honolulu, HI 96813, USA
    J Am Diet Assoc 108:529-33. 2008
    ..When detailed information is not available, the same default nutrient profiles can be used when estimating intakes for these five ethnic groups...
  23. doi request reprint Overweight and obesity at different times in life as risk factors for non-Hodgkin's lymphoma: the multiethnic cohort
    Gertraud Maskarinec
    Cancer Research Center of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 17:196-203. 2008
    ..These findings indicate that weight at age 21 may represent lifetime adiposity better than body weight at cohort entry. Alternatively, weight at age 21 may be more relevant for the etiology of NHL...
  24. ncbi request reprint Nonsteroidal anti-inflammatory drugs (NSAIDs) and mammographic density
    Gertraud Maskarinec
    Cancer Research Center of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Breast Cancer Res Treat 112:133-9. 2008
    ..Experimental studies need to be performed to study the effect, if any, of NSAID use on breast density...
  25. ncbi request reprint Dietary glycemic load, added sugars, and carbohydrates as risk factors for pancreatic cancer: the Multiethnic Cohort Study
    Ute Nöthlings
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI, USA
    Am J Clin Nutr 86:1495-501. 2007
    ..However, results so far are scarce and inconsistent...
  26. ncbi request reprint Calcium, vitamin D, and dairy product intake and prostate cancer risk: the Multiethnic Cohort Study
    Song Yi Park
    Cancer Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Am J Epidemiol 166:1259-69. 2007
    ....
  27. ncbi request reprint Lifestyle risk factors for chronic disease in a multiethnic population: an analysis of two prospective studies over a 20-year period
    Gertraud Maskarinec
    Cancer Research Center of Hawaii, Honolulu, HI 96813, USA
    Ethn Dis 17:597-603. 2007
    ..This study investigated changes in risk factors in Hawaii over 20 years and compared health behaviors among ethnic groups with well-documented differences in disease risk...
  28. ncbi request reprint Dietary fiber and colorectal cancer risk: the multiethnic cohort study
    Abraham M Y Nomura
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Cancer Causes Control 18:753-64. 2007
    ..To investigate the association of dietary fiber with colorectal cancer..
  29. ncbi request reprint Fat and meat intake and prostate cancer risk: the multiethnic cohort study
    Song Yi Park
    Cancer Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Int J Cancer 121:1339-45. 2007
    ..However, overall, our findings from a large cohort study of ethnically diverse population give no indication that intake of fat and meat substantially affects prostate cancer risk...
  30. ncbi request reprint Calcium and vitamin D intake and risk of colorectal cancer: the Multiethnic Cohort Study
    Song Yi Park
    Cancer Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Am J Epidemiol 165:784-93. 2007
    ..77, 95% CI: 0.59, 1.01; women: RR = 0.66, 95% CI: 0.49, 0.89). The findings support the hypothesis of protective roles for calcium, vitamin D, and dairy products in the risk of colorectal cancer...
  31. pmc Carotenoid intake and colorectal cancer risk: the multiethnic cohort study
    Song Yi Park
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii 96813, USA
    J Epidemiol 19:63-71. 2009
    ..To examine associations between the intake of individual and total carotenoids and the risk of colorectal cancer, we analyzed prospective data from the Multiethnic Cohort Study...
  32. ncbi request reprint Dietary energy density is associated with overweight status among 5 ethnic groups in the multiethnic cohort study
    Nancy C Howarth
    Cancer Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI, USA
    J Nutr 136:2243-8. 2006
    ..Our findings suggest that consumption of an energy dense diet is a risk factor for higher BMI in both men and women across ethnic groups...
  33. doi request reprint The prevalence of obesity in ethnic admixture adults
    Cheryl L Albright
    Prevention and Control Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii, USA
    Obesity (Silver Spring) 16:1138-43. 2008
    ..To determine whether the prevalence of obesity in ethnic admixture adults varies systematically from the average of the prevalence estimates for the ethnic groups with whom they share a common ethnicity...
  34. pmc Association of Helicobacter pylori infection and diet on the risk of gastric cancer: a case-control study in Hawaii
    Meira Epplein
    Epidemiology Program, Cancer Research Center of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Cancer Causes Control 19:869-77. 2008
    ..Utilizing data from a case-control study among residents in Hawaii, we examined the association of diet, presence of H. pylori, and non-cardia gastric cancer risk...
