Richard Kolodner


Affiliation: University of California
Country: USA


  1. Graham W, Putnam C, Kolodner R. The properties of Msh2-Msh6 ATP binding mutants suggest a signal amplification mechanism in DNA mismatch repair. J Biol Chem. 2018;293:18055-18070 pubmed publisher
  2. Srivatsan A, Li B, Szakal B, Branzei D, Putnam C, Kolodner R. The Swr1 chromatin-remodeling complex prevents genome instability induced by replication fork progression defects. Nat Commun. 2018;9:3680 pubmed publisher
  3. Goellner E, Putnam C, Graham W, Rahal C, Li B, Kolodner R. Identification of Exo1-Msh2 interaction motifs in DNA mismatch repair and new Msh2-binding partners. Nat Struct Mol Biol. 2018;25:650-659 pubmed publisher
    ..Our results identified two modes of Exo1 recruitment and a peptide module that mediates interactions between Msh2 and other proteins, and they support a model in which Exo1 functions in MMR by being tethered to the Msh2-Msh6 complex. ..
  4. request reprint
    Kolodner R, Tytell J, Schmeits J, Kane M, Gupta R, Weger J, et al. Germ-line msh6 mutations in colorectal cancer families. Cancer Res. 1999;59:5068-74 pubmed
    ..Our data suggest that germ-line msh6 mutations predispose individuals to primarily late-onset, familial colorectal carcinomas that do not fulfill classic criteria for HNPCC. ..
  5. Goellner E, Putnam C, Kolodner R. Exonuclease 1-dependent and independent mismatch repair. DNA Repair (Amst). 2015;32:24-32 pubmed publisher
    ..Here, we review what is known about the Exo1-independent and Exo1-dependent subpathways, including studies of mutations in MMR genes that specifically disrupt either subpathway. ..
  6. Smith C, Bowen N, Graham W, Goellner E, Srivatsan A, Kolodner R. Activation of Saccharomyces cerevisiae Mlh1-Pms1 Endonuclease in a Reconstituted Mismatch Repair System. J Biol Chem. 2015;290:21580-90 pubmed publisher
    ..The availability of this reconstituted MMR reaction should now make it possible to better study both Exo1-independent and Exo1-dependent MMR. ..
  7. Bowen N, Kolodner R. Reconstitution of Saccharomyces cerevisiae DNA polymerase ε-dependent mismatch repair with purified proteins. Proc Natl Acad Sci U S A. 2017;114:3607-3612 pubmed publisher
    ..These results demonstrate that Pol ε can act in eukaryotic MMR in vitro. ..
  8. Kolodner R, Mendillo M, Putnam C. Coupling distant sites in DNA during DNA mismatch repair. Proc Natl Acad Sci U S A. 2007;104:12953-4 pubmed
  9. Goellner E, Smith C, Campbell C, Hombauer H, Desai A, Putnam C, et al. PCNA and Msh2-Msh6 activate an Mlh1-Pms1 endonuclease pathway required for Exo1-independent mismatch repair. Mol Cell. 2014;55:291-304 pubmed publisher

More Information


  1. Putnam C, Kolodner R. Pathways and Mechanisms that Prevent Genome Instability in Saccharomyces cerevisiae. Genetics. 2017;206:1187-1225 pubmed publisher
    ..Integrated models for the formation and suppression of GCRs are discussed. ..
  2. Srivatsan A, Putnam C, Kolodner R. Analyzing Genome Rearrangements in Saccharomyces cerevisiae. Methods Mol Biol. 2018;1672:43-61 pubmed publisher
    ..cerevisiae genome. The assays also allow for the isolation of individual genome rearrangements for structural studies, and a method for analyzing genome rearrangements by next-generation DNA sequencing is provided. ..