Rahul M Kohli

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. doi request reprint Grand challenge commentary: The chemistry of a dynamic genome
    Rahul M Kohli
    Division of Infectious Disease, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Chem Biol 6:866-8. 2010
  2. pmc AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation
    Christopher S Nabel
    Department of Medicine, Raymond and Ruth Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Nat Chem Biol 8:751-8. 2012
  3. pmc Local sequence targeting in the AID/APOBEC family differentially impacts retroviral restriction and antibody diversification
    Rahul M Kohli
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 285:40956-64. 2010
  4. pmc The curious chemical biology of cytosine: deamination, methylation, and oxidation as modulators of genomic potential
    Christopher S Nabel
    Department of Medicine, Raymond and Ruth Perelman School of Medicine, University of Pennsylvania, Philadelphia, 19104, United States
    ACS Chem Biol 7:20-30. 2012
  5. pmc Nucleic acid determinants for selective deamination of DNA over RNA by activation-induced deaminase
    Christopher S Nabel
    Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 110:14225-30. 2013
  6. pmc TET enzymes, TDG and the dynamics of DNA demethylation
    Rahul M Kohli
    1 Department of Medicine, Raymond and Ruth Perelman School of Medicine, University of Pennsylvania, Philadelphia 19104, USA 2 Department of Biochemistry and Biophysics, Raymond and Ruth Perelman School of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Nature 502:472-9. 2013
  7. pmc APOBEC3 inhibition of mouse mammary tumor virus infection: the role of cytidine deamination versus inhibition of reverse transcription
    Alyssa L Macmillan
    Department of Microbiology, Institute for Immunology and Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Virol 87:4808-17. 2013
  8. pmc Different modes of retrovirus restriction by human APOBEC3A and APOBEC3G in vivo
    Spyridon Stavrou
    Department of Microbiology, Institute for Immunology and Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS Pathog 10:e1004145. 2014
  9. pmc A portable hot spot recognition loop transfers sequence preferences from APOBEC family members to activation-induced cytidine deaminase
    Rahul M Kohli
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 284:22898-904. 2009

Collaborators

Detail Information

Publications10

  1. doi request reprint Grand challenge commentary: The chemistry of a dynamic genome
    Rahul M Kohli
    Division of Infectious Disease, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Chem Biol 6:866-8. 2010
    ..These transformations significantly expand nature's diversity and may profoundly alter our view of DNA's coding potential...
  2. pmc AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation
    Christopher S Nabel
    Department of Medicine, Raymond and Ruth Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Nat Chem Biol 8:751-8. 2012
    ..Our results indicate that the steric requirements for cytosine deamination are one intrinsic barrier to the proposed function of deaminases in DNA demethylation...
  3. pmc Local sequence targeting in the AID/APOBEC family differentially impacts retroviral restriction and antibody diversification
    Rahul M Kohli
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 285:40956-64. 2010
    ..Although other mechanisms may also contribute, our results suggest that local sequence targeting by AID/APOBEC3 enzymes represents an elegant example of co-evolution of enzyme specificity with its target DNA sequence...
  4. pmc The curious chemical biology of cytosine: deamination, methylation, and oxidation as modulators of genomic potential
    Christopher S Nabel
    Department of Medicine, Raymond and Ruth Perelman School of Medicine, University of Pennsylvania, Philadelphia, 19104, United States
    ACS Chem Biol 7:20-30. 2012
    ..Taken together, this rich medley of alterations renders cytosine a genomic "wild card", whose context-dependent functions make the base far more than a static letter in the code of life...
  5. pmc Nucleic acid determinants for selective deamination of DNA over RNA by activation-induced deaminase
    Christopher S Nabel
    Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 110:14225-30. 2013
    ..These data suggest a role for nucleotide sugar pucker in explaining the molecular basis for AID's DNA selectivity and, more generally, suggest how other nucleic acid-modifying enzymes may distinguish DNA from RNA. ..
  6. pmc TET enzymes, TDG and the dynamics of DNA demethylation
    Rahul M Kohli
    1 Department of Medicine, Raymond and Ruth Perelman School of Medicine, University of Pennsylvania, Philadelphia 19104, USA 2 Department of Biochemistry and Biophysics, Raymond and Ruth Perelman School of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Nature 502:472-9. 2013
    ..Methylation, oxidation and repair now offer a model for a complete cycle of dynamic cytosine modification, with mounting evidence for its significance in the biological processes known to involve active demethylation. ..
  7. pmc APOBEC3 inhibition of mouse mammary tumor virus infection: the role of cytidine deamination versus inhibition of reverse transcription
    Alyssa L Macmillan
    Department of Microbiology, Institute for Immunology and Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Virol 87:4808-17. 2013
    ..Our data suggest that while APOBEC3-mediated cytidine deamination of MMTV may occur, it is not the major means by which APOBEC3 restricts MMTV infection in vivo. This may reflect the long-term coexistence of MMTV and APOBEC3 in mice...
  8. pmc Different modes of retrovirus restriction by human APOBEC3A and APOBEC3G in vivo
    Spyridon Stavrou
    Department of Microbiology, Institute for Immunology and Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS Pathog 10:e1004145. 2014
    ..We have thus developed an in vivo system for understanding how human A3 proteins use different modes of restriction, as well as a means for testing therapies that disrupt HIV Vif-A3G interactions. ..
  9. pmc A portable hot spot recognition loop transfers sequence preferences from APOBEC family members to activation-induced cytidine deaminase
    Rahul M Kohli
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 284:22898-904. 2009
    ....