  35. pmc Mammographic density as a predictor of breast cancer outcome
    Gertraud Maskarinec
    Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Future Oncol 6:351-4. 2010
    ..Future studies that incorporate additional risk factors, such as obesity, need to examine the role of mammographic density in larger patient populations before including breast density in treatment decision models...
  36. pmc Plasma 25-hydroxyvitamin D levels and the risk of colorectal cancer: the multiethnic cohort study
    Christy G Woolcott
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 19:130-4. 2010
    ..46). In summary, this study provides evidence of an association between vitamin D status and reduced risk of colorectal cancer in an ethnically diverse population...
  37. pmc Dietary patterns and the risk of non-Hodgkin lymphoma: the Multiethnic Cohort
    Eva Erber
    Cancer Research Center of Hawai i, University of Hawaii, Honolulu, HI, USA
    Leuk Lymphoma 50:1269-75. 2009
    ..03). The lack of significant results in men and women indicates a limited role of diet in NHL etiology, but dietary patterns might have ethnic- and subgroup-specific effects on NHL...
  38. pmc Urinary phytoestrogen excretion and postmenopausal breast cancer risk: the multiethnic cohort study
    Marc T Goodman
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Cancer Prev Res (Phila) 2:887-94. 2009
    ..07). Our results provide some support to the hypothesis that a diet rich in isoflavones from soy products reduces the risk of postmenopausal breast cancer, particularly in populations with comparatively high excretion of phytoestrogens...
  39. pmc Dietary vitamin D and risk of non-Hodgkin lymphoma: the multiethnic cohort
    Eva Erber
    Cancer Research Center of Hawai i, University of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Br J Nutr 103:581-4. 2010
    ..High dietary intake of vitamin D did not show a protective effect against NHL within the MEC except among African Americans, possibly because vitamin D production due to sun exposure is limited in this population...
  40. pmc Plasma carotenoids, retinol, and tocopherols and postmenopausal breast cancer risk in the Multiethnic Cohort Study: a nested case-control study
    Meira Epplein
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Breast Cancer Res 11:R49. 2009
    ..This multiethnic nested case-control study sought to examine the association of plasma carotenoids, retinol, and tocopherols with postmenopausal breast cancer risk...
  41. pmc Nonsteroidal antiinflammatory drugs and risk of gastric adenocarcinoma: the multiethnic cohort study
    Meira Epplein
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu, 96813, USA
    Am J Epidemiol 170:507-14. 2009
    ..92, 95% CI: 0.53, 1.60; P(trend) = 0.45). In this study, the authors found aspirin use to be inversely associated with distal gastric adenocarcinoma, particularly of the intestinal type...
  42. pmc Diabetes prevalence and body mass index differ by ethnicity: the Multiethnic Cohort
    Gertraud Maskarinec
    Cancer Research Center of Hawaii, 1236 Lauhala St, Honolulu, HI 96813, USA
    Ethn Dis 19:49-55. 2009
    ..The objectives of this study were to estimate the prevalence of diabetes among participants of the Multiethnic Cohort (MEC) and to examine the association of body mass index (BMI) with self-reported diabetes by ethnicity...
  43. pmc Breast cancer risk and hysterectomy status: the Multiethnic Cohort study
    Christy G Woolcott
    Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Cancer Causes Control 20:539-47. 2009
    ..Because hysterectomy prevalence varies by ethnicity, the secondary objective was to examine whether inclusion of women with hysterectomies affects the estimates of breast cancer risk by ethnicity...
  44. pmc Elevated plasma gamma-tocopherol and decreased alpha-tocopherol in men are associated with inflammatory markers and decreased plasma 25-OH vitamin D
    Robert V Cooney
    University of Hawaii at Manoa, Honolulu, Hawaii 96813, USA
    Nutr Cancer 60:21-9. 2008
    ..We hypothesize that plasma levels of tocopherols may serve as markers of systemic inflammation, complicating epidemiologic assessment of their role in cancer etiology...
  45. pmc Circulating fatty acids and prostate cancer risk in a nested case-control study: the Multiethnic Cohort
    Song Yi Park
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Cancer Causes Control 20:211-23. 2009
    ..Dietary fat, including specific fatty acids, has been proposed to contribute to prostate cancer pathogenesis, but findings from the studies based on biomarkers have been conflicting...
