Rahul M Kohli
Affiliation: University of Pennsylvania
- Grand challenge commentary: The chemistry of a dynamic genomeRahul M Kohli
Division of Infectious Disease, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Nat Chem Biol 6:866-8. 2010..These transformations significantly expand nature's diversity and may profoundly alter our view of DNA's coding potential...
- AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylationChristopher S Nabel
Department of Medicine, Raymond and Ruth Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Nat Chem Biol 8:751-8. 2012..Our results indicate that the steric requirements for cytosine deamination are one intrinsic barrier to the proposed function of deaminases in DNA demethylation...
- APOBEC3 inhibition of mouse mammary tumor virus infection: the role of cytidine deamination versus inhibition of reverse transcriptionAlyssa L Macmillan
Department of Microbiology, Institute for Immunology and Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Virol 87:4808-17. 2013..Our data suggest that while APOBEC3-mediated cytidine deamination of MMTV may occur, it is not the major means by which APOBEC3 restricts MMTV infection in vivo. This may reflect the long-term coexistence of MMTV and APOBEC3 in mice...
- The curious chemical biology of cytosine: deamination, methylation, and oxidation as modulators of genomic potentialChristopher S Nabel
Department of Medicine, Raymond and Ruth Perelman School of Medicine, University of Pennsylvania, Philadelphia, 19104, United States
ACS Chem Biol 7:20-30. 2012..Taken together, this rich medley of alterations renders cytosine a genomic "wild card", whose context-dependent functions make the base far more than a static letter in the code of life...
- Nucleic acid determinants for selective deamination of DNA over RNA by activation-induced deaminaseChristopher S Nabel
Departments of Medicine and Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104
Proc Natl Acad Sci U S A 110:14225-30. 2013..These data suggest a role for nucleotide sugar pucker in explaining the molecular basis for AID's DNA selectivity and, more generally, suggest how other nucleic acid-modifying enzymes may distinguish DNA from RNA. ..