  46. doi request reprint Nutritional risk factors for gastrointestinal cancers: the multiethnic cohort study
    Laurence N Kolonel
    Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, Hawaii 96813, USA
    World Rev Nutr Diet 98:131-49. 2008
  47. ncbi request reprint Association of vegetable, fruit, and grain intakes with colorectal cancer: the Multiethnic Cohort Study
    Abraham M Y Nomura
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Am J Clin Nutr 88:730-7. 2008
    ..It is uncertain whether or not vegetables, fruit, or grains protect against colorectal cancer...
  48. pmc Legume and isoflavone intake and prostate cancer risk: The Multiethnic Cohort Study
    Song Yi Park
    Cancer Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Int J Cancer 123:927-32. 2008
    ..The findings of our study suggest that legume intake is associated with a moderate reduction in prostate cancer risk and that the isoflavones in soy products are probably not responsible for this effect...
  49. pmc Diabetes incidence based on linkages with health plans: the multiethnic cohort
    Gertraud Maskarinec
    Cancer Research Center, University of Hawaii, Honolulu, Hawaii, USA
    Diabetes 58:1732-8. 2009
    ..Using the Hawaii component of the Multiethnic Cohort (MEC), we estimated diabetes incidence among Caucasians, Japanese Americans, and Native Hawaiians...
  50. pmc Soy intake is related to a lower body mass index in adult women
    Gertraud Maskarinec
    Cancer Research Center of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Eur J Nutr 47:138-44. 2008
    ..Experimental and epidemiologic studies suggest that soy may promote weight loss...
  51. ncbi request reprint Trends of breast cancer incidence and risk factor prevalence over 25 years
    Gertraud Maskarinec
    Cancer Research Center, Honolulu, HI 96813, USA
    Breast Cancer Res Treat 98:45-55. 2006
    ..To examine the trends in the prevalence of breast cancer risk factors in relation to breast cancer incidence trends and to explore whether the changes in risk factors differed by ethnicity in Hawaii over a 25-year period...
  52. ncbi request reprint Trends and dietary determinants of overweight and obesity in a multiethnic population
    Gertraud Maskarinec
    Cancer Research Center of Hawaii, Honolulu, 96813, USA
    Obesity (Silver Spring) 14:717-26. 2006
    ..To describe trends in BMI among different ethnic groups in Hawaii and to explore the relation of nutrient and food intake with excess weight...
  53. pmc Factors associated with dietary supplement use among healthy adults of five ethnicities: the Multiethnic Cohort Study
    Janet A Foote
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Am J Epidemiol 157:888-97. 2003
    ..Participants whose lifestyles were healthier were more likely to use dietary supplements. Therefore, it may be difficult to separate the effects of supplement use from other lifestyle factors when studying disease etiology...
  54. ncbi request reprint Mammographic density and breast cancer risk: the multiethnic cohort study
    Gertraud Maskarinec
    Cancer Etiology Program, Cancer Research Center of Hawaii, Honolulu, HI 96813, USA
    Am J Epidemiol 162:743-52. 2005
    ..Because the risk estimates appeared higher for Caucasians and Native Hawaiians than for Japanese women, ethnicity-specific models may be necessary to predict risk from breast density in different ethnic groups...
  55. ncbi request reprint Association of an exon 1 polymorphism in the IGFBP3 gene with circulating IGFBP-3 levels and colorectal cancer risk: the multiethnic cohort study
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Suite 407, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 14:1319-21. 2005
    ..95; 95% CI, 1.35-2.83) than the colon (OR, 1.16; 95% CI, 0.92-1.45). These data suggest that the exon 1 G2133C missense variant in IGFBP3 may be a susceptibility factor for colorectal cancer...
  56. ncbi request reprint The MTHFR C677T polymorphism and colorectal cancer: the multiethnic cohort study
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Suite 407, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 14:1198-203. 2005
    ..It also suggests that this effect may be specific to advanced colon cancer...
  57. ncbi request reprint Ethnic differences in trends and determinants of cigarette smoking in Hawaii
    Gertraud Maskarinec
    Cancer Research Center of Hawaii, Honolulu, Hawaii 96813, USA
    Ethn Dis 15:316-23. 2005
    ..The goal of this project was to investigate the trends and predictors of cigarette smoking among a population of Caucasians, Japanese, Chinese, Filipino, and Native Hawaiians...
  58. ncbi request reprint Dietary patterns using the Food Guide Pyramid groups are associated with sociodemographic and lifestyle factors: the multiethnic cohort study
    Song Yi Park
    Cancer Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    J Nutr 135:843-9. 2005
    ..These findings support the hypothesis that dietary patterns are influenced by interrelated sociocultural, demographic, and other lifestyle factors and may be useful in investigations of diet-disease relations...
  59. ncbi request reprint Association of dietary vitamin A, carotenoids, and other antioxidants with the risk of ovarian cancer
    Ko Hui Tung
    Cancer Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 14:669-76. 2005
    ..Questions still remain regarding the effects of confounding factors, such as menopause, tobacco smoking, and alcohol drinking, on the association between antioxidants and ovarian cancer development...
  60. ncbi request reprint Effect of anovulation factors on pre- and postmenopausal ovarian cancer risk: revisiting the incessant ovulation hypothesis
    Ko Hui Tung
    Cancer Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Am J Epidemiol 161:321-9. 2005
    ....
  61. ncbi request reprint T29C polymorphism in the transforming growth factor beta1 gene and postmenopausal breast cancer risk: the Multiethnic Cohort Study
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI, USA
    Cancer Epidemiol Biomarkers Prev 13:412-5. 2004
    ..Given the strong biological rationale and the scarce and divergent epidemiologic data to date, additional investigations of the relationship between breast cancer and genetic variants in the TGF-beta signaling pathway appear warranted...
  62. ncbi request reprint Adherence to the Food Guide Pyramid recommendations among Japanese Americans, Native Hawaiians, and whites: results from the Multiethnic Cohort Study
    Sangita Sharma
    Cancer Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu 96813, USA
    J Am Diet Assoc 103:1195-8. 2003
    ..However, subjects in this energy-intake group also consumed more than three times as much discretionary fat, added sugar, and alcohol...
  63. ncbi request reprint MTHFR polymorphisms, diet, HRT, and breast cancer risk: the multiethnic cohort study
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Suite 407, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 13:2071-7. 2004
    ..This is consistent with the role of MTHFR in facilitating the flow of folate for thymidylate and purine synthesis and with the increased nucleic acid need resulting from the hyperproliferative effect of HRT on mammary epithelial cells...
  64. ncbi request reprint Liquid chromatographic-photodiode array mass spectrometric analysis of dietary phytoestrogens from human urine and blood
    Adrian A Franke
    Cancer Research Center of Hawai i, 1236 Lauhala Street, Honolulu, HI 96813, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 777:45-59. 2002
    ..Other successful applications of this assay in clinical and epidemiologic studies validated the developed method and confirmed previous results on the negative association between urinary isoflavone excretion and breast cancer risk...
  65. ncbi request reprint Meat and fat intake as risk factors for pancreatic cancer: the multiethnic cohort study
    Ute Nöthlings
    Cancer Research Center of Hawaii, Honolulu, HI, USA
    J Natl Cancer Inst 97:1458-65. 2005
    ..We analyzed data from the prospective Multiethnic Cohort Study to investigate associations between intake of meat, other animal products, fat, and cholesterol and pancreatic cancer risk...
  66. ncbi request reprint Dietary intakes and health-related behaviours of Korean American women born in the USA and Korea: the Multiethnic Cohort Study
    Song Yi Park
    Cancer Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Public Health Nutr 8:904-11. 2005
    ..This study assessed and compared heath-related behaviours and nutrient and food group intakes between US-born and Korea-born Korean American women...
  67. ncbi request reprint A comparison of two methods of measuring food group intake: grams vs servings
    Ute Nöthlings
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    J Am Diet Assoc 106:737-9. 2006
    ..00 for poultry, and 1.00 for fish. Because there was little effect on the ranking of study participants' intakes due to the method of calculating food group consumption, the two measures are interchangeable in disease risk models...
  68. ncbi request reprint Sun exposure, diet, and melanoma in Hawaii Caucasians
    Loic Le Marchand
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, 96813, USA
    Am J Epidemiol 164:232-45. 2006
    ..These data provide additional evidence for the association of constitutional susceptibility factors, intense sun exposure (particularly before age 20 years), and alcohol consumption with melanoma risk...
  69. ncbi request reprint Association of dairy products, lactose, and calcium with the risk of ovarian cancer
    Marc T Goodman
    Cancer Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Am J Epidemiol 156:148-57. 2002
    ..003), although a nonsignificant inverse gradient in risk was also found in relation to calcium supplement intake. These results suggest that intake of low-fat milk, calcium, or lactose may reduce the risk of ovarian cancer...
  70. ncbi request reprint Feasibility of collecting buccal cell DNA by mail in a cohort study
    L Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii 96813, USA
    Cancer Epidemiol Biomarkers Prev 10:701-3. 2001
    ....
  71. pmc The association of body size, reproductive factors and thyroid cancer
    M T Goodman
    Epidemiology Program, University of Hawaii, Honolulu 96813
    Br J Cancer 66:1180-4. 1992
    ....
  72. pmc Incidence trends and ethnic patterns for childhood leukaemia in Hawaii: 1960-1984
    M T Goodman
    Cancer Research Center, University of Hawaii, Honolulu 96813
    Br J Cancer 60:93-7. 1989
    ..Among females, incidence was higher among whites, Filipinos, Hawaiians and Chinese than among US whites, and lower among Japanese. Thus, there were notable sex differences in the ethnic distribution of this disease...
  73. ncbi request reprint Combined effects of well-done red meat, smoking, and rapid N-acetyltransferase 2 and CYP1A2 phenotypes in increasing colorectal cancer risk
    L Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii 96813, USA
    Cancer Epidemiol Biomarkers Prev 10:1259-66. 2001
    ....
  74. ncbi request reprint Correlation of dietary intake and colorectal cancer incidence among Mexican-American migrants: the multiethnic cohort study
    Kristine R Monroe
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
    Nutr Cancer 45:133-47. 2003
    ....
  75. ncbi request reprint Residential magnetic field exposure and breast cancer risk: a nested case-control study from a multiethnic cohort in Los Angeles County, California
    Stephanie J London
    Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Epidemiol 158:969-80. 2003
    ..49, 1.18)). Stronger measured fields were not significantly associated with increased risk. These data suggest that residential magnetic field exposures commonly experienced by US women do not influence risk of breast cancer...
  76. ncbi request reprint The association of glycemic load and carbohydrate intake with colorectal cancer risk in the Multiethnic Cohort Study
    Nancy C Howarth
    Cancer Epidemiology Program, Cancer Research Center of Hawai i, University of Hawai i, Honolulu, HI 96813, USA
    Am J Clin Nutr 88:1074-82. 2008
    ..High-glycemic-load diets may increase colorectal cancer risk through hyperinsulinemic effects...
  77. ncbi request reprint Modeling and E-M estimation of haplotype-specific relative risks from genotype data for a case-control study of unrelated individuals
    Daniel O Stram
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Hum Hered 55:179-90. 2003
    ..1]) the differences between the three methods are very small and in particular that the single imputation method may be expected to work extremely well...
  78. pmc Stage at diagnosis and survival in a multiethnic cohort of prostate cancer patients
    Ingrid Oakley-Girvan
    Stanford University School of Medicine, Stanford, California 94305 5405, USA
    Am J Public Health 93:1753-9. 2003
    ..We evaluated the effects of socioeconomic status and comorbidity on stage of disease and survival among 1509 population-based prostate cancer patients...
  79. ncbi request reprint Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasia
    Henry J Lin
    Division of Medical Genetics, Department of Pediatrics, and the Research and Education Institute at Harbor University of California, Los Angeles Medical Center, Torrance, California 90502, USA
    Cancer Epidemiol Biomarkers Prev 11:1305-15. 2002
    ..28-1.56; 138 cases and 258 controls). Consistency of the results across all three of the studies is potentially compatible with a protective effect of the polymorphism, mimicking aspirin...
  80. ncbi request reprint The relationship between twenty missense ATM variants and breast cancer risk: the Multiethnic Cohort
    Philip Bretsky
    University of Southern California Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA
    Cancer Epidemiol Biomarkers Prev 12:733-8. 2003
    ..Although a single missense variant (L546V) appeared to act as a modest predictor of risk, the remaining variants were no more common in breast cancer cases as compared with controls...
  81. ncbi request reprint A comprehensive haplotype analysis of CYP19 and breast cancer risk: the Multiethnic Cohort
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, USC Norris Comprehensive Cancer Center, 1441 Eastlake Ave, Rm 4441, Los Angeles, CA 90089 9175, USA
    Hum Mol Genet 12:2679-92. 2003
    ..31; 95% CI, 1.11-1.54). Our findings suggest the hypothesis that women with the long-range CYP19 haplotype 2b-3c may be carriers of a predisposing breast cancer susceptibility allele...
  82. ncbi request reprint Breast cancer in a multiethnic cohort in Hawaii and Los Angeles: risk factor-adjusted incidence in Japanese equals and in Hawaiians exceeds that in whites
    Malcolm C Pike
    Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Cancer Epidemiol Biomarkers Prev 11:795-800. 2002
    ..The adjusted RR of NHs is 65% greater than that of Ws, and that of migrant Latinas is 16% lower than that of Ws. Elucidating the causes of the high rates in NHs is now a major focus of our efforts...
  83. ncbi request reprint Gastric carcinoma: pathology findings in a multiethnic population
    Grant N Stemmermann
    Department of Pathology, University of Cincinnati, Cincinnati, Ohio 45267 0529, USA
    Cancer 95:744-50. 2002
    ..This study focuses on demographic differences in subsite locations and histologic types of gastric carcinoma...
  84. ncbi request reprint Haplotype-based association studies of IGFBP1 and IGFBP3 with prostate and breast cancer risk: the multiethnic cohort
    Iona Cheng
    Department of Epidemiology and Biostatistics and Center for Human Genetics, University of California San Francisco, San Francisco, California, USA
    Cancer Epidemiol Biomarkers Prev 15:1993-7. 2006
    ..Our results suggest that common genetic variation in the IGFBP1 and IGFBP3 genes do not substantially influence prostate and breast cancer susceptibility...
  85. ncbi request reprint Segregation analysis of prostate cancer in 1,719 white, African-American and Asian-American families in the United States and Canada
    Gail Gong
    Stanford University School of Medicine, Department of Health Research and Policy, CA 94305 5405, USA
    Cancer Causes Control 13:471-82. 2002
    ..However, higher observed frequencies in brothers than fathers may merely reflect the strong temporal changes in US incidence rates...
  86. ncbi request reprint Choosing haplotype-tagging SNPS based on unphased genotype data using a preliminary sample of unrelated subjects with an example from the Multiethnic Cohort Study
    Daniel O Stram
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, Calif 90033, USA
    Hum Hered 55:27-36. 2003
    ..A candidate set of htSNPS of a given size is chosen so as to maximize the minimum value of R2h over the common haplotypes, h...
  87. ncbi request reprint Clarifying the PROGINS allele association in ovarian and breast cancer risk: a haplotype-based analysis
    Celeste Leigh Pearce
    Department of Preventive Medicine, Norris Comprehensive Cancer Center, University of Southern California, Keck School of Medicine, Los Angeles, CA 90089, USA
    J Natl Cancer Inst 97:51-9. 2005
    ..We set out to refine the association between common variation at the PGR gene locus and these two diseases...
  88. ncbi request reprint Risk of early-onset prostate cancer in relation to germ line polymorphisms of the vitamin D receptor
    Ingrid Oakley-Girvan
    Department of Health Research and Policy, Stanford University School of Medicine, HRP Redwood Building, T204, Stanford, CA 94305 5405, USA
    Cancer Epidemiol Biomarkers Prev 13:1325-30. 2004
    ..S. Whites. If the FokI association noted here were causal, this difference could account for some of the disease burden among African Americans and some of the excess risk in African Americans compared with Whites...
  89. ncbi request reprint Risk factors for renal cell cancer: the multiethnic cohort
    Veronica Wendy Setiawan
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Am J Epidemiol 166:932-40. 2007
    ..045). Compared with nondrinkers, men who drank >or=1 drinks/day had a 31% lower risk (95% CI: 0.49, 0.96). Results show that body mass index, smoking, and hypertension are risk factors for renal cell cancer in both sexes...
  90. ncbi request reprint Dietary fiber intake and endogenous serum hormone levels in naturally postmenopausal Mexican American women: the Multiethnic Cohort Study
    Kristine R Monroe
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
    Nutr Cancer 58:127-35. 2007
    ..The suggestive findings relating increased estrogen levels to avocado and grapefruit intakes need confirmation...
  91. pmc Multiple regions within 8q24 independently affect risk for prostate cancer
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    Nat Genet 39:638-44. 2007
    ..None of the prostate cancer risk variants aligns to a known gene or alters the coding sequence of an encoded protein...
  92. ncbi request reprint Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
    Cancer Res 67:1893-7. 2007
    ..Thus, although genetic variation in CYP19A1 produces measurable differences in estrogen levels among postmenopausal women, the magnitude of the change was insufficient to contribute detectably to breast cancer...
  93. pmc Lung cancer incidence in never smokers
    Heather A Wakelee
    Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, USA
    J Clin Oncol 25:472-8. 2007
    ..However, data on this topic, particularly lung cancer incidence rates in never smokers, are limited...
  94. ncbi request reprint Common genetic variation in IGF1 and prostate cancer risk in the Multiethnic Cohort
    Iona Cheng
    Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    J Natl Cancer Inst 98:123-34. 2006
    ..Insulin-like growth factor I (IGF-I) appears to play a role in prostate development and carcinogenesis. We investigated whether genetic variation at the IGF1 locus is associated with prostate cancer risk...
  95. ncbi request reprint Ethnic disparity in the relationship between obesity and plasma insulin-like growth factors: the multiethnic cohort
    Katherine Delellis Henderson
    Keck School of Medicine, University of Southern California, Los Angeles, California 90033 0800, USA
    Cancer Epidemiol Biomarkers Prev 15:2298-302. 2006
    ....
  96. ncbi request reprint Racial/ethnic differences in endometrial cancer risk: the multiethnic cohort study
    Veronica Wendy Setiawan
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Am J Epidemiol 165:262-70. 2007
    ..92) for Latinas. Results from this study show that the interethnic differences in endometrial cancer risk do not appear to be explained by differences in the distribution of known risk factors among women of different races/ethnicities...
  97. ncbi request reprint Ethnic and racial differences in the smoking-related risk of lung cancer
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA 90089 9175, USA
    N Engl J Med 354:333-42. 2006
    ..There is remarkable variation in the incidence of lung cancer among ethnic and racial groups in the United States...
  98. ncbi request reprint Flavonols and pancreatic cancer risk: the multiethnic cohort study
    Ute Nöthlings
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI
    Am J Epidemiol 166:924-31. 2007
    ..lowest quartile = 0.41, 0.55, 0.27, 0.55, respectively) but not never or former smokers. This study provides evidence for a preventive effect of flavonols on pancreatic cancer, particularly for current smokers...
  99. ncbi request reprint Sequence variants of estrogen receptor beta and risk of prostate cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium
    Yen Ching Chen
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 16:1973-81. 2007
    ..Estrogen receptor beta (ESR2) may play a role in modulating prostate carcinogenesis through the regulation of genes related to cell proliferation and apoptosis...
  100. pmc IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3)
    Alpa V Patel
    Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, Georgia, United States of America
    PLoS ONE 3:e2578. 2008
    ..In summary, the impact of genetic variation in IGF1 and IGFBP3 on circulating IGF levels does not appear to substantially influence breast cancer risk substantially among primarily Caucasian postmenopausal women...
  101. ncbi request reprint Nutrition and physical activity and chronic disease prevention: research strategies and recommendations
    Ross L Prentice
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M3 A410, Seattle, WA 98109 1024, USA
    J Natl Cancer Inst 96:1276-87. 2004
    ....

Research Grants15

  1. Multiethnic Cohort Study of Diet and Cancer
    Laurence Kolonel; Fiscal Year: 2007
    ..Findings from the Multiethnic Cohort Study should help not only to identify dietary and other risk factors for cancer, but also to better understand the basis for ethnic variations in cancer incidence. ..
  2. MULTIETHNIC/MINORITY COHORT STUDY OF DIET AND CANCER
    Laurence Kolonel; Fiscal Year: 2002
    ..Findings from this study should help to elucidate relationships of diet to cancer, and to better understand the basis for ethnic variations in cancer incidence. ..
  3. MULTIETHNIC MINORITY COHORT STUDY OF DIET AND CANCER
    Laurence Kolonel; Fiscal Year: 1993
    ..The findings should contribute significantly to the future primary prevention of cancer...